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Cancer Immunology, Immunotherapy

Issue 1/2026

Content (35 Articles)

Discontinuation of immunotherapy and its effect on prognosis in recurrent or metastatic nasopharyngeal carcinoma patients: a retrospective analysis

Yingpeng Peng, Xi Chu, Dasong Zha, Linghan Meng, Jijin Yao, Tianze Liu, Qiaodan Liu, Xiwei Xu, Siyang Wang, Mingyuan Chen, Rui You, Youping Liu

Long-term outcome of neoadjuvant tislelizumab plus chemotherapy in locally advanced esophageal squamous cell carcinoma

Hao Yin, Xinyu Yang, Yujie Chen, Hongtao Duan, Jie Wang, Xuqiang Liao, Guangyu Yao, Fei Liang, Hong Fan, Gao Li, Yihua Sun, Xiaolong Yan, Peiyuan Wang, Lijie Tan

Stereotactic ablative radiotherapy-driven immunosuppression is associated with poorer progression-free survival in cancer patients

Jessica Oliver, Hannah Reed, Lorenzo Capitani, Ashley Poon-King, Ashleigh Young, Stefan Milutinovic, Mateusz Kuczynski, Owen Nicholas, Thomas Rackley, Catherine Pembroke, Andrew Godkin, Awen M. Gallimore

Spatial patterns and prognostic relevance of CD1a+ immature and CD208+ mature dendritic cells in colorectal cancer from non-tumor adjacent mucosa to liver metastases

Sergii Pavlov, Esraa Ali, Wenjing Ye, Lenka Červenková, Filip Ambrozkiewicz, Ondřej Vyčítal, Ondřej Daum, Václav Liška, Kari Hemminki, Andriy Trailin

Identification of HLA class II-restricted T cell receptors against shared PIK3CA mutations in patients with epithelial cancers

  • Open Access
  • Research

S. M. Rafiqul Islam, Samantha Seitter, Maria Parkhurst, Frank J. Lowery, Miaki Fukuhara, Sanghyun P. Kim, Noam Levin, Jared J. Gartner, Satyajit Ray, Todd Prickett, Victoria Hill, Paul F. Robbins, Stephanie L. Goff, Steven A. Rosenberg, Nikolaos Zacharakis

Immune biomarkers for head and neck cancer

Navid Sobhani, Alberto D’Angelo, Fernanda G. Kugeratski, Tristan Nguyen, Rachel M. Morris, Raheleh Roudi, Nikta Kia, Luca Pianta, Riccardo Morello, Stuart Winter, Daniele Generali, Alexandro Membrino

Combined CD25-targeted near infrared photoimmunotherapy (NIR-PIT) and intratumor IL-15 enhance the effectiveness of anti-PD-1 immunotherapy

  • Open Access
  • Research

Makoto Kano, Aki Furusawa, Hiroshi Fukushima, Seiichiro Takao, Shuhei Okuyama, Hiroshi Yamamoto, Motofumi Suzuki, Miyu Kano, Ko Kitamura, Peter L. Choyke, Hisataka Kobayashi

Elevated antidrug antibodies against atezolizumab and associated clinical outcomes in advanced non-small-cell lung cancer

Miran Jang, Chan Kim, So Jung Kong, Hannah Yang, Won Suk Lee, Ho Yun Lee, Hong Jae Chon, Se-Hoon Lee

Pomalidomide enhances CAR-T cell therapeutic efficacy and remodels immune microenvironment in lymphoid malignancies

  • Open Access
  • Research

Yi Zhou, Yan Yu, Linzhi Xie, Liwen Wang, Yuhan Yan, Qian Cheng, Jing Liu, Chang Zhang, Xin Li

Gut microbial metabolite butyrate boosts p53-expressing telomerase-specific oncolytic adenovirus efficacy by enhancing infectivity and activating MHC-I/cGAS-STING

Masaki Sakamoto, Shinji Kuroda, Tetsuya Katayama, Yu Mikane, Shunya Hanzawa, Daisuke Kadowaki, Yusuke Yoshida, Yuki Hamada, Ryoma Sugimoto, Chiaki Yagi, Masashi Hashimoto, Nobuhiko Kanaya, Yoshihiko Kakiuchi, Satoru Kikuchi, Kunitoshi Shigeyasu, Hiroshi Tazawa, Shunsuke Kagawa, Yasuo Urata, Toshiyoshi Fujiwara

Chronic stress promotes pancreatic ductal adenocarcinoma progression via complement C5a-recruited myeloid-derived suppressor cells

Siyuan Yang, Li Xiao, Pingqian Qi, Ziqing Liu, Zhuomin Chen, Ruijia Wei, Ruishan He, Qiwen Yu, Zizhou Yan, Suyi Xiong, Mengmeng Wang, Yanjuan Deng, Jinping Hu, Lv Zhou, Zhen Feng, Huan Deng

Exploration of the benefits and resistance mechanisms of immunotherapy based on PD-L1 expression, circulating tumor DNA and T-cell receptor profiles in advanced gastric cancer

Miaomiao Gou, Niansong Qian, Yong Zhang, Bingfa Yan, Zhikuan Wang, Guanghai Dai

RERE-AS1 as a regulator of immune modulation and therapeutic response in breast cancer

Shaohui Jiang, Weijie He, Zhimin Li, Haodong He, Yuehua Li, Meiling Wen, Hongbo Zhu, Pengfei Luo

Immunomodulatory effects of lenvatinib in patients with advanced thyroid cancer

Prashant Changoer, Chunying Peng, Pepijn van Houten, Liesbeth van Emst, Janneke E. W. Walraven, Petronella B. Ottevanger, Martin Jaeger, Romana T. Netea-Maier

Efficacy and safety of hepatic arterial infusion chemotherapy plus lenvatinib and PD-1/PD-L1 inhibitors versus systemic chemotherapy plus lenvatinib and PD-1/PD-L1 inhibitors in advanced unresectable cholangiocarcinoma: a retrospective cohort study

Zhenzhen Zhang, Meixia Wang, Guobin Chen, Yanfang Wu, Xiaochun Chen, Xinkun Guo, Boheng Zhang

Innate CD8 T-cells as a potential predictive biomarker for deep molecular response in chronic myeloid leukemia patients

Emilie Cayssials, Lucie Lefèvre, Amandine Decroos, Florence Jacomet, Nathalie Piccirilli, Florence Tartarin, François Guilhot, Jean-Claude Chomel, Philippe Rousselot, Franck E. Nicolini, Stéphanie Ragot, Jean-Marc Gombert, Lydia Roy, André Herbelin, Alice Barbarin

Th7R predicts chemo-immunotherapy response and survival in small cell lung cancer

  • Open Access
  • SCLC
  • Research

Shota Takei, Ayako Shiono, Satoshi Yamasaki, Ou Yamaguchi, Atsuto Mouri, Yu Miura, Kosuke Hashimoto, Hisao Imai, Kyoichi Kaira, Hiroshi Kagamu

The ATR inhibitor tuvusertib (M1774) sensitizes prostate carcinoma to natural killer cell-mediated cytotoxicity, which is further augmented by the IL-15 receptor superagonist N-803

Cailyn A. Lee, Jeffrey Schlom, James W. Hodge, Kellsye P. Fabian

A selective IDO1 inhibitor, KHK2455, improves efficacy of PD-L1 blockade by modulating both innate and adaptive immunity in a mouse melanoma model

Masato Saito, Kana Kunieda, Toshihiko Ishii, Shoko Koshiba, Rui Ohashi, Yutaka Kanda, Takuji Yamada

Tumor-associated high endothelial venules are associated with enhanced lymphocyte infiltration and favorable prognosis in resected hepatocellular carcinoma

Shu Aoyama, Takehiro Noda, Hirofumi Akita, Yosuke Mukai, Kazuki Sasaki, Shinichiro Hasegawa, Daisaku Yamada, Yoshito Tomimaru, Tadafumi Asaoka, Hidenori Takahashi, Shogo Kobayashi, Junzo Shimizu, Azumi Ueyama, Takuro Saito, Kansuke Kido, Eiichi Morii, Hisashi Wada, Yuichiro Doki, Hidetoshi Eguchi

Radiation therapy causes a STING and MyD88-independent upregulation of CD80 and CD86 in macrophages and monocytes that limits tumor control

  • Open Access
  • Research

Aanchal Preet Kaur, Jason R. Baird, Alejandro F. Alice, Gwen Kramer, David Friedman, Eva Moran, Marka Crittenden, Michael J. Gough

Preclinical evaluation of CAR-T cell immunotherapy with a fully human EpCAM-specific scFv against pancreatic cancer

Ying-Ying Fan, Ya-Ling Liu, Xiao-Fan Liu, Si-Qi Jiang, Hui Yang, Hao-Ran Zhang, Ping Wei, Qian-Rong Huang

FUBP3 mediates MXI1 stability to silence RRAS and hinder MAPK signaling in acute megakaryoblastic leukemia progression

Ying Zhu, Jinying Liu, Jiqiang Zeng, Zhirui Liu, Zhimin Yan, Shanrong Zhang, Huixi Luo, Zhipeng Wu, Jiawei Lu, Fang Qiu, Junsong Ye, Chen Lu

Modeling anti-tumor immune responses using patient-derived melanoma organoids

  • Open Access
  • Research

Kamila Kaminska, Bengt Phung, Jacob Karlström, Martin Lauss, Katja Harbst, Teresa Svensson, Kristian Pietras, Kari Nielsen, Ana Carneiro, Henrik Ekedahl, Karolin Isaksson, Göran Jönsson

SLC16A3 in lung adenocarcinoma regulates glycolysis and lactate release to facilitate M2 polarization of tumor-associated macrophages

  • Open Access
  • Research

Peirui Chen, Qiusha Qing, Hongxia Gao, Zheng Qin, Jing Lv

Multi-omics profiling reveals an immunosuppressive plasma cell subset within tertiary lymphoid structures in cervical cancer

  • Open Access
  • Research

Qingyu Huang, Fuhao Wang, Xiaohui Li, Wenxue Zou, Zhou Huang, Xia Li, Wenhui Yang, Tianyu Lei, Shengqin Yue, Qian Wang, Qi An, Bicheng Zhang, Cong Wang, Chao Liu, Qinyong Hu

Correction: Development and activity of canine B7-H3-CAR.CIK lymphocytes against sarcomas: preclinical evidence and perspectives for human clinical translation

Raffaella De Maria, Chiara Donini, Sonia Capellero, Annamaria Massa, Federica Galvagno, Alessia Proment, Letizia Vitali, Elisa Vigna, Elisa Landoni, Gianpietro Dotti, Valeria Leuci, Paolo Accornero, Luiza Cesar Conti, Matteo Olimpo, Enrico Berrino, Giovanni Grignani, Anna Sapino, Dario Sangiolo, Luca Aresu

Commensal bacteria antigen-mediated immune response enhances anti-tumor immunity

  • Open Access
  • Research

Jessica Tzu-Chieh Lee, Soo Ngoi, Brian Deng, Megan Hill, Kai He, Yi Yang, Bei Liu

Dissecting the role of SEPHS1 in shaping an immunosuppressive microenvironment to promote tumor progression

Yunqing Liu, Yaxin Cheng, Wenxi Ji, Xiaotian Yuan, Guanjun Chen, Yiqi Tan, YuJie Cui, Yulong Huang, Zhijie Gao, Ke Cao

A cytokine-based serum proteomic score is a prognostic biomarker for immunotherapy in head and neck cancer

Md Saiful Islam Saif, Kartik Sehgal, Ze Zhang, Rondi A. Butler, John K. Wiencke, Annette M. Molinaro, Julianna Miller, Hannah G. Stolrow, Keisuke Shirai, Lucas A. Salas, Devin C. Koestler, Robert Haddad, Brock C. Christensen, Karl T. Kelsey

Efficacy and safety of sequential versus concurrent administration of immune checkpoint inhibitors with radiotherapy in solid tumors: a systematic review and network meta-analysis

Jiwon Baek, Sieun Lee, Doran Kim, Hye Kyung Jin, EunYoung Kim

Pseudomonas aeruginosa induces tumor pyroptosis and immune activation to enhance checkpoint blockade in colorectal cancer

Yanan Hu, Rong Li, Jiaxi Feng, Ningyi Sun, Wei Zheng, Xin Jin, Guodong Wang, Yi He, Yiwei Hao, Jun Zhang, Ke Ren, Xin Wu

Afatinib exerts an inhibitory effect on T cell-mediated cytotoxicity

Masaru Yokomura, Seiji Nagano, Hiroshi Kawamoto, Yoshihiko Hirohashi, Toshihiko Torigoe, Takahiro Asakage, Ryohei Katayama

Combinatorial approaches for cancer immunotherapy

Sheila Spada, Ayman Oweida

Comparison of induction chemotherapy with/without PD-1 inhibitors followed by concurrent chemoradiotherapy in locally advanced head and neck squamous cell carcinoma

Yongchao Yu, Zan Jiao, Tong Wu, Kang Ning, Taonong Cai, Zhongyuan Yang, Weichao Chen, Mingjie Jiang, Ankui Yang

Dec 25
Issue: 12/2025
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Issue: 2/2026

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Keynote webinar | Spotlight on progress in colorectal cancer

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
Prof. Harpreet Wasan
Prof. Edward Giovannucci
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Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images