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European Journal of Medical Research
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Open Access 01-12-2017 | Review

Clinical application prospect of umbilical cord-derived mesenchymal stem cells on clearance of advanced glycation end products through autophagy on diabetic wound

Authors: Yanfu Han, Tianjun Sun, Ran Tao, Yanqing Han, Jing Liu

Published in: European Journal of Medical Research | Issue 1/2017

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Abstract

Nowadays, wound healing delay due to diabetes is considered to be closely related to the accumulation of advanced glycation end products (AGEs). Although mesenchymal stem cells (MSCs) exhibit positive effects on diabetic wound healing, related mechanisms are still not fully elucidated. It has been reported that MSCs can improve the activity of autophagy in injured tissues, thereby playing an important role in wound healing. The autophagy induced by MSCs may be beneficial to diabetic wound healing via removing AGEs, which provide new ideas for clinical treatment of diabetic wounds with the potential of broad application prospects. In this study, the current research situation and application prospect of umbilical cord-derived MSCs on the clearance of AGEs in diabetic wound were reviewed.
Literature
1.
Wang R, Feng Y, Di B. Comparisons of negative pressure wound therapy and ultrasonic debridement for diabetic foot ulcers: a network meta-analysis. Int J Clin Exp Med. 2015;8(8):12548–56.PubMedPubMedCentral
2.
Nazaruk J, Borzym-Kluczyk M. The role of triterpenes in the management of diabetes mellitus and its complications. Phytochem Rev. 2015;14(4):675–90.CrossRefPubMed
3.
Pepe D, Elliott CG, Forbes TL, Hamilton DW. Detection of galectin-3 and localization of advanced glycation end products (AGE) in human chronic skin wounds. Histol Histopathol. 2014;29(2):251–8.PubMed
4.
Chang PC, Tsai SC, Jheng YH, Lin YF, Chen CC. Soft-tissue wound healing by anti-advanced glycation end-products agents. J Dent Res. 2014;93(4):388–93.CrossRefPubMed
5.
Niu Y, Cao X, Song F, Xie T, Ji X, Miao M, Dong J, Tian M, Lin Y, Lu S. Reduced dermis thickness and AGE accumulation in diabetic abdominal skin. Int J Low Extrem Wounds. 2012;11(3):224–30.CrossRefPubMed
6.
Tian M, Qing C, Niu Y, Dong J, Cao X, Song F, Ji X, Lu S. The relationship between inflammation and impaired wound healing in a diabetic rat burn model. J Burn Care Res. 2016;37(2):e115–24.CrossRefPubMed
7.
Grimm S, Ernst L, Grötzinger N, Höhn A, Breusing N, Reinheckel T, Grune T. Cathepsin D is one of the major enzymes involved in intracellular degradation of AGE-modified proteins. Free Radic Res. 2010;44(9):1013–26.CrossRefPubMed
8.
Grimm S, Horlacher M, Catalgol B, Hoehn A, Reinheckel T, Grune T. Cathepsins D and L reduce the toxicity of advanced glycation end products. Free Radic Biol Med. 2012;52(6):1011–23.CrossRefPubMed
9.
Peng KY, Horng LY, Sung HC, Huang HC, Wu RT. Hepatocyte growth factor has a role in the amelioration of diabetic vascular complications via autophagic clearance of advanced glycation end products: Dispo85E, an HGF inducer, as a potential botanical drug. Metabolism. 2011;60(6):888–92.CrossRefPubMed
10.
Lu K, Psakhye I, Jentsch S. Autophagic clearance of polyQ proteins mediated by ubiquitin-Atg8 adaptors of the conserved CUET protein family. Cell. 2014;158(3):549–63.CrossRefPubMed
11.
12.
13.
Stappenbeck TS, Miyoshi H. The role of stromal stem cells in tissue regeneration and wound repair. Science. 2009;324(5935):1666–9.CrossRefPubMed
14.
Wan J, Xia L, Liang W, Liu Y, Cai Q. Transplantation of bone marrow-derived mesenchymal stem cells promotes delayed wound healing in diabetic rats. J Diabetes Res. 2013;2013:1–11.CrossRef
15.
Navone SE, Pascucci L, Dossena M, Ferri A, Invernici G, Acerbi F, Cristini S, Bedini G, Tosetti V, Ceserani V, Bonomi A, Pessina A, Freddi G, Alessandrino A, Ceccarelli P, Campanella R, Marfia G, Alessandri G, Parati EA. Decellularized silk fibroin scaffold primed with adipose mesenchymal stromal cells improves wound healing in diabetic mice. Stem Cell Res Ther. 2014;5(1):7.CrossRefPubMedPubMedCentral
16.
Ma D, Kua JE, Lim WK, Lee ST, Chua AW. In vitro characterization of human hair follicle dermal sheath mesenchymal stromal cells and their potential in enhancing diabetic wound healing. Cytotherapy. 2015;17(8):1036–51.CrossRefPubMed
17.
Shrestha C, Zhao L, Chen K, He H, Mo Z. Enhanced healing of diabetic wound by subcutaneous administration of human umbilical cord derived stem cells and their conditioned media. Int J Endocrinol. 2013;2013:1–10.
18.
Fong CY, Tam K, Cheyyatraivendran S, Gan SU, Gauthaman K, Armugam A, Jeyaseelan K, Choolani M, Biswas A, Bongso A. Human Wharton’s jelly stem cells and its conditioned medium enhance healing of excisional and diabetic wounds. J Cell Biochem. 2014;115(2):290–302.CrossRefPubMed
19.
Xiao M, Li L, Hu Q, Liu L, Chu W, Zhang H. Rapamycin reduces burn wound progression by enhancing autophagy in deep second-degree burn in rats. Wound Repair Regen. 2013;21(6):852–9.CrossRefPubMed
20.
Xie K, Tian L, Guo X, Li K, Li J, Deng X, Li Q, Xia Q, Zhong Y, Huang Z, Liu J, Li S, Yang W, Cao Y. BmATG5 and BmATG6 mediate apoptosis following autophagy induced by 20-hydroxyecdysone or starvation. Autophagy. 2016;12(2):381–96.CrossRefPubMedPubMedCentral
21.
22.
Han YF, Sun TJ, Han YQ, Xu G, Liu J, Tao R. Clinical perspectives on mesenchymal stem cells promoting wound healing in diabetes mellitus patients by inducing autophagy. Eur Rev Med Pharmacol Sci. 2015;19(14):2666–70.PubMed
23.
Chen W, Wu Y, Li L, Yang M, Shen L, Liu G, Tan J, Zeng W, Zhu C. Adenosine accelerates the healing of diabetic ischemic ulcers by improving autophagy of endothelial progenitor cells grown on a biomaterial. Sci Rep. 2015;5:11594.CrossRefPubMedPubMedCentral
24.
Jung J, Choi JH, Lee Y, Park JW, Oh IH, Hwang SG, Kim KS, Kim GJ. Human placenta-derived mesenchymal stem cells promote hepatic regeneration in CCl4-injured rat liver model via increased autophagic mechanism. Stem Cells. 2013;31(8):1584–96.CrossRefPubMed
25.
Zhou Z, You Z. Mesenchymal stem cells alleviate LPS-induced acute lung injury in mice by MiR-142a-5p-controlled pulmonary endothelial cell autophagy. Cell Physiol Biochem. 2016;38(1):258–66.CrossRefPubMed
26.
Zhao K, Hao H, Liu J, Tong C, Cheng Y, Xie Z, Zang L, Mu Y, Han W. Bone marrow-derived mesenchymal stem cells ameliorate chronic high glucose-induced β-cell injury through modulation of autophagy. Cell Death Dis. 2015;6(e1885):1–13.
27.
Shin JY, Park HJ, Kim HN, Oh SH, Bae JS, Ha HJ, Lee PH. Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models. Autophagy. 2014;10(1):32–44.CrossRefPubMedPubMedCentral
28.
Wang K, Liu R, Li J, Mao J, Lei Y, Wu J, Zeng J, Zhang T, Wu H, Chen L, Huang C, Wei Y. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR and hypoxia-induced factor 1ɑ-mediated signaling. Autophagy. 2011;7(9):966–78.CrossRefPubMed
29.
Andrikopoulou E, Zhang X, Sebastian R, Marti G, Liu L, Milner SM, Harmon JW. Current insights into the role of HIF-1 in cutaneous wound healing. Curr Mol Med. 2011;11(3):218–35.CrossRefPubMed
30.
Arno AI, Amini-Nik S, Blit PH, Al-Shehab M, Belo C, Herer E, Tien CH, Jeschke MG. Human Wharton’s jelly mesenchymal stem cells promote skin wound healing through paracrine signaling. Stem Cell Res Ther. 2014;5(1):28–40.CrossRefPubMedPubMedCentral
Metadata
Title
Clinical application prospect of umbilical cord-derived mesenchymal stem cells on clearance of advanced glycation end products through autophagy on diabetic wound
Authors
Yanfu Han
Tianjun Sun
Ran Tao
Yanqing Han
Jing Liu
Publication date
01-12-2017
Publisher
BioMed Central
Published in
European Journal of Medical Research / Issue 1/2017
Electronic ISSN: 2047-783X
DOI
https://doi.org/10.1186/s40001-017-0253-1

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