Skip to main content
Top

Open Access 08-06-2024 | Chronic Pancreatitis | Original Article

An Improved Assessment Method to Estimate (Poly)phenol Intake in Adults with Chronic Pancreatitis

Authors: Katharine Siprelle, Ashley J. Kennedy, Emily B. Hill, Alice Hinton, Ni Shi, Peter Madril, Elizabeth Grainger, Christopher Taylor, Marcia Nahikian-Nelms, Colleen Spees, Fred K. Tabung, Phil A. Hart, Kristen M. Roberts

Published in: Digestive Diseases and Sciences

Login to get access

Abstract

Background

Insights into (poly)phenol exposure represent a modifiable factor that may modulate inflammation in chronic pancreatitis (CP), yet intake is poorly characterized and methods for assessment are underdeveloped.

Aims

The aims are to develop and test a method for estimating (poly)phenol intake from a 90-day food frequency questionnaire (FFQ) using the Phenol-Explorer database and determine associations with dietary patterns in CP patients versus controls via analysis of previously collected cross-sectional data.

Methods

Fifty-two CP patients and 48 controls were recruited from an ambulatory clinic at a large, academic institution. To assess the feasibility of the proposed methodology for estimating dietary (poly)phenol exposure, a retrospective analysis of FFQ data was completed. Mann–Whitney U tests were used to compare (poly)phenol intake by group; Spearman correlations and multivariable-adjusted log-linear associations were used to compare (poly)phenol intakes with dietary scores within the sample.

Results

Estimation of (poly)phenol intake from FFQs was feasible and produced estimates within a range of intake previously reported. Total (poly)phenol intake was significantly lower in CP vs controls (463 vs. 567mg/1000kcal; p = 0.041). In adjusted analyses, higher total (poly)phenol intake was associated with higher HEI-2015 (r = 0.34, p < 0.001), aMED (r = 0.22, p = 0.007), EDIH (r = 0.29, p < 0.001), and EDIP scores (r = 0.35, p < 0.001), representing higher overall diet quality and lower insulinemic and anti-inflammatory dietary potentials, respectively.

Conclusions

Using enhanced methods to derive total (poly)phenol intake from an FFQ is feasible. Those with CP have lower total (poly)phenol intake and less favorable dietary pattern indices, thus supporting future tailored dietary intervention studies in this population.

Graphical Abstract

Appendix
Available only for authorised users
Literature
3.
go back to reference O’Brien SJ, Omer E. Chronic pancreatitis and nutrition therapy. Nutr Clin Pract. 2019;34:S13–S26.PubMedCrossRef O’Brien SJ, Omer E. Chronic pancreatitis and nutrition therapy. Nutr Clin Pract. 2019;34:S13–S26.PubMedCrossRef
6.
go back to reference Roberts KM, Golian P, Nahikian-Nelms M, Hinton A, Madril P, Basch K et al. Does the healthy eating index and Mediterranean diet score identify the nutritional adequacy of dietary patterns in chronic pancreatitis? Dig Dis Sci. 2019;64:2318–2326.PubMedCrossRef Roberts KM, Golian P, Nahikian-Nelms M, Hinton A, Madril P, Basch K et al. Does the healthy eating index and Mediterranean diet score identify the nutritional adequacy of dietary patterns in chronic pancreatitis? Dig Dis Sci. 2019;64:2318–2326.PubMedCrossRef
7.
go back to reference Komar HM, Hart PA, Cruz-Monserrate Z, Conwell DL, Lesinski GB. Local and systemic expression of immunomodulatory factors in chronic pancreatitis. Pancreas. 2017;46:986–993.PubMedPubMedCentralCrossRef Komar HM, Hart PA, Cruz-Monserrate Z, Conwell DL, Lesinski GB. Local and systemic expression of immunomodulatory factors in chronic pancreatitis. Pancreas. 2017;46:986–993.PubMedPubMedCentralCrossRef
8.
9.
go back to reference Neveu V, Perez-Jimenez J, Vos F, Crespy V, du Chaffaut L, Mennen L et al. Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. Database 2010;2010:bap024.PubMedPubMedCentralCrossRef Neveu V, Perez-Jimenez J, Vos F, Crespy V, du Chaffaut L, Mennen L et al. Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. Database 2010;2010:bap024.PubMedPubMedCentralCrossRef
10.
go back to reference Kristal AR, Kolar AS, Fisher JL, Plascak JJ, Stumbo PJ, Weiss R et al. Evaluation of web-based, self-administered, graphical food frequency questionnaire. J Acad Nutr Diet. 2014;114:613–621.PubMedPubMedCentralCrossRef Kristal AR, Kolar AS, Fisher JL, Plascak JJ, Stumbo PJ, Weiss R et al. Evaluation of web-based, self-administered, graphical food frequency questionnaire. J Acad Nutr Diet. 2014;114:613–621.PubMedPubMedCentralCrossRef
11.
go back to reference Ribichini E, Stigliano S, Rossi S, Zaccari P, Sacchi MC, Bruno G et al. Role of fibre in nutritional management of pancreatic diseases. Nutrients. 2019;11:2219.PubMedPubMedCentralCrossRef Ribichini E, Stigliano S, Rossi S, Zaccari P, Sacchi MC, Bruno G et al. Role of fibre in nutritional management of pancreatic diseases. Nutrients. 2019;11:2219.PubMedPubMedCentralCrossRef
12.
go back to reference Conwell DL, Lee LS, Yadav D, Longnecker DS, Miller FH, Mortele KJ et al. American pancreatic association practice guidelines in chronic pancreatitis: evidence-based report on diagnostic guidelines. Pancreas. 2014;43:1143–1162.PubMedPubMedCentralCrossRef Conwell DL, Lee LS, Yadav D, Longnecker DS, Miller FH, Mortele KJ et al. American pancreatic association practice guidelines in chronic pancreatitis: evidence-based report on diagnostic guidelines. Pancreas. 2014;43:1143–1162.PubMedPubMedCentralCrossRef
14.
go back to reference Kennedy AJ. The Assessment of Polyphenols in Ulcerative Colitis. Columbus: The Ohio State University; 2019. Kennedy AJ. The Assessment of Polyphenols in Ulcerative Colitis. Columbus: The Ohio State University; 2019.
15.
go back to reference Zamora-Ros R, Knaze V, Rothwell JA, Hemon B, Moskal A, Overvad K et al. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur J Nutr. 2016;55:1359–1375.PubMedCrossRef Zamora-Ros R, Knaze V, Rothwell JA, Hemon B, Moskal A, Overvad K et al. Dietary polyphenol intake in Europe: the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Eur J Nutr. 2016;55:1359–1375.PubMedCrossRef
16.
go back to reference Knaze V, Rothwell JA, Zamora-Ros R, Moskal A, Kyro C, Jakszyn P et al. A new food-composition database for 437 polyphenols in 19,899 raw and prepared foods used to estimate polyphenol intakes in adults from 10 European countries. Am J Clin Nutr. 2018;108:517–524.PubMedCrossRef Knaze V, Rothwell JA, Zamora-Ros R, Moskal A, Kyro C, Jakszyn P et al. A new food-composition database for 437 polyphenols in 19,899 raw and prepared foods used to estimate polyphenol intakes in adults from 10 European countries. Am J Clin Nutr. 2018;108:517–524.PubMedCrossRef
17.
go back to reference Perez-Jimenez J, Fezeu L, Touvier M, Arnault N, Manach C, Hercberg S et al. Dietary intake of 337 polyphenols in French adults. Am J Clin Nutr. 2011;93:1220–1228.PubMedCrossRef Perez-Jimenez J, Fezeu L, Touvier M, Arnault N, Manach C, Hercberg S et al. Dietary intake of 337 polyphenols in French adults. Am J Clin Nutr. 2011;93:1220–1228.PubMedCrossRef
18.
go back to reference Plaza M, Domínguez-Rodríguez G, Castro-Puyana M, Marina ML. Polyphenols analysis and related challenges. In: G CM, ed. Elsevier; 2018; 177–232. Plaza M, Domínguez-Rodríguez G, Castro-Puyana M, Marina ML. Polyphenols analysis and related challenges. In: G CM, ed. Elsevier; 2018; 177–232.
19.
go back to reference Zamora-Ros R, Cayssials V, Jenab M, Rothwell JA, Fedirko V, Aleksandrova K et al. Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Eur J Epidemiol. 2018;33:1063–1075.PubMedPubMedCentralCrossRef Zamora-Ros R, Cayssials V, Jenab M, Rothwell JA, Fedirko V, Aleksandrova K et al. Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Eur J Epidemiol. 2018;33:1063–1075.PubMedPubMedCentralCrossRef
20.
go back to reference Xu Y, Le Sayec M, Roberts C, Hein S, Rodriguez-Mateos A, Gibson R. Dietary assessment methods to estimate (poly)phenol Intake in epidemiological studies: a systematic review. Adv Nutr. 2021;12:1781–1801.PubMedPubMedCentralCrossRef Xu Y, Le Sayec M, Roberts C, Hein S, Rodriguez-Mateos A, Gibson R. Dietary assessment methods to estimate (poly)phenol Intake in epidemiological studies: a systematic review. Adv Nutr. 2021;12:1781–1801.PubMedPubMedCentralCrossRef
21.
go back to reference Wang ZJ, Ohnaka K, Morita M, Toyomura K, Kono S, Ueki T et al. Dietary polyphenols and colorectal cancer risk: the Fukuoka colorectal cancer study. World J Gastroenterol. 2013;19:2683–2690.PubMedPubMedCentralCrossRef Wang ZJ, Ohnaka K, Morita M, Toyomura K, Kono S, Ueki T et al. Dietary polyphenols and colorectal cancer risk: the Fukuoka colorectal cancer study. World J Gastroenterol. 2013;19:2683–2690.PubMedPubMedCentralCrossRef
22.
go back to reference Vetrani C, Vitale M, Bozzetto L, Della Pepa G, Cocozza S, Costabile G et al. Association between different dietary polyphenol subclasses and the improvement in cardiometabolic risk factors: evidence from a randomized controlled clinical trial. Acta Diabetol. 2018;55:149–153.PubMedCrossRef Vetrani C, Vitale M, Bozzetto L, Della Pepa G, Cocozza S, Costabile G et al. Association between different dietary polyphenol subclasses and the improvement in cardiometabolic risk factors: evidence from a randomized controlled clinical trial. Acta Diabetol. 2018;55:149–153.PubMedCrossRef
23.
go back to reference Tresserra-Rimbau A, Medina-Remon A, Perez-Jimenez J, Martinez-Gonzalez MA, Covas MI, Corella D et al. Dietary intake and major food sources of polyphenols in a Spanish population at high cardiovascular risk: the PREDIMED study. Nutr Metab Cardiovasc Dis. 2013;23:953–959.PubMedCrossRef Tresserra-Rimbau A, Medina-Remon A, Perez-Jimenez J, Martinez-Gonzalez MA, Covas MI, Corella D et al. Dietary intake and major food sources of polyphenols in a Spanish population at high cardiovascular risk: the PREDIMED study. Nutr Metab Cardiovasc Dis. 2013;23:953–959.PubMedCrossRef
24.
go back to reference Burkholder-Cooley N, Rajaram S, Haddad E, Fraser GE, Jaceldo-Siegl K. Comparison of polyphenol intakes according to distinct dietary patterns and food sources in the Adventist Health Study-2 cohort. Br J Nutr. 2016;115:2162–2169.PubMedPubMedCentralCrossRef Burkholder-Cooley N, Rajaram S, Haddad E, Fraser GE, Jaceldo-Siegl K. Comparison of polyphenol intakes according to distinct dietary patterns and food sources in the Adventist Health Study-2 cohort. Br J Nutr. 2016;115:2162–2169.PubMedPubMedCentralCrossRef
25.
go back to reference Grosso G, Stepaniak U, Topor-Madry R, Szafraniec K, Pajak A. Estimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE study. Nutrition. 2014;30:1398–1403.PubMedPubMedCentralCrossRef Grosso G, Stepaniak U, Topor-Madry R, Szafraniec K, Pajak A. Estimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE study. Nutrition. 2014;30:1398–1403.PubMedPubMedCentralCrossRef
26.
go back to reference Huang Q, Braffett BH, Simmens SJ, Young HA, Ogden CL. Dietary polyphenol intake in US adults and 10-year trends: 2007–2016. J Acad Nutr Diet. 2020;120:1821–1833.PubMedCrossRef Huang Q, Braffett BH, Simmens SJ, Young HA, Ogden CL. Dietary polyphenol intake in US adults and 10-year trends: 2007–2016. J Acad Nutr Diet. 2020;120:1821–1833.PubMedCrossRef
27.
go back to reference Rothwell JA, Urpi-Sarda M, Boto-Ordonez M, Llorach R, Farran-Codina A, Barupal DK et al. Systematic analysis of the polyphenol metabolome using the phenol-explorer database. Mol Nutr Food Res. 2016;60:203–211.PubMedCrossRef Rothwell JA, Urpi-Sarda M, Boto-Ordonez M, Llorach R, Farran-Codina A, Barupal DK et al. Systematic analysis of the polyphenol metabolome using the phenol-explorer database. Mol Nutr Food Res. 2016;60:203–211.PubMedCrossRef
28.
go back to reference Panagiotakos DB, Pitsavos C, Arvaniti F, Stefanadis C. Adherence to the Mediterranean food pattern predicts the prevalence of hypertension, hypercholesterolemia, diabetes and obesity, among healthy adults; the accuracy of the MedDietScore. Prev Med. 2007;44:335–340.PubMedCrossRef Panagiotakos DB, Pitsavos C, Arvaniti F, Stefanadis C. Adherence to the Mediterranean food pattern predicts the prevalence of hypertension, hypercholesterolemia, diabetes and obesity, among healthy adults; the accuracy of the MedDietScore. Prev Med. 2007;44:335–340.PubMedCrossRef
29.
go back to reference Guenther PM, Reedy J, Krebs-Smith SM. Development of the healthy eating index-2005. J Am Diet Assoc. 2008;108:1896–1901.PubMedCrossRef Guenther PM, Reedy J, Krebs-Smith SM. Development of the healthy eating index-2005. J Am Diet Assoc. 2008;108:1896–1901.PubMedCrossRef
30.
go back to reference Tabung FK, Smith-Warner SA, Chavarro JE, Wu K, Fuchs CS, Hu FB et al. Development and validation of an empirical dietary inflammatory index. J Nutr. 2016;146:1560–1570.PubMedPubMedCentralCrossRef Tabung FK, Smith-Warner SA, Chavarro JE, Wu K, Fuchs CS, Hu FB et al. Development and validation of an empirical dietary inflammatory index. J Nutr. 2016;146:1560–1570.PubMedPubMedCentralCrossRef
31.
go back to reference Tabung FK, Wang W, Fung TT, Hu FB, Smith-Warner SA, Chavarro JE et al. Development and validation of empirical indices to assess the insulinaemic potential of diet and lifestyle. Br J Nutr. 2016;116:1787–1798.PubMedPubMedCentralCrossRef Tabung FK, Wang W, Fung TT, Hu FB, Smith-Warner SA, Chavarro JE et al. Development and validation of empirical indices to assess the insulinaemic potential of diet and lifestyle. Br J Nutr. 2016;116:1787–1798.PubMedPubMedCentralCrossRef
32.
go back to reference Roberts KM, Grainger EM, Thomas-Ahner JM, Hinton A, Gu J, Riedl K et al. Dose-dependent increases in ellagitannin metabolites as biomarkers of intake in humans consuming standardized black raspberry food products designed for clinical trials. Mol Nutr Food Res. 2020;64:e1900800.PubMedPubMedCentralCrossRef Roberts KM, Grainger EM, Thomas-Ahner JM, Hinton A, Gu J, Riedl K et al. Dose-dependent increases in ellagitannin metabolites as biomarkers of intake in humans consuming standardized black raspberry food products designed for clinical trials. Mol Nutr Food Res. 2020;64:e1900800.PubMedPubMedCentralCrossRef
33.
go back to reference Knobloch TJ, Ryan NM, Bruschweiler-Li L, Wang C, Bernier MC, Somogyi A et al. Metabolic regulation of glycolysis and AMP activated protein kinase pathways during Black Raspberry-mediated oral cancer chemoprevention. Metabolites. 2019;9:140.PubMedPubMedCentralCrossRef Knobloch TJ, Ryan NM, Bruschweiler-Li L, Wang C, Bernier MC, Somogyi A et al. Metabolic regulation of glycolysis and AMP activated protein kinase pathways during Black Raspberry-mediated oral cancer chemoprevention. Metabolites. 2019;9:140.PubMedPubMedCentralCrossRef
34.
go back to reference Gu J, Thomas-Ahner JM, Riedl KM, Bailey MT, Vodovotz Y, Schwartz SJ et al. Dietary Black Raspberries impact the colonic microbiome and phytochemical metabolites in mice. Mol Nutr Food Res. 2019;63:e1800636.PubMedCrossRef Gu J, Thomas-Ahner JM, Riedl KM, Bailey MT, Vodovotz Y, Schwartz SJ et al. Dietary Black Raspberries impact the colonic microbiome and phytochemical metabolites in mice. Mol Nutr Food Res. 2019;63:e1800636.PubMedCrossRef
35.
go back to reference Burkholder-Cooley NM, Rajaram SS, Haddad EH, Oda K, Fraser GE, Jaceldo-Siegl K. Validating polyphenol intake estimates from a food-frequency questionnaire by using repeated 24-h dietary recalls and a unique method-of-triads approach with 2 biomarkers. Am J Clin Nutr. 2017;105:685–694.PubMedPubMedCentralCrossRef Burkholder-Cooley NM, Rajaram SS, Haddad EH, Oda K, Fraser GE, Jaceldo-Siegl K. Validating polyphenol intake estimates from a food-frequency questionnaire by using repeated 24-h dietary recalls and a unique method-of-triads approach with 2 biomarkers. Am J Clin Nutr. 2017;105:685–694.PubMedPubMedCentralCrossRef
36.
go back to reference Giger U, Stanga Z, DeLegge MH. Management of chronic pancreatitis. Nutr Clin Pract. 2004;19(1):37–49.PubMedCrossRef Giger U, Stanga Z, DeLegge MH. Management of chronic pancreatitis. Nutr Clin Pract. 2004;19(1):37–49.PubMedCrossRef
37.
go back to reference Dutta SK, Hlasko J. Dietary fiber in pancreatic disease: effect of high fiber diet on fat malabsorption in pancreatic insufficiency and in vitro study of the interaction of dietary fiber with pancreatic enzymes. Am J Clin Nutr. 1985;41:517–525.PubMedCrossRef Dutta SK, Hlasko J. Dietary fiber in pancreatic disease: effect of high fiber diet on fat malabsorption in pancreatic insufficiency and in vitro study of the interaction of dietary fiber with pancreatic enzymes. Am J Clin Nutr. 1985;41:517–525.PubMedCrossRef
38.
go back to reference Naska A, Lagiou A, Lagiou P. Dietary assessment methods in epidemiological research: current state of the art and future prospects. F1000Res. 2017;6:926.PubMedPubMedCentralCrossRef Naska A, Lagiou A, Lagiou P. Dietary assessment methods in epidemiological research: current state of the art and future prospects. F1000Res. 2017;6:926.PubMedPubMedCentralCrossRef
39.
go back to reference Fung TT, Rexrode KM, Mantzoros CS, Manson JE, Willett WC, Hu FB. Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women. Circulation. 2009;119:1093–1100.PubMedPubMedCentralCrossRef Fung TT, Rexrode KM, Mantzoros CS, Manson JE, Willett WC, Hu FB. Mediterranean diet and incidence of and mortality from coronary heart disease and stroke in women. Circulation. 2009;119:1093–1100.PubMedPubMedCentralCrossRef
40.
go back to reference Bakirhan H, Pehlivan M, Uyar Cankay T, Kocak M. Migraine severity, disability, and duration: is a good diet quality, high intake of phytochemicals and polyphenols important? Front Nutr. 2022;9:1041907.PubMedPubMedCentralCrossRef Bakirhan H, Pehlivan M, Uyar Cankay T, Kocak M. Migraine severity, disability, and duration: is a good diet quality, high intake of phytochemicals and polyphenols important? Front Nutr. 2022;9:1041907.PubMedPubMedCentralCrossRef
41.
go back to reference Vitale M, Della Pepa G, Costabile G, Bozzetto L, Cipriano P, Signorini S et al. Association between diet quality and index of non-alcoholic steatohepatitis in a large population of people with type 2 diabetes: data from the TOSCA.IT study. Nutrients. 2022;14:5339.PubMedPubMedCentralCrossRef Vitale M, Della Pepa G, Costabile G, Bozzetto L, Cipriano P, Signorini S et al. Association between diet quality and index of non-alcoholic steatohepatitis in a large population of people with type 2 diabetes: data from the TOSCA.IT study. Nutrients. 2022;14:5339.PubMedPubMedCentralCrossRef
43.
go back to reference Ahn-Jarvis J, Lombardo E, Cruz-Monserrate Z, Badi N, Crowe O, Kaul S et al. Reduction of inflammation in chronic pancreatitis using a soy bread intervention: a feasibility study. Pancreatology. 2020;20:852–859.PubMedCrossRef Ahn-Jarvis J, Lombardo E, Cruz-Monserrate Z, Badi N, Crowe O, Kaul S et al. Reduction of inflammation in chronic pancreatitis using a soy bread intervention: a feasibility study. Pancreatology. 2020;20:852–859.PubMedCrossRef
44.
go back to reference Stoner GD, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V et al. Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. J Clin Pharmacol. 2005;45(10):1153–1164.PubMedCrossRef Stoner GD, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V et al. Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. J Clin Pharmacol. 2005;45(10):1153–1164.PubMedCrossRef
45.
go back to reference Gonzalez-Sarrias A, Gimenez-Bastida JA, Garcia-Conesa MT, Gomez-Sanchez MB, Garcia-Talavera NV, Gil-Izquierdo A et al. Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice. Mol Nutr Food Res. 2010;54:311–322.PubMedCrossRef Gonzalez-Sarrias A, Gimenez-Bastida JA, Garcia-Conesa MT, Gomez-Sanchez MB, Garcia-Talavera NV, Gil-Izquierdo A et al. Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice. Mol Nutr Food Res. 2010;54:311–322.PubMedCrossRef
46.
go back to reference Hill EB, Kennedy AJ, Roberts KM, Riedl KM, Grainger EM, Clinton SK. Considerations for use of the phenol-explorer database to estimate dietary (poly)phenol Intake. J Acad Nutr Diet. 2021;121:833–834.PubMedCrossRef Hill EB, Kennedy AJ, Roberts KM, Riedl KM, Grainger EM, Clinton SK. Considerations for use of the phenol-explorer database to estimate dietary (poly)phenol Intake. J Acad Nutr Diet. 2021;121:833–834.PubMedCrossRef
47.
go back to reference Arija V, Abellana R, Ribot B, Ramon JM. Biases and adjustments in nutritional assessments from dietary questionnaires. Nutr Hosp. 2015;31:113–118.PubMed Arija V, Abellana R, Ribot B, Ramon JM. Biases and adjustments in nutritional assessments from dietary questionnaires. Nutr Hosp. 2015;31:113–118.PubMed
48.
go back to reference Sohrab G, Hosseinpour-Niazi S, Hejazi J, Yuzbashian E, Mirmiran P, Azizi F. Dietary polyphenols and metabolic syndrome among Iranian adults. Int J Food Sci Nutr. 2013;64:661–667.PubMedCrossRef Sohrab G, Hosseinpour-Niazi S, Hejazi J, Yuzbashian E, Mirmiran P, Azizi F. Dietary polyphenols and metabolic syndrome among Iranian adults. Int J Food Sci Nutr. 2013;64:661–667.PubMedCrossRef
49.
go back to reference Tabung FK, Satija A, Fung TT, Clinton SK, Giovannucci EL. Long-term change in both dietary insulinemic and inflammatory potential is associated with weight gain in adult women and men. J Nutr. 2019;149:804–815.PubMedPubMedCentralCrossRef Tabung FK, Satija A, Fung TT, Clinton SK, Giovannucci EL. Long-term change in both dietary insulinemic and inflammatory potential is associated with weight gain in adult women and men. J Nutr. 2019;149:804–815.PubMedPubMedCentralCrossRef
50.
go back to reference Verhaegh BP, Reijven PL, Prins MH, Brouns JH, Masclee AA, Keulemans YC. Nutritional status in patients with chronic pancreatitis. Eur J Clin Nutr. 2013;67:1271–1276.PubMedCrossRef Verhaegh BP, Reijven PL, Prins MH, Brouns JH, Masclee AA, Keulemans YC. Nutritional status in patients with chronic pancreatitis. Eur J Clin Nutr. 2013;67:1271–1276.PubMedCrossRef
Metadata
Title
An Improved Assessment Method to Estimate (Poly)phenol Intake in Adults with Chronic Pancreatitis
Authors
Katharine Siprelle
Ashley J. Kennedy
Emily B. Hill
Alice Hinton
Ni Shi
Peter Madril
Elizabeth Grainger
Christopher Taylor
Marcia Nahikian-Nelms
Colleen Spees
Fred K. Tabung
Phil A. Hart
Kristen M. Roberts
Publication date
08-06-2024
Publisher
Springer US
Published in
Digestive Diseases and Sciences
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-024-08417-6
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Webinar | 06-02-2024 | 20:00 (CET)

Mastering chronic pancreatitis pain: A multidisciplinary approach and practical solutions

Severe pain is the most common symptom of chronic pancreatitis. In this webinar, experts share the latest insights in pain management for chronic pancreatitis patients. Experts from a range of disciplines discuss pertinent cases and provide practical suggestions for use within clinical practice.

Sponsored by: Viatris

Developed by: Springer Healthcare