Validation of risk assessment scores in predicting venous thromboembolism in patients with lung cancer receiving immune checkpoint inhibitors
- Open Access
- 01-12-2024
- Checkpoint Inhibitors
- Research
Published in:
- Authors
- Jiarui Zhang
- Yufang Xie
- Linhui Yang
- Mengzhu Yang
- Rui Xu
- Dan Liu
- Published in
- BMC Pulmonary Medicine | Issue 1/2024
Abstract
Introduction
Several risk scores have been proposed to predict venous thromboembolism (VTE) in hospitalized patients. However, their predictive performances in lung cancer patients receiving immune checkpoint inhibitors (ICIs) is unclear. We aimed to validate and compare their performances of the Caprini, Padua and Khorana risk scores in lung cancer patients receiving ICIs.
Methods
This was a retrospective cohort study of patients with lung cancer treated with ICIs at West China Hospital between January 2018 and March 2022. The primary outcome was VTE during 12 months of follow-up from the first day of treatment with ICIs. The predictive performances of risk scores was determined using receiver operating characteristic (ROC) curve analysis.
Results
Among the 1115 eligible patients with lung cancer who received ICIs, 105 patients (9.4%) experienced VTE during the 12-month follow-up period. There was a statistically significant difference in the cumulative incidence of VTE between the different risk levels as determined by Caprini and Padua scores (all P < 0.001). However, no significant difference was observed for the Khorana score (P = 0.488). The Caprini and Padua scores demonstrated good discriminative performances (AUC 0.743, 95% CI 0.688-0.799 for Caprini score; AUC 0.745, 95% CI 0.687‐0.803 for Padua score), which were significantly better than that of the Khorana score (AUC 0.553, 95% CI, 0.493‐0.613) (P < 0.05).
Conclusion
In our study, the Caprini and Padua risk scores had better discriminative ability than the Khorana score to identify lung cancer patients treated with ICIs who were at high risk of VTE.
Advertisement
- Title
- Validation of risk assessment scores in predicting venous thromboembolism in patients with lung cancer receiving immune checkpoint inhibitors
- Authors
-
Jiarui Zhang
Yufang Xie
Linhui Yang
Mengzhu Yang
Rui Xu
Dan Liu
- Publication date
- 01-12-2024
- Publisher
- BioMed Central
- Published in
-
BMC Pulmonary Medicine / Issue 1/2024
Electronic ISSN: 1471-2466 - DOI
- https://doi.org/10.1186/s12890-024-03323-z
This content is only visible if you are logged in and have the appropriate permissions.
This content is only visible if you are logged in and have the appropriate permissions.
