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Cancer Immunology, Immunotherapy

Issue 12/2025

Content (30 Articles)

The impact of tislelizumab immunotherapy on multiple primary lung cancer presenting as ground-glass nodules: preliminary results analysis from a single-arm, phase II trial

Junfei Wu, Xiangning Fu, Yi Gao, Shenghui Qin, Jing Xiong, Rirong Qu, Yixin Cai

Ki-67 expression stratifies PD-L1-high NSCLC for immune checkpoint inhibitor plus chemotherapy: a real-world biomarker validation

Ning Yang, Xiting Chen, Haoqiang Wang, Peng Liu, Baiyang Liu, Bo Xie, Juan Zhou

The antitumor mechanism of immuno-flap treatment in a rat model of head and neck cancer

  • Open Access
  • Research

Hiroaki Mori, Yasuto Akiyama, Chie Maeda, Akari Kanematsu, Tadashi Ashizawa, Kazue Yamashita, Haruo Miyata, Akira Iizuka, Tomoatsu Ikeya, Yoshichika Yasunaga, Jun Araki

MS4A1 regulates M1-polarized tumor-associated macrophage infiltration, angiogenesis, and cancer progression through the HIPPO pathway in lung adenocarcinoma

  • Open Access
  • Research

Weitong Gao, Ruqiong Wang, Shuangshuang Yang, Yingnan Shi, Mengen Cui, Renjie Jiang, Rou Li, Yan Yu, Dexin Jia, Dehai Che

Tumor microenvironment remodeling across thyroid cancer differentiation states revealed by spatial transcriptomics

Jungirl Seok, Hongyoon Choi, Eun Kyung Lee, Chang Hwan Ryu, Dongjoo Lee, Junsun Ryu, Seog Yun Park, Yuh-Seog Jung

Increased CD103−CD8+ TILs with TPEX phenotype replenish anti-tumor T cell pool in mismatch repair-proficient CRC

Jinsheng Liu, Jintao Zeng, Ting Zhou, Mi Wu, Xiufang Weng

CD40 transcriptomic expression patterns across malignancies: implications for clinical trials of CD40 agonists

Yuji Uehara, Daisuke Nishizaki, Yu Fujiwara, Hirotaka Miyashita, Suzanna Lee, Sarabjot Pabla, Paul DePietro, Heidi Ko, Taylor J. Jensen, Jason K. Sicklick, Shumei Kato, Razelle Kurzrock

The immunophenotype of immune checkpoint-induced bullous pemphigoid: a cohort study

Nada Saffuri, Ilanit Boyango, Itay Cohen, Zenab Ali-Saleh, Marwan Dawood, Ziyad Khamaysi, Dean Yogev, Emily Avitan-Hersh

Advancing CIK cell immunotherapy: highlights from the second international conference on DC-CIK and CAR-CIK approaches

Amit Sharma, Dario Sangiolo, Antonio Rosato, Jingjing Pu, Jian Hou, Sarah Tettamanti, Marta Serafini, Kevin Aaron Fenix, Martino Introna, Alessandro Rambaldi, Xiubao Ren, Ingo G. H. Schmidt-Wolf

A meta-analysis of experimentally validated neo-epitopes: patterns, biases, and opportunities

  • Open Access
  • Research

Alessandro Sette, Ibel Carri, Daniel Marrama, Angela Frentzen, Jarjapu Mahita, Nina Blazeska, Randi Vita, Morten Nielsen, Yat-Tsai Richie Wan, Hannah Carter, Stephen Schoenberger, Bjoern Peters, Zeynep Koşaloğlu‐Yalçın

CAR-T cells immunotherapy in the treatment of glioblastoma

Aleksandra Królikowska, Maciej Tarnowski

Biology and evolving management of resectable dMMR/MSI-H cancers: current status and future perspectives

Tokiyoshi Tanegashima, Masaki Shiota, Kayo Toyosaki, Kouta Funakoshi, Masatoshi Eto

Combined CHK1 and PD-L1 blockade as a novel therapeutic strategy against stemness and immunosuppression in ovarian cancer

Mengqing Chen, Lin Huang, Mengna Zhu, Jing Cai, Feiquan Ying, Lin Liu, Wenhan Li, Si Sun, Yiping Wen

Generating CAR-macrophages to target endothelin B receptor-positive tumors

Cyril Lherminier, Narciso Costa, Amaury Herbet, Marie Hautière, Aloïse Mabondzo, Jérémie Martinet, Didier Boquet

A matrix stiffness gene signature identifies SLC20A1 as a novel mechano-immunological checkpoint enabling synergistic immunotherapy in pancreatic ductal adenocarcinoma

  • Open Access
  • Research

Chuanbing Zhao, Yu Lu, Long He, Yunpeng Zhang, Tao Yin

Integrative analysis of single-cell and bulk transcriptome data reveals age-related immune cell alterations in primary glioblastoma associated with prognosis

Zefan Jing, Bojun Qiu, Chenyang Ai, Chunhui Wang, Xinrun Wang, Boyang Li, Lin Hou, Bin Yin, Wei Han, Xiaozhong Peng

Development of the rationale of a personalized cancer vaccine based on the in situ vaccine effect of radiotherapy: a mechanistic study of the POLARSTAR trial

Kai Pang, Peilin Sun, Xinzhi Liu, Dan Yang, Pengfei Zhao, Yongjie Huang, Shun Cao, Yang Gao, Guangyong Chen, Huajing Yu, Liping Duan, Yingchi Yang, Zhongtao Zhang

Combining molecular patterns and clinical data for better immune checkpoint inhibitor prediction in metastatic urothelial carcinoma

M. Váradi, O. Horváth, E. Soós, A. Csizmarik, B. Németh, B. Győrffy, I. Kenessey, H. Reis, F. Koll, C. Oláh, B. Hadaschik, U. Krafft, V. Grünwald, F. Mairinger, M. Wessolly, M. J. Hoffmann, C. M. Grunewald, G. Niegisch, C. L. Cotarelo, A. Maráz, L. Kuthi, A. M. Szász, Z. Herold, M. Posta, B. Bátai, P. Nyirády, T. Szarvas

Efficacy and safety of low-molecular-weight heparin or rivaroxaban combined with immunotherapy and chemotherapy in the treatment of advanced nonsmall cell lung cancer: a prospective, randomized, controlled clinical study

Hongchuan Zhang, Junfeng Li, Guangjin Yuan, Shengyuan Huang, Xuemei Li

Sustained remission with PD-1 and BTK inhibitors maintenance after chimeric antigen receptor T-cell therapy in CNS lymphoma

Lingzi Yu, Nana Ping, Rui Zou, Qian Zhu, Junhong Li, Xiao Zhang, Fan Xia, Jiajie He, Jiajie Tu, Danqing Kong, Depei Wu, Zhengming Jin, Changju Qu

B Cell dysfunction in tumor-draining lymph nodes predicts relapse in oral squamous cell carcinoma

  • Open Access
  • Research

Vilma Liljeström, Pedro Farrajota Neves da Silva, Rusana Bark, Alexandra Elliot, Linda Marklund, Gregori Margolin, Susanna Kumlien Georén, Lars-Olaf Cardell, Krzysztof Piersiala

Real-world evidences on adjuvant Pembrolizumab for renal cell carcinoma: results from the multicenter real-world ARON-1 study

Ray Manneh Kopp, Francesco Massari, Enrique Grande, Timothy J. Schieber, Yüksel Ürün, Jindřich Kopecký, Javier Molina-Cerrillo, Umberto Basso, Jakub Kucharz, Thomas Büttner, Renate Pichler, Ondrej Fiala, Zin W. Myint, Luca Galli, Tomas Buchler, Mimma Rizzo, Hatice Bolek, Maria T. Bourlon, Vincenza Conteduca, Alvaro Pinto, Alessandro Rizzo, Matteo Rosellini, Giandomenico Roviello, Anca Zgura, Veronica Mollica, Antonia Partl, Ahmet Yildirim, Umut Akova, Sebastiano Buti, Fernando Sabino Marques Monteiro, Andrey Soares, Camillo Porta, Mehmet Asim Bilen, Haoran Li, Matteo Santoni

Comparative analysis of immunochemotherapy with versus without radiation therapy for stage IVB esophageal squamous cell carcinoma confined to non-regional nodal metastases: a multicenter propensity score matching study

Qi Liu, Junqiang Chen, Yuanji Xu, Wenbin Shen, Jinjun Ye, Honglei Luo, Xizhi Zhang, Wenyang Liu, Yujin Xu, Yingying Zhang, Anwen Liu, Xiaopeng Li, Hong Ge, Qifeng Wang, Hui Luo, Lina Zhao, Conghua Xie, Qin Lin, Congying Xie, Jianping Xiong, Weiwei Chen, Luhua Wang, Kuaile Zhao

Research progress in the construction and application of immunotherapy resistance models

  • Open Access
  • Review

Huiling Li, Shenzhan Wang, Xiaoxi Li, Chao Wu, Yingnan Feng, Xin Hu, Lan Zhang, Xianzhe Dong

Construction and application of a humanized mouse model for prostate cancer in immunotherapy

Wenwen Guo, Hui Li, Yong Zhao, Jing Qin, Han Meng, Xu Ge, Caiqin Zhang, Changhong Shi

CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8+CD103+ cDC1 and TRM cell responses

Zhaojia Wu, Zhenyu Yang, Tauqeer Iftikhar, Gary Groot, Scot C. Leary, Nicolas Baniak, Shahid Ahmed, Mark Bosch, Michael Moser, Wenjun Zhang, Junhong Jiang, Jim Xiang

The FSTL1-DIP2A axis is a significant biomarker for predicting anti-PD1 therapeutic efficacy in advanced gastric cancer

Chie Kudo-Saito, Hiroshi Imazeki, Kengo Nagashima, Hirokazu Shoji, Kai Tsugaru, Naoki Takahashi, Takeshi Kawakami, Yusuke Amanuma, Takeru Wakatsuki, Fumio Nagashima, Yukiya Narita, Yoshiyuki Yamamoto, Rika Kizawa, Kei Muro, Narikazu Boku

Automatically quantifying spatial heterogeneity of immune and tumor hypoxia environment and predicting disease-free survival for patients with rectal cancer

Shenlun Chen, Zonglin Liu, Jiazhou Wang, Zhiyuan Zhang, Andre Dekker, Leonard Wee, Petros Kalendralis, Yiqun Sun, Tong Tong

Fruquintinib plus sintilimab in previously bevacizumab-treated, pMMR/MSS refractory metastatic colorectal cancer: a phase 2 clinical trial

Wen. Zhang, Cai-Feng. Gong, Jing-Long. Huang, Tian-Yi. Liu, Yong-Kun. Sun, Zhi-Chao. Jiang, Wang. Qu, Lin. Yang, Ying. Xin, Fei-Long. Zhao, Yue-zong. Bai, Ai-Ping. Zhou

Early trajectory of inflammatory cytokines following tarlatamab administration in three advanced SCLC patients

Takuma Imakita, Kohei Fujita, Yuki Yamamoto, Osamu Kanai, Yuta Okada, Shogo Toyama, Takanori Ito, Issei Oi, Kiminobu Tanizawa

Nov 25
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Keynote webinar | Spotlight on progress in colorectal cancer

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CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
Prof. Harpreet Wasan
Prof. Edward Giovannucci
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Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images