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Current Cardiology Reports

Emerging CRISPR Therapies for Precision Gene Editing and Modulation in the Cardiovascular Clinic

  • 17-09-2024
  • Cardiomyopathy
  • Regenerative Medicine (SM Wu, Section Editor)
Published in:
Authors
Nicholas J. Legere
J. Travis Hinson
Published in
Current Cardiology Reports | Issue 11/2024

Abstract

Purpose of Review

Outline the growing suite of novel genome editing tools powered by CRISPR-Cas9 technology that are rapidly advancing towards the clinic for the treatment of cardiovascular disorders.

Recent Findings

A diversity of new genome editors and modulators are being developed for therapies across myriad human diseases. Recent breakthroughs have improved the efficacy, safety, specificity, and delivery of CRISPR-mediated therapies that could impact heart disease in the next decade, though several challenges remain.

Summary

Many iterations of the original CRISPR system have been developed seeking to leverage its vast therapeutic potential. As examples, nuclease-free editing, precision single-nucleotide editing, gene expression regulation, and epigenomic modifications are now feasible with the current CRISPR-mediated suite of enzymes. These emerging tools will be indispensable for the development of novel cardiovascular therapeutics as demonstrated by recent successes in both basic research laboratories and pre-clinical models. Here, we provide an overview of current and emerging CRISPR-mediated technologies as they pertain to the cardiovascular system, highlighting successful implementations and future challenges.
Title
Emerging CRISPR Therapies for Precision Gene Editing and Modulation in the Cardiovascular Clinic
Authors
Nicholas J. Legere
J. Travis Hinson
Publication date
17-09-2024
Publisher
Springer US
Keyword
Cardiomyopathy
Published in
Current Cardiology Reports / Issue 11/2024
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-024-02125-3
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window
Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME