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Early Hyperosmolarity and Favorable Outcome in Severe Traumatic Brain Injury? Take it with a Grain of Salt

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Excerpt

Weed and McKibben [1, 2] first reported brain tissue shrinkage and reduced cerebrospinal fluid pressure after intravenous injection of concentrated salt solutions. These findings challenged notions of fixed brain volume held by Kellie [3] and contemporaries. With the advent of continuous intracranial pressure (ICP) measurement [4], these experiments formed the foundation of hyperosmolar therapy for traumatic brain injury (TBI). Early approaches used varying concentrations of sodium chloride, glucose, glycerol, and urea [512]. Mannitol was predominately used starting in the 1960s [13], with hypertonic saline adopted in the 1980s [5, 14]. …
Title
Early Hyperosmolarity and Favorable Outcome in Severe Traumatic Brain Injury? Take it with a Grain of Salt
Authors
Jennifer C. Laws
Amelia W. Maiga
Mayur B. Patel
Michael S. Wolf
Publication date
12-07-2024
Publisher
Springer US
Published in
Neurocritical Care / Issue 3/2024
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-024-02033-y
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