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Cancer Immunology, Immunotherapy

Issue 9/2025

Content (23 Articles)

Precision sniper for solid tumors: CAR-NK cell therapy

Sisi Li, Jiajie Jing, Yueming Chen, Enjie Chi, Bingyan Wang, Ziwen Xie, Wenya Yang, Hongqiang Shen, Jianping Pan

Preclinical evaluation of a CCL19 immune-potentiated DNA cancer vaccine

  • Open Access
  • Research

Søren Vester Kofoed, Marina Barrio-Calvo, Michail Angelos Pavlidis, Daniela Kleine-Kohlbrecher, Mads Lausen, Cherie Lunabjerg-Vestergaard, Nadia Viborg, Christian Garde, Birgitte Rønø, Stine Friis

Deletion of gasdermin D promotes granulocytic myeloid-derived suppressor cell differentiation by decreased release of mitochondrial DNA to promote tumor escape

Min Gu, Weiwei Chen, Shizhen Ding, Zhijie Lin, Li Qian, Weiming Xiao, Xiaoqin Jia, Guotao Lu, Weijuan Gong

VHL restoration in clear cell renal cell carcinoma improves NK cell infiltration and function

Le Tong, Apple Hui Min Tay, Weiyingqi Cui, Yaxuan Liu, Yanhong Su, Jiawen Lyu, Leila Hoedemakers, Ying Yang, Monika Ehnman, Barbara Seliger, Par Nordlund, Felix Haglund de Flon, Shi Yong Neo, Andreas Lundqvist

Prediction of response to neoadjuvant chemotherapy in patients with muscle-invasive urothelial bladder cancer: role of immune-related gene expression

Hadeer Mahmoud, Abeer M. Abd El-Aziz, Osama Ezzat, Hany Ibrahim Kenawy, Ahmed A. Shokeir

GPX4 is a key ferroptosis regulator orchestrating T cells and CAR-T-cells sensitivity to ferroptosis

  • Open Access
  • Research

Marta Kłopotowska, Iwona Baranowska, Szymon Hajduk, Anna Jurga, Natalia Leśniowska, Michał Łaźniewski, Monika Granica, Marta Krawczyk, Milena Dziewicka, Agnieszka Graczyk, Jan Słupski, Radosław Zagożdżon, Dariusz Plewczynski, Magdalena Winiarska, Malgorzata Bajor

Combination of low-intensity pulsed ultrasound irradiating immune organs with immune checkpoint blockade augments systemic anti-tumor immunity on low tumor burden 4T-1 breast cancer

Jixi Li, Linqing Wen, Yujun Guo, Dan Yao, Bihang Sun, Hai Mou, Nianzhi Chen, Kun Zhou, Yan Wang, Wenzhi Chen

BAP1 as a predictive biomarker of therapeutic response to oncolytic vaccinia virus for metastatic renal cell carcinoma therapy

Jee Soo Park, Won Sik Jang, Myung Eun Lee, Jongchan Kim, Keunhee Oh, Namhee Lee, Won Sik Ham

Comparing neoadjuvant targeted therapy plus transarterial chemoembolization versus triple therapy including immunotherapy in hepatocellular carcinoma: a Chinese multicentre study

Hao Yu, Quan Yuan, Rui Yu, Rongjie Ye, Shuqi Yang, Ming Niu, Yunyun Sun, Jingpeng Ke, Liuxing Feng, Ping Guo, Yujian Liu, Jingrui Yang, Zaifa Hong, Taozhu Ye, Weixiang Ni, Xin Wang, Zhenhao Xie, Jiahuan Xu, Chuncheng Lin, Lizhi Lv, Shuangjia Wang, Chao Zhan

IL-1R2 promotes tumorigenesis and modulates the tumor immune microenvironment in colorectal cancer

Yanyan Lang, Hao Huang, Hongwei Jiang, Shaoxian Wu, Zhang Fang, Dachuan Zhang, Heya Qian, Yingting Liu, Maoling Yuan, Bin Xu, Lujun Chen, Xiao Zheng, Jingting Jiang

Neoantigen load as a predictor of relapse in early-stage NSCLC: features that agonise and antagonise prognosis

  • Open Access
  • NSCLC
  • Research

Linda Ye, Ian Dick, Bruce W. Robinson, Jenette Creaney, Alec Redwood

A pan-cancer comparative analysis of the cancer genome atlas transcriptomic TIL-immune signatures

  • Open Access
  • Research

Kyle J. Hitscherich, Darryl Nousome, Aaron J. Dinerman, Victoria Dulemba, Frank J. Lowery, Naris Nilubol

Cathepsin S regulates antitumor immunity through autophagic degradation of PD-L1 in colorectal cancer cells

Sina Taheri Baghmisheh, Chung-Hsing Chen, Yu-Min Yeh, Peng-Chan Lin, Po-Chuan Chen, Ren-Hao Chan, Jui-Wen Kang, Chung-Ta Lee, Hui-Ju Tsai, Yu-Chen Fang, Chun Hei Antonio Cheung, Kwang-Yu Chang, Jang-Yang Chang, Shang-Hung Chen

Exploring IgSF11 as a potential immune checkpoint and immunotherapeutic target in breast cancer

  • Open Access
  • Research

Ibtissam Rezouki, Basma Zohair, Hamza Benthami, Mehdi Karkouri, Ibtissam Razzouki, Abdallah Badou

Inosine shapes PD-1 blockade responses and synergizes with dual PD-1/CTLA-4 immunotherapy to enhance antitumor immunity

  • Open Access
  • Research

Yoichiro Narikawa, Atsuo Kuramasu, Masahiro Hosonuma, Masakazu Murayama, Eiji Funayama, Akiko Sasaki, Yuta Baba, Hitoshi Toyoda, Junya Isobe, Kohei Tajima, Rie Nakashima, Aya Sasaki, Yuki Maruyama, Yoshitaka Yamazaki, Midori Shida, Toshiaki Tsurui, Yuya Hirasawa, Hirotsugu Ariizumi, Tomoyuki Ishiguro, Risako Suzuki, Ryotaro Ohkuma, Yutaro Kubota, Takehiko Sambe, Mayumi Tsuji, Satoshi Wada, Atsushi Horiike, Shinichi Kobayashi, Takuya Tsunoda, Sei Kobayashi, Hitome Kobayashi, Tatsunori Oguchi, Toshikazu Shimane, Yuji Kiuchi, Kiyoshi Yoshimura

The transcription factor FOXA1 upregulates PYCR1-mediated autophagy to suppress antitumor immunity in lung adenocarcinoma

  • Open Access
  • Research

Kui Liu, Xiaoyan Yang, Xuemei Tang, Bo Tang

A platform for multisite immune profiling of premetastatic pancreatic cancer at single-cell resolution

  • Open Access
  • Research

Elishama N. Kanu, Ashley A. Fletcher, Jiayin Bao, Ethan S. Agritelley, Julia Button, Austin M. Eckhoff, Karrie Comatas, Tao Wang, Bin-Jin Hwang, Michael E. Lidsky, Sabino Zani, Dan G. Blazer, Peter J. Allen, Zhicheng Ji, Frank J. Lowery, Sri Krishna, Nicholas D. Klemen, Daniel P. Nussbaum, Erika J. Crosby

Heat up, silence on: IDO1 gene silencing in THP-1-derived dendritic cells triggered by magnetic hyperthermia

  • Open Access
  • Research

Daniela Ferreira, Laura Asín, Javier Idiago-López, Valeria Grazú, Jesús M. de la Fuente, Raluca M. Fratila, Pedro V. Baptista, Alexandra R. Fernandes

Spautin-1 inhibits the growth of diffuse large B-cell lymphoma by inducing mitochondrial damage-mediated PANoptosis and anti-tumor immunity

Jingjing Wu, Yuan Deng, Yong Gao, Bin Wei

Soluble PD-L1 (sPD-L1) as a biomarker of durable response and survival in patients with advanced non-small cell lung cancer (NSCLC) treated with first-line immune checkpoint inhibitors (ICIs)

  • Open Access
  • NSCLC
  • Research

Adrien Costantini, Paul Takam Kamga, Elvire Pons-Tostivint, Delphine Fradin, Jean-François Emile, Etienne Giroux-Leprieur

Interleukin 15 (IL15)-based near-infrared photoimmunotherapy

Motofumi Suzuki, Aki Furusawa, Hiroshi Yamamoto, Makoto Kano, Miyu Kano, Seiichiro Takao, Shuhei Okuyama, Peter L. Choyke, Hisataka Kobayashi

Efficacy of adjuvant therapy regimens administered during the perioperative period in resectable non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Jiarui Zhao, Baiyang Huang, Min Li, Xingpeng Wang, Jingyu Zhu, Kaiyue Wang, Jing Xu, Xiaohan Wang, Xue Meng, Guoxin Cai

Cytotoxic CD4⁺ T cells exhibit an immunosuppressive shift in checkpoint immunotherapy resistance in melanoma patients

Heekyong R. Bae, Byeongchan Son, Kyoungho Hwang, Suntae Kim, Howard A. Young, Eun-Young Kwon

Aug 25
Issue: 8/2025
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Issue: 10/2025

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Keynote webinar | Spotlight on progress in colorectal cancer

On-demand video coming soon

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
Prof. Harpreet Wasan
Prof. Edward Giovannucci
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Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images