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12 Cases

A 63-year-old man presents for work-up of pancytopenia with recurrent fever. He presents in reduced general condition, with hepatosplenomegaly but without palpable lymph nodes. Laboratory diagnosis reveals bicytopenia, hyperferritinaemia, elevated levels of soluble interleukin 2 receptor (sIL2-R) and C-reactive protein (CRP). How do you proceed?

A 66-year-old female patient with pre-existing osteoporosis and rheumatoid arthritis reported large haematomas all over her body, especially on the extremities, which had been increasing for about five days. No trauma is remembered. She also complains of marked fatigue. What is your tentative diagnosis?

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An 86-year-old male patient with long-standing seropositive rheumatoid arthritis is under regular rheumatological care. There is currently no systemic therapy, but the latest laboratory examination revealed persistent neutropenia. How do you proceed diagnostically?

This content was originally published in German and has been translated to English.