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Current Pain and Headache Reports

Capsaicin in the Management of Peripheral Neuropathy: A Review

  • 01-12-2025
  • Capsaicin
  • Anesthetic Techniques in Pain Management (D Wang, Section Editor)
Published in:
Authors
Rabiul Ryan
Ramzan Judge
Jesse Lou
Andrew Ng
Published in
Current Pain and Headache Reports | Issue 1/2025

Abstract

Purpose of Review

The purpose of this review is to provide an update on the efficacy and safety of capsaicin in the treatment of neuropathic pain.

Recent Findings

Capsaicin can provide prolonged relief from pain in various neuropathies. One proposed mechanism is the ability to cause degeneration of hypersensitized nerve tissue and incite regeneration of healthy nerve fibers. Capsaicin provides more significant relief than placebo and is non-inferior to pregabalin in the treatment of peripheral neuropathy. It is emerging as an alternative but effective and well-tolerated treatment for neuropathy due to diverse pathologic conditions.

Summary

Capsaicin, a natural agonist at the TRPV1 receptor, has been studied for its therapeutic role in neuropathic pain. Capsaicin is an effective treatment with significant reduction in both diabetic and non-diabetic neuropathic pain. Due to its topical application, it is associated with fewer systemic adverse events and therefore, an attractive option in the treatment of peripheral neuropathy.
Title
Capsaicin in the Management of Peripheral Neuropathy: A Review
Authors
Rabiul Ryan
Ramzan Judge
Jesse Lou
Andrew Ng
Publication date
01-12-2025
Publisher
Springer US
Published in
Current Pain and Headache Reports / Issue 1/2025
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-025-01423-x
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