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Clinical and Experimental Nephrology

27-09-2024 | Chronic Kidney Disease | Original article

Effect of age, sex, and chronic kidney disease on urinary creatinine excretion in Japanese patients

Authors: Shigehiro Yasui, Taro Horino, Keita Mitani, Yoshio Terada, Yoshiyasu Okuhara, Yutaka Hatakeyama

Published in: Clinical and Experimental Nephrology

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Abstract

Background

Urinary creatinine levels are used to estimate the excretion rates of certain analytes from the respective analyte-to-creatinine ratios. We clarified the influence of age and sex on estimated daily urinary creatinine excretion (eUCrE) based on the urinary creatinine level and daily urine volume.

Methods

All inpatients aged ≥ 18 years who attended the Kochi Medical School Hospital with serum and urinary creatinine measurement results were enrolled. Serum and urinary creatinine concentrations were extracted from the database and fluctuations with sex and age were investigated. The eUCrE was calculated for patients with early morning spot urine protein excretion (UPE), and daily urine volume was measured on the same day.

Results

Overall, 643 participants (322 men, 321 women) were enrolled. The eUCrE levels of men and women aged 18 − 64 and 18 − 44 years, respectively, significantly exceeded 1 g/day. Those of women aged 65–74 and ≥ 75 years were significantly lower than 1 g/day. Each age group was further categorised into Groups A (patients with eGFR ≥ 30 mL/min/1.73 m2 and UPE < 0.5 g/gCr), B (eGFR ≥ 30 mL/min/1.73 m2 and UPE ≥ 0.5 g/gCr), and C (eGFR < 30 mL/min/1.73 m2 and UPE ≥ 0.5 g/gCr). The eUCrE levels were the highest in Group A, followed by Groups B and C.

Conclusion

This study revealed age-, sex-, and renal function-related biases in adjusted values using urinary biomarkers, including proteinuria and creatinine ratio.
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Metadata
Title
Effect of age, sex, and chronic kidney disease on urinary creatinine excretion in Japanese patients
Authors
Shigehiro Yasui
Taro Horino
Keita Mitani
Yoshio Terada
Yoshiyasu Okuhara
Yutaka Hatakeyama
Publication date
27-09-2024
Publisher
Springer Nature Singapore
Published in
Clinical and Experimental Nephrology
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-024-02569-5

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