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Cancer Immunology, Immunotherapy

Issue 7/2025

Content (45 Articles)

HIF-PH inhibitors induce pseudohypoxia in T cells and suppress the growth of microsatellite stable colorectal cancer by enhancing antitumor immune responses

Yuehua Chen, Toshiaki Ohara, Yusuke Hamada, Yuze Wang, Miao Tian, Kazuhiro Noma, Hiroshi Tazawa, Masayoshi Fujisawa, Teizo Yoshimura, Akihiro Matsukawa

Osteosarcoma cell–derived CCL2 facilitates lung metastasis via accumulation of tumor-associated macrophages

Hiroya Kondo, Hiroshi Tazawa, Tomohiro Fujiwara, Aki Yoshida, Miho Kure, Koji Demiya, Nobuhiko Kanaya, Toshiaki Hata, Koji Uotani, Joe Hasei, Toshiyuki Kunisada, Shunsuke Kagawa, Yusuke Yoshioka, Toshifumi Ozaki, Toshiyoshi Fujiwara

Clinical characteristics, outcomes, and predictive modeling of patients diagnosed with immune checkpoint inhibitor therapy-related pneumonitis

Antonious Hazim, Irene Riestra Guiance, Jacob Shreve, Gordon Ruan, Damian McGlothlin, Allison LeMahieu, Robert Haemmerle, Keith Mcconn, Richard C. Godby, Lisa Kottschade, Anna Schwecke, Casey Fazer-Posorske, Tobias Peikert, Eric Edell, Konstantinos Leventakos, Ashley Egan

Extracellular PKM2 modulates cancer immunity by regulating macrophage polarity

  • Open Access
  • Research

Guangda Peng, Bin Li, Hongwei Han, Yi Yuan, Falguni Mishra, Yang Huang, Zhi-Ren Liu

Pembrolizumab plus Lenvatinib in patients with metastatic Renal Cell Carcinoma: real-world evidences from the international ARON- 1 study

Camillo Porta, Francesco Massari, Tarek Taha, Enrique Grande, Maria T. Bourlon, Ravindran Kanesvaran, Umberto Basso, Javier Molina-Cerrillo, Teresa Alonso-Gordoa, Zin W. Myint, Giuseppe Fornarini, Thomas Buttner, Se Hoon Park, Yüksel Ürün, Ugo De Giorgi, Renate Pichler, Pasquale Rescigno, Tomas Buchler, Hana Studentova, Bohuslav Melichar, Jawaher Ansari, Veronica Mollica, Jakub Kucharz, Mimma Rizzo, Alessandro Rizzo, Ray Manneh Kopp, Sebastiano Buti, Fernando Sabino Marques Monteiro, Andrey Soares, Aristotelis Bamias, Matteo Santoni

Knockdown NEK7 stimulates anti-tumor immune responses by NLRP3/PD-L1 signaling in esophageal cancer

Li Wang, Yurong Cheng, Weiqiang Li, Jing Wang, Zhe Liu, Yaoxian Xiang, Xin Liu, Kangjie Wang, Dong Yan

The combination of SH003 and DTX induces cytotoxic cell infiltration in anti-PD1 resistant lung cancer

Yu-Jeong Choi, Sang-Eun Lee, Daeun Kim, Hae-In Lim, Da Kyung Choi, Bong Kyu Park, Chan-Yong Jeon, Seong-Gyu Ko

KLF12 as a potential biomarker for lateral pelvic lymph node metastases in advanced rectal cancer

Tianxian Xiao, Fangze Wei, Sicheng Zhou, Fuqiang Zhao, Fei Huang, Liu Qian

Characterization of the aryl hydrocarbon receptor as a potential candidate to improve cancer T cell therapies

  • Open Access
  • Research

Valentine De Castro, Oumaïma Abdellaoui, Barbara Dehecq, Babacar Ndao, Patricia Mercier-Letondal, Alexandra Dauvé, Francine Garnache-Ottou, Olivier Adotévi, Romain Loyon, Yann Godet

Recombinant antibodies from clonally expanded cancer-associated plasma cells

Wonkyung Kim, Ji-Hye Oh, Chae Won Park, Hyori Kim, Young Gwang Kang, Da Eun Oh, Hee Jin Lee, Ji Hun Kim, Chang Ohk Sung

Enhancing mesothelin CAR T cell therapy for pancreatic cancer with an oncolytic herpes virus boosting CAR target antigen expression

Mona Alhussein Aboalela, Mohamed Abdelmoneim, Shigeru Matsumura, Ibrahim Ragab Eissa, Itzel Bustos-Villalobos, Patricia Angela Sibal, Yu Orikono, Yuhei Takido, Yoshinori Naoe, Hideki Kasuya

KLRG1 expression induces functional exhaustion of NK cells in colorectal cancer patients

Cairui Xu, Kangli Cao, Along Ma, Meijuan Zheng, Yuanhong Xu, Ling Tang

ARHGDIB as a prognostic biomarker and modulator of the immunosuppressive microenvironment in glioma

Xuejun Yan, Rongnian Li, Jing Xu, Hua Liu, Minmin He, Xingjun Jiang, Caiping Ren, Quanwei Zhou

Mast cells-intestinal cancer cells crosstalk is mediated by TNF-alpha and sustained by the IL-33/ST2 axis

  • Open Access
  • Research

Chiara Dal Secco, Silvia Tonon, Caterina Trevisan, Eleonora Martinis, Viviana Valeri, Marta Codrich, Gianluca Tell, Barbara Frossi, Carlo E. M. Pucillo

Improved efficacy of concurrent anti-PD1 antibody plus AVD versus ABVD in patients with newly diagnosed early unfavorable and advanced stage classic Hodgkin lymphoma: a retrospective matched cohort study

Mengqiu Wu, Peng Sun, Baitian Zhao, Hang Yang, Yi Xia, Man Nie, Qingqing Cai, Huiqiang Huang, He Huang, Zhongjun Xia, Yu Wang, Zhiming Li, Panpan Liu

Actionable heterogeneity of hepatocellular carcinoma therapy-induced senescence

Pujan Engels, Andras Szolek, Sebastian Hörner, Georgios Vavouras Syrigos, Kim Hebbel, Michelle Schmidtke, Min Zhou, Maria Mateo-Tortola, Caroline Schönfeld, Sylwia Anna Stefanczyk, Katharina Wolter, Sepideh Babaei, Michael Schindler, Manfred Claassen, Daniel Dauch, Lars Zender, Ana Tapía-Abellán, Alexander N. R. Weber

Carry-over effect of immunotherapy in patients with advanced hepatocellular carcinoma

Chien-Huai Chuang, Ching-Tso Chen, Chih-Hung Hsu, Yu-Yun Shao

Biomarker, efficacy and safety analysis of transcatheter arterial chemoembolization combined with atezolizumab and bevacizumab for unresectable hepatocellular carcinoma

Shaobo Zhang, Zebin Zhu, Lianxin Liu, Björn Nashan, Shugeng Zhang

Unraveling the complex role of tumor-associated neutrophils within solid tumors

Yingxin Wang, Jiakang Ma, Yuhao Liu, Weiheng Cui, Xiaodong Chu, Yusheng Lin, Lu Wang

NECTIN4 regulates the cell surface expression of CD155 in non-small cell lung cancer cells and induces tumor resistance to PD-1 inhibitors

  • Open Access
  • NSCLC
  • Research

Shun Mizusaki, Yasuto Yoneshima, Eiji Iwama, Tadayuki Nakashima, Ritsu Ibusuki, Daisuke Shibahara, Kohei Otsubo, Kentaro Tanaka, Isamu Okamoto

Molecular mimicry between parasites and cancer: a novel approach for developing cancer vaccines and therapeutic antibodies

Maha Mohamed Eissa, Sonia Rifaat Ahmed Allam, Cherine Adel Ismail, Rasha Abdelmawla Ghazala, Nahla El Skhawy, Eman Ibrahim El-said Ibrahim

Molecular subtyping dictates therapeutic response to anti-PD-L1 immunotherapy in ES-SCLC

  • Open Access
  • SCLC
  • Research

Qianqian Zhang, Guoxin Wang, Wenjie Yan, Dong Wang, Jie Yin, Yong Song, Mingxiang Ye, Tangfeng Lv

Targeted CD47 checkpoint blockade using a mesothelin-directed antibody construct for enhanced solid tumor-specific immunotherapy

Anna Reischer, Alexandra Leutbecher, Björn Hiller, Enrico Perini, Kieron White, Alejandra Hernández-Cáceres, Alexandra Schele, Benjamin Tast, Lisa Rohrbacher, Lis Winter, Bastian Czogalla, Sven Mahner, Heinrich Flaswinkel, Heinrich Leonhardt, Lorenza Wyder, Christian Wichmann, Denis Maenner, Fabian Trillsch, Mirjana Kessler, Karl-Peter Hopfner, Nadja C. Fenn, Marion Subklewe

LAG3 as a marker of immune activation in esophageal squamous carcinoma treated with concurrent chemoradiotherapy

Yuxuan Zhang, Zijing Zhou, Yuanyuan Rui, Fanhao Kong, Zhoubo Guo, Gang Zhao, Jun Wang, Jiacheng Li, Fangdong Zhao, Hui Huang, Fang Fang, Jiarui Zhang, Tian Zhang, Wencheng Zhang, Ping Wang, Xi Chen, Peng Zhen, Qingsong Pang

Impact of rheumatoid factors on the function of therapeutic monoclonals specific for PD-1/PD-L1

Barry D. Hock, Liping Goddard, Lachlan J. Dobson, Sean A. MacPherson, John L. O’Donnell, Judith L. McKenzie, Alexander D. McLellan

Transarterial chemoembolization combined with tyrosine kinase inhibitors and/or immune checkpoint inhibitors induced hypothyroidism is associated with improved overall survival in hepatocellular carcinoma

Shengyuan Xu, Ruipeng Zheng, Chenghao Sun, Ri Sa

Analyses of single-cell RNA sequencing uncover the role of intratumoral Helicobacter pylori in shaping tumor progression and immunity in gastric cancer

Jiao Xu, Jin Yang, Qi Sun, Jingbo Chang, Fan Wang

Clinical, immune cell, and genetic features predicting survival and long-term response to first-line chemo-immunotherapy treatment for non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Liling Huang, Haohua Zhu, Liyuan Dai, Yu Feng, Xinrui Chen, Zucheng Xie, Xingsheng Hu, Yutao Liu, Xuezhi Hao, Lin Lin, Hongyu Wang, Shengyu Zhou, Jiarui Yao, Le Tang, Xiaohong Han, Yuankai Shi

Exosomal PD-L1 derived from hypoxia nasopharyngeal carcinoma cell exacerbates CD8+ T cell suppression by promoting PD-L1 upregulation in macrophages

  • Open Access
  • Research

Xiaofei Yuan, Xiong Liu, Di Jiang, Zijun Zheng, Xuemin Ma, Shuting Wu, Xiangping Li, Juan Lu, Ming Fu

Immunotyping of thyroid cancer for clinical outcomes and implications

Jin Xu, Zhen Luo, Dayong Xu, Mujing Ke, Cheng Tan

Correction: Monitoring peripheral blood data supports the prediction of immunotherapy response in advanced non‑small cell lung cancer based on real‑world data

  • Open Access
  • NSCLC
  • Correction

Ana D. Ramos‑Guerra, Benito Farina, Jaime Rubio Pérez, Anna Vilalta‑Lacarra, Jon Zugazagoitia, Germán Peces‑Barba, Luis M. Seijo, Luis Paz‑Ares, Ignacio Gil‑Bazo, Manuel Dómine Gómez, María J. Ledesma‑Carbayo

Correction: Normalization of tumor vasculature by imiquimod: proposal for a new anticancer therapeutic indication for a TLR7 agonist

  • Open Access
  • Correction

Magdalena Jarosz-Biej, Justyna Czapla, Joanna Ciepła, Ryszard Smolarczyk, Alina Drzyzga, Dorota Sprus-Lipka, Ewelina Pilny, Sybilla Matuszczak, Tomasz Cichoń

Chaperonin containing TCP1 subunit 5 as a novel pan-cancer prognostic biomarker for tumor stemness and immunotherapy response: insights from multi-omics data, integrated machine learning, and experimental validation

Jiajun Li, Nuo Xu, Leyin Hu, Jiayue Xu, Yifan Huang, Deqi Wang, Feng Chen, Yi Wang, Jiani Jiang, Yanggang Hong, Huajun Ye

Pembrolizumab-axitinib versus nivolumab-cabozantinib as first-line therapy in patients with metastatic renal cell carcinoma: a retrospective real-world comparison (ARON-1)

Matteo Santoni, Giandomenico Roviello, Enrique Grande, Ugo De Giorgi, Ondrej Fiala, Emmanuel Seront, Javier Molina-Cerrillo, Renate Pichler, Zin W. Myint, Jakub Kucharz, Ravindran Kanesvaran, Thomas Büttner, Martin Pichler, Umberto Basso, Jindrich Kopecky, Maria T. Bourlon, Linda Cerbone, Tomas Buchler, Alvaro Pinto, Alfonso Gómez de Liaño, Caterina Gianni, Anca Zgura, Pasquale Rescigno, Jawaher Ansari, Orazio Caffo, Zsófia Küronya, Maria Giuseppa Vitale, Dipen Bhuva, Martina Catalano, Nuno Vau, Ray Manneh Kopp, Sebastiano Buti, Aristotelis Bamias, Camillo Porta, Kaisa Sunela, Francesco Massari

Stabilized iRGD modification enhances NY-ESO-1 TCR-T infiltration in solid tumors and synergizes with PD-1 blockade

Yirong Wu, Lanqun Qin, Jiayu Wang, Ziyao Xie, Xinyu Su, Xiang Li, Yueling Yang, Rong Huang, Mengke Zhao, Lianjun Zhao, Zhengyun Zou

Inhibition of head and neck squamous cell carcinoma by Bruton’s tyrosine kinase inhibitor ibrutinib is associated with reduction of immunosuppressive T cells

Anna R. Bopp, Felipe F. Lamenza, Puja Upadhaya, Nathan M. Ryan, Natalie Kazmierowicz, Pete P. Jordanides, Arham Siddiqui, Sherefuddin H. Pracha, Peyton Roth, O. Hans Iwenofu, Steve Oghumu

Impact of innate lymphoid cell type 2 in chronic lymphocytic leukemia on the function of treg and CD8+ T cells through IL-9

Ruixue Yang, Xuejiao Zeng, Xierenguli Alimu, Jianhua Qu

Efficacy and safety of local–regional therapy combined with chemotherapy, immune checkpoint inhibitors and lenvatinib as first-line treatment in advanced intrahepatic cholangiocarcinoma: a multicenter retrospective cohort study

Shuofeng Li, Guanhua Yu, Mingming Wang, Shi Feng, Shanshan Wang, Mingjian Piao, Chengjie Li, Zixiang Zhou, Ziyu Xun, Boyu Sun, Jiongyuan Li, Nan Zhang, Hu Li, Xiaobo Yang, Zhenyu Zhu, Haitao Zhao

Prognostic significance of osteosarcopenia and its effects on immune response in patients with stage II/III gastric cancer

Yuki Hirase, Takaaki Arigami, Daisuke Matsushita, Masataka Shimonosono, Yusuke Tsuruda, Ken Sasaki, Kenji Baba, Yota Kawasaki, Takao Ohtsuka

Cancer therapy via neoepitope-specific monoclonal antibody cocktails

Colin J. Hartman, Asmaa O. Mohamed, Girja S. Shukla, Stephanie C. Pero, Yu-Jing Sun, Roberto S. Rodríguez-Jimenez, Nicholas F. Genovese, Nico M. Kohler, Thomas R. Hemphill, Yina H. Huang, David N. Krag, Margaret E. Ackerman

Correction: Infectious complications distribution following CLL1 CAR-T cell therapy for acute myeloid leukemia

Jianmei Xu, Huan Zhang, Yifan Zhao, Xiaomei Zhang, Shujing Guo, Xiaoxue Shi, Xia Xiao, Hairong Lyu, Yu Zhang, Xiaoyuan He, Mingfeng Zhao

Correction: Gut microbiota affects PD-L1 therapy and its mechanism in melanoma

Shiqi Liu, Jiahui Liu, Yingwu Mei, Wenjuan Zhang

Oncolytic adenovirus encoding variant interleukin-2 combined with chemotherapy enables PD-L1 inhibition in pancreatic cancer models

Santeri A. Pakola, Nea Ojala, Tatiana V. Kudling, James H. A. Clubb, Elise Jirovec, Mirte van der Heijden, Victor Arias, Lyna Haybout, Saru Basnet, Susanna Grönberg-Vähä-Koskela, Dafne C. A. Quixabeira, Joao M. Santos, Victor Cervera-Carrascon, Otto Hemminki, Anna Kanerva, Harri Mustonen, Pauli Puolakkainen, Hanna Seppänen, Akseli Hemminki

Single-cell RNA sequencing analysis reveals a lack of CXCL13+ T cell subsets associated with the recurrence of cervical squamous cell carcinoma following concurrent chemoradiotherapy

Xia Li, Yanmei Cheng, Mei Ji, Junqi Liu, Zhao Zhao, Qitai Zhao

Predictive factors and nomogram for the risk of cytokine release syndrome with anti-CD3 × CD20 bispecific antibodies for Chinese patients

Peng Sun, Cui Chen, Bai-Tian Zhao, Bo-Yan Zhang, Hang Yang, Yu Wang, Fei Xu, Kang-Ming Huang, Yin-Ting Liu, Mei-Shuo Ouyang, Jia-Jia Huang, Pan-Pan Liu, Ying Guo, Zhi-Ming Li

Jun 25
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Issue: 8/2025

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Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images