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Cardiovascular Diabetology

Issue 1/2025

Content (465 Articles)

Longitudinal changes in remnant cholesterol and the risk of cardiovascular disease

Yijun Zhang, Qin Xu, Xue Tian, Xue Xia, Shuohua Chen, Fen Liu, Shouling Wu, Anxin Wang

Visceral adipose tissue mediates the relationship between left ventricular global longitudinal strain and insulin resistance among adults living with type 2 diabetes

Pavel Martinez-Dominguez, Paola Gomez-Aviles, Kenya Bautista-García, Neftali Eduardo Antonio-Villa, Enrique C. Guerra, Paloma Almeda-Valdes, Alexandro J. Martagón, Alejandro Campos Munoz, Maria Jose Santa-Ana-Bayona, Erick Alexanderson, Carlos A. Aguilar Salinas, Nilda Espinola-Zavaleta

Deep-learning prediction of cardiovascular outcomes from routine retinal images in individuals with type 2 diabetes

Mohammad Ghouse Syed, Emanuele Trucco, Muthu R. K. Mookiah, Chim C. Lang, Rory J. McCrimmon, Colin N. A. Palmer, Ewan R. Pearson, Alex S. F. Doney, Ify R. Mordi

Long-term prognostic impact of glucagon-like peptide-1 receptor agonist before ST-segment elevation myocardial infarction in patients with type 2 diabetes: a nationwide cohort study

Jasmine Melissa Madsen, Alexander Krüger Kjaer, Jacob Thomsen Lønborg, Lars Køber, Charlotte Glinge, Reza Jabbari, Thomas Engstrøm

The additive effect of the stress hyperglycemia ratio on type 2 diabetes: a population-based cohort study

Cancan Cui, Jiayin Song, Lingyu Zhang, Ning Han, Wanqi Xu, Chen Sheng, Guangda Xin, Xiaofeng Cui, Lili Yu, Lin Liu

NLRP3 inflammasome-modulated angiogenic function of EPC via PI3K/ Akt/mTOR pathway in diabetic myocardial infarction

Jia-Peng Li, Shu Qiu, Guang-Jie Tai, Yi-Ming Liu, Wei Wei, Meng-Meng Fu, Pan-Qi Fang, Joseph Nicolao Otieno, Tungalag Battulga, Xiao-Xue Li, Ming Xu

Joint association of triglyceride glucose index (TyG) and a body shape index (ABSI) with stroke incidence: a nationwide prospective cohort study

Ruiying Zhang, Jianan Hong, Yaoling Wu, Liling Lin, Shuying Chen, Yingxiu Xiao

Impact of remnant cholesterol on short-term and long-term prognosis in patients with prediabetes or diabetes undergoing coronary artery bypass grafting: a large-scale cohort study

  • Open Access
  • CABG
  • Research

Zhongchen Li, Chunyu Yu, Heng Zhang, Runze Chen, Yan Zhao, Zhe Zheng

Triglyceride-independent associations between circulating levels of apolipoprotein C-III and biomarkers of inflammation

Dídac Llop, Pere Rehues, Silvia Paredes, Montse Guardiola, Josefa Girona, Roser Rosales, Yaiza Esteban, Lluís Masana, Daiana Ibarretxe, Joan-Carles Vallvé, Josep Ribalta

Predicting 28-day all-cause mortality in patients admitted to intensive care units with pre-existing chronic heart failure using the stress hyperglycemia ratio: a machine learning-driven retrospective cohort analysis

Xiao-han Li, Xing-long Yang, Bin-bin Dong, Qi Liu

Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts

Yanqiu Huang, Yi Zhou, Yadan Xu, Xiaoyu Wang, Ziyi Zhou, Kang Wu, Qiqi Meng, Liao Wang, Yang Yang, Hong Gao, Juan Ji, Xu Jiang, Yang Yang, Lipeng Hao, Hui Wang

Association between triglyceride-glucose (TyG) related indices and cardiovascular diseases and mortality among individuals with metabolic dysfunction-associated steatotic liver disease: a cohort study of UK Biobank

Yanan Qiao, Yue Wang, Cheng Chen, Yueqing Huang, Chunhua Zhao

Association between estimated glucose disposal rate and cardiovascular diseases in patients with diabetes or prediabetes: a cross-sectional study

Jinhao Liao, Linjie Wang, Lian Duan, Fengying Gong, Huijuan Zhu, Hui Pan, Hongbo Yang

Correction: SGLT2-inhibitors in diabetic patients with severe aortic stenosis and cardiac damage undergoing transcatheter aortic valve implantation (TAVI)

Pasquale Paolisso, Marta Belmonte, Emanuele Gallinoro, Roberto Scarsini, Luca Bergamaschi, Leonardo Portolan, Matteo Armillotta, Giuseppe Esposito, Elisabetta Moscarella, Giovanni Benfari, Claudio Montalto, Monika Shumkova, Elayne Kelen de Oliveira, Francesco Angeli, Mateusz Orzalkiewicz, Margherita Fabroni, Nurcan Baydaroglu, Andrea Raffaele Munafò, Daniele Oreste D’Atri, Matteo Casenghi, Lucia Scisciola, Michelangela Barbieri, Raffaele Marfella, Felice Gragnano, Edoardo Conte, Dario Pellegrini, Alfonso Ielasi, Daniele Andreini, Martin Penicka, Jacopo Andrea Oreglia, Paolo Calabrò, Antonio Bartorelli, Carmine Pizzi, Tullio Palmerini, Marc Vanderheyden, Francesco Saia, Flavio Ribichini, Emanuele Barbato

Longitudinal DNA methylation profiles in saliva of offspring from mothers with gestational diabetes: associations with early childhood growth patterns

Teresa M. Linares-Pineda, Alfonso Lendínez-Jurado, Alberto Piserra-López, María Suárez-Arana, María Pozo, María Molina-Vega, María José Picón-César, Sonsoles Morcillo

Echocardiographic phenotypes of diabetic myocardial disorder: evolution over 15 months follow-up in the ARISE-HF trial

Thomas H. Marwick, Carolyn Lam, Yuxi Liu, Stefano Del Prato, Julio Rosenstock, Javed Butler, Justin Ezekowitz, Nasrien E. Ibrahim, W. H. Wilson Tang, Faiez Zannad, Riccardo Perfetti, James L. Januzzi

Triglyceride-glucose index: carotid intima-media thickness and cardiovascular risk in a European population

Chiara Pavanello, Massimiliano Ruscica, Sofia Castiglione, Giuliana Germana Mombelli, Antonia Alberti, Laura Calabresi, Cesare Riccardo Sirtori

Improving 10-year cardiovascular risk prediction in patients with type 2 diabetes with metabolomics

Ruijie Xie, Teresa Seum, Sha Sha, Kira Trares, Bernd Holleczek, Hermann Brenner, Ben Schöttker

Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study

Liye Lai, Dave Laurence Juntilla, Monica Del C Gomez-Alonso, Harald Grallert, Barbara Thorand, Aiman Farzeen, Wolfgang Rathmann, Juliane Winkelmann, Holger Prokisch, Christian Gieger, Christian Herder, Annette Peters, Melanie Waldenberger

ICAM1 blockade improves ischemic muscle reperfusion in diabetic mice

  • Open Access
  • Research

Ninon Foussard, Célia Bourguignon, Virginie Grouthier, Caroline Caradu, Candice Chapouly, Alain-Pierre Gadeau, Thierry Couffinhal, Marie-Ange Renault

Caloric restriction and its mimetics in heart failure with preserved ejection fraction: mechanisms and therapeutic potential

Alexander Fuerlinger, Alina Stockner, Simon Sedej, Mahmoud Abdellatif

Association between atherogenic index of plasma and future risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study

  • Open Access
  • Original Article

Gaoshu Zheng, Jijie Jin, Fei Wang, Qianrong Zheng, Jiaxin Shao, Jiangnan Yao, Pan Huang, Hao Zhou, Jianghua Zhou

Diabetes mellitus risk in post-myocardial infarction patients: FINDRISC versus self-assessment—a cross sectional study

Karianne Nölken, Jakob Linseisen, Philip Raake, Christine Meisinger, Timo Schmitz

Correction: Excessive occupational sitting increases risk of cardiovascular events among working individuals with type 1 diabetes in the prospective Finnish Diabetic Nephropathy Study

Matias Seppälä, Heidi Lukander, Johan Wadén, Marika I. Eriksson, Valma Harjutsalo, Per-Henrik Groop, Lena M. Thorn

Advances in cardiac organoid research: implications for cardiovascular disease treatment

  • Open Access
  • Review

Ziteng Huang, Keran Jia, Yadan Tan, Yang Yu, Wudian Xiao, Xiangyu Zhou, Jingyan Yi, Chunxiang Zhang

The additional impact of metabolic syndrome on left ventricular deformation and myocardial energetic efficiency impairment in ischemia with nonobstructive coronary arteries patients

Chen-Yan Min, Yue Gao, Yuan Li, Yi-Ning Jiang, Ying-Kun Guo, Hua-Yan Xu, Rong Xu, Xi Liu, Li-Ting Shen, Zhi-Gang Yang

Age-dependent effects of SGLT2 inhibitors on stroke risk in geriatric patients with diabetes and atrial fibrillation

Su-Kiat Chua, Jien-Jiun Chen, Pang-Shuo Huang, Fu-Chun Chiu, Yi-Chih Wang, Juey-Jen Hwang, Chih-Hsien Wang, Sheng-Nan Chang, Chia-Ti Tsai

Clonal hematopoiesis of indeterminate potential and type 2 diabetes mellitus among patients with STEMI: from a prospective cohort study combing bidirectional Mendelian randomization

Xiaoxiao Zhao, Jiannan Li, Shaodi Yan, Yu Tan, Runzhen Chen, Nan Li, Jinying Zhou, Chen Liu, Peng Zhou, Yi Chen, Hongbing Yan, Hanjun Zhao, Li Song

Association of sodium–glucose cotransporter-2 inhibitors with mortality across the spectrum of myocardial infarction: a systematic review and meta-analysis

Michele Maremmani, Ramin Ebrahimi, Marco Centola, Felice Achilli, Valentina Capone, Eduardo Bossone, Christian Templin, Davide Di Vece

A new kid in town: Cardiovascular Diabetology—Endocrinology Reports

  • Open Access
  • Editorial

Enrique Z. Fisman, Francisco Westermeier, Gaetano Santulli

Association between non-insulin-based insulin resistance indicators and frailty progression: a national cohort study and mendelian randomization analysis

Hui Tian, Yong-meng Li, Cheng-qiang Wang, Guo-qiang Chen, Ying Lian

Association between insulin resistance indices and outcomes in patients with heart failure with preserved ejection fraction

Weicheng Ni, Ruihao Jiang, Di Xu, Jianhan Zhu, Jing Chen, Yuanzhen Lin, Hao Zhou

Association of different insulin resistance surrogates with all-cause and cardiovascular mortality among the population with cardiometabolic multimorbidity

Hongqiang Zhang, Zhixin Tu, Sihua Liu, Jumei Wang, Jie Shi, Xingyu Li, Rongdongqing Shi, Minghui Chen, Tong Yue, Sihui Luo, Yu Ding, Xueying Zheng

Triglyceride-glucose-body mass index and the incidence of cardiovascular diseases: a meta-analysis of cohort studies

Xiyun Rao, Ziyi Xin, Qingwen Yu, Lanlan Feng, Yongmin Shi, Ting Tang, Xuhan Tong, Siqi Hu, Yao You, Shenghui Zhang, Jiake Tang, Xingwei Zhang, Mingwei Wang, Ling Liu

Atherogenic index of plasma and coronary artery disease: a systematic review and meta-analysis of observational studies

Ramin Assempoor, Mohammad Shahabaddin Daneshvar, Aryan Taghvaei, Alireza Sattari Abroy, Amir Azimi, John R. Nelson, Kaveh Hosseini

Nε-carboxyethyl-lysin influences atherosclerotic plaque stability through ZKSCAN3 acetylation-regulated macrophage autophagy via the RAGE/LKB1/AMPK1/SIRT1 pathway

Zhongwei Liu, Jing Liu, Xiqiang Wang, Yong Zhang, Yanpeng Ma, Gongchang Guan, Ya Yuwen, Ni He, Hanxiu Liu, Xingfeng Yu, Sen Ma, Junkui Wang, Jin Zhang, Ling Zhu, Yulian Zhang

Impact of diabetes remission or progression on the incidence of cardiovascular disease in Japan: historical cohort study using a nationwide claims database

Chihiro Shimayama, Kazuya Fujihara, Laymon Khin, Hiroki Takizawa, Chika Horikawa, Takaaki Sato, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Hirohito Sone

Association of estimated glucose disposal rate with metabolic syndrome prevalence and mortality risks: a population-based study

Xiaoli Chen, Aihua Li, Qilin Ma

Obesity-induced mesenteric PVAT remodelling is sexually dimorphic, but not driven by ovarian hormones

Lisa Ivatt, Mhairi Paul, Allende Miguelez-Crespo, Patrick W. F. Hadoke, Matthew A. Bailey, Ruth A. Morgan, Mark Nixon

Correlation between atherogenic index of plasma and cardiovascular disease risk across Cardiovascular–kidney–metabolic syndrome stages 0–3: a nationwide prospective cohort study

  • Open Access
  • Research

Yaohua Hu, Yu Liang, Jian Li, Xinyang Li, Mengyuan Yu, Wenpeng Cui

Proteinuria and the risk of Incident atrial fibrillation according to glycemic stages: a nationwide population-based cohort study

Muhan Yeo, So-Ryoung Lee, Eue-Keun Choi, JungMin Choi, Kyung-Yeon Lee, Soonil Kwon, Hyo-Jeong Ahn, Bong-Seong Kim, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip

Does diabetes modify the triglyceride–glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants

Jun Zhang, Qiye Zhan, Zhihao Deng, Ling Lin, Zhaolan Feng, Huabin He, Deju Zhang, Huilei Zhao, Xiang Gu, Xiaoping Yin, Peng Yu, Xiao Liu

Correction: Multi-modal characterisation of early-stage, subclinical cardiac deterioration in patients with type 2 diabetes

Ambre Bertrand, Andrew Lewis, Julia Camps, Vicente Grau, Blanca Rodriguez

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and cardiometabolic protection: historical development and future challenges

Francisco Westermeier, Enrique Z. Fisman

Triglyceride-glucose index predicts adverse cardiovascular events in patients with H-type hypertension combined with coronary heart disease: a retrospective cohort study

Changjiang Li, Shun Zhao, Yingkai Li, Songyuan He, Wen Jian, Yanci Liu, Zichao Cheng, Hongyu Peng

Association between triglyceride-glucose-body mass index and risk of aortic stenosis progression in patients with non-severe aortic stenosis: a retrospective cohort study

  • Open Access
  • Research

Zhen Guo, Zhenyu Xiong, Lixiang He, Shaozhao Zhang, Xinghao Xu, Guanzhong Chen, Mengjie Xie, Wenjing Zhang, Ziwen Hui, Jiaying Li, Xinxue Liao, Xiaodong Zhuang

The triglyceride–glucose index and its obesity-related derivatives as predictors of all-cause and cardiovascular mortality in hypertensive patients: insights from NHANES data with machine learning analysis

Chenyang Li, Zixi Zhang, Xiaoqin Luo, Yichao Xiao, Tao Tu, Chan Liu, Qiming Liu, Cancan Wang, Yongguo Dai, Zeying Zhang, Cheng Zheng, Jiafeng Lin

Bone marrow mesenchymal stem cell-derived extracellular vesicles alleviate diabetes-exacerbated atherosclerosis via AMPK/mTOR pathway-mediated autophagy-related macrophage polarization

Libo Liu, Ziyu An, Huan Zhang, Xueqi Wan, Xin Zhao, Xueyao Yang, Jinfan Tian, Xiantao Song

Correction: Relationship between changes in the triglyceride glucose-body mass index and frail development trajectory and incidence in middle-aged and elderly individuals: a national cohort study

  • Open Access
  • Correction

Kai Guo, Qi Wang, Lin Zhang, Rui Qiao, Yujia Huo, Lipeng Jing, Xiaowan Wang, Zixuan Song, Siyu Li, Jinming Zhang, Yanfang Yang, Jinli Mahe, Zhengran Liu

Association between the atherogenic index of plasma and long-term risk of type 2 diabetes: a 12-year cohort study based on the Japanese population

Qianxing Zhou, Yamei Wu, Mingkang Li

Association between the cumulative estimated glucose disposal rate and incident cardiovascular disease in individuals over the age of 50 years and without diabetes: data from two large cohorts in China and the United States

  • Open Access
  • Research

Jin Zhang, Ziyi Sun, Yufei Li, Yuhan Yang, Wenjie Liu, Mengwen Huang, Kuiwu Yao

Association of triglyceride-glucose related indices with mortality among individuals with MASLD combined with prediabetes or diabetes

Yiheng Zhang, Juanli Wu, Tao Li, Yundong Qu, Yan Wang

Associations of carbohydrate quality and cardiovascular risk factors vary among diabetes subtypes

Katharina S. Weber, Sabrina Schlesinger, Janina Goletzke, Klaus Straßburger, Oana-Patricia Zaharia, Sandra Trenkamp, Robert Wagner, Wolfgang Lieb, Anette E. Buyken, Michael Roden, Christian Herder, M. Roden, H. Al-Hasani, B. Belgardt, G. Bönhof, G. Geerling, R. Guthoff, C. Herder, A. Icks, K. Jandeleit-Dahm, J. Kotzka, O. Kuß, E. Lammert, W. Rathmann, S. Schlesinger, V. Schrauwen-Hinderling, J. Szendroedi, S. Trenkamp, R. Wagner

The association of triglyceride-glucose and triglyceride-glucose related indices with the risk of heart disease in a national cohort study

  • Open Access
  • Research

Xiaodi Tang, Kexin Zhang, Rong He

The association between stress-induced hyperglycemia ratio and cardiovascular events as well as all-cause mortality in patients with chronic kidney disease and diabetic nephropathy

Boning Cao, Zhendong Guo, Dan-Ting Li, Le-Ying Zhao, Zhen Wang, Ya-Bin Gao, Yao-Xian Wang

Assessment of six insulin resistance surrogate indexes for predicting stroke incidence in Chinese middle-aged and elderly populations with abnormal glucose metabolism: a nationwide prospective cohort study

Luqing Jiang, Tengxiao Zhu, Wenjing Song, Ying Zhai, Yu Tang, Fengxia Ruan, Zichen Xu, Lei Li, Xia Fu, Daoqin Liu, Aidong Chen, Qiwen Wu

Baseline atherogenic index of plasma and its trajectory predict onset of type 2 diabetes in a health screened adult population: a large longitudinal study

Yongbing Sun, Xinbei Lin, Zhi Zou, Caiwen Zhao, Ao Liu, Jing Zhou, Zhonglin Li, Xiaoling Wu, Shewei Dou, Jiadong Zhu, Tao Li, Xue Lv, Yong Wang, Yongli Li

Assessment of stress hyperglycemia ratio to predict all-cause mortality in patients with critical cerebrovascular disease: a retrospective cohort study from the MIMIC-IV database

Yuwen Chen, Jian Xu, Fan He, An’an Huang, Jie Wang, Bingchen Liu, Qucheng Wei

A sex-disaggregated analysis of the prognostic value of lean type 2 diabetes mellitus in the adult population with acute myocardial infarction

Gwyneth Kong, Jaycie Koh, Jobelle Chia, Bryan Neo, Yiming Chen, Grace Cao, Bryan Chong, Mark Muthiah, Hui Wen Sim, Gavin Ng, Chieh Yang Koo, Chin Meng Khoo, Mark Yan-Yee Chan, Poay-Huan Loh, Nicholas W. S. Chew

Ferroptosis: mechanism and role in diabetes-related cardiovascular diseases

Ziyi Wang, Chao Wu, Dong Yin, Kefei Dou

Predicting cardiovascular outcomes in Chinese patients with type 2 diabetes by combining risk factor trajectories and machine learning algorithm: a cohort study

Qi Huang, Xiantong Zou, Zhouhui Lian, Xianghai Zhou, Xueyao Han, Yingying Luo, Shuohua Chen, Yanxiu Wang, Shouling Wu, Linong Ji

Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling

Mandy O. J. Grootaert, Alessandra Pasut, Jana Raman, Steven J. Simmonds, Bram Callewaert, Ümare Col, Mieke Dewerchin, Peter Carmeliet, Stephane Heymans, Elizabeth A. V. Jones

The protective role of SGLT2 inhibitors on aortic aneurysm mediated by oxidative stress and inflammation in type 2 diabetes mellitus

Rujie Zheng, Wenjuan Song, Jie Lu, Mingyue Yuan, Xiaotong Sun, Chengzhi Lu

Cardiac magnetic resonance quantified epicardial fat volume is associated with complex coronary artery disease among diabetics

Shimaa Sayed Khidr, Bakeer Mohamed Bakeer, Hatem Abdel-Rahman Helmy, Heba Mahmoud El-Naggar

The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study

Changchang Fang, Nanqin Peng, Jiang Cheng, Xiyu Zhang, Wenli Gu, Zicheng Zhu, Xiaoping Yin, Zhiwei Yan, Jing Zhang, Peng Yu, Xiao Liu

Association of baseline and trajectory of triglyceride-glucose index with the incidence of cardiovascular autonomic neuropathy in type 2 diabetes mellitus

Qiong Huang, Wenbin Nan, Baimei He, Zhenhua Xing, Zhenyu Peng

Roxadustat improves diabetic myocardial injury by upregulating HIF-1α/UCP2 against oxidative stress

Tingting Fang, Congcong Ma, Bingyun Yang, Meiyu Zhao, Luning Sun, Ningning Zheng

Defining patient-reported outcomes in diabetes, obesity, cardiovascular disease, and chronic kidney disease for clinical practice guidelines - perspectives of the taskforce of the Guideline Workshop

Katharine Barnard-Kelly, Tadej Battelino, Frank C. Brosius, Antonio Ceriello, Francesco Cosentino, James R. Gavin III, Francesco Giorgino, Jennifer Green, Linong Ji, Monika Kellerer, Sue Koob, Mikhail Kosiborod, Nebojsa Lalic, Nikolaus Marx, Prashant Nedungadi, Christopher G. Parkin, Helena W. Rodbard, René D. Rötzer, Lars Rydén, Wayne Huey-Herng Sheu, Eberhard Standl, Britta Tendal Jeppesen, Pinar Topsever, Per Olav Vandvik, Christoph Wanner, Oliver Schnell

The synergistic effect of the triglyceride-glucose index and a body shape index on cardiovascular mortality: the construction of a novel cardiovascular risk marker

Hao-ming He, Ying-ying Xie, Qiang Chen, Yi-ke Li, Xue-xi Li, Sun-jing Fu, Na Li, Yan-ru Han, Yan-xiang Gao, Jin-gang Zheng

The role of glucagon-like peptide-1 receptor (GLP-1R) agonists in enhancing endothelial function: a potential avenue for improving heart failure with preserved ejection fraction (HFpEF)

Darshan Hullon, Ghasaq K. Subeh, Yelizaveta Volkova, Karolina Janiec, Adam Trach, Ruslan Mnevets

Challenges in the diagnosis of heart failure with preserved ejection fraction in individuals with obesity

Bas M. van Dalen, Jie Fen Chin, Praveen A. Motiram, Anneke Hendrix, Mireille E. Emans, Jasper J. Brugts, B. Daan Westenbrink, Rudolf A. de Boer

Clonal hematopoiesis of indeterminate potential, health indicators, and risk of cardiovascular diseases among patients with diabetes: a prospective cohort study

Ying Sun, Yuefeng Yu, Lingli Cai, Bowei Yu, Wenying Xiao, Xiao Tan, Yu Wang, Yingli Lu, Ningjian Wang

Impact of sodium‒glucose cotransporter‐2 inhibitors in patients with recent versus previous myocardial infarction: a systematic review and meta-analysis

Pedro Gabriel Scardini, Eric Shih Katsuyama, Alonzo Armani Prata, Julia Marques Fernandes, Christian Ken Fukunaga, Wilson Falco Neto, Ana Carolina Covre Coan, Naieli Machado de Andrade, Abraão Santana Silva, Rafael Petri Pinheiro, Luciana Gioli Pereira, Remo H. M. Furtado

Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes

Renata Risi, Rocco Amendolara, Angelo Lauria Pantano, Valeria Fassino, Luca D’Onofrio, Lucia Coraggio, Daniela Luverà, Davide Masi, Mikiko Watanabe, Lucio Gnessi, Raffaella Buzzetti, Ernesto Maddaloni

Association between the GMI/HbA1c ratio and preclinical carotid atherosclerosis in type 1 diabetes: impact of the fast-glycator phenotype across age groups

Carlos Puig-Jové, Clara Viñals, Ignacio Conget, Carmen Quirós, Irene Vinagre, Belén Berrocal, Antonio-Jesús Blanco-Carrasco, Montserrat Granados, Alex Mesa, Tonet Serés-Noriega, Marga Giménez, Verónica Perea, Antonio J. Amor

Predicting major adverse cardiac events in diabetes and chronic kidney disease: a machine learning study from the Silesia Diabetes-Heart Project

Hanna Kwiendacz, Bi Huang, Yang Chen, Oliwia Janota, Krzysztof Irlik, Yang Liu, Marta Mantovani, Yalin Zheng, Mirela Hendel, Julia Piaśnik, Wiktoria Wójcik, Uazman Alam, Janusz Gumprecht, Gregory Y. H. Lip, Katarzyna Nabrdalik

Stress hyperglycemia ratio and machine learning model for prediction of all-cause mortality in patients undergoing cardiac surgery

Yingjian Pei, Yajun Ma, Ying Xiang, Guitao Zhang, Yao Feng, Wenbo Li, Yinghua Zhou, Shujuan Li

Association between the systemic immune-inflammation index and metabolic syndrome and its components: results from the multi-ethnic study of atherosclerosis (MESA)

Azra Ramezankhani, Maryam Tohidi, Farzad Hadaegh

Association of body composition with left ventricular remodeling and outcomes in diabetic heart failure with reduced ejection fraction: assessment of sarcopenic obesity using cardiac MRI

Ke Shi, Ge Zhang, Rong Xu, Xue-Ming Li, Li Jiang, Yue Gao, Hua-Yan Xu, Yuan Li, Ying-Kun Guo, Zhi-Gang Yang

Development and validation of prediction models for stroke and myocardial infarction in type 2 diabetes based on health insurance claims: does machine learning outperform traditional regression approaches?

Anna-Janina Stephan, Michael Hanselmann, Medina Bajramovic, Simon Schosser, Michael Laxy

Associations of estimated glucose disposal rate with frailty progression: results from two prospective cohorts

Zhaoping Wang, Jinghan Zhu, Shuaijun Xuan, Sihang Dong, Zhida Shen, Songzan Chen, Di He, He Huang

Association of insulin resistance surrogates with disease severity and adverse outcomes in chronic thromboembolic pulmonary hypertension: a multicenter cohort study

Luyang Gao, Sicheng Zhang, Sicong Li, Manqing Luo, Ping Lin, Zhihui Zhao, Qing Zhao, Tao Yang, Anqi Duan, Yijia Wang, Qi Wang, Qin Luo, Yansong Guo, Zhihong Liu

Phenotype-based clusters, inflammation and cardiometabolic complications in older people before the diagnosis of type 2 diabetes: KORA F4/FF4 cohort study

Marie-Theres Huemer, Maria C. Spagnuolo, Haifa Maalmi, Robert Wagner, Gidon J. Bönhof, Margit Heier, Wolfgang Koenig, Wolfgang Rathmann, Katsiaryna Prystupa, Jana Nano, Dan Ziegler, Annette Peters, Michael Roden, Barbara Thorand, Christian Herder

Deficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction

Feng Shao, Johanna Wieland, Yixin Wang, Merve Keles, Zenghui Meng, Santosh Lomada, Miao Qin, Veronika Leiss, Abel Martin-Garrido, Manuela Fuhrmann, Yi Qiu, Felix A. Trogisch, Christiane Vettel, Joerg Heineke, Yuxi Feng

Inverse relationship between circulating sphingosine-1-phosphate and precursor species and coronary artery calcification score in type 2 diabetes

Wilfried Le Goff, Olivier Bourron, Clément Materne, Sophie Galier, Franck Phan, Sophie Tan-Chen, Isabelle Guillas, Agnès Hartemann, Joe-Elie Salem, Alban Redheuil, Fabienne Foufelle, Hervé Le Stunff, Eric Hajduch, Maryse Guerin

Impaired microcirculation in the skin and subclinical atherosclerosis in individuals with dysglycaemia in a large population-based cohort

John Cederqvist, Karin Rådholm, Fredrik H. Nystrom, Jan Engvall, Sara Bergstrand, Ingemar Fredriksson, Tomas Strömberg, Carl Johan Östgren

Association of glucagon-like peptide-1 receptor agonists with cardiovascular and kidney outcomes in type 2 diabetic kidney transplant recipients

Li-Chun Lin, Jui-Yi Chen, Thomas Tao-Min Huang, Vin-Cent Wu

Advanced serum lipoprotein and glycoprotein profiling for cardiovascular event prediction in type 2 diabetes mellitus: the LIPOCAT study

Núria Amigó, Esmeralda Castelblanco, Josep Julve, Neus Martínez-Micaelo, Núria Alonso, Marta Hernández, Josep Ribalta, Montse Guardiola, Pere Torán-Monserrat, Victor Lopez-Lifante, Cecilia Herrero-Alonso, Ingrid Arteaga, Emilio Ortega, Josep Franch-Nadal, Didac Mauricio

Sacubitril/Valsartan partially alleviates myocardial infarction injury by activating the FGF21 signaling pathway via PPARs

Wenjuan Wei, Guangsen Xu, Jiaer Gao, Guiyun Wang, Ye Wang, Caiyan Li, Junwei Zheng, Huiying Lu, Yunyan Lu, Kun Wang, Hongtao Xu, Cong Wang, Xuebo Pan

Cellular crosstalk in organotypic vasculature: mechanisms of diabetic cardiorenal complications and SGLT2i responses

Wenting Wang, Yanfei Liu, Qian Xu, Longkun Liu, Mengmeng Zhu, Yiwen Li, Jing Cui, Keji Chen, Yue Liu

Associations of triglyceride glucose-body mass index with short-term mortality in critically ill patients with ischemic stroke

Qingrong Ouyang, Lei Xu, Ming Yu

Association between triglyceride-glucose related indices and all-cause and cardiovascular mortality among the population with cardiovascular-kidney-metabolic syndrome stage 0–3: a cohort study

Peng Zhang, Degang Mo, Wenhua Zeng, Hongyan Dai

Insights into the complex relationship between triglyceride glucose-waist height ratio index, mean arterial pressure, and cardiovascular disease: a nationwide prospective cohort study

  • Open Access
  • Research

Jie Xu, Dihui Cai, Yuheng Jiao, Yingying Liao, Yinyin Shen, Yunli Shen, Wei Han

Lipid-lowering therapy and LDL target attainment in type 2 diabetes: trends from the Italian Associations of Medical Diabetologists database

Antonio Rossi, Davide Masi, Rita Zilich, Fabio Baccetti, Walter Baronti, Pierpaolo Falcetta, Lelio Morviducci, Nicoletta Musacchio, Marco Muselli, Alessandro Ozzello, Enrica Salomone, Damiano Verda, Maria Vezenkova, Riccardo Candido, Paola Ponzani

Relationship between atherogenic index of plasma and length of stay in critically ill patients with atherosclerotic cardiovascular disease: a retrospective cohort study and predictive modeling based on machine learning

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Yu Guo, Fuxu Wang, Shiyin Ma, Zhi Mao, Shuangmei Zhao, Liutao Sui, Chucheng Jiao, Ruogu Lu, Xiaoyan Zhu, Xudong Pan

The association between novel metabolic parameters and all-cause/cardiovascular mortality in patients with metabolic syndrome is modified by age

Jiajun Liu, Yihui Fu, Pengpeng Liang, Zhangxiao Song, Yue Li, Hongyan Wu

The impact of metformin on kidney disease progression and mortality in diabetic patients using SGLT2 inhibitors: a real-world cohort study

Timna Agur, Tali Steinmetz, Shira Goldman, Boris Zingerman, Dana Bielopolski, Eviatar Nesher, Ittai Fattal, Eshcar Meisel, Benaya Rozen-Zvi

Comparison of triglyceride glucose index and modified triglyceride glucose indices in predicting cardiovascular diseases incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study

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Jianan Hong, Ruiying Zhang, Haoxian Tang, Shiwan Wu, Yequn Chen, Xuerui Tan

Comprehensive evaluation of diabetes subtypes in a European cohort reveals stronger differences of lifestyle, education and psychosocial parameters compared to metabolic or inflammatory factors

Nathalie Rohmann, Johannes Epe, Corinna Geisler, Kristina Schlicht, Kathrin Türk, Katharina Hartmann, Lucy Kruse, Julia Koppenhagen, Ahmad Yusuf Kohestani, Tanja Adam, Corinna Bang, Andre Franke, Dominik M. Schulte, Tim Hollstein, Matthias Laudes

Association between triglyceride glucose index and biological aging in U.S. adults: National Health and Nutrition Examination Survey

Li-ya Pan, Li Jin

BDH1 overexpression alleviates diabetic cardiomyopathy through inhibiting H3K9bhb-mediated transcriptional activation of LCN2

Bu-tuo Xu, Sheng-rong Wan, Qi Wu, Yi-hang Xing, Yan-qiu He, Wei Huang, Yang Long, Chun-xiang Zhang, Yong Xu, Zong-zhe Jiang

Associations of triglyceride glucose-body mass index and the combination of sedentary behavior and physical activity with risks of all-cause mortality and myocardial infarction: a cohort study from the UK biobank

Ying Zhu, Tianci Yao, Li Tian, Yan Zhang, Qinmei Ke

Atherogenic index of plasma, high sensitivity C-reactive protein and incident diabetes among middle-aged and elderly adults in China: a national cohort study

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Tongshuai Wang, Mengru Zhang, Wenxing Shi, Yongzhen Li, Tiantian Zhang, Wenming Shi

Long-term trajectory of estimated glomerular filtration rate in ambulatory patients with type 2 diabetes and heart failure: clinical insights and prognostic implications

Maria Teresa Julián, Pau Codina, Josep Lupón, Elisabet Zamora, Alejandra Pérez-Montes de Oca, Mar Domingo, Evelyn Santiago-Vacas, Andrea Borrellas, María Ruiz-Cueto, Carlos González-Gallego, Maribel Troya, Gregorio A. Romero-González, Nuria Alonso, Antoni Bayes-Genis

Aortic valve calcification across stages of dysglycemia in middle-aged individuals from the general population

Anne Wang, Carl Johan Östgren, Anna Norhammar, David Kylhammar, Tomas Jernberg, Lars Lind, Stefan Söderberg, Anders Blomberg, Gunnar Engström, Göran Bergström, Magnus Settergren, Bahira Shahim

Circulating mitochondrial DNA signature in cardiometabolic patients

Alessandro Mengozzi, Silvia Armenia, Nicolò De Biase, Lavinia Del Punta, Federica Cappelli, Emiliano Duranti, Virginia Nannipieri, Rossana Remollino, Domenico Tricò, Agostino Virdis, Stefano Taddei, Nicola Riccardo Pugliese, Stefano Masi

A one-week reduced-carbohydrate diet to mitigate iatrogenic peripheral hyperinsulinemia does not improve insulin sensitivity or endothelial function in a randomized, crossover trial in patients with type 1 diabetes

Justin M. Gregory, T. Jordan Smith, Sara H. Duffus, David Brooks, M. Naweed Akbar, Margaret-Anne Huntley, JoAnn A. Gottlieb, Lauren M. LeStourgeon, Christopher S. Wilson, Joshua A. Beckman, Alan D. Cherrington

Triglyceride-glucose index correlates with the incidences and prognoses of cardiac arrest following acute myocardial infarction: data from two large-scale cohorts

Huiruo Liu, Liangshan Wang, Hong Wang, Xing Hao, Zhongtao Du, Chenglong Li, Xiaotong Hou

Joint assessment of abdominal obesity and non-traditional lipid parameters for primary prevention of cardiometabolic multimorbidity: insights from the China health and retirement longitudinal study 2011–2018

Hurong Lai, Yansong Tu, Caifeng Liao, Shan Zhang, Ling He, Jian Li

Potential benefits of GLP-1 receptor agonist in dialysis patients with type 2 diabetes: the need for comprehensive pharmacokinetic and hemodialysis analyses

Hsuan-Wen Lai, Jui-Yi Chen, Vin-Cent Wu, Chun Yin See

Echocardiographic and biomarker characteristics in diabetes, coronary artery disease or both: insights from HOMAGE trial

Luca Monzo, Masatake Kobayashi, João Pedro Ferreira, Zohra Lamiral, Christian Delles, Andrew L. Clark, Frank Edelmann, Arantxa González, Stephane Heymans, Pierpaolo Pellicori, Johannes Petutschnigg, Job A. J. Verdonschot, Patrick Rossignol, John G. F. Cleland, Faiez Zannad, Nicolas Girerd

Assessing the impact of insulin resistance trajectories on cardiovascular disease risk using longitudinal targeted maximum likelihood estimation

Yaning Feng, Liangying Yin, Haoran Huang, Yongheng Hu, Sitong Lin

Additive association of blood group A allele with 15 cardiometabolic diseases: a UK Biobank life-course study

Ran Zhao, Wenyan Xian, Yihao Ma, Valerio Napolioni, Patrick W. C. Lau, Xiao-Li Tian, Yann Le Guen, Andre Franke, Jie Huang

Can cardiovascular health and its modifiable healthy lifestyle offset the increased risk of all-cause and cardiovascular deaths associated with insulin resistance?

Jiajun Qiu, Jin’e Li, Shan Xu, Haixia Zeng, Yuying Zhang, Shiqi Yang, Lixuan Fang, Jiadian Huang, Hongtao Zhou, Jiaying Feng, Yujie Zhan, Jianping Liu

Triglyceride glucose index predicts long-term mortality and major adverse cardiovascular events in patients with type 2 diabetes

Matilde Sbriscia, Dalila Colombaretti, Angelica Giuliani, Silvia Di Valerio, Lucia Scisciola, Iryna Rusanova, Anna Rita Bonfigli, Fabiola Olivieri, Jacopo Sabbatinelli

Cholesterol, high-density lipoprotein, and glucose index versus triglyceride–glucose index in predicting cardiovascular disease risk: a cohort study

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Degang Mo, Peng Zhang, Miao Zhang, Hongyan Dai, Jun Guan

Cardiometabolic risk factors and disease trends for atrial fibrillation in individuals with type 1 diabetes: a nationwide registry study

Lara El Khalili, Linn El Khalili, Araz Rawshani, Jan Borén, Deepak L. Bhatt, Hertzel C. Gerstein, Darren K. McGuire, Edvin Helleryd, Elmir Omerovic, Björn Eliasson, Truuls Råmunddal, Naveed Sattar, Aidin Rawshani

Correction: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and cardiometabolic protection: historical development and future challenges

Francisco Westermeier, Enrique Z. Fisman

Association between the triglyceride glucose-Chinese visceral adiposity index and new-onset stroke risk: a national cohort study

Mengdie Wang, Bing Gao, Fei Huang

Proteomic signatures of type 2 diabetes predict the incidence of coronary heart disease

Yujian Li, Dun Li, Jing Lin, Lihui Zhou, Weiling Yang, Xin Yin, Chenjie Xu, Zhi Cao, Yaogang Wang

GPR30-driven fatty acid oxidation targeted by ginsenoside Rd maintains mitochondrial redox homeostasis to restore vascular barrier in diabetic retinopathy

Kai Tang, Congcong Huang, Zhengjie Huang, Zhen Wang, Ninghua Tan

Correction to: Age-dependent effects of SGLT2 inhibitors on stroke risk in geriatric patients with diabetes and atrial fibrillation

Su-Kiat Chua, Jien-Jiun Chen, Pang-Shuo Huang, Fu-Chun Chiu, Yi-Chih Wang, Juey-Jen Hwang, Chih-Hsien Wang, Sheng-Nan Chang, Chia-Ti Tsai

Higher hemoglobin levels are associated with impaired left ventricular global strains in metabolic syndrome: a 3.0 T CMR feature tracking study

Xue Li, Shi-Qin Yu, Zhi-Gang Yang, Bi-Yue Hu, Ke Shi, Jing Wang, Xue-Ming Li, Ge Zhang, Wen-Rong Li, Rong Xu, Yuan Li

Association of atherogenic index of plasma trajectory with the incidence of cardiovascular disease over a 12-year follow-up: findings from the ELSA cohort study

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Xicong Li, Lifei Lu, Yubiao Chen, Baiyun Liu, Bei Liu, Heshen Tian, Huajing Yang, Ruiwei Guo

Metabolomic profiling reveals early biomarkers of gestational diabetes mellitus and associated hepatic steatosis

Youngae Jung, Seung Mi Lee, Jinhaeng Lee, Yeonjin Kim, Woojoo Lee, Ja Nam Koo, Ig Hwan Oh, Kue Hyun Kang, Byoung Jae Kim, Sun Min Kim, Jeesun Lee, Ji Hoi Kim, Yejin Bae, Sang Youn Kim, Gyoung Min Kim, Sae Kyung Joo, Dong Hyeon Lee, Joon Ho Moon, Bo Kyung Koo, Sue Shin, Errol R. Norwitz, Geum-Sook Hwang, Joong Shin Park, Won Kim

Evaluation of glycemic status and subclinical atherosclerosis in familial hypercholesterolemia subjects with or without LDL receptor mutation

Francesco Di Giacomo Barbagallo, Giosiana Bosco, Maurizio Di Marco, Sabrina Scilletta, Nicoletta Miano, Marco Musmeci, Marina Martedì, Ana M. González-Lleó, Daiana Ibarretxe, Ernestina Marianna De Francesco, Roberta Malaguarnera, Antonino Di Pino, Luís Masana, Francesco Purrello, Salvatore Piro, Roberto Scicali

Piezo1 deletion mitigates diabetic cardiomyopathy by maintaining mitochondrial dynamics via ERK/Drp1 pathway

Weipin Niu, Xin Liu, Bo Deng, Tianying Hong, Cuifen Wang, Yameng Yan, Jiali Liu, Yuehua Jiang, Jing Li

The adverse effect of metabolic syndrome on left ventricular global strains and myocardial energetic efficiency in non-ischemic dilated cardiomyopathy patients: a cardiac magnetic resonance study

Meng-Ting Shen, Yuan Li, Ke Shi, Jin Wang, Li Jiang, Yu Jiang, Yue Gao, Shi-Qin Yu, Xue-Ming Li, Wei-Feng Yan, Zhi-Gang Yang

Dysglycaemia is associated with the pattern of valvular calcification in micro-computed tomography analysis: an observational study in patients with severe aortic stenosis

Magdalena Kopytek, Kamila W. Undas, Jacek Tarasiuk, Sebastian Wroński, Michał Ząbczyk, Joanna Natorska

Accelerometer-derived “weekend warrior” physical activity pattern and incident type 2 diabetes

Zhi Cao, Jiahao Min, Chenjie Xu

Association of triglyceride-glucose index trajectories with the risk of worsening heart failure in elderly patients with chronic heart failure and type 2 diabetes: a competing risk analysis

Yingying Lai, Cailong Lin, Xindong Liu, Yuting Liu, Hua Cai, Nannan Zhao, Yushuo Gao, Ziyi Yi, Jianyu Huang, Min Li, Lin Xu

The impact of hypercortisolism beyond metabolic syndrome on left ventricular performance: a myocardial work analysis

Floran Sahiti, Mario Detomas, Vladimir Cejka, Kristina Hoffmann, Götz Gelbrich, Stefan Frantz, Mathias Kroiss, Peter U. Heuschmann, Stefanie Hahner, Martin Fassnacht, Timo Deutschbein, Stefan Störk, Caroline Morbach

Association between triglyceride glucose-body mass index and the trajectory of cardio-renal-metabolic multimorbidity: insights from multi-state modelling

Haoxian Tang, Jingtao Huang, Xuan Zhang, Xiaojing Chen, Qinglong Yang, Nan Luo, Hanyuan Lin, Jianan Hong, Shiwan Wu, Cuihong Tian, Mengyue Lin, Junshuang Tang, Jiasheng Wen, Pan Chen, Liwen Jiang, Youti Zhang, Kaihong Yi, Xuerui Tan, Yequn Chen

Exploring the impact of metabolic comorbidities on epicardial adipose tissue in heart failure with preserved ejection fraction

Nassiba Menghoum, Maria Chiara Badii, Martin Leroy, Marie Parra, Clotilde Roy, Sibille Lejeune, David Vancraeynest, Agnes Pasquet, Dulce Brito, Barbara Casadei, Christophe Depoix, Gerasimos Filippatos, Damien Gruson, Frank Edelmann, Vanessa M. Ferreira, Renaud Lhommel, Masliza Mahmod, Stefan Neubauer, Alexandre Persu, Stefan Piechnik, Kristian Hellenkamp, Ignatios Ikonomidis, Bartosz Krakowiak, Burkert Pieske, Elisabeth Pieske-Kraigher, Fausto Pinto, Piotr Ponikowski, Michele Senni, Jean-Noël Trochu, Nancy Van Overstraeten, Rolf Wachter, Bernhard L. Gerber, Jean-Luc Balligand, Christophe Beauloye, Anne-Catherine Pouleur

Impact of glycemic control metrics on short- and long-term mortality in transcatheter aortic valve replacement patients: a retrospective cohort study from the MIMIC-IV database

Qingyun Yu, Qingan Fu, Xiaowei Ma, Huijian Wang, Yunlei Xia, Yue Chen, Penghui Li, Yue Li, Yanqing Wu

Eplerenone, diabetes, and chronic kidney disease in patients hospitalized for acute heart failure: findings from the EARLIER trial

Masatake Kobayashi, Akira Yamashina, Kazuhiro Satomi, Masataka Watanabe, Ryu Takagi, Ayako Tezuka, Shin Ito, Masanori Asakura, Masafumi Kitakaze

The prognostic significance of stress hyperglycemia ratio in evaluating all-cause and cardiovascular mortality risk among individuals across stages 0–3 of cardiovascular–kidney–metabolic syndrome: evidence from two cohort studies

Mo-Yao Tan, Yu-Jun Zhang, Si-Xuan Zhu, Shan Wu, Ping Zhang, Ming Gao

Association between triglyceride–glucose index and mortality in critically ill patients with atrial fibrillation: a retrospective cohort study

Rong Ding, Erjing Cheng, Miao Wei, Liya Pan, Lu Ye, Yi Han, Xuan Zhang, Chao Xue, Jiannan Gong, Hui Zhao

BMI-residualized data uncovers a cluster of people with type 2 diabetes and increased serum ferritin protected from cardiovascular disease

Laura Gallardo-Nuell, Jordi Blanch, Yenny Leal, Daniel E Coral, Talita Duarte-Salles, Giuseppe N. Giordano, Paul W. Franks, Ewan R. Pearson, Geltrude Mingrone, Carel W le Roux, Rafael Ramos, José Manuel Fernández-Real

Cardiovascular abnormalities already occurred in newly-diagnosed patients with early-onset type 2 diabetes

Hong Lian, Qian Ren, Wei Liu, Rui Zhang, Xiantong Zou, Simin Zhang, Yingying Luo, Wei Deng, Qiuping Wang, Lin Qi, Yufeng Li, Wenbo Wang, Liyong Zhong, Pengkai Zhang, Chengcheng Guo, Li Li, Yating Li, Tianhao Ba, Chaochao Yang, Lili Huo, Yan’ai Wang, Chunxia Li, Dejun Hao, Yajing Zhang, Yan Xu, Fang Wang, Xiangqing Wang, Fang Zhang, Siqian Gong, Wenjia Yang, Xueyao Han, Linong Ji

Early hemodynamic impact of SGLT2 inhibitors in overweight cardiometabolic heart failure: beyond fluid offloading to vascular adaptation– a preliminary report

Nadia Salerno, Jessica Ielapi, Angelica Cersosimo, Isabella Leo, Assunta Di Costanzo, Giuseppe Armentaro, Salvatore De Rosa, Angela Sciacqua, Sabato Sorrentino, Daniele Torella

Association between C-reactive protein-triglyceride glucose index and stroke risk in different glycemic status: insights from the China Health and Retirement Longitudinal Study (CHARLS)

Guijun Huo, Yao Tang, Zhanao Liu, Junjie Cao, Zhichao Yao, Dayong Zhou

Pericoronary adipose tissue attenuation predicts compositional plaque changes: a 12-month longitudinal study in individuals with type 2 diabetes without symptoms or known coronary artery disease

Katrine Schultz Overgaard, Thomas Rueskov Andersen, Laurits Juhl Heinsen, Gokulan Pararajasingam, Roda Abdulkadir Mohamed, Freja Sønder Madsen, Irmelin Irene Aagaard Biesenbach, Kurt Højlund, Jess Lambrechtsen, Søren Auscher, Kenneth Egstrup

Heart rate variability tests for diagnosing cardiovascular autonomic neuropathy in patients with type 2 diabetes mellitus in advanced stages of kidney disease

João Soares Felício, Maria Antônia Matos Araújo, Gabriela Nascimento de Lemos, Isabel Jacob Fernandes, Licia Oliveira Ruivo, Ester da Gama Chambouleyron, Lilian de Souza D’Albuquerque Silva, Caroline Filgueira Nunes, Gisely Mouta de Andrade Paes, Franciane Trindade Cunha de Melo, Pedro Paulo Freire Piani, Ana Regina Bastos Motta, Valéria Suênya Galvão Leal, Ana Carolina Contente Braga de Souza, Natercia Neves Marques de Queiroz, Márcia Costa dos Santos, Karem Mileo Felício, Priscila Alcântara Barbosa de Figueiredo

Oxidative stress and inflammation mediate the adverse effects of cadmium exposure on all-cause and cause-specific mortality in patients with diabetes and prediabetes

Jingqi Liu, Kehan Chen, Mingyuan Tang, Qunzheng Mu, Shirong Zhang, Jiayuan Li, Jiaqiang Liao, Xia Jiang, Chuan Wang

Anti-CD3 monoclonal antibody in treating patients with type 1 diabetes: an updated systematic review and meta-analysis

Qi Wu, Rui Wei, Xinyue Liao, Xiaona Cui, Haining Wang, Tianpei Hong

Joint association of estimated glucose disposal rate and systemic inflammation response index with mortality in cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study

Yuwen Chen, Wenbin Lian, Lunzhe Wu, An’an Huang, Deliang Zhang, Bingchen Liu, Yuangang Qiu, Qucheng Wei

Relationship between hemoglobin glycation index and myocardial mechano-energetic efficiency in non-diabetic individual

Chiara M. A. Cefalo, Mariangela Rubino, Teresa Vanessa Fiorentino, Velia Cassano, Gaia Chiara Mannino, Alessia Riccio, Elena Succurro, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti

Joint association of the triglyceride–glucose index and stress hyperglycemia ratio with incidence and mortality risks of new-onset atrial fibrillation during sepsis: a retrospective cohort study

Zhihong Zuo, Zijing Zhou, Qiang Liu, Ruizheng Shi, Ting Wu

Elevated triglyceride-glucose index is a risk factor for cardiovascular events in adults with type 1 diabetes: a cohort study

Rosa Oh, Seohyun Kim, Sang Ho Park, Myunghwa Jang, So Hyun Cho, Ji Yoon Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Gyuri Kim, Jae Hyeon Kim

Incremental predictive value of liver fat fraction based on spectral detector CT for major adverse cardiovascular events in T2DM patients with suspected coronary artery disease

Min Wang, Tanglin Wei, Li Sun, Yanhua Zhen, Ruobing Bai, Xiaomei Lu, Yue Ma, Yang Hou

Lipidomic analysis reveals metabolism alteration associated with subclinical carotid atherosclerosis in type 2 diabetes

Maria Barranco-Altirriba, Joana Rossell, Núria Alonso, Ralf J. M. Weber, Emilio Ortega, Gavin R. Lloyd, Marta Hernandez, Oscar Yanes, Jordi Capellades, Catherine Winder, Alexandra Junza, Mireia Falguera, Josep Franch-Nadal, Warwick B. Dunn, Alexandre Perera-Lluna, Esmeralda Castelblanco, Didac Mauricio

Improved prediction and risk stratification of major adverse cardiovascular events using an explainable machine learning approach combining plasma biomarkers and traditional risk factors

Xi-Ru Zhang, Wen-Fang Zhong, Rui-Yan Liu, Jie-Lin Huang, Jing-Xiang Fu, Jian Gao, Pei-Dong Zhang, Dan Liu, Zhi-Hao Li, Yan He, Hongwei Zhou, Zhuang Li

Associations between cardiometabolic indices and the onset of metabolic dysfunction-associated steatotic liver disease as well as its progression to liver fibrosis: a cohort study

Ziping Song, Xinlei Miao, Shuang Liu, Manling Hu, Xiaoling Xie, Yuting Sun, Song Leng

Metabolic rewiring and inter-organ crosstalk in diabetic HFpEF

Lingyun Luo, Yuyue Zuo, Lei Dai

Temporal prevalence and prognostic impact of diabetes mellitus and albuminuria in heart failure with preserved ejection fraction

Nousjka P. A. Vranken, Xinyu Li, Heleen Bouman, Sanne G. J. Mourmans, Anouk Achten, Arantxa Barandiarán Aizpurua, Hans-Peter Brunner-La Rocca, Christian Knackstedt, Vanessa P. M. van Empel, Jerremy Weerts

Combined effect of skeletal muscle mass loss and elevated insulin resistance on heart failure risk in older adults: a community-based longitudinal cohort study

Weike Liu, Hua Zhang, Xin Wang, Huajing Song, Yanli Yao, Zhendong Liu, Juan Wang, Yuqi Guo

AGE induced macrophage-derived exosomes induce endothelial dysfunction in diabetes via miR-22-5p/FOXP1

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Yang Ji, Huanzhen Chen, Lihua Pang, Changnong Chen, Sha Wang, Jing Chen, Lei Fang, Benrong Liu, Yongruo Cheng, Shiming Liu, Yun Zhong

Exercise and dietary interventions in the management of diabetic cardiomyopathy: mechanisms and implications

Ling Zhong, Xiaojie Hou, Yan Tian, Xianghui Fu

Preeclampsia as an independent predictor of atherosclerosis progression in women with type 1 diabetes: a 5-year prospective study

Alex Mesa, Carlos Puig-Jové, Adriana Pané, Irene Vinagre, Eva López-Quesada, Eva Meler, Núria Alonso-Carril, Carmen Quirós, Antonio J. Amor, Verónica Perea

Insulin resistance quantified by estimated glucose disposal rate predicts cardiovascular disease incidence: a nationwide prospective cohort study

Shiyi Tao, Lintong Yu, Jun Li, Ji Wu, Xuanchun Huang, Zicong Xie, Tiantian Xue, Yonghao Li, Lilan Su

Association between systemic inflammation biomarkers and incident cardiovascular disease in 423,701 individuals: evidence from the UK biobank cohort

Pei Qin, Frederick K. Ho, Carlos A. Celis-Morales, Jill P. Pell

Estimated glucose disposal rate outperforms other insulin resistance surrogates in predicting incident cardiovascular diseases in cardiovascular-kidney-metabolic syndrome stages 0–3 and the development of a machine learning prediction model: a nationwide prospective cohort study

Bingtian Dong, Yuping Chen, Xiaocen Yang, Zhengdong Chen, Hua Zhang, Yuan Gao, Enfa Zhao, Chaoxue Zhang

Joint association of triglyceride glucose index (TyG) and body roundness index (BRI) with stroke incidence: a national cohort study

Bingxue Wang, Liying Li, Ying Tang, Xingwu Ran

A different perspective on studying stroke predictors: joint models for longitudinal and time-to-event data in a type 2 diabetes mellitus cohort

F. J. San Andrés-Rebollo, J. Cárdenas-Valladolid, J. C. Abanades-Herranz, P. Vich-Pérez, J. M. de Miguel-Yanes, M. Guillán, M. A. Salinero-Fort, A. M. Sobrado-de Vicente-Tutor, M. Sanz-Pascual, M. Arnalte-Barrera, S. Pulido-Fernández, E. M. Donaire-Jiménez, C. Montero-Lizana, M. Domínguez-Paniagua, P. Serrano-Simarro, R. Echegoyen-de Nicolás, P. Gil-Díaz, I. Cerrada-Somolinos, R. Martín-Cano, A. Cava-Rosado, T. Mesonero-Grandes, E. Gómez-Navarro, A. Maestro-Martín, A. Muñoz-Cildoz, M. E. Calonge-García, M. Martín-Bun, P. Carreño-Freire, J. Fernández-García, A. Morán-Escudero, J. Martínez-Irazusta, E. Calvo-García, A. M. Alayeto-Sánchez, C. Reyes-Madridejos, M. J. Bedoya-Frutos, B. López-Sabater, J. Innerarity-Martínez, A. Rosillo-González, A. I. Menéndez-Fernández, F. Mata-Benjumea, C. Martín-Madrazo, M. J. Gomara-Martínez, C. Bello-González, A. Pinilla-Carrasco, M. Camarero-Shelly, A. Cano-Espin, J. Castro Martin, B. de Llama-Arauz, A. de Miguel-Ballano, M. A. García-Alonso, J. N. García-Pascual, M. I. González-García, C. López-Rodríguez, M. Miguel-Garzón, M. C. Montero-García, S. Muñoz-Quiros-Aliaga, S. Núñez-Palomo, O. Olmos-Carrasco, N. Pertierra-Galindo, G. Reviriego-Jaén, P. Rius-Fortea, G. Rodríguez-Castro, J. M. San Vicente-Rodríguez, M. E. Serrano-Serrano, M. M. Zamora-Gómez, M. P. Zazo-Lázaro

Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications

Chunxiao Cheng, Yuanjiao Liu, Lingyun Sun, Jiayao Fan, Xiaohui Sun, Ju-Sheng Zheng, Lin Zheng, Yimin Zhu, Dan Zhou

Impaired cardiac branched-chain amino acid metabolism in a novel model of diabetic cardiomyopathy

Junko Asakura, Manabu Nagao, Masakazu Shinohara, Tetsuya Hosooka, Naoya Kuwahara, Makoto Nishimori, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Sho Matsui, Tsutomu Sasaki, Tadahiro Kitamura, Hiromasa Otake, Tatsuro Ishida, Wataru Ogawa, Ken-Ichi Hirata, Ryuji Toh

Association between atherogenic index of plasma and new-onset stroke in a population with cardiovascular-kidney-metabolic syndrome stages 0–3: insights from CHARLS

Yingcheng Liu, Wenlong Li, Hanwen Zhou, Haijiao Zeng, Jiaming Jiang, Qian Wang, Tian Liu, Xinjing Liu, Pinyi Chen, Xiaoni Zhong

The association between the triglyceride–glucose index and vulnerable plaques in patients with type 2 diabetes mellitus: insights from coronary computed tomography angiography

Yu-Shan Zhang, Rui Shi, Yi-Ning Jiang, Yue Gao, Yu Jiang, Jin Wang, Wen-Rong Li, Jia-Ke Li, Zhi-Gang Yang, Yuan Li

Chain effect of lifecourse reproductive characteristics and body fat and muscle on cardiovascular disease in women: a Mendelian randomization study

Dong Liu, Chun Dou, Chaojie Ye, Lijie Kong, Zheng Zhu, Mingling Chen, Jie Zheng, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen, Guang Ning, Weiqing Wang, Yufang Bi, Tiange Wang

Exploring the effect of dapagliflozin on coronary inflammation in type 2 diabetes patients based on the coronary artery perivascular fat attenuation index

Xuehua Liu, Tian Zhang, Rong Fu, Dan Liu, Jingyi Zhang, Qing Hu, Guangyao Song, Luping Ren

Sex differences in myocardial flow reserve among individuals with type 2 diabetes: insights from the DiaHeart study

Anne-Cathrine Skriver-Møller, Philip Hasbak, Ida K. B. Rasmussen, Martin B. Blond, Victor S. Wasehuus, Mats C. H. Lassen, Morten Lindhardt, Allan Kofoed-Enevoldsen, Urd L. Kielgast, Emilie H. Zobel, Jens P. Goetze, Lene Holmvang, Tor Biering-Sørensen, Peter Rossing, Andreas Kjaer, Rasmus S. Ripa, Tine W. Hansen

Impact of diabetes and glycemic status on ventricular–arterial coupling in the general population

Hannes Holm, Haris Zilic, Amra Jujic, Linda Johnsson, Gunnar Engström, Peter M. Nilsson, Carl Johan Östgren, David Kylhammar, Jan Engvall, Martin Magnusson

Correction: The association of triglyceride-glucose and triglyceride-glucose related indices with the risk of heart disease in a national cohort study

  • Open Access
  • Correction

Xiaodi Tang, Kexin Zhang, Rong He

Long-term impact of diabetes on mortality in patients undergoing unprotected left main PCI: a propensity score-matched analysis from the BIA-LM registry

Paweł Kralisz, Emil Julian Dąbrowski, Sławomir Dobrzycki, Wiktoria Urszula Kozłowska, Patrycja Oliwia Lipska, Konrad Nowak, Kamil Gugała, Przemysław Prokopczuk, Grzegorz Mężyński, Michał Święczkowski, Marcin Kożuch

Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study

Damien Denimal, Maharajah Ponnaiah, Franck Phan, Anne-Caroline Jeannin, Alban Redheuil, Joe-Elie Salem, Samia Boussouar, Pauline Paulstephenraj, Suzanne Laroche, Chloé Amouyal, Agnès Hartemann, Fabienne Foufelle, Olivier Bourron

Real-world effectiveness of adding newer generation GLP-1RA to SGLT2i in type 2 diabetes

Nathorn Chaiyakunapruk, Xi Tan, Yuanjie Liang, Mico Guevarra, Lin Xie, Alice Y. Y. Cheng

SETD7 drives diabetic endothelial dysfunction through FBXO45-mediated GPX4 ubiquitylation

Wen Zhong, Ruoxue Chen, Jialin Zhao, Yuyu Zhang, Jintao He, Huibin Wang, Feng Zhu, Chunxiang Fan, Xinhua Liu

Association of stress hyperglycemia ratio with short-term and long-term prognosis in patients undergoing coronary artery bypass grafting across different glucose metabolism states: a large-scale cohort study

  • Open Access
  • CABG
  • Research

Zhongchen Li, Runze Chen, Zhiwei Zeng, Peng Wang, Chunyu Yu, Shuo Yuan, Xiaoting Su, Yan Zhao, Heng Zhang, Zhe Zheng

Association between stress hyperglycemia ratio (SHR) and long-term mortality in patients with ischemic stroke: a retrospective cohort study

Man Huang, Wan Wang, Dong-mei Ren, Yan-qing Chen, Ying Li, Yan Li, Wu-lin Li, Fei Wang

Dyslipidemia and aging: the non-linear association between atherogenic index of plasma (AIP) and aging acceleration

QianKun Yang, XianJie Zhu, Li Zhang, Fei Luo

The effect of empagliflozin on peripheral microvascular dysfunction in patients with heart failure with preserved ejection fraction

Sanne G. J. Mourmans, Anouk Achten, Raquel Hermans, Marijne J. E. Scheepers, Elisa D’Alessandro, Geertje Swennen, Janneke Woudstra, Yolande Appelman, Harry van Goor, Casper Schalkwijk, Christian Knackstedt, Jerremy Weerts, Etto C. Eringa, Vanessa P. M. van Empel

Association between atherogenic index of plasma with all-cause and cardiovascular mortality in individuals with Cardiovascular-Kidney-Metabolic syndrome

  • Open Access
  • Research

Qianrong Zheng, Zhenyang Cao, Jiayi Teng, Qian Lu, Pan Huang, Jianghua Zhou

Cardiomyocyte-specific NHE1 overexpression confers protection against myocardial infarction during hyperglycemia

Kai Jiang, Fanghua Su, Ruhua Deng, Yue Xu, Anqi Qin, Xun Yuan, Dongmei Xing, Yang Chen, Dandan Wang, Lan Shen, John Hwa, Lei Hou, Yaozu Xiang

Cardiorenal protection with dapagliflozin in patients with type 2 diabetes mellitus and chronic coronary syndrome undergoing percutaneous coronary intervention: a registry cross-sectional study

Zinan Zhao, Naixin Zheng, Tianqi Zhang, Chi Zhang, Yuwei Li, Ming Lan, Ni Zhang, Hui Li, Hu Ai, Deping Liu

The landscape of novel antidiabetic drugs in diabetic HFpEF: relevant mechanisms and clinical implications

Xiangling Duan, Xiaomeng Zhang, Bao Sun

CVOT summit report 2024: new cardiovascular, kidney, and metabolic outcomes

Oliver Schnell, Jaime Almandoz, Lisa Anderson, Katharine Barnard-Kelly, Tadej Battelino, Matthias Blüher, Luca Busetto, Doina Catrinou, Antonio Ceriello, Xavier Cos, Thomas Danne, Colin M. Dayan, Stefano Del Prato, Beatriz Fernández-Fernández, Paola Fioretto, Thomas Forst, James R. Gavin, Francesco Giorgino, Per-Henrik Groop, Igor A. Harsch, Hiddo J. L. Heerspink, Lutz Heinemann, Mahmoud Ibrahim, Michel Jadoul, Sarah Jarvis, Linong Ji, Naresh Kanumilli, Mikhail Kosiborod, Ulf Landmesser, Sofia Macieira, Boris Mankovsky, Nikolaus Marx, Chantal Mathieu, Barbara McGowan, Tatjana Milenkovic, Othmar Moser, Dirk Müller-Wieland, Nikolaos Papanas, Dipesh C. Patel, Andreas F. H. Pfeiffer, Dario Rahelić, Helena W. Rodbard, Lars Rydén, Elke Schaeffner, C. Wendy Spearman, Alin Stirban, Frank Tacke, Pinar Topsever, Luc Van Gaal, Eberhard Standl

Relationship between stress hyperglycaemic ratio (SHR) and critical illness: a systematic review

Guoyuan Song, Xiujuan Liu, Zihe Lu, Jingyue Guan, Xinyue Chen, Yichen Li, Gang Liu, Gang Wang, Fangfang Ma

Integrating adipsin with novel cardiometabolic and inflammatory indices for enhanced early prediction of gestational diabetes mellitus: a prospective cohort study

Meizhi Cai, Xuan Jiang, Xinyi Xu, Sidi Zhao, Yue Sun, Yushuo Yang, Ping Yang, Chen Fang, Yifan Huang

Impact of baseline left ventricular ejection fraction and body mass index on the effect of 24-week Ipragliflozin treatment on left ventricular diastolic function in patients with type 2 diabetes and chronic kidney disease: insights from the PROCEED trial

Hiroki Teragawa, Atsushi Tanaka, Kanae Takahashi, Chikage Oshita, Yuko Uchimura, Nozomu Kamei, Hiroyuki Hirai, Michio Shimabukuro, Isao Taguchi, Yosuke Okada, Koichi Node

Correction: Visceral adipose tissue mediates the relationship between left ventricular global longitudinal strain and insulin resistance among adults living with type 2 diabetes

  • Open Access
  • Correction

Pavel Martinez-Dominguez, Paola Gomez-Aviles, Kenya Bautista-García, Neftali Eduardo Antonio-Villa, Enrique C. Guerra, Paloma Almeda-Valdes, Alexandro J. Martagón, Alejandro Campos Munoz, Maria Jose Santa-Ana-Bayona, Erick Alexanderson, Carlos A. Aguilar Salinas, Nilda Espinola-Zavaleta

Epicardial Adipose Tissue and Heterogeneity Parameters Combined with Inflammatory Cells to Predict the Value of Heart Failure with Preserved Ejection Fraction Patients Post Myocardial Infarction

Yu-jiao Song, Xiao-ying Zhao, Lu-jing Wang, Ting Ning, Ming-tian Chen, Pei Liu, Si-wen Chen, Xin-xiang Zhao

Association of obesity- and insulin resistance-related indices with subclinical carotid atherosclerosis in type 1 diabetes: a cross-sectional study

Dongli Yang, Jie Zhou, Malgorzata A. Garstka, Qian Xu, Qiaoyue Li, Li Wang, Lijun Ren, Qiuhe Ji, Tao Liu

Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on cardiovascular outcomes in older adults with type 2 diabetes mellitus: a target trial emulation study

Weihong Zeng, Tiansheng Wang, Til Stürmer, Na He, Peng Shen, Hongbo Lin, Xiaodong Guan, Yang Xu

Metabolic pathways mediating insulin resistance and gestational diabetes mellitus discovered by high-dimensional systematic Mendelian randomization

Wei Chen, Mingjuan Luo, Jingyi Guo, Suna Wang, Dandan Yan, Xiaohui Feng, Yunting Huang, Tao Zeng, Li Shen, Rong Zhang, Jing Yan, Cheng Hu, Weituo Zhang, Xiangtian Yu

Effects of empagliflozin on functional capacity, LV filling pressure, and cardiac reserves in patients with type 2 diabetes mellitus and heart failure with preserved ejection fraction: a randomized controlled open-label trial

Artem Ovchinnikov, Alexandra Potekhina, Anastasiia Filatova, Olga Svirida, Kristina Zherebchikova, Fail Ageev, Evgeny Belyavskiy

Life’s Essential 8 cardiovascular health, cardiovascular-kidney-metabolic syndrome stages, and incident cardiovascular events: a nationwide 10-year prospective cohort study in China

  • Open Access
  • Research

Mian Li, Min Xu, Yi Ding, Hong Lin, Guijun Qin, Tiange Wang, Yu Xu, Yuhong Chen, Shuangyuan Wang, Zhiyun Zhao, Jie Zheng, Li Yan, Lixin Shi, Zhengnan Gao, Lulu Chen, Tianshu Zeng, Ruying Hu, Zhen Ye, Xuefeng Yu, Gang Chen, Qing Su, Yiming Mu, Xulei Tang, Qin Wan, Guixia Wang, Feixia Shen, Xuejiang Gu, Zuojie Luo, Yingfen Qin, Li Chen, Xinguo Hou, Yanan Huo, Qiang Li, Hong Qiao, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Guang Ning, Jieli Lu, Weiqing Wang, Yufang Bi

Long-term dual-trajectories of TyG and LAP and their association with cardiometabolic multimorbidity in midlife: the CARDIA study

  • Open Access
  • Research

Lingqu Zhou, Junjie Wang, Zirui Zhou, Liangjiao Wang, Qi Guo, Hui Zeng, Ziyue Zhong, Yinyin Zhang

Combined assessment of stress hyperglycemia ratio and glycemic variability to predict all-cause mortality in critically ill patients with atherosclerotic cardiovascular diseases across different glucose metabolic states: an observational cohort study with machine learning

Fuxu Wang, Yu Guo, Yuru Tang, Shuangmei Zhao, Kaige Xuan, Zhi Mao, Ruogu Lu, Rongyao Hou, Xiaoyan Zhu

The association between different insulin resistance surrogates and all-cause mortality and cardiovascular mortality in patients with metabolic dysfunction-associated steatotic liver disease

Xin Gao, Tianyi Chen, Feilong Zhou, Yanmei Sun, Jiaqi Zhang, Xinhao Li, Weijie Zhao, Yunxin Li, Yanlong Shi, Kaiyi Niu, Yizhu Wang, Yewei Zhang, Wei Zhang

Circulating mediators linking cardiometabolic diseases to HFpEF: a mediation Mendelian randomization analysis

Mingzhi Lin, Jiuqi Guo, Hongqian Tao, Zhilin Gu, Wenyi Tang, Fuliang Zhou, Yanling Jiang, Ruyi Zhang, Dalin Jia, Yingxian Sun, Pengyu Jia

Association between cumulative changes of the triglyceride glucose index and incidence of stroke in a population with cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study

Lifei Lu, Yubiao Chen, Baiyun Liu, Xicong Li, Jiale Wang, Zhengchang Nie, Xiaodong Fu

Diabetes mellitus aggravates myocardial inflammation and oxidative stress in aortic stenosis: a mechanistic link to HFpEF features

Melissa Herwig, Marcel Sieme, Andrea Kovács, Muchtiar Khan, Andreas Mügge, Wolfgang E. Schmidt, Ferhat Elci, Shan Sasidharan, Peter Haldenwang, Jan Wintrich, Benjamin Sasko, Ibrahim Akin, Máthé Domokos, Francesco Paneni, Ibrahim El-Battrawy, Zoltán V. Varga, Francisca Saraiva, Adelino F. Leite-Moreira, Péter Ferdinandy, Loek van Heerebeek, Inês Falcão-Pires, Nazha Hamdani

Correction: Deficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction

  • Open Access
  • Correction

Feng Shao, Johanna Wieland, Yixin Wang, Merve Keles, Zenghui Meng, Santosh Lomada, Miao Qin, Veronika Leiss, Abel Martin-Garrido, Manuela Fuhrmann, Yi Qiu, Felix A. Trogisch, Christiane Vettel, Joerg Heineke, Yuxi Feng

Extracellular vesicle-associated miR-515-5p from adipose tissue regulates placental metabolism and fetal growth in gestational diabetes mellitus

Nanthini Jayabalan, Soumyalekshmi Nair, Andrew Lai, Katherin Scholz-Romero, Melissa Razo-Azamar, Valeska Ormazabal, Ratana Lim, Flavio Carrion, Dominic Guanzon, Gregory E. Rice, Harold David McIntyre, Martha Lappas, Carlos Salomon

Sacubitril/Valsartan attenuates progression of diabetic cardiomyopathy through immunomodulation properties: an opportunity to prevent progressive disease

Narainrit Karuna, Lauren Kerrigan, Kevin Edgar, Mark Ledwidge, Ken McDonald, David J. Grieve, Chris J. Watson

Atherogenic lipid parameters in people with normal glucose tolerance: implications from elevated 1-hour post-load plasma glucose

Chunyu Yang, Xin Chai, Yachen Wang, Di Li, Dongli Zhu, Kaipeng Liang, Jinping Wang, Zhiwei Yang, Qiuhong Gong, Juan Zhang, Ruitai Shao

The effects of SGLT2i on cardiac metabolism in patients with HFpEF: Fact or fiction?

Francesca Cinti, Renzo Laborante, Luigi Cappannoli, Cassandra Morciano, Shawn Gugliandolo, Alfredo Pontecorvi, Francesco Burzotta, Maria Donniacuo, Donato Cappetta, Giuseppe Patti, Andrea Giaccari, Domenico D’Amario

How does biological age acceleration mediate the associations of obesity with cardiovascular disease? Evidence from international multi-cohort studies

Lin Hu, Jiayuan Li, Zihuan Tang, Peng Gong, Zongqi Chang, Chen Yang, Tianpei Ma, Shuang Jiang, Chunxia Yang, Tao Zhang

Use of an insulin titration protocol based on continuous glucose monitoring in postoperative cardiac surgery patients with type 2 diabetes and prediabetes: a randomized controlled trial

Sun-Joon Moon, Min-Su Kim, Yun Tae Kim, Ha-Eun Lee, Young-Woo Lee, Su-Ji Lee, Euy-Suk Chung, Cheol-Young Park

Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets

Simin Delalat, Innas Sultana, Hersh Osman, Marcel Sieme, Saltanat Zhazykbayeva, Melissa Herwig, Heidi Budde, Árpád Kovács, Mustafa Kaçmaz, Eda Göztepe, Natalie Borgmann, Gelareh Shahriari, Benjamin Sasko, Jan Wintrich, Peter Haldenwang, Wolfgang E. Schmidt, Wiebke Fenske, Muchtiar Khan, Kornelia Jaquet, Andreas Mügge, Domokos Máthé, Viktória E. Tóth, Zoltán V. Varga, Péter Ferdinandy, Ibrahim El-Battrawy, Loek van Heerebeek, Nazha Hamdani

Correction: Cost‑effectiveness of finerenone in chronic kidney disease associated with type 2 diabetes in The Netherlands

Sara W. Quist, Alexander V. van Schoonhoven, Stephan J. L. Bakker, Michał Pochopień, Maarten J. Postma, Jeanni M. T. van Loon, Jeroen H. J. Paulissen

A validated multivariable machine learning model to predict cardio-kidney risk in diabetic kidney disease

James L. Jr. Januzzi, Naveed Sattar, Muthiah Vaduganathan, Craig A. Magaret, Rhonda F. Rhyne, Yuxi Liu, Serge Masson, Javed Butler, Michael K. Hansen

Correction: Insights into the complex relationship between triglyceride glucose-waist height ratio index, mean arterial pressure, and cardiovascular disease: a nationwide prospective cohort study

  • Open Access
  • Correction

Jie Xu, Dihui Cai, Yuheng Jiao, Yingying Liao, Yinyin Shen, Yunli Shen, Wei Han

Effect of glycemic status on myocardial deformation and microvascular function in uncomplicated pediatric type 1 diabetes mellitus: cardiac magnetic resonance imaging

Lu Zhang, Shan Huang, Xueming Li, Zhi Yang, Pengfei Ye, Ran Sun, Huayan Xu, Rong Xu, Meng Zhang, Ying Liu, Chuanjie Yuan, Jin Wu, Yingkun Guo

The role of diabetes mellitus on delirium onset: a systematic review and meta-analysis

Klara Komici, Carlo Fantini, Gaetano Santulli, Leonardo Bencivenga, Grazia Daniela Femminella, Germano Guerra, Pasquale Mone, Giuseppe Rengo

Cardiovascular disease in women with type 1 diabetes: a narrative review and insights from a population-based cohort analysis

Alex Mesa, Josep Franch-Nadal, Elena Navas, Dídac Mauricio

The predictive significance of the triglyceride-glucose index in forecasting adverse cardiovascular events among type 2 diabetes mellitus patients with co-existing hyperuricemia: a retrospective cohort study

Jianyong Zhao, Na Li, Shiqi Li, Jiaqing Dou

Association between the atherogenic index of plasma and incident hypertension across different blood pressure states: a national cohort study

Degang Mo, Peng Zhang, Miao Zhang, Hongyan Dai, Guoan Wang

Association between atherogenicity indices and prediabetes: a 5-year retrospective cohort study in a general Chinese physical examination population

Xianli Qiu, Yong Han, Changchun Cao, Yuheng Liao, Haofei Hu

Impact of SGLT2-inhibitors on acute kidney injury in diabetic patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI)

Pasquale Paolisso, Marta Belmonte, Emanuele Gallinoro, Roberto Scarsini, Luca Bergamaschi, Leonardo Portolan, Matteo Armillotta, Giuseppe Esposito, Elisabetta Moscarella, Claudio Montalto, Elayne Kelen de Oliveira, Francesco Angeli, Mateusz Orzalkiewicz, Margherita Fabroni, Verdiana Galli, Nurcan Baydaroglu, Francesca Di Lenarda, Pasquale Policastro, Carlo Terrone, Davide Ausiello, Giose Vincelli, Matteo Casenghi, Lucia Scisciola, Raffaele Marfella, Felice Gragnano, Edoardo Conte, Dario Pellegrini, Alfonso Ielasi, Daniele Andreini, Jacopo Andrea Oreglia, Paolo Calabrò, Antonio L. Bartorelli, Tullio Palmerini, Francesco Saia, Flavio Ribichini, Michelangela Barbieri, Marc Vanderheyden, Carmine Pizzi, Emanuele Barbato

Cardiovascular risk profile in subjects with diabetes: Is SCORE2-Diabetes reliable?

Sabrina Scilletta, Maurizio Di Marco, Nicoletta Miano, Stefania Capuccio, Marco Musmeci, Giosiana Bosco, Francesco Di Giacomo Barbagallo, Marina Martedì, Francesca La Rocca, Alessio Vitale, Roberto Scicali, Salvatore Piro, Antonino Di Pino

Perivascular adipose tissue dysfunction contributes to thoracic aortic aneurysm development

Zhenguo Wang, Wenjuan Mu, Ruiyan Xu, Juan Zhong, Wenhao Xiong, Xiangjie Zhao, Xiubin Liang, Yanhong Guo, Jifeng Zhang, Zhi-Sheng Jiang, Bo Yang, Y. Eugene Chen, Lin Chang

Refining the link between obesity and heart failure: insights from GLP-1 receptor agonist trials and studies adopting direct adiposity measures

Nicola Riccardo Pugliese, Francesco Paneni, Domenico Tricò, Alessandra Violet Bacca, Nicolò De Biase, Hermann Dalpiaz, Alessandro Mengozzi, Agostino Virdis, Lorenzo Ghiadoni, Stefano Taddei, Reinhold Kreutz, Konstantinos Tsioufis, Stefano Masi

Cumulative blood pressure load as a predictor of arterial stiffness progression and incident diabetic kidney disease: a multicenter longitudinal study

Cong Liu, Bangqun Ji, Yao Liang, Juan Shi, Yufan Wang, Tingyu Ke, Li Li, Dong Zhao, Yuancheng Dai, Qijuan Dong, Fengmei Xu, Ying Peng, Weiqing Wang, Qidong Zheng, Yifei Zhang

Metabolic profiling of frailty, associations with type 2 diabetes and interaction with genetic susceptibility

Yuxiang Wang, Shuang Chen, Yue Li, Qi Lu, Rui Li, Jun-Xiang Chen, Ji-Juan Zhang, Hancheng Yu, Hanrui Xu, Jinchi Xie, Xianli Li, Gang Liu, An Pan, Tingting Geng, Yun-Fei Liao

Impact of sodium–glucose transport protein-2 (SGLT2) inhibitors on the inflammasome pathway in acute myocardial infarction in type 2 diabetes mellitus: a comprehensive review

Thomas T. Yoo, In Hae Baek, Liset Stoletniy, Anthony Hilliard, Antoine Sakr, Desislava Doycheva

Correction: Association of different insulin resistance surrogates with all-cause and cardiovascular mortality among the population with cardiometabolic multimorbidity

  • Open Access
  • Correction

Hongqiang Zhang, Zhixin Tu, Sihua Liu, Jumei Wang, Jie Shi, Xingyu Li, Rongdongqing Shi, Minghui Chen, Tong Yue, Sihui Luo, Yu Ding, Xueying Zheng

Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study

Jin Wang, Wei-Feng Yan, Ke Shi, Hua-Yan Xu, Shi-Qin Yu, Ying-Kun Guo, Li Jiang, Yue Gao, Yu-Jiang, Xue-Ming Li, Yuan Li, Zhi-Gang Yang

Increased prevalence and risk of atherosclerotic cardiovascular disease in individuals with Type 1 diabetes and metabolic dysfunction-associated steatotic liver disease

Jonathan Mertens, Jonas Weyler, Eveline Dirinck, Luisa Vonghia, Wilhelmus J. Kwanten, Luc F. Van Gaal, Benedicte Y. De Winter, Sven Francque, Christophe De Block

Epigenetic crossroads in metabolic and cardiovascular health: the role of DNA methylation in type 2 diabetes and cardiovascular diseases

Suneesh Kaimala, Lidya K. Yassin, Mohammad I. K. Hamad, Mohammed Z. Allouh, Prabha Sampath, Juma AlKaabi, Melvin Khee-Shing Leow, Safa Shehab, Suraiya Anjum Ansari, Bright Starling Emerald

Effects of dapagliflozin on the progression of left ventricular dysfunction in type 2 diabetes mellitus: a randomized controlled trial

Thomas H. Marwick, Amera Halabi, Cheng Hwee Soh, Annie Curtin, Ashleigh-Georgia Sherrif, Atro Azad, Leah Wright

Statin-induced risk of diabetes does not reduce cardiovascular benefits in primary prevention: a 6-year propensity-score matched study in a large population

Maria Lembo, Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Stanislovas S. Jankauskas, Paola Gallo, Roberto Piccinocchi, Carmine Morisco, Gaetano Piccinocchi, Luca Bardi, Stefano Cristiano, Giovanni Esposito, Giuseppe Giugliano, Fahimeh Varzideh, Maria Virginia Manzi, Bruno Trimarco, Gaetano Santulli

The impact of dietary interventions on cardiometabolic health

  • Open Access
  • Review

Erind Gjermeni, Raluca Fiebiger, Linnaeus Bundalian, Antje Garten, Torsten Schöneberg, Diana Le Duc, Matthias Blüher

Tenascin-C drives cardiovascular dysfunction in a mouse model of diabetic cardiomyopathy

Zsuzsanna Arnold, Christopher Dostal, Petra Lujza Szabó, Ibrahim Aykac, Ana Isabel Antunes Goncalves, Silva Laura Sousa, Simge Baydar, Heidi Budde, Barnabás Váradi, György L. Nadasy, Mária Szekeres, Camilla Hage, Lars H. Lund, Sarah Costantino, Dietmar Abraham, Karin Zins, Seth Hallström, Martin Bilban, Bence Ágg, Nazha Hamdani, Péter Ferdinandy, Francesco Paneni, Attila Kiss, Bruno K. Podesser

SREBP1 deficiency aggravates vascular calcification via iASPP-triggered ferroptosis of vascular smooth muscle cells

Yunhui Wu, Binhong Yang, Haoqi Sun, Meijuan Cheng, Jingjing Jin, Dongxue Zhang, Lixin Chang, Shenglei Zhang, Yaling Bai, Jinsheng Xu

Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease

Jing Xu, Hangyu Chen, Jingang Yang, Yanmin Yang, Yuan Wu, Jun Zhang, Jiansong Yuan, Tianjie Wang, Tao Tian, Jia Li, Xueyan Zhao, Xiaojin Gao, Jie Lu, Lin Li, Lei Zhang, Xuehui Li, Long Chen, Chuan He, Chaoran Dong, Jian Lin, Weixian Yang, Yuejin Yang

Sex-specific cardiometabolic multimorbidity, metabolic syndrome and left ventricular function in heart failure with preserved ejection fraction in the UK Biobank

Ambre Bertrand, Xin Zhou, Andrew Lewis, Thomas Monfeuga, Ramneek Gupta, Vicente Grau, Blanca Rodriguez

Pseudohypoxia caused by germline genetic alterations in the VHL gene is associated with increased diabetes and cardiovascular risk: a UK biobank study

Reut Halperin, Roi Horwitz, Yair Schwarz, Amit Tirosh

Treatment with orforglipron, an oral glucagon like peptide-1 receptor agonist, is associated with improvements of CV risk biomarkers in participants with type 2 diabetes or obesity without diabetes

Sean Wharton, Julio Rosenstock, Manige Konige, Yanzhu Lin, Kevin Duffin, Jonathan Wilson, Hiya Banerjee, Valentina Pirro, Christof Kazda, Kieren Mather

Causal association of modifiable factors with cardiometabolic multimorbidity: an exposome-wide Mendelian randomization investigation

Dun Li, Jing Lin, Hongxi Yang, Lihui Zhou, Yujian Li, Zhe Xu, Li Sun, Xinyu Zhang, Weili Xu, Yaogang Wang

Impact of steatotic liver diseases on diabetes mellitus risk in patients with atrial fibrillation: a nationwide population study

Hyunho Ryu, So-Ryoung Lee, Eue-Keun Choi, Young-Hae Go, Kyung-Yeon Lee, JungMin Choi, Seokmoon Han, Jae-Hyun Kim, Hyo-Jeong Ahn, Soonil Kwon, Bong-Seoung Kim, Kyung-Do Han, Seil Oh, Gregory Y. H. Lip

Type 2 diabetes worsens the outcome of ischemia/reperfusion in female STEMI patients and female db/db mice with HFpEF cardiometabolic phenotype

Ivana Iveljic, Megan Young, Elvira Corhodzic, Fenn Cullen, Hiran A. Prag, Michael P. Murphy, Dunja Aksentijevic

Characterizing trajectories of diabetes-related health parameters before diabetes diagnosis in diabetes subtypes: analysis of a 20-year long prospective cohort study in Sweden

Tatjana P. Liedtke, Eike A. Strathmann, Emma Ahlqvist, Olof Asplund, Charlena S. Penz, Paula Stürmer, Cara Övermöhle, Anton Lager, Boel Brynedal, Hrafnhildur Gudjonsdottir, Wolfgang Lieb, Katharina S. Weber

Correction: Association of non-insulin-based insulin resistance indices with disease severity and adverse outcome in idiopathic pulmonary arterial hypertension: a multi-center cohort study

Sicheng Zhang, Luyang Gao, Sicong Li, Manqing Luo, Lichuan Chen, Qunying Xi, Zhihui Zhao, Qing Zhao, Tao Yang, Qixian Zeng, Xin Li, Zhihua Huang, Anqi Duan, Yijia Wang, Qin Luo, Yansong Guo, Zhihong Liu

Correction: Association between triglyceride–glucose index and mortality in critically ill patients with atrial fibrillation: a retrospective cohort study

Rong Ding, Erjing Cheng, Miao Wei, Liya Pan, Lu Ye, Yi Han, Xuan Zhang, Chao Xue, Jiannan Gong, Hui Zhao

Interleukin-1β in circulating mononuclear cells predicts steatotic liver disease improvement after weight loss in subjects with obesity and prediabetes or type 2 diabetes

Paola Giustina Simeone, Sarah Costantino, Rossella Liani, Romina Tripaldi, Augusto Di Castelnuovo, Armando Tartaro, Alessandro Mengozzi, Francesco Cosentino, Francesco Cipollone, Agostino Consoli, Francesco Paneni, Francesca Santilli

Cumulative exposures to glycaemia and lipids are associated with coronary artery disease in type 1 diabetes: a call for action

Rebecka Bergdal, Valma Harjutsalo, Per-Henrik Groop, Stefan Mutter

Vascular effects of perivascular adipose tissue-derived chemerin in obesity-associated cardiovascular disease

Andy W. C. Man, Ning Xia, Huige Li

Novel insights into beta cell ER stress CHOP and its role in HFpEF development

  • Open Access
  • Research

Balaji Srinivas, Paula Fortuno, Hongmei Peng, Jiang Xu, Hamid Suhail, Hani N. Sabbah, Nour-Eddine Rhaleb, Khalid Matrougui

Stress hyperglycemia ratio and the risk of new-onset chronic diseases: results of a national prospective longitudinal study

Zhuang Ma, Lanlan Wu, Zheng Huang

Correction: Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study

Liye Lai, Dave Laurence Juntilla, Monica Del C. Gomez-Alonso, Harald Grallert, Barbara Thorand, Aiman Farzeen, Wolfgang Rathmann, Juliane Winkelmann, Holger Prokisch, Christian Gieger, Christian Herder, Annette Peters, Melanie Waldenberger

Tirzepatide, a dual GIP/GLP1-receptor co-agonist preserves cardiac function and improves survival in angiotensin II-induced heart failure model in mice: comparison to liraglutide

Zsombor I. Hegedűs, Márk E. Jakab, Tamás G. Gergely, Nabil V. Sayour, Andrea Kovács, Sára Antal, Tamás Kovács, Péter Ferdinandy, Zoltán V. Varga, Viktória E. Tóth

Association of atherogenic index of plasma and its modified indices with stroke risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0–3: a longitudinal analysis based on CHARLS

Xiaoyan Wang, Pengfei Wen, Yun Liao, Tao Wu, Lin Zeng, Yuxing Huang, Xiaomei Song, Zhen Xiong, Lisha Deng, Dingjun Li, Shuchuan Miao

Impact of different hypertensive disorders of pregnancy on cardiovascular disease risk and all-cause mortality in women with type 1 diabetes

Kaarina Rimpeläinen, Fanny Jansson Sigfrids, Daniel Gordin, Miira M. Klemetti, Valma Harjutsalo, Per-Henrik Groop, Lena M. Thorn

Beyond overweight, visceral adiposity is associated with estimation of cardiovascular risk in patients living with type 1 diabetes: findings from the SFDT1 cohort

Laurence Salle, Jean-Baptiste Julla, Guy Fagherazzi, Pierre Gourdy, Erika Bezerra Parente, Hélène Hanaire, Sopio Tatulashvili, Emmanuel Disse, Sylvia Franc, Samy Hadjadj, Etienne Larger, Caroline Sanz, Patricia Vaduva, René Valero, Amélie Bonnefond, Emmanuel Cosson, Gloria A. Aguayo, Jean-Pierre Riveline

Associations of different insulin resistance-related indices with the incidence and progression trajectory of cardiometabolic multimorbidity: a prospective cohort study from UK biobank

Zhenyu Tian, Lu Yang, Yifei Li, Yueqing Huang, Jianmin Yang, Fei Xue

Atrial dysfunction: a contrast-free marker for HFpEF in obese diabetics—insights from comprehensive CMR and serum biomarker analyses

Rebecca Elisabeth Beyer, Maximilian Leo Müller, Patrick Doeblin, Stefanie Maria Werhahn, Amedeo Chiribiri, Carsten Tschöpe, Smita Sampath, G. Brandon Atkins, Dawn Cislak, An Bautmans, John Palcza, Tom McAvoy, Asad Abu Bakar, Anita Y. H. Lee, Xuemei Zhao, Maximilian G. Posch, Johannes Wieditz, Radu Tanacli, Victoria Zieschang, Mithal Nassar, Seyedeh Mahsa Zamani, Christian Stehning, Frank Edelmann, Djawid Hashemi, Sebastian Kelle

Daily low dose aspirin halves incident type 2 diabetes in elderly subjects with prediabetes: a five-year longitudinal cohort study in a real-word population

Maria Lembo, Valentina Trimarco, Daniela Pacella, Raffaele Izzo, Maria Virginia Manzi, Stanislovas S. Jankauskas, Roberto Piccinocchi, Paola Gallo, Carmine Morisco, Luca Bardi, Gaetano Piccinocchi, Stefano Cristiano, Giuseppe Giugliano, Giovanni Esposito, Gaetano Santulli, Bruno Trimarco

Retraction Note: Protective role of arachidonic acid against diabetic myocardial ischemic injury: a translational study of pigs, rats, and humans

  • Open Access
  • Retraction Note

Yunhui Lv, Kai Li, Shuo Wang, Xiaokang Wang, Guangxin Yue, Yangyang Zhang, Xin Lv, Ping Zhao, Shiping Wang, Qi Zhang, Qiuju Li, Jinyan Zhu, Jubo Li, Peng Peng, Yue Li, Jiafei Luo, Xue Zhang, Jianzhong Yang, Baojie Zhang, Xuemin Wang, Min Zhang, Chen Shen, Xin Wang, Miao Wang, Zhen Ye, Yongchun Cui

The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI study

Li Jiang, Yuan Li, Xue-Ming Li, Ke Shi, Han Fang, Wei‑Feng Yan, Ying‑Kun Guo, Hua‑Yan Xu, Zhi-Gang Yang

Association of prediabetes and insulin resistance on prognosis of patients with moderate-to-severe coronary artery calcification: a prospective cohort study

Enmin Xie, Huimin Cai, Zixiang Ye, Min Yang, Lei Feng, Chenggang Zhu, Jia Li, Kefei Dou

Interpretable machine learning analysis of immunoinflammatory biomarkers for predicting CHD among NAFLD patients

Wenyuan Dong, Hongcheng Jiang, Yu Li, Luo Lv, Yuxin Gong, Bao Li, Hongjie Wang, Hesong Zeng

Efficacy and safety of Tafolecimab in Chinese patients with type 2 diabetes and hypercholesterolemia: a post-hoc analysis of pooled data from three phase 3 trials

Litong Qi, Hua Shen, Meng Chai, Beijian Chen, Yongming He, Xiaoxia Shi, Qiufang Lian, Wang Zhao, Yanling Qu, Lei Qian, Jianwei Zhang, Haoyu Li, Yujie Zhou, Yong Huo

Cardiometabolic heart failure with preserved ejection fraction: from molecular signatures to personalized treatment

Era Gorica, Martin A. Geiger, Ludovica Di Venanzio, Natalia Atzemian, Jan Alphard Kleeberger, Dominique Grigorian, Alessia Mongelli, Besa Emini Veseli, Shafeeq A. Mohammed, Frank Ruschitzka, Andreas J. Flammer, David Niederseer, Sarah Costantino, Francesco Paneni

Human cardiac tissues produce lower contractile stress and exhibit slower cross-bridge cycling in type 2 diabetes

  • Open Access
  • Research

J. H. Musgrave, J.-C. Han, M.-L. Ward, N. Kang, A. J. Taberner, K. Tran

Determinants of temporal change in telomere length and its associations with chronic complications and mortality in type 2 diabetes: the Fremantle diabetes study phase II

Chieh-Hsin Yang, Michael L H Huang, Wendy A Davis, Alicia J Jenkins, Timothy M E Davis

Single nuclei RNA-sequencing unveils alveolar macrophages as drivers of endothelial damage in obese HFpEF-related pulmonary hypertension

Era Gorica, Jacopo Spezzini, Iliana Papadopoulou, Marialucia Telesca, Valeria Masciovecchio, Shafeeq A. Moahmmed, Alessandro Mengozzi, Hung-Wei Cheng, Natalia Atzemian, Ludovica Di Venanzio, Alessia Mongelli, Omer Dzemali, Vincenzo Calderone, Francesco Paneni, Christian M. Matter, Burkhard Ludewig, Frank Ruschitzka, Sarah Costantino

Metabotype identification via fasting and postprandial metabolomics and its association with type 2 diabetes incidence

Keyong Deng, David A. Hughes, Renée de Mutsert, Astrid van Hylckama Vlieg, Saskia le Cessie, Frits R. Rosendaal, Dennis O. Mook-Kanamori, Ko Willems van Dijk, Nicholas J. Timpson, Ruifang Li-Gao

A scoring model integrating CXCL9, GDF15, FGF21, and NfL, predicts long-term mortality in type 2 diabetes: a retrospective study

Matilde Sbriscia, Sara Caccese, Francesca Marchegiani, Rina Recchioni, Giulia Matacchione, Chiara Giordani, Emanuele Francini, Stefano Salvioli, Maria Conte, Matteo Landolfo, Anna Rita Bonfigli, Federica Turchi, Jacopo Sabbatinelli, Fabiola Olivieri, Angelica Giuliani

Prognostic value of lipoprotein(a) for cardiovascular events after lower limb revascularization in diabetic patients with chronic limb-threatening ischemia

Federico Biscetti, Maria Margherita Rando, Maria Anna Nicolazzi, Flavia Angelini, Roberto Iezzi, Luis H. Eraso, Paul J. Dimuzio, Dario Pitocco, Massimo Massetti, Antonio Gasbarrini, Andrea Flex

Acid sphingomyelinase promotes diabetic cardiomyopathy via disruption of mitochondrial calcium homeostasis

Yu Wei, Yang Ji, Jiahui Meng, Li Yu, Yongzhong Tang, Wei-Jin Fang

Muscle-specific miR-499-5p delivered by small extracellular vesicles impairs endothelial function and ischemic hindlimb recovery in diabetic mice

  • Open Access
  • Research

Zhongjian Cheng, May M. Truongcao, Vandana Mallaredy, Maria Cimini, Charan Thej, Darukeshwara Joladarashi, Carolina Gonzalez, Cindy Benedict, Suresh K. Verma, Venkata Naga Srikanth Garikipati, Raj Kishore

Association between modified triglyceride glucose indices and stroke risk in middle-aged and older Chinese adults: a prospective cohort study

Jiaan Sun, Xianglong Meng, Lichun Guo, Chongwen Nian, Haina Li, Wanxin Huang

Remnant–to–LDL cholesterol discordance as a predictor of thromboembolic events in anticoagulated patients with atrial fibrillation: a report from the prospective Murcia AF project III (MAFP-III) cohort study

Eva Soler-Espejo, Yang Chen, José Miguel Rivera-Caravaca, María Pilar Ramos-Bratos, Raquel López-Gálvez, Francisco Marín, Vanessa Roldán, Gregory Y.H. Lip

Prevalence and thrombotic risk of SGLT-2 inhibitor-associated erythrocytosis: a retrospective cohort study

Ji Yun Lee, Ju-Hyun Lee, Eun-Jung Jung, Woochan Park, Jeongmin Seo, Minsu Kang, Eun Hee Jung, Sang-A Kim, Koung Jin Suh, Ji-Won Kim, Se Hyun Kim, Jeong-Ok Lee, Jin Won Kim, Yu Jung Kim, Keun-Wook Lee, Jee Hyun Kim, Soo-Mee Bang

Triglyceride-glucose-related indices and risk of cardiovascular disease and mortality in individuals with cardiovascular–kidney–metabolic (CKM) syndrome stages 0–3: a prospective cohort study of 282,920 participants in the UK Biobank

Kun Liu, Jinling Hu, Yueqing Huang, Dingliu He, Jing Zhang

Association between trajectory of triglyceride-glucose index and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective cohort study

Shangsong Shi, Feng Xue, Tingbo Jiang, Lin Ling

Combined impact of prediabetes and fatty liver index on cardiometabolic outcomes and mortality in middle aged adults: a nationwide cohort study

Young Sang Lyu, Minae Park, Hee Kyung Kim, Sojeong Park, Ji Yong Park, A Ram Hong, Jee Hee Yoon, Seogsong Jeong, Youngmin Yoon, Jin Hwa Kim, Sang Yong Kim, Ho-Cheol Kang, Wonsuk Choi

Preclinical atherosclerosis and prediabetes: a cross-sectional metabolic assessment in apparently healthy population

Natalia Zieleniewska, Jacek Jamiołkowski, Marcin Kondraciuk, Michal Ciborowski, Katarzyna Ptaszyńska, Małgorzata Chlabicz, Marlena Dubatówka, Urszula Roszkowska, Irina Kowalska, Karol Kamiński

The triglyceride-glucose index, a marker of insulin resistance, as a predictor of thrombotic risk in atrial fibrillation

José Miguel Rivera-Caravaca, Eva Soler-Espejo, María Pilar Ramos-Bratos, Raquel López-Gálvez, Eduardo González-Lozano, Gregory Y. H. Lip, Francisco Marín, Vanessa Roldán

Maternal coronary heart disease and mortality following hypertensive disorders of pregnancy and/or diabetes

Angela M. Malek, Dulaney A. Wilson, Julio Mateus, Emily A. Ash, Tanya N. Turan, Daniel T. Lackland, Kelly J. Hunt

Glyoxalase-1 overexpression attenuates arterial wall stiffening in diabetic mice

Margarita G. Pencheva, Eline Berends, Koen W. F. van der Laan, Alessandro Giudici, Petra Niessen, Jean L. J. M. Scheijen, Philippe Vangrieken, Peter Leenders, Tammo Delhaas, Florian Caiment, Martina Kutmon, Fabiola M. Trujillo, Kristiaan Wouters, Sébastien Foulquier, Bart Spronck, Koen D. Reesink, Casper G. Schalkwijk

Derivatives of the triglyceride–glucose index and their association with incident hypertension in prehypertensive individuals: a 4-year cohort study augmented by mendelian randomization

Mengmeng Wang, Tianqi Teng, Nan Zhang, Jiachao Xu, Zihan Dong, Qingying Jiao, Ning Zhang, Haichu Yu

Glucagon-like peptide-1 receptor agonist in myocardial infarction and atherosclerotic cardiovascular disease risk reduction: a comprehensive meta-analysis of number needed to treat, efficacy and safety

Ansel Shao Pin Tang, Jovan Teng Yuan Hsu, Sheena Kar Shuan Chong, Jingxuan Quek, Genevieve Shek, Farisah Sulaimi, Kai En Chan, Vickram Vijay Anand, Bryan Chong, Anurag Mehta, Sue-Anne Toh, Mark Muthiah, Georgios K. Dimitriadis, Carel W. le Roux, Mark Yan-Yee Chan, Mamas Andreas Mamas, Yip Han Chin, Nicholas W. S. Chew

Stress hyperglycemia ratio as a biomarker for early mortality risk stratification in cardiovascular disease: a propensity-matched analysis

Mingxing Lei, Yan Li, Longcan Cheng, Nan Tang, Jie Song, Mi Song, QingQing Su, Mingxuan Liu, Shihui Fu, Feng Lin, Yuan Gao

Distinct types of protein modifications in diabetic endothelial dysfunction

Qianyou Zhou, Xintong Ge, Zhaojing Chen, Danyi Cao, Yun Chen, Jiahai Shi, Guoliang Meng

Effects of RAS and SGLT2 inhibitors alone or in combination on end-stage kidney disease and/or all-cause death in patients with both diabetes and hypertension: a nationwide cohort study

Sangmo Hong, Kyungdo Han, Kyung-Soo Kim, Cheol-Young Park

Association of temporal MASLD with type 2 diabetes, cardiovascular disease and mortality

Eugene Han, Kyung-Do Han, Yong-ho Lee, Kyung-Soo Kim, Sangmo Hong, Jung Hwan Park, Cheol-Young Park

Impact of diabetes mellitus on myocardial function and clinical outcomes in patients with significant aortic regurgitation

Yuting Tan, Yujie Zhang, Qiuyu Cai, Ruohan Zhao, Weidong Luo, Jingrong Jiang, Jiawei Shi, Tianshu Liu, Li Qiu, Jing Wang

Editorial Expression of Concern: Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1

Andrew Moore, Amol Shindikar, Ingrid Fomison-Nurse, Federica Riu, Pujika E. Munasinghe, Thrishila Parshu Ram, Pankaj Saxena, Sean Coffey, Richard W. Bunton, Ivor F. Galvin, Michael J. A. Williams, Costanza Emanueli, Paolo Madeddu, Rajesh Katare

Correction: Statin-induced risk of diabetes does not reduce cardiovascular benefits in primary prevention: a 6-year propensity-score matched study in a large population

Maria Lembo, Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Stanislovas S. Jankauskas, Paola Gallo, Roberto Piccinocchi, Carmine Morisco, Gaetano Piccinocchi, Luca Bardi, Stefano Cristiano, Giovanni Esposito, Giuseppe Giugliano, Fahimeh Varzideh, Maria Virginia Manzi, Bruno Trimarco, Gaetano Santulli

Cardiac digital twins: a tool to investigate the function and treatment of the diabetic heart

  • Open Access
  • Review

Marina Strocchi, Daniel J. Hammersley, Brian P. Halliday, Sanjay K. Prasad, Steven A. Niederer

AI-Driven segmentation and morphogeometric profiling of epicardial adipose tissue in type 2 diabetes

Fan Feng, Abdallah I. Hasaballa, Ting Long, Xinyi Sun, Justin Fernandez, Carl-Johan Carlhäll, Jichao Zhao

C-C chemokine ligand 5 from women subcutaneous adipose tissue has a central role in vascular aging

Laura Le Pelletier, Kenza Ngono Ayissi, Jennifer Gorwood, Emilie Capel, Romain Morichon, Matthieu Mantecon, Martine Auclair, Rohia Alili, Christine Katlama, Lise Cuzin, Michael Atlan, Carine Beaupère, Christine Poitou, Franck Boccara, Bruno Fève, Jacqueline Capeau, Claire Lagathu, Véronique Béréziat

C-reactive protein-triglyceride glucose index in evaluating cardiovascular disease and all-cause mortality incidence among individuals across stages 0–3 of cardiovascular–kidney–metabolic syndrome: a nationwide prospective cohort study

Huiwen Ou, Miaomiao Wei, Xin Li, Xiaoshuang Xia

Low LDL particle levels associate with coronary arteries free from atherosclerosis in long-term type 1 diabetes: the Dialong study

Marte Narum, Jacob Juel Christensen, Kirsten B. Holven, Tore Julsrud Berg, Kari Anne Sveen

Prognostic impact of type 2 diabetes mellitus and coronary microvascular dysfunction in patients undergoing rotational atherectomy during PCI

Lijun Feng, Yuxuan Zhang, Chenyun Zhang, Zining Chen, Jingnan Pan, Zhiling Gao, Delong Chen, Abuduwufuer Yidilisi, Jiacheng Fang, Yiyue Zheng, Tingting Mei, Jiantao Liu, Jianping Xiang, Jinlong Zhang, Changling Li, Jifang Cheng, Jian’an Wang, Jun jiang

Association between triglyceride-glucose-body mass index and adverse prognosis in elderly patients with severe heart failure and type 2 diabetes: a retrospective study based on the MIMIC-IV database

Jing Cheng, Qi Cheng, Yingting Wu, Jiashun Yin, Fei He

Interpretable machine learning-guided single-cell mapping deciphers multi-lineage pancreatic dysregulation in type 2 diabetes

Xueqin Xie, Changchun Wu, Yuhe Yang, Wei Su, Fuying Dao, Jian Huang, Zheng Shi, Hao Lyu, Hao Lin

Association of novel triglyceride-glucose-related indices with incident stroke in early-stage cardiovascular-kidney-metabolic syndrome

Yong Yue, Pengcheng Li, Zhengyu Sun, Rumi Murayama, Zongping Li, Kenji Hashimoto, Ye Zhang

Trace elements and risk of diabetes-related vascular complications: results from the EPIC-Potsdam cohort study

Barbaros Eroglu, Fabian Eichelmann, Olga Kuxhausf, Anna P. Kipp, Tanja Schwerdtle, Hajo Haase, Lutz Schomburg, Matthias B. Schulze

Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident cardiovascular disease in middle-aged and older Chinese adults: a nationwide cohort study

Xiujuan Ma, Xiaodong Ma, Yulong Wang, Gang Qiu, Chunjuan Zhang

Triglyceride-glucose index: a novel assessment tool for all-cause mortality in critical stroke patients—a retrospective analysis of the eICU-CRD database

Bo Wu, Wanli Yu, Gang Zhang, Haotian Jiang, Nan Wu

Diabetic kidney disease phenotypes and the risk of cardiovascular events: The Silesia Diabetes-Heart Project

Oliwia Janota-Sosińska, Marta Mantovani, Krzysztof Irlik, Hanna Kwiendacz, Anna Olejarz, Patrycja Pabis, Aleksandra Włosowicz-Momot, Julia Piaśnik, Wiktoria Wójcik, Paulina Szromek-Białek, Uazman Alam, Janusz Gumprecht, Gregory Y. H. Lip, Katarzyna Nabrdalik

Triglyceride glucose-weight-adjusted waist index as a cardiovascular mortality predictor: incremental value beyond the establishment of TyG-related indices

Jiajun Qiu, Jin’e Li, Shan Xu, Jingqi Yang, Haixia Zeng, Yuying Zhang, Shiqi Yang, Lixuan Fang, Jiadian Huang, Hongtao Zhou, Jiaying Feng, Yujie Zan, Jia Zhan, Jianping Liu

Efficacy and safety of dapagliflozin in patients hospitalized with COVID-19 with and without type 2 diabetes: a prespecified analysis of the DARE-19 randomized trial

Mohammad Abdel Jawad, Remo H. M. Furtado, Russell Esterline, Jan Oscarsson, Samvel B. Gasparyan, Gary G. Koch, Felipe Martinez, Omar Mukhtar, Subodh Verma, Anna Maria Langkilde, Philip Ambery, Shachi Patel, Kensey Gosch, Sheryl L. Windsor, Ronaldo V. P. Soares, Diogo D. F. Moia, Matthew Aboudara, Ali Javaheri, J. F. Kerr Saraiva, Lilia Nigro Maia, Otavio Berwanger, Andrew J. Sauer, Mikhail N. Kosiborod

Glucokinase activator, circulating metabolites, and cardio-cerebrovascular diseases: a Mendelian randomization study

Xiaohan Wang, Weimeng Cheng, Tingting Xu, Ping He, Tianyue Li, Ying Zhang, Zhonghai Wei

Hypoglycemia and glycemic variability in acute myocardial infarction: the lesser-known aspects of glycemic control

Claudia Lucci, Alessandro Marongiu, Stefano Genovese, Mario Mazza, Nicola Cosentino, Giancarlo Marenzi

Microvascular dysfunction across organs in heart failure with preserved ejection fraction: the PROSE-HFpEF case-control study

Jerremy Weerts, Blanche L. M. Schroen, Arantxa Barandiarán Aizpurua, Tos T. J. M. Berendschot, Lloyd Brandts, Carroll A. B. Webers, Sami O. Simons, Steven J. R. Meex, Ronald Henry, Carla J. H. van der Kallen, Hans-Peter Brunner-La Rocca, Christian Knackstedt, Stephane R. B. Heymans, Rudolf A. de Boer, Vanessa P. M. van Empel, Alfons J. H. M. Houben

Specific targeting of adipose tissue metabolism is superior to caloric restriction in treating obesity-related HFpEF

Simon Sedej, Alina Stockner, Renate Schreiber, Abhinav Diwan, Rolf Breinbauer, Mahmoud Abdellatif

Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases

  • Open Access
  • Research

Jia-Hao Wang, Shan-Shan Dong, Wei Huang, Hao-An Wang, Shao-Shan Liu, Xiaoyi Ma, Ren-Jie Zhu, Wei Shi, Hao Wu, Ke Yu, Tian-Pei Zhang, Cong-Ru Wang, Yan Guo, Hanzhong Xue, Tie-Lin Yang

Association of C-reactive protein-triglyceride glucose index with the incidence and mortality of cardiovascular disease: a retrospective cohort study

Yu Sun, Yu Guo, Shiyin Ma, Zhi Mao, Deguo Meng, Kaige Xuan, Ruogu Lu, Xudong Pan, Xiaoyan Zhu

Erythrocytosis incidence and thromboembolic risk in heart failure with reduced ejection fraction treated with SGLT2 inhibitors: a nationwide register-based cohort study

Abdullahi Ahmed Mohamed, Camilla Fuchs Andersen, Daniel Mølager Christensen, Lise Da Riis-Vestergaard, Milan Mohammad, Mariam Elmegaard, Casper Binding, Christian Torp-Pedersen, Tor Biering-Sørensen, Morten Lock Hansen, Lars Køber, Andreas Glenthøj, Jesper Jensen, Charlotte Andersson, Morten Schou, Gunnar Gislason

Metabolomic profiling reveals interindividual metabolic variability and its association with cardiovascular-kidney-metabolic syndrome risk

  • Open Access
  • Research

Meng Zhou, Wenxiu Sun, Yuhan Gao, Bei Jiang, Tianwei Sun, Rui Xu, Xiujuan Zhang, Qian Wang, Qiuhui Xuan, Shizhan Ma

Association between the C-reactive protein-triglyceride glucose index and new-onset coronary heart disease among metabolically heterogeneous individuals

Yafang Chen, Wenjun Jia, Jianmin Guo, Han Yang, Xi Sheng, Liping Wei, Jiao Li

Does diabetes status modify the association between the triglyceride-glucose index and major adverse cardiovascular events in patients with coronary heart disease? A systematic review and meta-analysis of longitudinal cohort studies

Shicong Xu, Zhihui Zhang, Jing Li, Yiyan Ding, Yuanguo Chen, Yunxia Zhou, Shenglin Hu

Predictive value of the combined triglyceride-glucose and frailty index for cardiovascular disease and stroke in two prospective cohorts

Yi-Chang Zhao, Shi-Qi Wu, Jia-Kai Li, Zhi-Hua Sun, Bi-Kui Zhang, Rao Fu, Miao Yan

Advances and challenges of targeting epicardial adipose tissue (EAT) and perivascular adipose tissue (PVAT)

Dan Liu, Wujun Chen, Zhu Guo, Qun Gao, Bin Wang, Jie Wang, Weichao Hu, Chao Wang, Shuai Wang, Xiaolin Wu, Mantao Xu, Ganqiu Lan

Biological aging and incident cardiovascular diseases in individuals with diabetes: insights from a large prospective cohort study

Zhiwei Zeng, Chunyu Yu, Runze Chen, Zhongchen Li, Peng Wang, Xueying Wang, Xi Li, Zhe Zheng

Longitudinal study reveals plasma glycans associations with prediabetes/type 2 diabetes in KORA study

Jiefei Niu, Elke Rodriguez, Tamara Štambuk, Irena Trbojević-Akmačić, Nikol Mraz, Jochen Seissler, Thomas Skurk, Sabrina Schlesinger, Annette Peters, Gordan Lauc, Christian Gieger, Harald Grallert

Glucose metabolism in heterozygous familial hypercholesterolemia with a founder effect and a high diabetes prevalence: a cross-sectional study

Ana María González-Lleó, Yeray Brito-Casillas, Virginia Martín-Santana, Yaiza Gil-Quintana, Antonio Tugores, Roberto Scicali, Marta Riaño, Luisa Hernández-Baraza, Roberto Jiménez-Monzón, Josefa Girona, Francesco Di Giacomo Barbagallo, Luis Masana, Mauro Boronat, Ana M. Wägner, Rosa M. Sánchez-Hernández

Acetylsalicylic acid and vorapaxar are less active, while 4-methylcatechol is more active, in type 1 diabetic patients compared to healthy controls

Markéta Paclíková, Lukáš Konečný, Alejandro Carazo, Kateřina Matoušová, Lenka Kujovská Krčmová, Vladimír Blaha, Alena Šmahelová, Přemysl Mladěnka

Cardiometabolic risk stratification in pediatric obesity: evaluating the clinical utility of fasting insulin and BMI-SDS

Rasmus Stenlid, Sami El Amrani, Sara Y. Cerenius, Banu K. Aydin, Hannes Manell, Katharina Mörwald, Julia Lischka, Julian Gomahr, Thomas Pixner, Iris Ciba, Stefan K. James, Anders Forslund, Daniel Weghuber, Peter Bergsten

Epicardial adipose tissue volume is associated with impaired left ventricular strain in patients with metabolic syndrome: the mediating role of myocardial energetic efficiency

Wei-Feng Yan, Jin Wang, Yuan Li, Shi-Qin Yu, Yu Jiang, Xue-Ming Li, Yi-Ning Jiang, Ke Shi, Yue Gao, Shan Huang, Zhi-Gang Yang

Development and validation of a machine learning model for predicting vulnerable carotid plaques using routine blood biomarkers and derived indicators: insights into sex-related risk patterns

Yimin E, Zhichao Yao, Maolin Ge, Guijun Huo, Jian Huang, Yao Tang, Zhanao Liu, Ziyi Tan, Yuqi Zeng, Junjie Cao, Dayong Zhou

Global detection and management of dysglycaemic patients with coronary artery disease results from the INTERASPIRE survey from 14 countries across six WHO regions

Safi Moayad Al-Azzawy, John William McEvoy, Isabelle Johansson, Agnieszka Adamska, Guy De Backer, Iris Erlund, Sandra Ganly, Catriona Jennings, Kornelia Kotseva, Gregory Y. H. Lip, Linda Mellbin, Kausik K. Ray, Terhi Vihervaara, David Wood, Ana Abreu, Wael Almahmeed, Ade Meidian Ambari, Junbo Ge, Hosam Hasan-Ali, Yong Huo, Piotr Jankowski, Rodney M. Jimenez, Yong Li, Syadi Mahmood Zuhdi, Abel Makubi, Amam Chinyere Mbakwem, Lilian Mbau, Jose Luis Navarro Estrada, Okechukwu Samuel Ogah, Elijah Nyainda Ogola, Adalberto Quintero–Baiz, Mahmoud Umar Sani, Maria Ines Sosa Liprandi, Jack Wei Chieh Tan, Miguel Alberto Urina Triana, Tee Joo Yeo, Dirk De Bacquer, Lars Rydén

Improving cardiovascular risk stratification: the role of abdominal obesity in predicting MACEs

Carlo De Matteis, Stefano Petruzzelli, Giusi Graziano, Fabio Novielli, Ersilia Di Buduo, Salvatore Cantatore, Elsa Berardi, Gianfranco Antonica, Maria Arconzo, Marica Cariello, Marilina Florio, Lucilla Crudele, Antonio Moschetta

The novel triglyceride‒glucose-weighted adjusted waist index as a supplementary diagnostic tool for heart failure: evidence of improved reclassification beyond traditional TyG-related indices from a cross-sectional study

Yuqin Fan, Dan Ye, Kebin Zhou, Lu Cai, Longhui Yu

Association of triglyceride-glucose-related indices with all-cause and cause-specific mortality in individuals with prediabetes

Liwen Zhang, Weili Zhao, Panpan Zheng, Fang Huang, Lili Zhang, Yuxin Zhang, Xian Xiu, Pei Zhang, Zanchao Liu, Lipeng Liu

Mitochondrial ultrastructural pathology in diabetic cardiomyopathy: integrated analysis via scanning electron microscopy and 3D visualization imaging

Bo Wang, Linghao Dai, Haowei Liang, Jiayu He, Jiayi Zhou, Yang Guan, Hui Wang

Crosstalk between perivascular adipose tissue and adipocyte-derived peptide in the pathogenesis of diabetic cardiomyopathy

Yingjie Feng, Yajing Wang, Yifan Deng, Peifen Li, Penghua Fang, Zhenwen Zhang

The predictive value of atherogenic index of plasma and clonal hematopoiesis of indeterminate potential among patients with STEMI—from a prospective cohort study

Xiaoxiao Zhao, Jiannan Li, Runzhen Chen, Nan Li, Linghan Xue, Shaodi Yan, Chen Liu, Peng Zhou, Yi Chen, Hongbing Yan, Yu Tan, Hanjun Zhao, Li Song

Cardiovascular autonomic neuropathy defined by indices of heart rate variability is associated with cardiovascular disease: a longitudinal cohort study of participants with type 1 diabetes

Barbara H. Braffett, Laure El ghormli, Catherine Martin, Neil H. White, Irl B. Hirsch, Anne Bantle, Anders Carlson, Ellen Leschek, Rose Gubitosi-Klug, Elsayed Z. Soliman, Adrian Vella, Bruce A. Perkins, Ionut Bebu, Rodica Pop-Busui

Association of circulating metabolites and polygenic risk score with incident type 2 diabetes: a prospective community-based cohort study

Masato Takase, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Ippei Chiba, Sayuri Tokioka, Kotaro Nochioka, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Seizo Koshiba, Kazuki Kumada, Ikuko Motoike, Eiji Hishinuma, Akira Narita, Taku Obara, Mami Ishikuro, Hisashi Ohseto, Ippei Takahashi, Tomoko Kobayashi, Eiichi N. Kodama, Yohei Hamanaka, Masatsugu Orui, Soichi Ogishima, Satoshi Nagaie, Nobuo Fuse, Junichi Sugawara, Shinichi Kuriyama, Koichi Matsuda, Yoko Izumi, Kinuko Ohneda, Kengo Kinoshita, Atsushi Hozawa, Masayuki Yamamoto

Predictive value and robustness of the stress hyperglycemia ratio combined with hypertension for stroke risk: evidence from the CHARLS cohort

Yaxuan He, Yu Cao, Rong Xiang, Fang Wang

Prognostic value of triglyceride-glucose index combined with stress hyperglycemia ratio for all-cause mortality in critically ill patients with stroke

Tengli Li, Zhiheng Yi, Yangshen Huang, Yuhan Tan, Shan Gao, Tingting Wang, Shaowei Guo

The dual GLP-1 and GIP receptor agonist tirzapetide provides an unintended interaction with the β-adrenoceptors and plays a role in glucose metabolism in hyperglycemic or senescent cardiac cells

Dunya Aydos, Zeynep Busra Aksoy, Mehmet Altay Unal, Kamil Can Akcali, Ceylan Verda Bitirim, Belma Turan

Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and all-cause mortality in type 1 diabetes

Heli Segersvärd, Niina Sandholm, Valma Harjutsalo, Heidi Tikkanen, Riikka Kosonen, Mika Laine, Ilkka Tikkanen, Per-Henrik Groop, Päivi Lakkisto

Lipoprotein levels and statin treatment related to dementia and cognitive decline in individuals with type 2 diabetes: an observational analysis from the ADVANCE study

Peder af Geijerstam, John Chalmers, Miriam Pikkemaat, Ruth Peters, Michel Marre, Giuseppe Mancia, Mark Woodward, Katie Harris

Unveiling biomarkers via plasma metabolome profiling for diabetic macrovascular and microvascular complications

Zhixi Li, Yuhan Ren, Feng Jiang, Kai Zhang, Xuan Meng, Yingfeng Zheng, Mingguang He

A decline in renal function is associated with a reduction in myocardial mechano-energetic efficiency in individuals at high cardiometabolic risk

Chiara M. A. Cefalo, Teresa Vanessa Fiorentino, Mariangela Rubino, Velia Cassano, Gaia Chiara Mannino, Alessia Riccio, Elena Succurro, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti

Comparative cardiovascular outcomes and safety of hypoglycemic drug classes in patients with type 2 diabetes and hypertension: a multicenter cohort analysis

Zhiyuan Wei, Wanqian Xu, Yu Wang, Yu Tian, Zhongmin Wang, Shenqi Jing, Weina Liu, Sipeng Shen, Chenlong Qin, Xin Zhang, Jingsong Li, Yun Liu

Evaluative performance of TyG-ABSI versus traditional indices in relation to cardiovascular disease and mortality: evidence from the U.S. NHANES

  • Open Access
  • Research

Xin Zheng, Wenjing Zhang, Feng Yang, Leigang Wang, Bing Yu, Bin Liang

Effect of SGLT2 inhibitors on cardiac structure and function assessed by cardiac magnetic resonance: a systematic review and meta-analysis

Isabella Leo, Nadia Salerno, Stefano Figliozzi, Angelica Cersosimo, Jessica Ielapi, Kamil Stankowski, Giandomenico Bisaccia, Santo Dellegrottaglie, Giovanni Canino, Salvatore De Rosa, Sabato Sorrentino, Chiara Bucciarelli-Ducci, Daniele Torella

Lipid metabolism-related inflammatory indices (LMIIs) and incident peripheral artery diseases (PAD) in patients with type 2 diabetes mellitus (T2DM): a multicohort study from China and the UK biobank

Yingying Wang, Qijing Jiang, Xiaoyan Li, Bichen Ren, Bingzhe Li, Hao Li, Yuan Fang, Zhihui Dong, Lihong Huang

Impact of changes in conventional risk factors induced by once-weekly GLP-1 receptor agonist exenatide on cardiovascular outcomes: an EXSCEL post hoc analysis

Ruth L. Coleman, Amanda I. Adler, Robert J. Mentz, Marat Fudim, Naveed Sattar, Rury R. Holman

Associations between steatotic liver disease subtypes and incident atrial fibrillation in young adults: a nationwide cohort study

Jeayeon Park, Goh Eun Chung, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Kyungdo Han, Eun Ju Cho

Atherogenic index of plasma and its 5-year changes associated with type 2 diabetes risk: a 10-Year cohort study

Liuding Wen, Yuying Wu, Xueru Fu, Weifeng Huo, Aijun Xu, Canjie Piao, Jingli Kong, Yaqin Su, Jinliang Liang, Botang Guo, Ming Zhang, Dongsheng Hu, Yang Zhao

The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases

Haishuang Tang, Kaiwen Wang, Kaige Zheng, Zheng Wen, Yi Yang, Xin Nie, Qingyuan Liu, Shuo Wang

Coronary flow reserve increase after 4-year dapagliflozin treatment in patients with type 2 diabetes: the DAPAHEART follow-up study

Francesca Cinti, Cassandra Morciano, Andrea Guarneri, Luigi Cappannoli, GianPio Sorice, Shawn Gugliandolo, Umberto Capece, Amelia Splendore, Adriana Avolio, Teresa Mezza, Patricia Iozzo, Alfredo Pontecorvi, Maria Lucia Calcagni, Francesco Burzotta, Domenico D’Amario, Filippo Crea, Lucia Leccisotti, Andrea Giaccari

Left ventricular ejection fraction reserve and its association with myocardial perfusion, coronary calcification, and strain in type 2 diabetes without overt cardiovascular disease

Adam Chebli, Ida K. B. Rasmussen, Anne-Cathrine Skriver-Møller, Philip Hasbak, Martin B. Blond, Victor S. Wasehuus, Mats C. H. Lassen, Morten Lindhardt, Allan Kofoed-Enevoldsen, Urd L. Kielgast, Emilie H. Zobel, Lene Holmvang, Tor Biering-Sørensen, Peter Rossing, Rasmus S. Ripa, Andreas Kjaer, Tine W. Hansen

SGLT2 inhibitors and GLP-1 receptor agonists: impact on mortality in diabetic patients with cardiovascular disease

Ziad Arow, Tzipi Hornik-Lurie, Ranin Hilu, Ela Giladi, Yoav Arnson, Hana Vaknin-Assa, Abid Assali, David Pereg

Nocturnal hypoxemic burden is associated with worsening prognosis of chronic kidney disease in patients with type 2 diabetes

Sarah Driendl, Stefan Stadler, Mathias Baumert, Klaus J. Stark, Iris M. Heid, Jan Pec, Florian Zeman, Adrian Preiss, Carsten A. Böger, Tobias Bergler, Michael Arzt

Weight-independent amelioration of adipokine profile by enavogliflozin, a selective SGLT2 inhibitor, in patients with type 2 diabetes

Young Sang Lyu, Hansol Lee, Kyung-Soo Kim, Sangmo Hong, Cheol-Young Park

Pericoronary adipose tissue radiomics to improve risk stratification for patients with acute coronary syndrome: a multicenter retrospective cohort study

Jin Shang, Yanhua Zhen, Zhezhe Zhang, Ziyi Wang, Hang Xu, Yilong Pan, Hongyu Chen, Lu Sun, Xin Pan, Ronghui Ju, Yang Hou

Association between dynamic changes in the triglyceride-glucose index and prognosis in patients with acute ST-segment elevation myocardial infarction

Haiyan Jia, Weifeng Zhang, Shengqi Jia, Xinwei Jia, Shixin kang

The association between triglyceride glucose-waist height ratio index and cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study

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Longyan Lv, Ping Zhang, Xuerui Chen, Yan Gao

Effect of Empagliflozin on the plasma lipidome in patients with type 2 diabetes mellitus: results from the EmDia clinical trial

Katrin I. Bauer, Dhanwin Baker, Raissa Lerner, Thomas Koeck, Gregor Buch, Zlatka Fischer, Robin Martens, Ekaterina E. Esenkova, Maximilian Nuber, Miguel A. Andrade-Navarro, Vincent ten Cate, Stefan Tenzer, Philipp S. Wild, Laura Bindila, Elisa Araldi

Insulin resistance assessed by estimated glucose disposal rate predicts cardiovascular disease in stages 0–3 of cardiovascular-kidney-metabolic syndrome: a UK biobank cohort study

Hao Zhang, Sizhuang Huang, Yanwen Fang, Haihua Zhang, Weixian Yang, Mengyue Yu

Correction: Use of an insulin titration protocol based on continuous glucose monitoring in postoperative cardiac surgery patients with type 2 diabetes and prediabetes: a randomized controlled trial

Sun-Joon Moon, Min-Su Kim, Yun Tae Kim, Ha-Eun Lee, Young-Woo Lee, Su-Ji Lee, Euy-Suk Chung, Cheol-Young Park

Correction: Prognostic impact of type 2 diabetes mellitus and coronary microvascular dysfunction in patients undergoing rotational atherectomy during PCI

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Lijun Feng, Yuxuan Zhang, Chenyun Zhang, Zining Chen, Jingnan Pan, Zhiling Gao, Delong Chen, Abuduwufuer Yidilisi, Jiacheng Fang, Yiyue Zheng, Tingting Mei, Jiantao Liu, Jianping Xiang, Jinlong Zhang, Changling Li, Jifang Cheng, Jian’an Wang, Jun jiang

Correction: Intestinal fatty acid binding protein is associated with coronary artery disease in long-term type 1 diabetes—the Dialong study

Marte Narum, Ingebjørg Seljeflot, Vibeke Bratseth, Tore Julsrud Berg, Kari Anne Sveen

Treatment and associated outcomes of type 2 diabetes mellitus patients with a cardiovascular comorbidity and comparison with guideline recommendations: a German claims data analysis

Jens Aberle, Daniel Duerschmied, Martin Grond, Michael Lehrke, Stephan Martin, Sven-Oliver Tröbs, Michael Schultze, Nils Kossack, Lena Margareta Richter, Maximilian Gabler

Fixed-dose vs loose-dose combination antidiabetic therapy and cardiorenal outcomes in type 2 diabetes: a nationwide comparative effectiveness study

Qiaoling Liu, Paul Welsh, Carlos Celis-Morales, Jennifer S. Lees, Patrick B. Mark, Laura Pazzagli

Association of the triglyceride-glucose index combined with a body shape index with all-cause and cardiovascular mortality in individuals with cardiovascular-kidney-metabolic syndrome stage 0–3: findings from two prospective cohorts

Mingjie Chen, Jiajie Guo, Yuwen Shangguan, Zhonghua Sun, Xueling He, Qiang Tu, Qingkai Yan

The association between triglyceride-glucose index and all-cause/cardiovascular mortality in patients with different glucose metabolism statuses

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Jiajun Liu, Jinhua Kang, Pengpeng Liang, Zhangxiao Song, Guiyun Li, Xueshan Jin, Hongyan Wu

Accelerated biological aging mediates the associations of stress hyperglycemia ratio (SHR) with mortality in type 2 diabetes and obesity (diabesity)

Jinling Xu, Hui Zhou, Zhongjing Wang

Association of the triglyceride-glucose index and its combination with obesity indices with cardio-renal-metabolic multimorbidity: two decades of follow-up in the Tehran Lipid and Glucose Study

Soroush Soraneh, Navid Ebrahimi, Soroush Masrouri, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh

Cardiovascular and renal outcomes of dual combination therapies with glucagon-like peptide-1 receptor agonists and sodium-glucose transport protein 2 inhibitors: a systematic review and meta-analysis

Arveen Shokravi, Jayant Seth, G. B. John Mancini

Type 2 diabetes, sodium-glucose cotransporter-2 inhibitors and cardiovascular outcomes: real world evidence versus a randomised clinical trial

Puriya Daniel Würtz Yazdanfard, Kathrine Kold Sørensen, Bochra Zareini, Ulrik Pedersen-Bjergaard, Johan Sebastian Ohlendorff, Anders Munch, Mikkel Porsborg Andersen, Rasmus Bo Hasselbalch, Henrik Imberg, Viktor Tasseleus, Marcus Lind, Jonathan Valabhji, Pratik Choudhary, Kamlesh Khunti, Stefanie Schmid, Stefanie Lanzinger, Julia Mader, Thomas Alexander Gerds, Christian Torp-Pedersen

Effect of changes in the triglyceride-glucose index on atherogenic lipid profiles in coronary artery disease patients receiving lipid-lowering therapy: a prospective cohort study

Zhi-Fan Li, Zheng Yin, Xi Li, Meng-Ying Lu, Wen-Jia Zhang, Fang Luo, Yan-Lu Xu, Jian-Jun Li, Ke-Fei Dou, Xiao Wang, Hong Qiu, Na-Qiong Wu

An ensemble machine learning-based risk stratification tool for 30-day mortality prediction in critically ill cardiovascular patients

Mingxing Lei, Xiao Liu, Longcan Cheng, Yan Li, Nan Tang, Jie Song, Mi Song, Qingqing Su, Mingxuan Liu, Shihui Fu, Baisheng Sun, Yuan Gao

Relation of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio to residual risk in anticoagulated patients with atrial fibrillation: a report from the prospective Murcia AF Project III cohort

Eva Soler-Espejo, Yang Chen, José Miguel Rivera-Caravaca, María Pilar Ramos-Bratos, María Asunción Esteve-Pastor, Francisco Marín, Vanessa Roldán, Gregory Y. H. Lip

Characterizing echocardiographic abnormalities and their associated factors in patients with type 1 diabetes: a cross-sectional study

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Wenfeng Yang, Chu Lin, Xiaoling Cai, Zonglin Li, Fang Lv, Wenjia Yang, Geling Liu, Xiaolin Yang, Sha Li, Linong Ji

Planetary health diet, other plant-based diets and risk of type 2 diabetes: a prospective study from the UK Biobank

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María del Carmen Aznar de la Riera, Rosario Ortolá, Stefanos N. Kales, Esther García-Esquinas, Fernando Rodríguez-Artalejo, Mercedes Sotos-Prieto

Associations of six insulin resistance-related indices with the risk and progression of cardio-renal-metabolic multimorbidity: evidence from the UK biobank

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Lulu Liu, Guangzan Yu, Xuhou Ji, Yunlong Wang, Hua He

Testosterone therapy is associated with reduced risk of acute kidney injury, kidney failure with renal replacement therapy, and cardiovascular events in men with diabetes and hypogonadism

Fabrice Bonnet, Patricia Vaduva, Jean-Michel Halimi, Arnaud Dosda, Pierre-Henri Ducluzeau, Laetitia Koppe, Laurent Fauchier

Association between metabolic score for insulin resistance and future stroke risk in patients with cardiovascular-kidney-metabolic syndrome stages 0–3: a longitudinal analysis based on CHARLS

Huihong Wu, Yang Zhou, Xinxing Lai, Bin Ma, Lu Ding, Xiaojie Zhu, Zixin Chen, Ziwang Liu

Triglyceride glucose index in patients with acute coronary syndrome undergoing percutaneous coronary intervention predicts cardiovascular events: a cohort study

Senlin Hu, Haoyu Yan, Yang Sun, Daowen Wang, Hesong Zeng, Guanglin Cui

Endocrine-disrupting chemicals exposure: cardiometabolic health risk in humans

Cheng-Xu Ma, Xiao-Ni Ma, Hong-Li Li, Dídac Mauricio, Song-Bo Fu

Joint effects of triglyceride glucose index and its obesity-related derivatives with estimated glucose disposal rate on cardiometabolic multimorbidity in middle-aged and older Chinese adults: a nationwide cohort study

Xianlin Ruan, Yihang Ling, Jinming Chen, Yulong Xiang, Huangtao Ruan, Weipeng Zhang, Ling Jing, Xin Gao, Yibo He, Xiaozhao Lu, Tian Chang, Junyan Xu, Jiyan Chen

Development and evaluation of a machine learning prediction model for short-term mortality in patients with diabetes or hyperglycemia at emergency department admission

Per Wändell, Marcelina Wierzbicka, Karolina Sigurdsson, Anna Olofsson, Caroline Wachtler, Torgny Wessman, Olle Melander, Ulf Ekelund, Anders Björkelund, Axel C. Carlsson, Toralph Ruge

Dual modulation of lipid and glucose metabolism by a nutraceutical combination in patients at cardiometabolic risk: results from a multicenter randomized controlled trial

Daniela Pacella, Maria Lembo, Valentina Trimarco, Alessia Izzo, Maria Virginia Manzi, Stanislovas S. Jankauskas, Imma Forzano, Paola Gallo, Alessandra Spinelli, Carmine Morisco, Stefano Cristiano, Paola Ida Rozza, Eliana Esposito, Felicia Rozza, Lorena Esposito, Sun King B. Bear, Giuseppe Giugliano, Gaetano Santulli

Real-world cardiovascular effectiveness of sustained glucagon-like peptide 1 GLP-1 receptor agonist usage in type 2 diabetes

Kathrine Kold Sørensen, Puriya Daniel Würtz Yazdanfard, Bochra Zareini, Ulrik Pedersen-Bjergaard, Vanja Kosjerina, Mikkel Porsborg Andersen, Anders Munch, Johan Sebastian Ohlendorff, Stefanie Schmid, Stefanie Lanzinger, Pratik Choudhary, Clare Gillies, Safoora Gharibzadeh, Marcus Lind, Viktor Tasselius, Jens Michelsen, Thomas Alexander Gerds, Christian Torp-Pedersen

Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident stroke in middle-aged and older Chinese adults: a longitudinal analysis based on CHARLS

Yibo Yang, Aihua Liu

Association of epicardial fat volume index with coronary artery disease phenotypes based on anatomical and functional imaging: a linkage with the severity of coronary artery disease

Chunbo Wang, Wenji Yu, Xiaoyu Yang, Fan Sun, Yu Tian, Yue Yue, Feifei Zhang, Xiaoliang Shao, Yunmei Shi, Bao Liu, Jianfeng Wang, Sijin Li, Yuetao Wang

Plasma ALKAL2 levels are associated with coronary atherosclerosis in patients with type 2 diabetes mellitus

Yipaerguli Maimaiti, Minhui Wang, Shuai Chen, Feifei Li, Jingmeng Liu, Xinrui Wu, Jianjun Chen, Qiujing Chen, Weifeng Shen, Fenghua Ding, Yang Dai, Lin Lu

Deep learning-based coronary calcium score derived from non-gated chest CT and major adverse cardiovascular events in patients with type 2 diabetes mellitus

Yidan Xu, Yarong Yu, Xiaoying Ding, Jiajun Yuan, Lihua Yu, Xu Dai, Runjianya Ling, Yufan Wang, Jiayin Zhang

Cardiometabolic HFpEF with focus on type 2 diabetes mellitus

Era Gorica, Francesco Paneni

Association between atherogenic index of plasma (AIP) and all-cause and cardiovascular mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD): a cohort study based on NHANES 1999–2018

Meiping Gan, Bo Chen, Minghui Qin, Ling Zhang, Xiaolin Wang

Prognostic value of glycaemic variability for mortality in cardiogenic shock patients: a retrospective cohort study

Linfeng Xie, Suxin Luo

Association between cholesterol, high-density lipoprotein, and glucose index and risks of cardiovascular and all-cause mortality in patients with calcific aortic valve stenosis: the ARISTOTLE cohort study

Zhen Guo, Zhenyu Xiong, Wenjing Zhang, Guanzhong Chen, Mengjie Xie, Ziwei Zhou, Shaozhao Zhang, Menghui Liu, Jiaying Li, Xinxue Liao, Xiaodong Zhuang

Impact of glucometabolic status on type 4a myocardial infarction in patients with non–ST-segment elevation myocardial infarction: the role of stress hyperglycemia ratio

Matteo Armillotta, Luca Bergamaschi, Francesco Angeli, Marta Belmonte, Marcello Casuso Alvarez, Angelo Sansonetti, Damiano Fedele, Sara Amicone, Lisa Canton, Davide Bertolini, Andrea Impellizzeri, Francesca Bodega, Nicole Suma, Francesco Pio Tattilo, Daniele Cavallo, Ornella Di Iuorio, Khrystyna Ryabenko, Andrea Rinaldi, Francesco Saia, Gianni Casella, Jacopo Lenzi, Paola Rucci, Pasquale Paolisso, Carmine Pizzi

Cardio-kidney-metabolic complexity in patients with atrial fibrillation: an analysis from the prospective GLORIA-AF registry phase III

Giulio Francesco Romiti, Davide Antonio Mei, Bernadette Corica, Marco Proietti, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V. Huisman, Gregory Y. H. Lip

Activated protein C ameliorates diabetes-induced atherosclerosis by sustaining macrophage efferocytosis

Saira Ambreen, Amna Arif, Saikal Shamkeeva, Ahmed Elwakiel, Surinder Pal, Shihai Jiang, Muhammad Asad Farhan, Zuhir Halloul, John H. Griffin, Berend Isermann, Khurrum Shahzad

Genetic variation in the glucagon-like peptide-1 receptor protein encoding region is associated with higher heart rate variability, but not with neurodegeneration of the brain, retina, and peripheral nerves: The Maastricht study

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Frank C. T. van der Heide, Indra L. M. Steens, Archana Singh-Manoux, Séverine Sabia, Tan Lai Zhou, Sebastian Köhler, Miranda T. Schram, Carla J. H. van der Kallen, Tos T. J. M. Berendschot, Carroll A. B. Webers, Marleen M. J. van Greevenbroek, Anke Wesselius, Ilja C. W. Arts, Jacobus F. A. Jansen, Walter H. Backes, Thomas T. van Sloten, Gabriëlla A. M. Blokland, Coen D. A. Stehouwer

The role of insulin resistance in the longitudinal progression from NAFLD to cardiovascular-kidney-metabolic disease

Chao Hou, Xiangling Yuan, Min Peng, Xuan Shi, Dahong Yang, Fang Wang, Ke Song, Gelin Xu, Jianzhong Shi

Safety, pharmacokinetics and pharmacodynamics of Plozasiran in Chinese healthy volunteers

Fangfang Wang, Dong You, Xiaoye Niu, Jack Shi, Ye Li, Lihang Qi, Haiyan Li

Epicardial adipose tissue volume and arterial stiffness in people living with diabetes: the METAB-CV-PWV study

Omar Nouhou Koutcha, Sopio Tatulashvili, Nanthara Sritharan, Pierre Boutouyrie, Imen Rezgani, Marouane Boubaya, Mohamed Lamine Mariko, Lucie Allard, Meriem Sal, Coralie Bloch-Queyrat, Mohamed Zerguine, Pierre-Yves Brillet, Zouhour El Fekih, Rosa-Maria Bruno, Hélène Bihan, Emmanuel Cosson

Stratifying cardiovascular benefits from GLP-1RA: a multisource analysis of patient-level CVOT and real-world data using AI-driven methods

Mario Luca Morieri, Enrico Longato, Veronica Sciannameo, Emily Donatiello, Paola Berchialla, Angelo Avogaro, Agostino Consoli, Gian Paolo Fadini

Association of estimated glucose disposition rate with aging acceleration and mortality risk in individuals with cardiovascular-kidney-metabolic syndrome: evidence from two large national population-based studies

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Mo-Yao Tan, Zhen-Ni Jiang, Yao-Qin Li, Zi-Yu Li, Bin Niu

AI-quantified epicardial adipose tissue and prediction of future myocardial infarction in patients with cardiometabolic disease: a post-hoc analysis from the SCOT-HEART trial

Jolien Geers, Nipun Manral, Caroline Park, Guadalupe Flores Tomasino, Kajetan Grodecki, Joel Lenell, Mikolaj Buchwald, Aryabod Razipour, Jacek Kwiecinski, Hidenari Matsumoto, Mohamed Marwan, Stephan Achenbach, Daniel S. Berman, Marc R. Dweck, David E. Newby, Piotr J. Slomka, Michelle C. Williams, Damini Dey

The prognostic value of atherogenic index of plasma and thin-cap fibroatheroma among patients with STEMI: an optical coherence tomography prospective cohort study of real world

Xiaoxiao Zhao, Runzhen Chen, Nan Li, Linghan Xue, Chen Liu, Peng Zhou, Yi Chen, Shaodi Yan, Li Song, Hanjun Zhao, Jiannan Li, Hongbing Yan

High predicted cardiac event risk in youth with obesity and type 2 diabetes: a pooled cohort analysis

Noemi Malandrino, Faith S. Davis, Sophia B. Glaros, Ila N. Kacker, Samson L. Cantor, Natalie A. Macheret, Geethika Thota, Lilian Mabundo, Maureen Sampson, Alan Remaley, Marissa Lightbourne, Sheela N. Magge, Jack A. Yanovski, Stephanie T. Chung

Interplay of glycated hemoglobin and traditional risk factors for the risk of atherosclerotic cardiovascular disease and all-cause mortality in people without diabetes

Soroush Masrouri, Amirhossein Hasanpour, Navid Ebrahimi, Farzad Hadaegh

Insulin resistance-related indices, genetic risk, and the risk of cardiovascular disease in individuals with preclinical or clinical obesity: a large prospective cohort study in the UK biobank

Jinling Hu, Cong Shang, Yueqing Huang, Chaonan Sun, Jing Zhang

Drug-coated balloons and diabetes: a review

Marco Frazzetto, Sara Malakouti, Bharat Khialani, Filippo Luca Gurgoglione, Bernardo Cortese

Evaluation of four insulin resistance surrogate indicators for predicting short-term mortality in critically ill patients with ischemic stroke: a nationwide retrospective cohort study

Qingrong Ouyang, Chenqi Zhang, Hui Zhang, Taoying Xiong, Yangmei Chen, Peng Zhang

The relationship between C-reactive protein-triglyceride-glucose index and cardiovascular disease: insights from the China health and retirement longitudinal study (CHARLS)

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Lin Zhang, Shan Li, Dan Liu, JiaJia Gui, Jing Hu, Qian Wang, Wei Mao

Prognostic role of sarcopenia in heart failure patients

Giuseppe Armentaro, Cristiana Vitale, Velia Cassano, Marcello Magurno, Alberto Panza, Maria Rosangela Scarcelli, Carlo Alberto Pastura, Giandomenico Severini, Elisa Mazza, Marta Letizia Hribal, Francesco Andreozzi, Arturo Pujia, Tiziana Montalcini, Giuseppe Massimo Claudio Rosano, Angela Sciacqua

Association between the stress hyperglycemia ratio and elevated blood pressure among U.S. adolescents aged 12–17

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Liujie Zheng, Guoqiang Li, Yan Liu, Zhiyong Hou

Comparison of biological properties of human adipose tissue-derived mesenchymal stem/ stromal cells from healthy and diabetic donors: consequences for cell-based medicinal product development

Patrycja Dudek, Anna Łabędź-Masłowska, Zbigniew Madeja, Ewa Zuba-Surma

Associations between triglyceride-glucose-related indices and all-cause and cardiovascular mortality among individuals with atrial fibrillation and metabolic syndrome: a cohort study of the UK biobank

Lei Ding, Hongda Zhang, Yuandong Liu, Zihan Jiang, Fengyuan Yu, Yingjie Qi, Bin Zhou, Yujing Shen, Min Tang

Artificial intelligence identifies individuals with prediabetes using single-lead electrocardiograms

Daisuke Koga, Ryo Kaneda, Chikara Komiya, Satoshi Ohno, Akira Takeuchi, Kazunari Hara, Masato Horino, Jun Aoki, Rei Okazaki, Ryoko Ishii, Masanori Murakami, Kazutaka Tsujimoto, Kenji Ikeda, Hideki Katagiri, Hideyuki Shimizu, Tetsuya Yamada

Benefits of glucagon-like peptide-1 receptor agonists versus pioglitazone for cardio-hepatic outcomes: a territory-wide target trial emulation

Lanlan Li, David Tak-Wai Lui, Carol Ho-Yi Fong, Wing-Sun Chow, Ivan Chi-Ho Au, Xi Xiong, Brian Hung-Hin Lang, Carlos King-Ho Wong, Chi-Ho Lee

Correction: Cardiometabolic risk stratification in pediatric obesity: evaluating the clinical utility of fasting insulin and BMI-SDS

Rasmus Stenlid, Sami El Amrani, Sara Y. Cerenius, Banu K. Aydin, Hannes Manell, Katharina Mörwald, Julia Lischka, Julian Gomahr, Thomas Pixner, Iris Ciba, Stefan K. James, Anders Forslund, Daniel Weghuber, Peter Bergsten

Hunting for a coronary artery disease diagnosis in asymptomatic patients with diabetes mellitus: if, how and when

Francesca Santilli, Michael J. Blaha, Fabrizio Ricci, Paola Simeone

HFpEF as the predominant and underrecognized heart failure phenotype in type 2 diabetes: evidence from the DIABET-IC study

P. Gil-Millan, JA. Gimeno-Orna, L. Rodriguez-Padial, J. Muniz, V. Barrios, M. Anguita, A. Perez

Elevated triglyceride-glucose index and its combination with anthropometric indices as indicators of the risk of new-onset transient ischemic attack: a prospective cohort study

Zhehao Xiao, Ling Luo, Weipin Weng, Erhan Yu, Jiahao Zheng, Xiaodong Pan, Yanping Wang, Rui Wang

Empagliflozin-induced lipidome remodeling in type 2 diabetes: mechanistic insights and translational perspectives

Carmine Izzo, Albino Carrizzo

Stress hyperglycemia ratio modulates the impact of organ dysfunction on mortality risk in critically ill patients with atrial fibrillation: insights from the MIMIC-IV database

Huijun Jin, Xuefeng Xu, Bo Zhu, Jinglan Zhang

Increased high-risk plaque burden in type 2 diabetes: a 10-year follow-up study

Emilie L. Gaillard, Sophie H. M. Cramer, Nordin M. J. Hanssen, Michiel J. Bom, Steven A. J. Chamuleau, R. Nils Planken, Andrew D. Choi, S. Matthijs Boekholdt, Erik S. G. Stroes, Paul Knaapen, Nick S. Nurmohamed

Sex differences in the prognostic value of urinary albumin-to-creatinine ratio for coronary artery disease and cardiovascular events in people with type 2 diabetes and normoalbuminuria

Orlando Siverio-Morales, Ainhoa González-Luis, Carmen Mora-Fernández, Carolina Hernández-Carballo, Alberto Martín-Olivera, Juan F. Navarro-González, Javier Donate-Correa

Correction: Is pulmonary vascular remodeling an intermediate link between hyperglycemia and adverse outcomes in patients with idiopathic pulmonary arterial hypertension? Insights from a multi-center cohort study

Sicheng Zhang, Luyang Gao, Sicong Li, Manqing Luo, Qunying Xi, Ping Lin, Zhihui Zhao, Qing Zhao, Tao Yang, Qixian Zeng, Zhihua Huang, Xin Li, Anqi Duan, Yijia Wang, Qin Luo, Yansong Guo, Zhihong Liu

Neurodegeneration onset with glucagon-like peptide-1 receptor agonists in people with type 2 diabetes: a real-world multinational cohort study

Meir Schechter, Alisa Fishkin, Ofri Mosenzon, Dvora R. Sehtman-Shachar, Tali Cukierman-Yaffe, Gil Leibowitz, Genya Aharon-Hananel

Pgk1 activation restores endothelial metabolic homeostasis to alleviate vascular aging and atherosclerosis

Jinhong Lu, Jianji Wang, Yu Liu, Cuntai Zhang, Guojun Zhang, Yipeng Ge, Lei Liu

Electronic nose for detecting abnormal glucose metabolism in heart transplant recipients

Nynke Wijbenga, Annelot J. Muntinga, Marleen M. Goedendorp-Sluimer, Britt C. J. van Dijk, Stefan Roest, Jasper J. Brugts, Kadir Caliskan, Alina A. Constantinescu, Adrienne A. M. Zandbergen, Daniel Bos, Merel E. Hellemons, Olivier C. Manintveld

A six-year longitudinal study identifies a statin-independent association between low LDL-cholesterol and risk of type 2 diabetes

Maria Lembo, Valentina Trimarco, Daniela Pacella, Raffaele Izzo, Stanislovas S. Jankauskas, Roberto Piccinocchi, Paola Gallo, Luca Bardi, Gaetano Piccinocchi, Carmine Morisco, Stefano Cristiano, Giovanni Esposito, Giuseppe Giugliano, Maria Virginia Manzi, Gaetano Santulli, Bruno Trimarco

Proteome organ aging and cardiometabolic risk in a population at risk for heart failure

Kaiyong Qu, Elisa Dal Canto, Anne-Mar L. N. van Ommen, Sabrina Abou Kamar, Arco J. Teske, Maarten Jan Cramer, Marianne C. Verhaar, Dirk J. Duncker, Frans H. Rutten, Isabella Kardys, Roxana Menken, Leonard Hofstra, Igor I. Tulevski, G. Aernout Somsen, N. Charlotte Onland-Moret, Ernest Diez Benavente, Hester M. den Ruijter

Associations of longitudinal trajectories of triglyceride-glucose index combined with classical and novel obesity indices and cardiovascular disease: evidence from a nationwide prospective cohort study in China

Chao Wang, Shiming He, Guobo Xie, Shuhua Zhang, Zhiyu Xiong, Hengcheng Lu, Qun Wang, Lin Xie, Wei Wang, Yang Zou, Xue Li

A glucose time in range of 70% attenuates the senescence-inducing and pro-inflammatory effects of hyperglycemia

Rosalba La Grotta, Valeria Pellegrini, Francesca Carreras, Cesare Celeste Berra, Karolina Mužina, Barbara Jenko Bizjan, Klemen Dovc, Francesco Prattichizzo, Tadej Battelino, Antonio Ceriello

Favorable outcomes of SGLT2 inhibitor use in pacemaker recipients: a population-based study

Yuval Avidan, Asaf Danon, Dana Hadar, Amir Aker, Amir Yahav, Oren Caspi, Sameer Kassem

Precision integrated identification of predictive first-trimester metabolomics signatures for early detection of gestational diabetes mellitus

Sapna Sharma, Yalamanchili Venkata Subrahmanyam, Payal Gupta, Sangeetha Vadivel, Mohan Deepa, Ansh Tandon, Sreekumar Sreedevi, Uma Ram, Priyanka Narad, Dharmeshkumar Parmar, Ranjit Mohan Anjana, Anu Raghunathan, Muthuswamy Balasubramanyam, Viswanathan Mohan, Abhishek Sengupta, Jerzy Adamski, Ponnusamy Saravanan, Venkateswarlu Panchagnula, Dandamudi Usharani, Kuppan Gokulakrishnan

Association of cumulative changes in atherogenic index of plasma and its obesity-related derivatives with cardiovascular disease: emphasis on incremental risk of diabetes status

Na Zhang, Guobo Xie, Guoan Jian, Kun Jiang, Zihao Lu, Zhenyu Wang, Juan Wang, Houhui Lan, Wei Wang, Shiming He, Yang Zou, Chao Wang

Distinct immune-metabolic phenotypes underlie poor coronary collateral circulation

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Zi-Tong Guo, Hong-Mei Lai, Run-Xuan Hu, Ya-Jing Qiu, Jing Tao, Xiao-Lin Yu, Yi-Ning Yang

Impact of left ventricular dilatation on biventricular function and deformation in diabetes mellitus with reduced ejection fraction: a CMR feature tracking study

Wen-Rong Li, Rui Shi, Hua-Yan Xu, Ying-Kun Guo, Meng-Ting Shen, Jia-Ke Li, Yu-Shan Zhang, Jing Liu, Wei-Feng Yan, Chen-Yan Min, Rong Xu, Ran Sun, Yuan Li, Zhi-Gang Yang

Risk of all–cause death and pancreatic events following GLP-1 RA initiation in people with obesity or type 2 diabetes: observations from a federated research network

Enrico Tartaglia, Tommaso Bucci, Michele Rossi, Andrea Galeazzo Rigutini, Amir Askarinejad, Uazman Alam, Katarzyna Nabrdalik, Giuseppe Boriani, Gregory Y. H. Lip

Elevated triglyceride-glucose index and risk of thymoma-associated myasthenia gravis: a prospective analysis from the UK Biobank

Kangle Zhu, Jingwei Shi, Jingwei Zhao, Yi Zhao, Yao Zhang, Wuji Zhang, Mingjun Wei, Chu Zhou, Rusong Yang, Zhengcheng Liu, Zhuo Liu, Zhixiang Shen

Plasma metabolomics disentangles T2DM- and CAD-specific dysmetabolism and identifies potential biomarkers for CAD risk escalation in diabetic patients

Ting Hu, Wen Zhang, Xian Ding, Feifei Han, Zhuoling An

Clinical perspectives of new insights and tools to minimize the hypoglycaemia burden connected with type 2 diabetes pharmacotherapy

Eberhard Standl, Antonio Ceriello, Darren K. McGuire, Oliver Schnell, Rury R. Holman

Comparable performance of 1,5-anhydroglucitol and continuous glucose monitoring in detecting subclinical atherosclerosis in elderly patients with type 2 diabetes

Hang Su, Jiaying Ni, Jingyi Lu, Wei Lu, Wei Zhu, Yufei Wang, Xiaojing Ma, Danfeng Peng, Jian Zhou

Diabetes modifies the association between the triglyceride-glucose index and subclinical myocardial injury: A prospective cohort study

Ayiguli Abudukeremu, Jing Lv, Wei Liu, Fan Lu, Tongsheng Huang, Jing Zhang, Yunkun Liu, Yuling Zhang, Xiao Liu, Peng Yu

Association between the atherogenic index of plasma and major adverse cardiovascular events in individuals with metabolic syndrome: findings from the UK biobank

Yuanjia Hu, Wenlong Li, Jingyuan Nie, Changhong Zhang, Jing Zhou, Zuhai Hu, Hanwen Zhou, Xun Lei

Body mass index (BMI) associates with frequency of arterial hypertension and type 2 diabetes in obese patients candidates for bariatric surgery

Lucia La Sala, Luca Busetto, Valentina Carlini, Carmela Asteria, Andrea Peri, Alessandro Giovanelli, Silvia Magnani, Andrea Trabucchi, Michela Ravelli, Antonio E. Pontiroli

The mineralocorticoid receptor antagonist finerenone enhances cardiovascular recovery upon food intake normalization in obese mice

Monmirel-Fauconnier Manon, Pieronne-Deperrois Marie, Bonnard Benjamin, Frimat Coralie, Kong Linghui, Ni Dheasmhunaigh Amhrae, Nicol Lionel, Morchid Saïda, Renet Sylvanie, Dumesnil Anaïs, Richard Vincent, Fève Bruno, Jaisser Frédéric, Boulkroun Sheerazed, Mulder Paul, Ouvrard-Pascaud Antoine

Interplay among lipoprotein(a), hepatic and vascular damage in individuals with metabolic dysfunction

Serena Pelusi, Chiara Macchi, Francesco Malvestiti, Sara Margarita, Irene De Matteis, Giulia Periti, Jessica Rondena, Stefania Mira, Francesca Iemma, Martina Tranchina, Barbara Nardi, Carla Lucci, Cesare R. Sirtori, Oscar Millet, Jose M. Mato, Giovanni Targher, Daniele Prati, Massimiliano Ruscica, Luca Valenti, Serena Pelusi, Giulia Periti, Vittoria Moretti, Stefania Mira, Sara Margarita, Luisa Ronzoni, Daniele Marchelli, Hadi Heidgah Torgabehei, Alessandra Cazzaniga, Elena Sinopoli, Laura Cerami, Elia Casirati, Eniada Rrapaj, Divya Akkaldev, Francesco Malvestiti, Martina Tranchina, Francesca Ferrari, Giuseppe Lamorte, Valentina Vaira, Daniele Prati, Luca Valenti, Roberta D’Ambrosio, Giulia Tosetti, Massimo Iavarone Pietro Lampertico, Marco Maggioni, Emanuela Orsi, Annalisa Cespiati, Paola Dongiovanni, Anna Ludovica Fracanzani, Chiara Rosso, Angelo Armandi, Gian Paolo Caviglia, Elisabetta Bugianesi, Grazia Pennisi, Salvatore Petta, Antonio Liguori, Luca Miele, Giorgio Soardo, Francesco Paolo Russo, Alessandro Federico, Federica Tavaglione, Umberto Vespasiani-Gentilucci, Francesca Marchignoli, Loris Pironi, Teresa Pollicino

Neutrophil cathepsin G and risk of cardiovascular events in patients with diabetes mellitus

Francesco Baratta, Simona Bartimoccia, Daniele Pastori, Nicholas Cocomello, Vittoria Cammisotto, Valentina Castellani, Cristina Nocella, Maurizio Forte, Vittorio Picchio, Roberto Carnevale, Giovambattista Desideri, Pasquale Pignatelli, Francesco Violi

Ferroptosis in the pathogenesis of diabetic cardiomyopathy: mechanisms and therapeutic potential

Qingqing Zhao, Ming Wang, Ning Zhou, Yan Wang

Plasma inflammatory proteome profiles identify MASLD among children with overweight or obesity

Youxin Wang, Daniel Q. Huang, Pingping Zhang, Mingyue Wang, Yuying Wu, Enkar Nur, Li Li, Hui Wang

Joint association of urinary albumin-to-creatinine ratio within normal range and triglyceride-glucose index with incident cardiovascular disease: a prospective cohort study

Du Fengjun, Tang Junli, Lu Zilong, Chen Xiaorong, Zhang Jiyu, Xu Jianwei, Zhang Binyin, Dong Jing, Ren Jie, Xu Chunxiao, Gao Congcong, Guo Xiaolei, Wu Jing, Ma Jixiang

Impact of type 2 diabetes on the relationship between chronic kidney disease and cardiovascular outcomes in heart failure across ejection fraction: observational study from the Swedish heart failure and the Swedish National diabetes registries

Aurora Merolla, Valeria Valente, Christian Basile, Lina Benson, Francesco Cosentino, Ulf Dahlström, Soffia Gudbjörnsdottir, Patrizia Rovere-Querini, Lars H. Lund, Gianluigi Savarese, Giulia Ferrannini

Prognostic implications of quantified coronary atherosclerosis and myocardial perfusion in diabetes

  • Open Access
  • Research

Matias Mäenpää, Ruurt A. Jukema, Pepijn van Diemen, Sarah Bär, Pieter G. Raijmakers, Ralf Sprengers, Roel S. Driessen, Jeroen J. Bax, Paul Knaapen, Juhani Knuuti, Ibrahim Danad, Antti Saraste, Teemu Maaniitty

Effects of finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 diabetes and chronic kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR)

Atsushi Tanaka, Muthiah Vaduganathan, Takumi Imai, Yosuke Okada, Satomi Sonoda, Keiichi Torimoto, Satoru Suwa, Hiroki Teragawa, Motoaki Miyazono, Makoto Fukuda, Keisuke Yonezu, Naohiko Takahashi, Yuichi Yoshida, Kenichi Tanaka, Michio Shimabukuro, Yuki Hotta, Masao Moroi, Hiroki Niikura, Keisuke Kida, Kenichi Yokota, Daiju Fukuda, Kengo Tanabe, Yu Horiuchi, Shigeru Toyoda, Isao Taguchi, Hisako Yoshida, Toru Miyoshi, Masaomi Nangaku, Hirotaka Shibata, Koichi Node

Circulating long non-coding RNAs as predictors of type 2 diabetes mellitus development: results from the CORDIOPREV study

Hatim Boughanem, María José Párraga-Viúdez, Ana Ojeda-Rodríguez, Juan Luis Romero-Cabrera, Eugenia Ruiz-Díaz Narváez, Alejandro López-Moreno, José David Torres-Peña, Manuel Macías-González, Juan Francisco Alcalá-Díaz, Antonio Pablo Arenas-de Larriva, Pablo Pérez-Martínez, Javier Delgado-Lista, José López-Miranda, Oriol Alberto Rangel-Zuñiga

Association between triglyceride-glucose index combined with a body shape index and atherosclerotic cardiovascular disease risk varies by glycemic status: insights from the UK Biobank

  • Open Access
  • Research

Xinyi Shao, Zhaofu Tan, Lifu Sun, Yidian Fu, Aijun Chen, Jin Chen, Genlong Bai, Jingbo Zhang

Editorial Expression of Concern: High triglyceride‑glucose index and stress hyperglycemia ratio as predictors of adverse cardiac events in patients with coronary chronic total occlusion: a large‑scale prospective cohort study

Yanjun Song, Kongyong Cui, Min Yang, Chenxi Song, Dong Yin, Qiuting Dong, Ying Gao, Kefei Dou

Arterial collagen IV and laminin levels associate with type 2 diabetes, glycemic control, major adverse cardiac events, and mortality in coronary bypass patients

  • Open Access
  • Research

Anne-Sofie Allermann Faarvang, Martin Overgaard, Pia Søndergaard Jensen, Lars Peter Schødt Riber, Mette Wod, Lasse Bach Steffensen, Lars Melholt Rasmussen

Glucagon-like peptide-1 receptor agonists and risk for cardiovascular events in older adults treated with levothyroxine: a target trial emulation

Fanxing Du, Naykky M. Singh Ospina, Yishan Chen, Juan P. Brito, Qing Liu, Stephan Schmidt, Rozalina G. McCoy, Brian Cicali, Hui Shao, Tianze Jiao

Cardiovascular outcomes associated with incident diabetes during statin therapy: a nationwide propensity-matched cohort study

Ki-Chul Sung, Dongwoo Kang, Jungkuk Lee, Seung-Jae Lee, Eun Joo Cho, Jin-Ok Jeong, Moo-Yong Rhee, Da-Eun Sung

Integrative oral and gut microbiome profiling highlights microbial correlates of complications in type 1 diabetes: a cross-sectional analysis

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Exercise in CKM syndrome progression: a stage-specific approach to cardiovascular, metabolic, and renal health

  • Open Access
  • Research

Zacharias Papadakis

Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction

Anna Nowak-Szwed, Ceren Eyileten, Zofia Wicik, Sara Ahmadova, Jeff Palatini, Jolanta Siller-Matula, Dirk von Lewinski, Harald Sourij, Marek Postula

SCORE2-diabetes for predicting coronary artery disease: a cardiac CT study in a diabetic moderate-risk region population

Rocco Mollace, Matteo Nardin, Matteo Arzenton, Federica Testerini, Anita Fumagalli, Flavia Nicoli, Margherita Celeste Licastro, Alessandro Nudi, Valentina Bernardini, Federica Frascaro, Silvana Di Maio, Rossella Menghini, Elona Collaku, Giorgio Agati, Eleonora Corghi, Maria Lo Monaco, Davide Cao, Antonio Cardamone, Cristina Carresi, Anna Rita Coppoletta, Eugenio Martelli, Gianluca Campo, Giulio Stefanini, Erika Bertella, Massimo Federici

Temporal and subgroup disparities in mediation effects on cardiovascular outcomes with liraglutide and semaglutide: a post-hoc analysis of LEADER and SUSTAIN-6 trials

  • Open Access
  • Research

Zi-Yang Peng, Yu-Hsuan Lee, Huang-Tz Ou, Shihchen Kuo

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Keynote webinar | Spotlight on progress in colorectal cancer

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
Prof. Harpreet Wasan
Prof. Edward Giovannucci
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