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Published in: Neurotoxicity Research 2/2024

Open Access 01-04-2024 | Cannabinoid | Review

Interactions Between the Ubiquitin–Proteasome System, Nrf2, and the Cannabinoidome as Protective Strategies to Combat Neurodegeneration: Review on Experimental Evidence

Authors: Luis Angel Monsalvo-Maraver, Enid A. Ovalle-Noguez, Jade Nava-Osorio, Marisol Maya-López, Edgar Rangel-López, Isaac Túnez, Alexey A. Tinkov, Yousef Tizabi, Michael Aschner, Abel Santamaría, Students from Programa Delfín 2022

Published in: Neurotoxicity Research | Issue 2/2024

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Abstract

Neurodegenerative disorders are chronic brain diseases that affect humans worldwide. Although many different factors are thought to be involved in the pathogenesis of these disorders, alterations in several key elements such as the ubiquitin–proteasome system (UPS), the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway, and the endocannabinoid system (ECS or endocannabinoidome) have been implicated in their etiology. Impairment of these elements has been linked to the origin and progression of neurodegenerative disorders, while their potentiation is thought to promote neuronal survival and overall neuroprotection, as proved with several experimental models. These key neuroprotective pathways can interact and indirectly activate each other. In this review, we summarize the neuroprotective potential of the UPS, ECS, and Nrf2 signaling, both separately and combined, pinpointing their role as a potential therapeutic approach against several hallmarks of neurodegeneration.

Graphical Abstract

Literature
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Metadata
Title
Interactions Between the Ubiquitin–Proteasome System, Nrf2, and the Cannabinoidome as Protective Strategies to Combat Neurodegeneration: Review on Experimental Evidence
Authors
Luis Angel Monsalvo-Maraver
Enid A. Ovalle-Noguez
Jade Nava-Osorio
Marisol Maya-López
Edgar Rangel-López
Isaac Túnez
Alexey A. Tinkov
Yousef Tizabi
Michael Aschner
Abel Santamaría
Students from Programa Delfín 2022
Publication date
01-04-2024
Publisher
Springer US
Keyword
Cannabinoid
Published in
Neurotoxicity Research / Issue 2/2024
Print ISSN: 1029-8428
Electronic ISSN: 1476-3524
DOI
https://doi.org/10.1007/s12640-024-00694-3

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