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Intrahepatic cholangiocarcinoma as a unique subtype: key updates from current guidelines

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Excerpt

Cholangiocarcinoma (CCA) is the second most common primary liver cancer after hepatocellular carcinoma (HCC), accounting for approximately 10–15% of all primary liver cancers (Banales 2020). Biliary tract cancers (BTC) comprise a heterogeneous group of invasive adenocarcinomas originating from the gallbladder or cystic duct (GBC), and the biliary tree (CCA) (ESMO Guideline 2023). CCA is further subclassified into intrahepatic (iCCA), perihilar (pCCA), and distal (dCCA) subtypes, based on their anatomical location (EASL-ILCA Guideline 2023). ICCA arises between the bile ductules and the second-order bile ducts. …
Title
Intrahepatic cholangiocarcinoma as a unique subtype: key updates from current guidelines
Authors
Aaron Schindler
Timm Denecke
Daniel Seehofer
Florian van Bömmel
Thomas Berg
Publication date
01-12-2025
Publisher
Springer Berlin Heidelberg
Published in
Journal of Cancer Research and Clinical Oncology / Issue 12/2025
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-025-06342-3
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Image Credits
Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images