Open Access
22-05-2025 | Cervical Cancer | Case Report
HPV-associated squamous cell carcinoma and adenocarcinoma in distinct cervical sites: a case report
Authors:
Huihui Chen, Qingyi Wang, Min Kang, Wei Huang, Hao Zhang, Jiaxin Li, Donghan Xu, Lin Zhao, Bowen Wu, Xin Lin, Liqi Li, Yuhong Zheng, Yihao Niu, Jiaqi Zhou, Donghui Huang, Peiyu Yan
Published in:
BMC Infectious Diseases
|
Issue 1/2025
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Abstract
Background
The synchronous occurrence of adenocarcinoma and squamous cell carcinoma in distinct cervical regions is exceptionally rare. This report highlights a case of HPV-associated adenocarcinoma and squamous cell carcinoma at distinct sites in a patient with primary stage IA1 cervical cancer.
Case presentation
A 54-year-old female tested HPV type 18 positive in a routine physical exam. Cervical Liquid - based Cytology Test (LCT) showed Atypical Squamous Cells of Undetermined Significance (ASCUS). Colposcopy-directed biopsies revealed moderately differentiated squamous cell carcinoma at multiple sites (3, 6, 9, 12 o’clock positions and the ECC), with a clinical diagnosis of stage IA1. Preoperative abdominal MRI (including contrast enhancement) showed no lymph node enlargement, and urinary CT urography was normal. Squamous cell carcinoma antigen levels were within the normal range.
