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Peripartum cardiomyopathy: a comprehensive and contemporary review

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Heart Failure Reviews

Published in:

Open Access 30-09-2024 | Cardiomyopathy | Review

Peripartum cardiomyopathy: a comprehensive and contemporary review

Authors: Farai Russell Sigauke, Hopewell Ntsinjana, Nqoba Tsabedze

Published in: Heart Failure Reviews | Issue 6/2024

Abstract

Cardiovascular disease is a major non-communicable disease globally, with increasing prevalence, posing a significant public health challenge. It is the leading non-obstetric cause of perinatal morbidity and mortality, with a substantial number of cardiac fatalities occurring in individuals without any known pre-existing cardiovascular disease. Peripartum cardiomyopathy is a type of de novo heart failure that occurs in pregnant women in the late stages of pregnancy or following delivery. Despite extensive research, diagnosing and managing peripartum cardiomyopathy remains challenging, resulting in significant morbidity and mortality. Recent advancements and novel approaches have been made to better understand and manage peripartum cardiomyopathy, including molecular and non-molecular biomarkers, genetic predisposition and risk prediction, targeted therapies, multidisciplinary care, and improved patient education. This narrative review provides a comprehensive overview and new perspectives on peripartum cardiomyopathy, covering its epidemiology, updated pathophysiological mechanisms, diagnosis, management, and future research directions for healthcare professionals, researchers, and clinicians.

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Title: Peripartum cardiomyopathy: a comprehensive and contemporary review
Authors: Farai Russell Sigauke
Hopewell Ntsinjana
Nqoba Tsabedze
Publication date: 30-09-2024
Publisher: Springer US
Keywords: Cardiomyopathy
Biomarkers
Heart Failure
Published in: Heart Failure Reviews / Issue 6/2024
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-024-10435-5

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