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Translational Stroke Research

25-09-2024 | Cerebral Ischemia | Review

Blood–Brain Barrier Disruption and Imaging Assessment in Stroke

Authors: Yuchen Liang, Yueluan Jiang, Jiaxin Liu, Xuewei Li, Xinyue Cheng, Lei Bao, Hongwei Zhou, Zhenni Guo

Published in: Translational Stroke Research

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Abstract

Disruption of the blood–brain barrier (BBB) is an important pathological hallmark of ischemic stroke. Blood–brain barrier disruption (BBBD) is a consequence of ischemia and may also exacerbate damage to brain parenchyma. Therefore, maintaining BBB integrity is critical for the central nervous system (CNS) homeostasis. This review offers a concise overview of BBB structure and function, along with the mechanisms underlying its impairment following a stroke. In addition, we review the recent imaging techniques employed to study blood–brain barrier permeability (BBBP) in the context of ischemic brain injury with the goal of providing imaging guidance for stroke diagnosis and treatment from the perspective of the BBBD. This knowledge is vital for developing strategies to safeguard the BBB during cerebral ischemia.
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Metadata
Title
Blood–Brain Barrier Disruption and Imaging Assessment in Stroke
Authors
Yuchen Liang
Yueluan Jiang
Jiaxin Liu
Xuewei Li
Xinyue Cheng
Lei Bao
Hongwei Zhou
Zhenni Guo
Publication date
25-09-2024
Publisher
Springer US
Published in
Translational Stroke Research
Print ISSN: 1868-4483
Electronic ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-024-01300-6