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Open Access 01-03-2025 | CAR T-Cell Therapy | REVIEW

Evolving strategies for addressing CAR T-cell toxicities

Authors: Alexander W. Rankin, Brynn B. Duncan, Cecily Allen, Sara K. Silbert, Nirali N. Shah

Published in: Cancer and Metastasis Reviews | Issue 1/2025

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Abstract

The field of chimeric antigen receptor (CAR) T-cell therapy has grown from a fully experimental concept to now boasting a multitude of treatments including six FDA-approved products targeting various hematologic malignancies. Yet, along with their efficacy, these therapies come with side effects requiring timely and thoughtful interventions. In this review, we discuss the most common toxicities associated with CAR T-cells to date, highlighting risk factors, prognostication, implications for critical care management, patient experience optimization, and ongoing work in the field of toxicity mitigation. Understanding the current state of the field and standards of practice is critical in order to improve and manage potential toxicities of both current and novel CAR T-cell therapies as they are applied in the clinic.
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Metadata
Title
Evolving strategies for addressing CAR T-cell toxicities
Authors
Alexander W. Rankin
Brynn B. Duncan
Cecily Allen
Sara K. Silbert
Nirali N. Shah
Publication date
01-03-2025
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 1/2025
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-024-10227-1

ASH 2024 Annual Meeting Coverage

inMIND supports tafasitamab addition in follicular lymphoma

Combining tafasitamab with lenalidomide and rituximab significantly improves progression-free survival for patients with relapsed or refractory follicular lymphoma.

Featuring the official presentation video

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SPONSORED

Recent advances in the use of CAR T-cell therapies in relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma

In this webinar, Professor Martin Dreyling and an esteemed international panel of CAR T-cell therapy experts discuss the latest data on the safety, efficacy, and clinical impact of CAR T-cell therapies in the treatment of r/r DLBCL and r/r FL.

Please note, this webinar is not intended for healthcare professionals based in the US and UK.

Sponsored by:
  • Novartis Pharma AG
Chaired by: Prof. Martin Dreyling
Developed by: Springer Healthcare
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