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26-07-2023 | Cholangitis | CASE REPORT

A Case of Cholangitis as a Nivolumab-Induced Immune-Related Adverse Event in a Patient with Pulmonary Metastasis After Surgery for Oral Cancer

Authors: Satoshi Fukuzawa, Kenji Yamagata, Fumihiko Uchida, Masato Endo, Noriaki Sakamoto, Hiroki Bukawa

Published in: Journal of Maxillofacial and Oral Surgery

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Abstract

We report a case of cholangitis, an immune-related adverse event (irAE), caused by the administration of nivolumab in a patient with lung metastasis of oral cancer. A 72-year-old man developed pulmonary metastasis after surgery for oral cancer. Hepatic enzyme abnormalities were observed after the second session of treatment, and irAE cholangitis was diagnosed based on the results of the blood test results and endoscopy findings. We suggested steroid treatment, but the patient refused it. Therefore, he was treated with ursodeoxycholic acid. The cholangitis gradually deteriorated, the patients’ general condition worsened, and he died 169 days after the onset of cholangitis.
Literature
5.
go back to reference Ferris RL, Blumenschein G Jr, Fayette J et al (2015) Nivolumab vs investigator`s choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by tumor PD-L1 expression. Oral Oncol 33:3541–3543 Ferris RL, Blumenschein G Jr, Fayette J et al (2015) Nivolumab vs investigator`s choice in recurrent or metastatic squamous cell carcinoma of the head and neck: 2-year long-term survival update of CheckMate 141 with analyses by tumor PD-L1 expression. Oral Oncol 33:3541–3543
Metadata
Title
A Case of Cholangitis as a Nivolumab-Induced Immune-Related Adverse Event in a Patient with Pulmonary Metastasis After Surgery for Oral Cancer
Authors
Satoshi Fukuzawa
Kenji Yamagata
Fumihiko Uchida
Masato Endo
Noriaki Sakamoto
Hiroki Bukawa
Publication date
26-07-2023
Publisher
Springer India
Published in
Journal of Maxillofacial and Oral Surgery
Print ISSN: 0972-8279
Electronic ISSN: 0974-942X
DOI
https://doi.org/10.1007/s12663-023-01976-7
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