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29-10-2024 | Chronic Kidney Disease | Original Article

Association between urine creatinine excretion and bone mineral density in chronic kidney disease: Results from the KNOW-CKD study

Authors: Sang-Eun Kim, Sung Hoon Jung, Jihyun Yang, Hyang Kim, Kyu-Beck Lee, Jayoun Kim, Jong Cheol Jeong, Ji Yong Jung, Seung Hyeok Han, Kook-Hwan Oh, Young Youl Hyun

Published in: Journal of Nephrology

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Abstract

Background

Decreased lean body mass or muscle mass is associated with decreased bone mineral density in individuals with preserved renal function. However, the association between muscle mass and bone mineral density in chronic kidney disease (CKD) patients is not well known. The aim of this study was to assess the relationship between muscle mass estimated from urine creatinine (UCr) and bone mineral density in Korean CKD patients.

Methods

This cross-sectional study analyzed 1872 participants from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort. Participants underwent UCr (g/day) and bone mineral density measurements, which were measured at the lumbar spine, total hip, and femoral neck by dual-energy X-ray absorptiometry. Patients were divided into three groups according to the tertiles of 24 h UCr (T1-T3).

Results

The mean values for 24 h urine creatinine of T1, T2, and T3 were 0.83 ± 0.23 g, 1.18 ± 0.24 g, and 1.55 ± 0.38 g, respectively. A total of 172 patients were diagnosed with osteoporosis. The number of patients in each group was 92 (14.4%) in T1, 45 (7.3%) in T2, and 35 (5.7%) in T3. The odds ratio (95% confidence interval) for osteoporosis was 0.37 (0.20–0.69) for 1 g/day increase of UCr. Compared with T1, the odds ratios (95% confidence interval) for osteoporosis were 0.58 (0.39–0.87) for T2 and 0.51 (0.32–0.80) for T3.

Conclusion

Low 24-h UCr was associated with low bone mineral density. Low 24 h UCr was significantly and independently associated with osteoporosis in Korean pre-dialysis CKD patients. Further research is warranted to verify the influence of muscle mass on bone health in CKD.

Graphical abstract

Appendix
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Metadata
Title
Association between urine creatinine excretion and bone mineral density in chronic kidney disease: Results from the KNOW-CKD study
Authors
Sang-Eun Kim
Sung Hoon Jung
Jihyun Yang
Hyang Kim
Kyu-Beck Lee
Jayoun Kim
Jong Cheol Jeong
Ji Yong Jung
Seung Hyeok Han
Kook-Hwan Oh
Young Youl Hyun
Publication date
29-10-2024
Publisher
Springer International Publishing
Published in
Journal of Nephrology
Print ISSN: 1121-8428
Electronic ISSN: 1724-6059
DOI
https://doi.org/10.1007/s40620-024-02123-2

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