Skip to main content
Top
Published in:

Open Access 01-12-2023 | Central Nervous System Trauma | Editorial

Neuroinflammation and Brain Disease

Authors: A. Bersano, J. Engele, M.K.E. Schäfer

Published in: BMC Neurology | Issue 1/2023

Login to get access

Abstract

Starting from the perspective of an immune-privileged site, our knowledge of the inflammatory processes within the central nervous system has increased rapidly over the last 30 years, leading to a rather puzzling picture today. Of particular interest is the emergence of disease- and injury-specific inflammatory responses within the brain, which may form the basis for future therapeutic approaches. To advance this important topic, we invite authors to contribute research and clinical papers to the Collection “Neuroinflammation and Brain Disease”.
Literature
1.
go back to reference Carson MJ, Thrash JC, Walter B. The cellular response in neuroinflammation: the role of leukocytes, microglia and astrocytes in neuronal death and survival. Clin Neurosci Res. 2009;6(5):237–45.CrossRef Carson MJ, Thrash JC, Walter B. The cellular response in neuroinflammation: the role of leukocytes, microglia and astrocytes in neuronal death and survival. Clin Neurosci Res. 2009;6(5):237–45.CrossRef
2.
4.
go back to reference Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. Neuroinflammation in Alzheimer’s disease. Lancet Neurol. 2015;14(4):388–405.CrossRefPubMedPubMedCentral Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. Neuroinflammation in Alzheimer’s disease. Lancet Neurol. 2015;14(4):388–405.CrossRefPubMedPubMedCentral
5.
go back to reference Ransohoff RM. How neuroinflammation contributes to neurodegeneration. Science. 2016;353(6301):777–83.CrossRefPubMed Ransohoff RM. How neuroinflammation contributes to neurodegeneration. Science. 2016;353(6301):777–83.CrossRefPubMed
9.
go back to reference Cianciulli A, Porro C, Calvello R, Trotta T, Lofrumento DD, Panaro MA. Microglia mediated neuroinflammation: focus on PI3K modulation. Biomolecules. 2020;10(1):137.CrossRefPubMedPubMedCentral Cianciulli A, Porro C, Calvello R, Trotta T, Lofrumento DD, Panaro MA. Microglia mediated neuroinflammation: focus on PI3K modulation. Biomolecules. 2020;10(1):137.CrossRefPubMedPubMedCentral
10.
go back to reference Jadhav SP, Kamath SP, Choolani M, Lu J, Dheen ST. microRNA-200b modulates microglia‐mediated neuroinflammation via the cJun/MAPK pathway. J Neurochem. 2014;130(3):388–401.CrossRefPubMed Jadhav SP, Kamath SP, Choolani M, Lu J, Dheen ST. microRNA-200b modulates microglia‐mediated neuroinflammation via the cJun/MAPK pathway. J Neurochem. 2014;130(3):388–401.CrossRefPubMed
11.
go back to reference Becher B, Spath S, Goverman J. Cytokine networks in neuroinflammation. Nat Rev Immunol. 2017;17(1):49–59.CrossRefPubMed Becher B, Spath S, Goverman J. Cytokine networks in neuroinflammation. Nat Rev Immunol. 2017;17(1):49–59.CrossRefPubMed
13.
go back to reference Jadhav P, Karande M, Sarkar A, Sahu S, Sarmah D, Datta A, Chaudhary A, Kalia K, Sharma A, Wang X, Bhattacharya P. Glial cells response in stroke. Cell Mol Neurobiol. 2023;43:99–113.CrossRefPubMed Jadhav P, Karande M, Sarkar A, Sahu S, Sarmah D, Datta A, Chaudhary A, Kalia K, Sharma A, Wang X, Bhattacharya P. Glial cells response in stroke. Cell Mol Neurobiol. 2023;43:99–113.CrossRefPubMed
14.
go back to reference Jadhav P, Karande M, Sarkar A, Sahu S, Sarmah D, Datta A, Chaudhary A, Kalia K, Sharma A, Wang X, Bhattacharya P. Glial cells response in stroke. Cell Mol Neurobiol. 2023;43:99–113.CrossRefPubMed Jadhav P, Karande M, Sarkar A, Sahu S, Sarmah D, Datta A, Chaudhary A, Kalia K, Sharma A, Wang X, Bhattacharya P. Glial cells response in stroke. Cell Mol Neurobiol. 2023;43:99–113.CrossRefPubMed
15.
go back to reference Blencowe M, Arneson D, Ding J, Chen YW, Saleem Z, Yang X. Network modeling of single-cell omics data: challenges, opportunities, and progresses. Emerg Top Life Sci. 2019;3:379–98.CrossRefPubMedPubMedCentral Blencowe M, Arneson D, Ding J, Chen YW, Saleem Z, Yang X. Network modeling of single-cell omics data: challenges, opportunities, and progresses. Emerg Top Life Sci. 2019;3:379–98.CrossRefPubMedPubMedCentral
16.
go back to reference Tuohy MC, Hillman EMC, Marshall R, Agalliu D. The age-dependent immune response to ischemic stroke. Curr Opin Neurobiol. 2023;78:102670.CrossRefPubMed Tuohy MC, Hillman EMC, Marshall R, Agalliu D. The age-dependent immune response to ischemic stroke. Curr Opin Neurobiol. 2023;78:102670.CrossRefPubMed
17.
18.
go back to reference Hanscom M, Loane DJ, Shea-Donohue T. Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury. J Clin Invest. 2021;131(12):e143777. Hanscom M, Loane DJ, Shea-Donohue T. Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury. J Clin Invest. 2021;131(12):e143777.
19.
go back to reference Li X, Wang Q, Wu D, Zhang D-w, Li S-c, Zhang S-w, Chen X, Li W. The effect of a novel anticonvulsant chemical Q808 on gut microbiota and hippocampus neurotransmitters in pentylenetetrazole-induced seizures in rats. BMC Neurosci. 2022;23:7.CrossRefPubMedPubMedCentral Li X, Wang Q, Wu D, Zhang D-w, Li S-c, Zhang S-w, Chen X, Li W. The effect of a novel anticonvulsant chemical Q808 on gut microbiota and hippocampus neurotransmitters in pentylenetetrazole-induced seizures in rats. BMC Neurosci. 2022;23:7.CrossRefPubMedPubMedCentral
20.
go back to reference Yang C, Feng Z, Deng H, Dai L, He L, Yin L, Zhao J. CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis. BMC Neurosci. 2022;23:67.CrossRefPubMedPubMedCentral Yang C, Feng Z, Deng H, Dai L, He L, Yin L, Zhao J. CXCL1/CXCR2 is involved in white matter injury in neonatal rats via the gut–brain axis. BMC Neurosci. 2022;23:67.CrossRefPubMedPubMedCentral
21.
go back to reference Faden AI, Barrett JP, Stoica BA, Henry RJ. Bidirectional brain-systemic interactions and outcomes after TBI. Trends in Neuroscience. 2021;44:406–18.CrossRef Faden AI, Barrett JP, Stoica BA, Henry RJ. Bidirectional brain-systemic interactions and outcomes after TBI. Trends in Neuroscience. 2021;44:406–18.CrossRef
22.
go back to reference Ramiro L, Faura J, Simats A, García-Rodríguez P, Ma F, Martín L, Canals F, Rosell A, Montaner J. Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia. BMC Neurosci. 2023;24:7.CrossRefPubMedPubMedCentral Ramiro L, Faura J, Simats A, García-Rodríguez P, Ma F, Martín L, Canals F, Rosell A, Montaner J. Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia. BMC Neurosci. 2023;24:7.CrossRefPubMedPubMedCentral
24.
go back to reference Irimia A, Wang B, Aylward SR, Prastawa MW, Pace DF, Gerig G, Hovda DA, Kikinis R, Vespa PM, Van Horn JD. Neuroimaging of structural pathology and connectomics in traumatic brain injury: toward personalized outcome prediction. Neuroimage: Clin. 2012;1:1–17.CrossRefPubMed Irimia A, Wang B, Aylward SR, Prastawa MW, Pace DF, Gerig G, Hovda DA, Kikinis R, Vespa PM, Van Horn JD. Neuroimaging of structural pathology and connectomics in traumatic brain injury: toward personalized outcome prediction. Neuroimage: Clin. 2012;1:1–17.CrossRefPubMed
25.
go back to reference Bernhardt AM, Tiedt S, Teupser D, Dichgans M, Meyer B, Gempt J, Kuhn PH, Simons M, Palleis C, Weidinger E, Nübling G, Holdt L, Hönikl L, Gasperi C, Giesbertz P, Müller SA, Breimann S, Lichtenthaler SF, Kuster B, Mann M, Imhof A, Barth T, Hauck SM, Zetterberg H, Otto M, Weichert W, Hemmer B, Levin J. A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases. EBioMedicine. 2023;89:104456. Bernhardt AM, Tiedt S, Teupser D, Dichgans M, Meyer B, Gempt J, Kuhn PH, Simons M, Palleis C, Weidinger E, Nübling G, Holdt L, Hönikl L, Gasperi C, Giesbertz P, Müller SA, Breimann S, Lichtenthaler SF, Kuster B, Mann M, Imhof A, Barth T, Hauck SM, Zetterberg H, Otto M, Weichert W, Hemmer B, Levin J. A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases. EBioMedicine. 2023;89:104456.
Metadata
Title
Neuroinflammation and Brain Disease
Authors
A. Bersano
J. Engele
M.K.E. Schäfer
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2023
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-023-03252-0

Other articles of this Issue 1/2023

BMC Neurology 1/2023 Go to the issue