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Cancer Immunology, Immunotherapy

Issue 5/2025

Content (26 Articles)

Navigating TAM receptor dynamics in tumour immunotherapy

  • Open Access
  • Review

Jihao Yang, Guanmin Chen, Rui Wang, Chengcheng Song, Huaqiang Yi

The prognosis prediction value of CD69+ CD8+ tissue-resident memory T cell as a novel indicator of pathologic complete response heterogeneity following different neoadjuvant therapy regimen in esophageal squamous cell carcinoma

  • Open Access
  • Research

Ao Liu, Defeng Liu, Xiuli Liu, Yuxiang Chi, Longxiang Guo, Dianxing Li, Qiankun Wang, Yuanlin Li, Yi Li, Guiwen Zheng, Haiqun Lin, Qiuan Yang, Yaru Tian, Jinming Yu, Minghuan Li

Lymphocyte/monocyte to lactate dehydrogenase ratio prior to lymphodepletion impact the outcomes of patients with diffused large B cell lymphoma undergoing CAR-T cell therapy

Na Li, Na An, Sha Ma, Jiang Cao, Feng Zhu, Kunming Qi, Zhiling Yan, Hai Cheng, Wei Sang, Wei Chen, Depeng Li, Zhenyu Li, Kailin Xu, Ying Wang

Infectious complications distribution following CLL1 CAR-T cell therapy for acute myeloid leukemiass

Jianmei Xu, Huan Zhang, Yifan Zhao, Xiaomei Zhang, Shujing Guo, Xiaoxue Shi, Xia Xiao, Hairong Lyu, Yu Zhang, Xiaoyuan He, Mingfeng Zhao

MS275 induces tumor immunosuppression by upregulating PD-L1 and enhances the efficacy of anti-PD-1 immunotherapy in colorectal cancer

Deng Tang, Zhigang Mao, Sihan Chen, Mi Su, Siqi Lan, Ruiting Yan, Qi Xiang, Xianxian Zhao, Ji Zhang, Yufang Wang

Single-cell sequencing reveals tumor microenvironment features associated with the response to neoadjuvant immunochemotherapy in oral squamous cell carcinoma

  • Open Access
  • Research

Pu-Gen An, Wen-Jie Wu, Xiao Hu, Zi-Qi Zhang, Jie Zhang

Early local therapy in combination with PD-1/PD-L1 inhibitors in oligometastatic non-small cell lung cancer: results from a prospective multicenter observational study

  • Open Access
  • NSCLC
  • Research

Jie Gao, Aihua Lan, Xi Yang, Li Chu, Xiao Chu, Yue Zhou, Hongru Chen, Silai Yu, Yechun Pang, Jie Hu, Qian Chu, Jianjiao Ni, Zhengfei Zhu

A novel peptide targeting CCR7 inhibits tumor cell lymph node metastasis

Yixuan Sun, Yuzhen Qian, Lu Qiu, Xueqin Zhu, Haoming Ning, Liwei Pang, Xiaoshuang Niu, Yi Liu, Xiuman Zhou, Guanyu Chen, Wenjie Zhai, Yanfeng Gao

Antitumor effects of immunotherapy combined with BRAF and MEK inhibitors in BRAF V600E metastatic colorectal cancer

Eunyoung Tak, Hye-In An, Amy Sinyoung Lee, Kyuyoung Han, Jiwan Choi, Hyung-don Kim, Yong Sang Hong, Sun Young Kim, Eun Kyung Choi, Jeong Eun Kim, Tae Won Kim

PRGN-2009 and bintrafusp alfa for patients with advanced or metastatic human papillomavirus-associated cancer

Charalampos S. Floudas, Meghali Goswami, Renee N. Donahue, Julius Strauss, Danielle M. Pastor, Jason M. Redman, Isaac Brownell, Evrim B. Turkbey, Seth M. Steinberg, Lisa M. Cordes, Jennifer L. Marté, Maheen H. Khan, Sheri McMahon, Elizabeth Lamping, Michell Manu, Manuk Manukyan, Douglas E. Brough, Amy Lankford, Caroline Jochems, Jeffrey Schlom, James L. Gulley

Be cautious to adopt a second CAR T-cell infusion after failure of CD19/CD22 cocktail CAR T-cell therapy in relapsed/refractory B-NHL

  • Open Access
  • Research

Gaoxiang Wang, Meijuan Huang, Lijun Jiang, Xiaoying Zhang, Zhenhao Wang, Qiuxia Yu, Dengju Li, Yang Yang, Xin Yang, Yang Cao

Prognostic significance of cytotoxic-T-lymphocytes to immunosuppressive lymphocytes ratio (CIL) in laryngeal squamous cell carcinoma

  • Open Access
  • Research

Duo Zhang, Yu Heng, Qiu-yan Jin, Di Tang, Xiao-ke Zhu, Li-ming Lu, Chun-ping Wu, Lei Tao

DNA methylation-regulated HLA-C expression modulates immune responses and metabolic alterations to influence prognosis in mesothelioma

Huilin Zhang, Luanxue Yu, Yunqing Guo, Jiawei Ming, Zhenying Guo

Single-cell RNA sequencing reveals an IL1R2+Treg subset driving immunosuppressive microenvironment in HNSCC

  • Open Access
  • Research

Haiyan Guo, Chun Liu, Kun Wu, Yan Li, Zhen Zhang, Fuxiang Chen

Ex vivo-expanded and activated haploidentical natural killer cells infusion before autologous stem cell transplantation in high-risk neuroblastoma: a phase I/II pilot study

Tahereh Rostami, Mohammad Ahmadvand, Morteza Azari, Amir Kasaeian, Bahram Chahardouli, Mohammad Reza Shemshadi Nia, Mojtaba Azari, Mohammad Reza Rostami, Ramin Ahangar-Sirous, Azadeh Kiumarsi, Ghasem Janbabai

Microwave ablation combined with immune checkpoint inhibitor enhanced the antitumor immune activation and memory in rechallenged tumor mouse model

Fengkuo Xu, Jing Sang, Nan Wang, Meixiang Wang, Yahan Huang, Ji Ma, Huanan Chen, Qi Xie, Zhigang Wei, Xin Ye

RNF2 induces myeloid-derived suppressor cells chemotaxis and promotes hepatocellular carcinoma progression through the TRAF2-NF-κB signaling axis

Manman Liang, Jianghua Yang, Aiping Zhang, Na Zhong, Bin Quan, Zijian Wang, Wenying Zhao, Biao Geng, Yufeng Gao

A new era of cancer immunotherapy: vaccines and miRNAs

Gitika Sareen, Maneesh Mohan, Ashi Mannan, Kamal Dua, Thakur Gurjeet Singh

Multicenter evaluation of predictive clinical and imaging factors for pathological response in non-small cell lung cancer patients treated with neoadjuvant chemotherapy and immune checkpoint inhibitors

  • Open Access
  • NSCLC
  • Research

Mengzhe Zhang, Meng Yan, Zekun Li, Shuai Jiang, Zuo Liu, Pengpeng Zhang, Zhenfa Zhang

Expression of costimulatory molecule CD70 is prognostic in small cell lung cancer

  • Open Access
  • SCLC
  • Research

David Dora, Zsolt Megyesfalvi, Imre Vörös, Ágnes Paál, Peter Takacs, Daniela Dobos, Bence Lőrincz, Syeda Mahak Zahra Bokhari, Kenan Aloss, Gergely Pallag, Christopher Rivard, Hui Yu, Fred R. Hirsch, Anikó Görbe, Zoltán V. Varga, Zoltan Lohinai, Balazs Dome

Prognostic impact and landscape of cellular CXCR5 chemokine receptor expression in clear-cell renal cell carcinoma

Masashi Arai, Nobuyuki Tanaka, Kimiharu Takamatsu, Tetsushi Murakami, Shuji Mikami, Takeshi Imamura, Kohei Nakamura, Hiroshi Nishihara, Mototsugu Oya

SIRPα + CD209 + cell: a specialized antigen-presenting cell that contributes to anti-SIRPα/RT therapy in colorectal cancer

Yida Li, Weiqing Lu, Fan Xia, Yun Deng, Xin Jin, Yan Xuan, Yaqi Wang, Lijun Shen, Juefeng Wan, Hui Zhang, Yaqi Li, Xinxiang Li, Lili Huang, Zhen Zhang

Cohort-based pan-cancer analysis and experimental studies reveal ISG15 gene as a novel biomarker for prognosis and immunotherapy efficacy prediction

Jingjing Wei, Yingjia Zhuang, Chengfei Jiang, Lingyan Chen, Binbin Yuan, Yue Zhao, Happi Li, Jian-Hua Mao, Bo Hang, Chunping Ye, Lei Wang, Pin Wang

Gut microbiota affects PD-L1 therapy and its mechanism in melanoma

Shiqi Liu, Jiahui Liu, Yingwu Mei, Wenjuan Zhang

The effect of TIGIT and PD1 expression on T cell function and prognosis in adult patients with acute myeloid leukemia at diagnosis

Dai-Hong Xie, Si-Qi Li, Kai Sun, Jun Wang, Zong-Yan Shi, Ya-Zhe Wang, Yan Chang, Xiao-Ying Yuan, Hao Jiang, Qian Jiang, Ying-Jun Chang, Xiao-Jun Huang, Ya-Zhen Qin

Correction: Therapeutic effect of fully human anti-Nrp-1 antibody on non–small cell lung cancer in vivo and in vitro

  • Open Access
  • NSCLC
  • Correction

Bo Zhang, Qin Liu, Lin Li, Yingchun Ye, Xiyuan Guo, Wenfeng Xu, Ligang Chen, Xianming Mo, Siji Nian, Qing Yuan

Apr 25
Issue: 4/2025
Jun 25
Issue: 6/2025

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Keynote webinar | Spotlight on progress in colorectal cancer

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
Prof. Harpreet Wasan
Prof. Edward Giovannucci
Watch now
Image Credits
Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images