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Supportive Care in Cancer

CanRestoreFunction: Cancer-related fatigue management eHealth intervention- a pilot pragmatic randomized-control trial

Published in:
Authors
Anne B. Fleischer
Mary Insana Fisher
Wei-Wen Hsu
Published in
Supportive Care in Cancer | Issue 3/2026

Abstract

Purpose

To investigate the effect of an 8-week multi-modal eHealth cancer-related fatigue intervention in women with breast cancer. eHealth included remote education, individualized exercise, and weekly problem-solving sessions. Primary outcomes were recruitment/retention and cancer-related fatigue level. Quality of life was a secondary aim.

Methods

Women with Stage 0–3 breast cancer between 18–70 years who scored ≥ 4/10 on the One-Item Fatigue Scale, completed chemotherapy and/or radiation within 5 years, and did not have chronic fatigue, were randomly assigned to eHealth intervention (eHealth) (n = 18) or control (n = 24). Cancer-related fatigue and quality of life were measured before and after intervention using the Brief Fatigue Inventory and the Functional Assessment Cancer Therapy-General.

Results

Social media was an effective way to recruit participants into this study; however, more participants in the eHealth group dropped out than the control group. Both groups' fatigue scores significantly decreased over time (p = 0.001). eHealth decreases in fatigue reached a minimally clinically important difference (2.25), but control did not (1.3). Quality of life significantly improved in the eHealth group compared to the control (p = 0.03).

Conclusion

Multi-modal cancer-related fatigue eHealth intervention appears to clinically reduce fatigue and improve quality of life among women with breast cancer.
US Clinical Trial Register NCT05868187. Date registered: 2–7-2023. www.clinicalgrials.gov
Title
CanRestoreFunction: Cancer-related fatigue management eHealth intervention- a pilot pragmatic randomized-control trial
Authors
Anne B. Fleischer
Mary Insana Fisher
Wei-Wen Hsu
Publication date
01-03-2026
Publisher
Springer Berlin Heidelberg
Published in
Supportive Care in Cancer / Issue 3/2026
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI
https://doi.org/10.1007/s00520-026-10477-5
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