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BMC Cardiovascular Disorders

The methylation of TXNRD2 with chronic heart failure: the interaction effect between methylation regulation and clinical parameters-- a single center pilot study

Published in:
Authors
Rongrong Chen
Xufei Zhao
Bingqing Zhi
Rongqiang Zhang
Published in
BMC Cardiovascular Disorders | Issue 1/2025

Abstract

Objective

This study investigated the potential role of TXNRD2_FA44 promoter methylation in chronic heart failure (CHF) and its influence on disease mechanisms. Additionally, we explored the association between specific Cytosine-phosphate-Guanine (CpG) site methylation levels within the TXNRD2_FA44 promoter and various biochemical markers in CHF patients.

Methods

The study included 20 individuals suffering from chronic heart failure and an equal number of healthy participants. Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF–MS), CpG sites in the TXNRD2_FA44 promoter region were pinpointed and measured. The comparison of methylation levels was conducted between CHF patients and healthy individuals. Statistics was used to analyze the relationship between TXNRD2_FA44_CpG_27.28.29 and various key biochemical indicators.

Results

Patients with CHF exhibited significantly higher methylation levels at TXNRD2_FA44_CpG_27.28.29 compared to controls (P = 0.0008). This elevated methylation level correlated with levels of creatinine (Crea), estimated glomerular filtration rate (eGFR), percentage of lymphocytes (LYMPH), albumin (ALB), globulin (GLB), and the albumin-to-globin ratio (A/G) in CHF patients.

Conclusions

The methylation level of TXNRD2-FA44 in patients with chronic heart failure is significantly higher than controls, and the methylation level of TXNRD2-FA44 is related to multiple liver and kidney function indicators. These findings suggest that TXNRD2-FA44 could serve as a biomarker for CHF diagnosis and may affect the occurrence and development of CHF through liver and kidney function.
Title
The methylation of TXNRD2 with chronic heart failure: the interaction effect between methylation regulation and clinical parameters-- a single center pilot study
Authors
Rongrong Chen
Xufei Zhao
Bingqing Zhi
Rongqiang Zhang
Publication date
01-12-2025
Publisher
BioMed Central
Published in
BMC Cardiovascular Disorders / Issue 1/2025
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/s12872-025-04951-x
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  • Open Access
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  • Original Research

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