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Published in: Neurocritical Care 2/2022

21-03-2022 | Central Nervous System Trauma | Big Data in Neurocritical Care

Endotypes and the Path to Precision in Moderate and Severe Traumatic Brain Injury

Authors: Tej D. Azad, Pavan P. Shah, Han B. Kim, Robert D. Stevens

Published in: Neurocritical Care | Special Issue 2/2022

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Abstract

Heterogeneity is recognized as a major barrier in efforts to improve the care and outcomes of patients with traumatic brain injury (TBI). Even within the narrower stratum of moderate and severe TBI, current management approaches do not capture the complexity of this condition characterized by manifold clinical, anatomical, and pathophysiologic features. One approach to heterogeneity may be to resolve undifferentiated TBI populations into endotypes, subclasses that are distinguished by shared biological characteristics. The endotype paradigm has been explored in a range of medical domains, including psychiatry, oncology, immunology, and pulmonology. In intensive care, endotypes are being investigated for syndromes such as sepsis and acute respiratory distress syndrome. This review provides an overview of the endotype paradigm as well as some of its methods and use cases. A conceptual framework is proposed for endotype research in moderate and severe TBI, together with a scientific road map for endotype discovery and validation in this population.
Literature
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Metadata
Title
Endotypes and the Path to Precision in Moderate and Severe Traumatic Brain Injury
Authors
Tej D. Azad
Pavan P. Shah
Han B. Kim
Robert D. Stevens
Publication date
21-03-2022
Publisher
Springer US
Published in
Neurocritical Care / Issue Special Issue 2/2022
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-022-01475-6

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