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Cancer Immunology, Immunotherapy

Issue 11/2025

Content (28 Articles)

Expression of the inhibitory checkpoints LAG-3, TIM-3, and PD-1 in NK cells and T cells in acute myeloid leukemia: preserved expression of LAG-3 is associated with patient survival

Isabel Valhondo, Alejandra Pera, Fakhri Hassouneh, Nelson López-Sejas, Pablo Álvarez-Heredia, Juan M. Bergua, María José Arcos, Ignacio Casas-Avilés, Joaquín Sánchez-García, Josefina Serrano, Carmen Martín, Esther Durán, Corona Alonso, Rafael Solana, Raquel Tarazona

Tumor-draining lymph nodes respond to immune checkpoint inhibition and orchestrate tumor immune remodeling

Jinzhu Zhang, Jian Ma, Yaru Niu, Jialiang Liu, Zhexue Wang, Jinyuan Guo, Yongsheng Meng, Ruifang Sun, Zhen Zhang, Haiyi Liu, Juan Xu, Likun Zan, Xu Guan, Xishan Wang

Efficacy of PRaG therapy in microsatellite-stable metastatic colorectal cancer: a comparative analysis of PD-1/PD-L1 inhibitor-based combination therapies

Jiabao Yang, Xiangrong Zhao, Pengfei Xing, Yuehong Kong, Meiling Xu, Liyuan Zhang

Suppression of STK11 induces expansion of polymorphonuclear myeloid-derived suppressive cells and activation of immune signaling in breast cancer

Tzu-Hui Wei, Chi-Che Hsieh, Zhu-Jun Loh, Wei-Pang Chung, Kuo-Ting Lee, Yi-Ling Chen, Hui-Ping Hsu, Che-Hung Shen

Preclinical development of an mRNA-based multiepitope immunotherapeutic for glioblastoma

Johannes Lutz, Randi K. Feist, Tim Sonntag, Esteban Peguero-Sánchez, Katharina Wolter, Ronja Bick, Jens Bauer, Juliane S. Walz, Regina Heidenreich

A pan-cancer single-cell analysis reveals the effect of PD-1 blockades on tumor angiogenesis by inhibiting the endothelial CXCL12-CXCR4 axis

  • Open Access
  • Research

Mairedan Muhetarijiang, Pengwei Zhu, Han Zhang, Xiangjie Sun, Yakui Wu, Qianwen Xu, Ryan Justin, Chenxi Li, Dongchen Zhou, Biqi Zhang, Jun Liu, Xiaosheng Hu, Ting Chen

Local therapy overcomes primary resistance to target-immunotherapy combination in unresectable hepatocellular carcinoma

Xiangqi Chen, Mingjian Piao, Zixiang Zhou, Shanshan Wang, Shuofeng Li, Nan Zhang, Boyu Sun, Kai Liu, Xu Yang, Xiaobo Yang, Xiaohua Shi, Chengpei Zhu, Haitao Zhao

Intratumoral B cell and interferon signatures in newly diagnosed glioblastoma are associated with longer survival in patients treated with SurVaxM

Henry G. Withers, Sheila A. Figel, Jingxin Qiu, Manmeet Singh Ahluwalia, David Reardon, Ajay P. Abad, William T. Curry, Eric T. Wong, David M. Peereboom, Andrew Dhawan, Song Liu, Michael J. Ciesielski, Robert A. Fenstermaker

Profiling of circulating T-cells with prognostic and predictive value in early and advanced stage PDAC

  • Open Access
  • Research

Anastasia Xagara, Konstantina Vasilieva, Alexandros Kokkalis, Alexandros Lazarou, George Christodoulopoulos, Vasileios Papadopoulos, Evangelia Chantzara, Fillipos Koinis, Emmanouil Saloustros, Galatea Kallergi, Vassilis Georgoulias, Ioannis S. Pateras, Athanasios Kotsakis

Bevacizumab reduces PD-L1 Not PD-1 inhibitor-associated pneumonitis in non-small cell lung cancer patients

Linling Wang, Yasi Xu, Yanyan Zhao, Bing Xia, Lucheng Zhu

Comprehensive proteomic and pathological profiling identifies PRAS40 as a novel biomarker and mediator of primary immune checkpoint blockade resistance in non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Ning Mao, Cui He, Jia Kuang, Chunguang Wang, Zhao Yang

The single-cell atlas of colorectal cancer reveals cellular heterogeneity and key molecular features of the tumor immune microenvironment

JunHu Li, ZhiQiang Liu, BoYu Zhang, LiuPing You, YueNan Huang

Adjuvant immunotherapy fails to improve survival in ypStage I esophageal cancer after neoadjuvant immunochemotherapy

Yan Huang, Fan Dong, Caiyan Fang, Jiadi Wu, Zhichao Li, Jiyang Chen, Xiuying Xie, Hong Yang, Kongjia Luo, Jianhua Fu

CAR NK cell production from human cord blood NK progenitor cells is enhanced by stimulation of the IL-15 receptor

  • Open Access
  • Brief Report

Yosuke Kogue, Shunya Ikeda, Yuto Maehara, Ryuhei Kawamoto, Makiko Suga, Shuhei Kida, Kumi Shibata, Kazuhito Tsutsumi, Hiraku Murakami, Emiko Mizuta, Yo Mizutani, Yuta Yamaguchi, Daisuke Okuzaki, Naoki Hosen

Correction: T cell-derived small extracellular vesicles in cancer–immune interactions

  • Open Access
  • Correction

Ma Janelle Chichoco Garcia, Su Su Thae Hnit, Elena Shklovskaya, Yuling Wang

Integrating necroptosis and immune landscapes: a multi-omics-derived NecropImmScore stratifies prognosis and therapy in ovarian cancer

Fangfang Xu, Shufeng Kang, Shaohua Xu

NKG2D CAR-NK adoptive cellular immunotherapy combined with or without PD-1 blockade in the treatment of patients with metastatic colorectal cancer: an exploratory study

Danyang Wang, Bin Li, Guojie Shen, Hangyu Zhang, Yang Gao, Zhicheng Du, Xiaomeng Dai, Xuanwen Bao, Xudong Zhu, Zhou Tong, Dongxue Hu, Lulu Liu, Yi Zheng, Peng Zhao, Shu Wang, Weijia Fang

Overcoming NK cell resistance in triple-negative breast cancer via adcc with a humanized anti-CD147 antibody

Thanathat Pamonsupornwichit, Kanyarat Thongheang, Nuchjira Takheaw, Kanokporn Sornsuwan, Zaw Ye Htet, On-anong Juntit, Phatcharida Jantaree, Chatchai Tayapiwatana

Identification of two distinct uveal melanoma subtypes based on the immune cell infiltration of the primary tumour

Konstantinos Panagiotidis, Sally Owens, Grainne Finegan, Noel Horgan, Stefanos Tsavdaridis, Susan Kennedy, Achilleas Floudas

Development of antigen multimers for detection and evaluation of CAR T cells

  • Open Access
  • Research

Rasmus U. W. Friis, Maria Ormhøj, Cecilie S. Krüger-Jensen, Carlos Rodriguez Pardo, Hólmfridur Rósa Halldórsdóttir, Markus Barden, Nikolaj P. Kristensen, Keerthana Ramanathan, Mikkel R. Hansen, Hinrich Abken, Sine R. Hadrup

Assessment of tertiary lymphoid structures via 18F-FDG PET/CT scan in patients with pancreatic adenocarcinoma

Yu Yan, Xuan Zou, Xuan Lin, Xu Wang, Yusheng Chen, Mingjian Ma, Xu Wang, Mengxing Pan, Xianjun Yu, Chen Liu, He Cheng

Bacteria-derived DNA in serum extracellular vesicles as a biomarker for gastric cancer

Kaoru Fujikawa, Takuro Saito, Atsunari Kawashima, Kentaro Jingushi, Daisuke Motooka, Shigeto Nakai, Takaomi Hagi, Kota Momose, Kotaro Yamashita, Koji Tanaka, Tomoki Makino, Tsuyoshi Takahashi, Yukinori Kurokawa, Kazutake Tsujikawa, Hisashi Wada, Hidetoshi Eguchi, Yuichiro Doki

Bispecific antibodies (PD-1/CTLA-4) vs. PD-1 inhibitors with platinum-based chemotherapy±bevacizumab as first-line therapy for persistent, recurrent, or metastatic cervical cancer: a retrospective matched cohort study

Xin Wang, Yaqin Wu, Jian Huang, Dan Zong, Xia He

Nonclinical safety evaluation and pharmacokinetics of Ab612, a novel anti-L1CAM (CD171) therapeutic antibody candidate against solid cancer

Se-Ho Kim, Hee Su Chae, Soo Min Ko, Da Som Jeong, Ji-Young Lee, Young G. Shin, Seon-Joo Yoon, Woo-Chan Son

Correction: Integrated multi-omics analysis reveals clinical significance of hepatocyte nuclear factor-1β in tumor immune microenvironment, immunotherapy and prognostic prediction for colon adenocarcinoma

  • Open Access
  • Correction

Fushan Gao, Wenlin Gong, Haihua He, Zhen Zhang, Hongcai Yang, Fei Shao, Yibo Gao, Jie He

Correction: Gut microbiota affects PD-L1 therapy and its mechanism in melanoma

Shiqi Liu, Jiahui Liu, Yingwu Mei, Wenjuan Zhang

Correction: Tertiary lymphoid structures gene signature predicts response to immunotherapy plus chemotherapy in advanced non-small cell lung cancer

  • Open Access
  • NSCLC
  • Correction

Wei Du, Bijing Xiao, Xuan Yang, Jianhua Zhan, Haishuang Sun, Yunpeng Yang, Wenfeng Fang, Yan Huang, Dongchen Sun, Shaodong Hong, Li Zhang

Correction: Impact of lymph node dissection on survival after neoadjuvant immunochemotherapy for esophageal squamous cell cancer: a double-center real-world retrospective study

  • Open Access
  • Correction

Yan Huang, Xirui Lin, Caiyan Fang, Zhichao Li, Jiyang Chen, Xiuying Xie, Hansheng Wu, Hong Yang, Kongjia Luo, Jianhua Fu

Oct 25
Issue: 10/2025
Dec 25
Issue: 12/2025

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Keynote webinar | Spotlight on progress in colorectal cancer

On-demand video coming soon

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
Prof. Harpreet Wasan
Prof. Edward Giovannucci
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Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images