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Cancer Immunology, Immunotherapy

Issue 10/2025

Content (27 Articles)

Utility of [99mTc]Tc-tilmanocept, an immunosuppressive macrophage functional imaging agent in melanoma patients receiving checkpoint inhibitor treatment: a feasibility study

Sarah Boughdad, Sofiya Latifyan, Margret Schottelius, Michael Blue, Stéphanie Tissot, Christine Geldhof, Julien Costes, John O. Prior, Niklaus Schaefer

Real-world treatment practices and survival outcomes of patients with de novo metastatic nasopharyngeal carcinoma after chemoimmunotherapy

Qin Lin, Yuan Zhou, Lin-Feng Guo, Guan-Zhong Lu, San-Gang Wu

Circ_0074158 and QKI6: A regulatory axis for PD-L1 ubiquitination and immune evasion in NSCLC

  • Open Access
  • NSCLC
  • Research

Haihua Zhang, Xueying Liu, Jie Lei, Feng Tian, Xiaochen Liu, Feng Lv, Shuhong Kang, Ke Lan, Jian Wang, Xiaolong Yan, Yunfeng Ni

Upfront whole blood transcriptional patterns in patients receiving immune checkpoint inhibitors associate with clinical outcome

S. Hone Lopez, S. Loipfinger, A. Bhattacharya, M. Jalving, S. F. Oosting, T. J. N. Hiltermann, M. de Bruyn, E. G. E. de Vries, J. J. de Haan, R. S. N. Fehrmann

Immune checkpoint inhibitors combined with chemotherapy in conversion therapy for stage IV gastric cancer: a multicenter retrospective cohort study

Xingmao Huang, Xiangliu Chen, Jiahui Chen, Can Hu, Han Chen, Hang Chen, Jingquan Fang, Zeyao Ye, Yian Du, Pengfei Yu, Ling Huang

Impact of lymph node dissection on survival after neoadjuvant immunochemotherapy for esophageal squamous cell cancer: a double-center real-world retrospective study

Yan Huang, Xirui Lin, Caiyan Fang, Zhichao Li, Jiyang Chen, Xiuying Xie, Hansheng Wu, Hong Yang, Kongjia Luo, Jianhua Fu

The efficacy and safety of disitamab vedotin combined with immune checkpoint inhibitors in metastatic upper tract urothelial carcinoma: a multicenter real-world study

Cheoklong Ng, Taile Jing, Shicheng Yu, Jianjun Ye, Shun Zhang, Zhankui Jia, Qi Tang, Xiaoyi Hu, Minfeng Chen, Weiping Huang, Jitao Wu, Hai Bi, Zejun Yan, Haibo Shen, Wei Xiong, Zheng Liu, Jun Xiao, Tao Zhang, Xuedong Wei, Hailong Hu, Qing Yang, Yichu Yuan, Zhiyang Huang, Wei Xue, Yige Bao, Guoqing Ding, Dan Xia, Jiwei Huang

Dual targeting of solid tumors using cytokine-induced killer cells modified with a CAR anti-tenascin C and a secretable EGFRxCD3 bispecific antibody

Silvia Zaninelli, Irene Cattaneo, Rut Valgardsdottir, Roberta Frapolli, Ezia Bello, Marina Meroni, Andrea Gianatti, Silvia Panna, Paola Rizzo, Susanna Tomasoni, Maurizio D’Incalci, Martino Introna, Josée Golay, Alessandro Rambaldi

Development and activity of canine B7-H3-CAR.CIK lymphocytes against sarcomas: preclinical evidence and perspectives for human clinical translation

Raffaella De Maria, Chiara Donini, Sonia Capellero, Annamaria Massa, Federica Galvagno, Alessia Proment, Letizia Vitali, Elisa Vigna, Elisa Landoni, Gianpietro Dotti, Valeria Leuci, Paolo Accornero, Luiza Cesar Conti, Matteo Olimpo, Enrico Berrino, Giovanni Grignani, Anna Sapino, Dario Sangiolo, Luca Aresu

Tertiary lymphoid structures gene signature predicts response to immunotherapy plus chemotherapy in advanced non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Wei Du, Bijing Xiao, Xuan Yang, Jianhua Zhan, Haishuang Sun, Yunpeng Yang, Wenfeng Fang, Yan Huang, Dongchen Sun, Shaodong Hong, Li Zhang

GARP-expressing Tregs as a source of immunosuppressive TGF-β1 in human tumors

Pierre Van Meerbeeck, Douae Maatougui, Grégoire de Streel, Noora Vaherto, Etienne Marbaix, Frank Aboubakar Nana, Marc Van den Eynde, Alix Devaux, Javier Carrasco, Agnès Noel, Nicolas van Baren, Sophie Lucas

High baseline PD-1+ CD8 T Cells and TIGIT+ CD8 T Cells in circulation associated with response to PD-1 blockade in patients with non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Nikita Dutta, Johanna Svensson, George-Alehandro Saad, Marielle Mello, Ella A. Eklund, Ilayda Altinönder, Per Torstensson, Volkan I. Sayin, Anna Rohlin, Hervé Luche, Andreas Hallqvist, Sukanya Raghavan

High-plex imaging of hepatoblastoma and adjacent liver in pediatric patients reveals a predominant myeloid infiltrate expressing immune-checkpoints

Daniëlle Krijgsman, Stephanie A. Schubert, Lianne J. Kraaier, Yuyan Lu, Kristof van Avondt, Meggy E. L. Verdonschot, Jeanette H. W. Leusen, Marius C. van den Heuvel, Ruben H. de Kleine, Vincent E. de Meijer, Kathelijne C. J. Kraal, Ronald R. de Krijger, József Zsiros, Weng Chuan Peng, Yvonne Vercoulen

The efficacy and safety of neoadjuvant immunotherapy combined with chemotherapy for locally advanced gastric cancer: a single-center, real-world clinical study

Xuan Pan, Huayun Zhu, Xingwang Li, Siwen Liu, Shuchen Dong, Chao Yue, Pingping Wu, Yan Sun

The cGAS-STING pathway is a master regulator of OCT4 expression in persistent sarcoma cells and enhances cellular immunotherapy with NK and CIK lymphocytes

Giorgia Giordano, Alessandra Merlini, Federica Capozzi, Giulio Ferrero, Cristina Tucciarello, Shahab Majidi, Simona Comparato, Giulia Mesiano, Elisabetta Liuzzi, Federica Galvagno, Annamaria Massa, Silvia Brusco, Valeria Leuci, Chiara Riganti, Santina Cutrupi, Michele De Bortoli, Lorenzo D’Ambrosio, Dario Sangiolo, Giovanni Grignani, Ymera Pignochino

Dynamic remodeling of tertiary lymphoid structures in response to cancer therapy: a recent review

Chongyu Tan, Jinliang Huang, Ning Gao, Bingquan Wu, Matsika Juliet, Jiatong Xiao, Jiao Hu, Ping Liu, Jinbo Chen

Spatially resolved endothelial signaling via nampt-itga5 drives immune evasion in stem-like gastric cancer

Ji-Yong Sung, Jae-Ho Cheong, Eui Tae Kim

Nattokinase-driven remodeling of tumor microenvironment enhances the efficacy of MSLN-targeted CAR-T cell therapy in solid tumors

Lianfeng Zhao, Yan Zhang, Xinhao Yang, Tianyu Chen, Jiaqi Liu, Zhigang Guo

Stress induces corticosterone-mediated CD8+ T cell exhaustion to promote non-small cell lung cancer

  • Open Access
  • NSCLC
  • Research

Qiaoqi Zheng, Ji Zhuoga, Qian Weng, Huijie Zhang, Lingling Deng, Maimaititusun Yalikun, Peng Fu, Zaiquan Dong, Jingcheng Dong

Efficacy and safety of two-year fixed versus continuous immune checkpoint inhibitor therapy in advanced or metastatic non-small cell lung cancer: a systematic review

Toshali Pandey, Sajjad A. Bhatti

The protective role of γδ T cells in endometrial cancer

David P. Mysona, Akash Shah, Natalia Jaeger, Ahmad Almadadi, Brian Orr, Richard McIndoe, Marian Johnson, Robert Higgins, Bunja Rungruang, Sharad Ghamande, Catherine Hedrick, Klaus Ley

Single-cell transcriptomic analyses provide insights into SPP1+ TAM-mediated immune suppression and CD8+ T cell dysfunction in lung cancer

Rahma Taher Almgrami, Tengyue Zhang, Qitai Zhao, Mingming You, Jinyan Liu, Yi Zhang

Immunotherapy change overcomes acquired resistance after chemo-immunotherapy in unresectable biliary tract cancer

Xiangqi Chen, Zixiang Zhou, Shuofeng Li, Guanhua Yu, Shi Feng, Ze Zhou, Boyu Sun, Shanshan Wang, Kai Liu, Chengjie Li, Mingjian Piao, Mingming Wang, Yihong Zhang, Hu Li, Chengpei Zhu, Zhenyu Zhu, Haitao Zhao

Differentiation and mitochondrial metabolic characteristics of CD8+ T cells in malignant ascites of epithelial ovarian cancer and their correlation with estrogen signaling

Zouyu Jiang, Ying Zhou, Jiajuan Wu, Yu Shen, Danni Tang, Yuhong Wu, Qiuxia Qu, Juan Wang

Correction: Metastatic sites of baseline as predictors in recurrent or metastatic nasopharyngeal carinoma treated with PD-L1 inhibitor: a secondary analysis of multicenter, single-arm, phase II study (KL-A167)

  • Open Access
  • Correction

Yuantai Li, Yu Min, Zhigong Wei, Zheran Liu, Yiyan Pei, Yujie Yang, Kun Gao, Ge Song, Shihong Xu, Shuangshuang He, Junyou Ge, Yan Qing, Youneng Wei, Ping Ai, Ye Chen, Xingchen Peng

Correction: Association of lymphocyte subsets percentage with prognosis for recurrent or metastatic nasopharyngeal carcinoma patients receiving PD-L1 inhibitors

Jianming Diao, Zhigong Wei, Yiyan Pei, Junyou Ge, Yan Qing, Youneng Wei, Ye Chen, Xingchen Peng

Immune checkpoint inhibitors-associated acute kidney injury: a systematic review and meta-analysis of incidence, kidney recovery, and recurrent risk

Cheng-Wei Ho, Nai-Wen Kang, Tzu-Hsuan Yeh, Min-Hsiang Chuang, Wen-Wen Tsai, Hsien-Yi Wang, Vin-Cent Wu, Heng-Chih Pan, Jui-Yi Chen

Sep 25
Issue: 9/2025
Nov 25
Issue: 11/2025

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CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
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Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images