Issue 8/2025
Content (38 Articles)
Assessment of compartment-specific CD103-positive cells for prognosis prediction of colorectal cancer
- Open Access
- Colorectal Cancer
- Research
Anpei Huang, Yuanhui Wu, Ji Cui, Muyan Cai, Yumo Xie, Jialin Zou, Maram Alenzi, Hui Yang, Pinzhu Huang, Meijin Huang
NLRP3 activation promotes cGAS/STING signaling and antitumor immunity by colorectal cancer cells
- Open Access
- Colorectal Cancer
- Research
Courtney Mowat, Daniel Schiller, Kristi Baker
Characteristics and outcomes of primary and secondary resistance to immune checkpoint inhibitors in hepatocellular carcinoma
- Open Access
- Checkpoint Inhibitors
- Research
Xiaowen Cui, Minghao Ruan, Yao Li, Cheng Yang, Jin Zhang, Riming Jin, Dong Wu, Wen Sun, Ruoyu Wang
Glutamate transporter SLC1A6 promotes resistance to immunotherapy in cancer
- Open Access
- Bladder Cancer
- Research
Chenchen Li, Yi Lin, Haoran Zheng, Hengda Zeng, Longhao Xu, Daqin Wu, Jianwen Lao, Peicong Cai, Shuai Liang, Chunhui Wang, Tianxin Lin, Wenlong Zhong
Tislelizumab and GP regimen neoadjuvant therapy followed by concurrent chemoradiotherapy with nimotuzumab in patients with stage IVA nasopharyngeal carcinoma: a retrospective study
- Open Access
- Cytostatic Therapy
- Research
Mingfen Lai, Shuai Li, Zhongwen Jin, Mingzhang Chang, Fangming Li, Peixin Yang, Yiming He, Qinhua Zhang
Extracellular vesicles derived from mature dendritic cells loaded with cDC1-specific chemokine XCL1 combined with chemotherapy-induced ICD for the treatment of castration-resistant prostate cancer
- Open Access
- Prostate Cancer
- Research
Zhongqiang Fan, Zhao Wang, Hui Zhang, Hao Zhang, Rui Zhao, Shimiao Zhu, Xiaoqiang Liu
Clinical efficacy and biomarkers of neoadjuvant chemoimmunotherapy in locally advanced esophageal squamous cell carcinoma
- Open Access
- Biomarkers
- Research
Siyou Deng, Qi Wang, Yueping Li, Ruijie Zhang, Jinjie Li, Yujie Zhang, Yixin Cai, Wei Sun, Jiang Chang, Ni Zhang, Li Zhang
Clinical factors associated with growth and neoantigen reactivity of tumor infiltrating lymphocytes from metastatic epithelial cancers
- Open Access
- Research
Alexandra M. Gustafson, Aaron J. Dinerman, Kyle J. Hitscherich, Maria R. Parkhurst, Hyunmi Halas, Donald E. White, Chuong D. Hoang, Jonathan M. Hernandez, Mei Li M. Kwong, Nicholas D. Klemen, Steven A. Rosenberg, Stephanie L. Goff, James C. Yang
Tertiary lymphoid structures in the microenvironment of colorectal cancer: exploring new therapeutic targets
- Open Access
- Colorectal Cancer
- Review
Nan-Nan Dai, Man-Yi Hu, Jian-Ping Wang, Zhi-Hui Dai, Li Xu, Tai-Wei Ye
Immunological synapse formation as a key mechanism in T cell-dependent bispecific antibody-mediated immune activation and cytotoxicity
- Open Access
- Cytokines
- Research
Rikuto Nakamura, Ryo Tsumura, Takahiro Anzai, Ryutaro Asano, Masahiro Yasunaga
Cell-specific nanoengineering strategy to disrupt tolerogenic signaling from myeloid-derived suppressor cells and invigorate antitumor immunity in pancreatic cancer
- Open Access
- Ruxolitinib
- Brief Report
Nilesh U. Deshpande, Anna Bianchi, Haleh Amirian, Iago De Castro Silva, Christine I. Rafie, Bapurao Surnar, Karthik Rajkumar, Akash Ashokan, Ifeanyichukwu C. Ogobuiro, Manan Patel, Erietta Stelekati, Shanta Dhar, Jashodeep Datta
Neo-antigen specific cancer vaccines for acute lymphoblastic leukemia—challenges, opportunities, and future directions
- Open Access
- Acute Lymphoblastic Leukemia
- Review
Victoria Bloch Blytt Sandstad, Signe Modvig, Morten Orebo Holmström
Correction: KLF12 as a potential biomarker for lateral pelvic lymph node metastases in advanced rectal cancer
- Open Access
- Rectal Cancer
- Correction
Tixian Xiao, Fangze Wei, Sicheng Zhou, Fuqiang Zhao, Fei Huang, Liu Qian
Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor-resistant tumors resulting in complete responses
- Open Access
- Cytokines
- Research
Jayalakshmi Lakshmipathi, Sreevidya Santha, Man Li, Yuping Qian, Simon F. Roy, Nadia Luheshi, Katerina Politi, Marcus Bosenberg, Jim Eyles, Viswanathan Muthusamy
Tumor-promoting function of paternally expressed gene 10 and its immunogenicity in inducing anti-tumor helper T cells in head and neck squamous cell carcinoma
- Open Access
- Research
Hiroki Komatsuda, Toshihiro Nagato, Akemi Kosaka, Takayuki Ohkuri, Takaaki Sasaki, Takumi Kumai, Michihisa Kono, Hidekiyo Yamaki, Risa Wakisaka, Shunsuke Yasuda, Takahiro Inoue, Ryusuke Hayashi, Nanami Ujiie, Ryosuke Sato, Kenzo Ohara, Kan Kishibe, Tatsuya Hayashi, Miki Takahara, Hiroya Kobayashi
T cell-derived small extracellular vesicles in cancer–immune interactions
- Open Access
- Review
Ma Janelle Chichoco Garcia, Su Su Thae Hnit, Elena Shklovskaya, Yuling Wang
Dissecting response to neoadjuvant immunotherapy-treated melanoma using cancer-immunity cycle-associated signatures
- Open Access
- Melanoma
- Brief Report
S. C. M. A. Wijnen, P. Dimitriadis, I. L. M. Reijers, A. M. Menzies, G. V. Long, L. F. A. Wessels, C. U. Blank
Simultaneous TGF-β and GITR pathway modulation promotes anti-tumor immunity in glioma
- Open Access
- Glioma
- Research
Daniela Lorizio, Manuela Silginer, Julia Friesen, Alan L. Epstein, Michael Weller, Patrick Roth
Diversity of mast cell subpopulations in the tumor microenvironment of colorectal cancer and their prognostic implications
- Open Access
- Colorectal Cancer
- Research
Tianyu Qiao, Chao Ding, Songtao Yu, Wenyang Li, Yonghou Zhao, Guiyu Wang
Salvianic acid A enhances anti-PD-1 therapy by promoting HEV-mediated stem-like CD8 T cells infiltration in TNBC
- Open Access
- Breast Cancer
- Research
Xiaoming Ding, Gai Liang, Yan Luo, Xiaomei Zhou, Qu Zhang, Bo Luo
TCR-based cellular immunotherapy for hepatocellular carcinoma: advances, challenges, and prospects
- Open Access
- Hepatocellular Carcinoma
- Review
Wanting Zeng, Wei Zhu, Guosheng Yuan, Jinzhang Chen, Zhanhui Wang, Jinlin Hou, De-Ke Jiang
Divergent therapeutic and prognostic impacts of immunogenic features in undifferentiated pleomorphic sarcoma and myxofibrosarcoma
- Open Access
- Sarcoma
- Research
Siddh van Oost, Debora M. Meijer, Zeynep B. Erdem, Marieke E. IJsselsteijn, Jessica Roelands, Suk Wai Lam, Melissa S. Boejharat, Brendy E. W. M. van den Akker, Ruud van der Breggen, Inge H. Briare-de Bruijn, Lukas J. A. C. Hawinkels, Anouk A. Kruiswijk, Manon van der Ploeg, Pauline M. Wijers-Koster, Rick L. Haas, Michiel A. J. van den Sande, Noel F. C. C. de Miranda, Judith V. M. G. Bovee
Favorable impact of zanubrutinib combined with R-CHOP regimen in MYD88-mutated new-diagnosed diffuse large B-cell lymphoma: a retrospective study with propensity score-matched analysis
- Open Access
- Zanubrutinib
- Research
Xiubin Xiao, Shunzong Yuan, Xilin Chen, Xia Liu, Ruiqing Zhao, Shihua Zhao, Yun Lu, Yi Ma, Junli Chen, Yueqi Wang, Nana Cheng, Hua Yin, Honghao Gao, Pan Feng, Wenrong Huang
Clinical outcomes following PD-1 inhibitor elective discontinuation in cutaneous squamous cell carcinoma: exploring treatment de-escalation
- Open Access
- Cutaneous Squamous Cell Carcinoma
- Research
Itamar Averbuch, Nofar Edri, Nethanel Asher, Gal Markel, Daniel Hendler, Hadas Ditzian Kugler, Eyal Yosefof, Noga Kurman
Impact of stratifin/14-3-3σ on survival and interstitial lung disease in patients with non-small cell lung cancer receiving immune checkpoint inhibitors
- Open Access
- NSCLC
- Research
Daiki Murata, Koichi Azuma, Kenta Murotani, Yoshiaki Zaizen, Tomoaki Hoshino
Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas
- Open Access
- Lymphoma
- Research
Jing Ma, Tina Sarén, Chuan Jin, Hyeong Su Kim, Paola Donaji Contreras Pineda, Marina de Bernard, Rose-Marie Amini, Veronica Rondahl, Gunilla Enblad, Di Yu, Magnus Essand
A high proportion of CD38 (high) CD16 (low) NK cells in colorectal cancer can interrupt immune surveillance and favor tumor growth
- Open Access
- Colorectal Cancer
- Research
Xueling Wang, Li Li, Xianqin Song, Kehua Fang, Xiaotian Chang
Gut modulation to regulate NF-κB in colorectal and gastric cancer therapy and inflammation
- Open Access
- Respiratory Microbiota
- Review
Rowan Kearns
Correlation between T cell immunity and the duration of EGFR-TKI resistance acquisition in patients harboring EGFR mutations
- Open Access
- Osimertinib
- Research
Atsuto Mouri, Kyoichi Kaira, Ou Yamaguchi, Ayako Shiono, Yu Miura, Kosuke Hashimoto, Satoshi Yamasaki, Fuyumi Nishihara, Hisao Imai, Kunihiko Kobayashi, Hiroshi Kagamu
Real-world effectiveness and safety of first-line chemoimmunotherapy combinations in metastatic non-small cell lung cancer with programmed death ligand-1 < 50%: results from an Italian observational study
- Open Access
- Cytostatic Therapy
- Research
Alessandro Inno, Antonello Veccia, Ettore D’Argento, Floriana Morgillo, Elio Gregory Pizzutilo, Fabiana Vitiello, Alberto Pavan, Fiorella Lombardo, Marco Russano, Vincenzo Sforza, Francesca Colamartini, Carlo Genova, Rita Chiari, Antonella Cristofano, Alessandro Delconte, Emanuela Vattemi, Alessandra Dessi, Daniele Galanti, Simona Busato, Giovanni Palazzolo, Clementina Savastano, Antonio Bianco, Francesco Verderame, Cristina Mazzi, Fabiana Marchetti, Stefania Kinspergher, Denis Occhipinti, Carminia Maria Della Corte, Daniele Piscazzi, Marina Gilli, Emilio Bria, Orazio Caffo, Stefania Gori
Single-cell RNA sequencing and multi-omics analysis of prognosis-related staging in papillary thyroid cancer
- Open Access
- Thyroid Cancer
- Research
Guo Ji, Hanlin Sun, Simo Chen, Xuechen Sun, Le Chang, Ruting Xie, Runzhi Huang, Lijun Zheng, Zhengyan Chang
TGF-β3 promotes vascular normalization of prostate cancer to potentiate immunotherapy and chemotherapy
- Open Access
- Prostate Cancer
- Research
Qiliang Teng, Niu Wang, Hanqi Lei, Tongyu Tong, Yupeng Guan, Mengjun Huang, Fei Cao, Bin Xu, Jia Yang, Yimian Huo, Wenping Chen, Ran Bi, Xuanqi Wang, Zhenyu Wang, Fu-Ying Tian, Bo Zhao, Jun Pang
Comprehensive analysis of exosome-related gene signature in multiple myeloma prognosis and immune microenvironment evaluation
- Open Access
- Multiple Myeloma
- Research
Dong Zheng, Bingxin Zhang, Quanqiang Wang, Sisi Zheng, Yibo Xia, Ziwei Zheng, Zhili Lin, Shuxia Zhu, Xinyi Zhang, Luning Cui, Hansen Ying, Tianyu Zhang, Shujuan Zhou, Zixing Chen, Enqing Lan, Yu Zhang, Xuanru Lin, Jingjing Chen, Honglan Qian, Xudong Hu, Yan Zhuang, Zuoting Xie, Xiangjing Zhou, Zhouxiang Jin, Songfu Jiang, Yongyong Ma
Concurrent treatment with transarterial immunoembolization of hepatic metastases and systemic immune checkpoint inhibitors to overcome immune evasion in patients with metastatic uveal melanoma
- Open Access
- Checkpoint Inhibitors
- Research
Natalie J. Miller, Sharon W. Kwan, Jacob B. Leary, Daniel S. Hippe, William McCamy, Joshua R. Veatch, Evan T. Hall, Wayne L. Monsky, Shailender Bhatia
Local–regional therapy combined with immune checkpoint inhibitors and lenvatinib versus immune checkpoint inhibitors plus chemotherapy in advanced intrahepatic cholangiocarcinoma: a multicenter cohort study
- Open Access
- Checkpoint Inhibitors
- Research
Shuofeng Li, Guanhua Yu, Mingming Wang, Shi Feng, An Zhang, Yu Wu, Zixiang Zhou, Shanshan Wang, Yihong Zhang, Mingjian Piao, Chengjie Li, Ziyu Xun, Boyu Sun, Jiongyuan Li, Nan Zhang, Hu Li, Yongliang Sun, Wen Zhang, Zhenyu Zhu, Haitao Zhao
Anti-TIGIT therapies: a review of preclinical and clinical efficacy and mechanisms
- Open Access
- Cancer Immunotherapy
- Review
Erin C. Sundstrom, Xueting Huang, Andrew J. Wiemer
Is adjuvant immunotherapy necessary after neoadjuvant chemoimmunotherapy in patients with resectable stage III NSCLC? A two-center real-world study
- Open Access
- NSCLC
- Research
Song Guan, Hui Wang, Zhaoxin Chen, Fengrui Guo, Guozhen Yi, Xingyu Du, Jingjing Yan, Cuimeng Tian
A multifunctional T-cell engager containing CD80 enhances prostate cancer treatment
- Open Access
- Prostate Cancer
- Research
Disen Nie, Yao Jiang, Hui Li, Keying Zhang, Zhengxuan Li, Tong Lu, Yu Li, Donghui Han, Changhong Shi, Nianzeng Xing, Fa Yang, Weihong Wen, Weijun Qin