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Current Cardiology Reports

Recent Advances in Positron Emission Tomography Radiotracers to Image Cardiac Amyloidosis

Published in:
Authors
Ardel J. Romero Pabón
Olivier F. Clerc
Shilpa Vijayakumar
Sarah A. M. Cuddy
Sharmila Dorbala
Published in
Current Cardiology Reports | Issue 11/2024

Abstract

Cardiac amyloidosis includes a group of protein-misfolding diseases characterized by fibril accumulation within the extracellular space of the myocardium and cardiac dysfunction. Cardiac amyloidosis has high mortality. Emerging radionuclide techniques have helped us to better understand disease pathogenesis, prognostication, and treatment response in cardiac amyloidosis.

Purpose of Review

To review recent advances in molecular imaging of cardiac amyloidosis using amyloid PET radiotracers.

Recent Findings

Multiple single center studies have shown that amyloid PET radiotracers allow definitive diagnosis and quantification of cardiac amyloid burden. These amyloid targeting tracers may provide means to improve early disease detection, risk stratification and treatment monitoring.

Summary

Amyloid PET imaging may inform definitive imaging-based diagnosis for therapeutic decisions, risk stratification, and treatment monitoring. More research in unselected cohorts of patients with suspected cardiac amyloidosis is needed to optimize the clinical implementation of amyloid PET imaging.
Title
Recent Advances in Positron Emission Tomography Radiotracers to Image Cardiac Amyloidosis
Authors
Ardel J. Romero Pabón
Olivier F. Clerc
Shilpa Vijayakumar
Sarah A. M. Cuddy
Sharmila Dorbala
Publication date
13-08-2024
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 11/2024
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-024-02114-6
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window
Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME