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Cancer and Metastasis Reviews

Issue 1/2025

Content (39 Articles)

Bystanders or active players: the role of extra centrosomes as signaling hubs

  • Open Access
  • REVIEW

Madison M. Purkerson, Sarah R. Amend, Kenneth J. Pienta

KIF18A inhibition: the next big player in the search for cancer therapeutics

  • REVIEW

Ain Syafiza Mohd Amin, Sarah Eastwood, Courtney Pilcher, Jia Q. Truong, Richard Foitzik, Joanne Boag, Kylie L. Gorringe, Jessica K. Holien

Vaping and tumor metastasis: current insights and progress

Yibo Xi, Lei Yang, Barbara Burtness, He Wang

Retraction Note: EET signaling in cancer

  • Retraction Note

Dipak Panigrahy, Emily R. Greene, Ambra Pozzi, Dao Wen Wang, Darryl C. Zeldin

Tissue-engineered patient-derived osteosarcoma models dissecting tumour-bone interactions

Tina Frankenbach-Désor, Isabella Niesner, Parveen Ahmed, Hans Roland Dürr, Alexander Klein, Thomas Knösel, Jonathan Gospos, Jacqui A. McGovern, Dietmar W. Hutmacher, Boris M. Holzapfel, Susanne Mayer-Wagner

Immunotherapy for leptomeningeal disease from solid tumors: current clinical outcomes and future opportunities

Eleanor C. Smith, Bryan T Mott, Emily Douglas, Stephen B. Tatter, Kounosuke Watabe

The roles of periostin derived from cancer-associated fibroblasts in tumor progression and treatment response

Yasmin De Oliveira Macena, Maria Eduarda Nunes Cezar, Cinthya Brunelly Ferreira Lira, Laryssa Bheatriz Dantas Machado De Oliveira, Thais Noronha Almeida, Ana Dora Alecio Virtuoso Costa, Bernardo Mansur Dantas De Araujo, Durval de Almeida Junior, Henrique Macêdo Dantas, Emanuel Cézar De Mélo, Sandra Taveiros de Araújo, Raimundo Rodrigues de França Júnior, Maria Amélia dos Santos Lemos Gurgel, Carlos Alberto de Carvalho Fraga

CAR T-cell therapy to treat multiple myeloma: current state and future directions

Siddhartha Thammineni Reddy, Hitomi Hosoya, Lekha Mikkilineni

Evolving strategies for addressing CAR T-cell toxicities

Alexander W. Rankin, Brynn B. Duncan, Cecily Allen, Sara K. Silbert, Nirali N. Shah

Influence of antibody–drug conjugate cleavability, drug-to-antibody ratio, and free payload concentration on systemic toxicities: A systematic review and meta-analysis

Shou-Ching Tang, Carrie Wynn, Tran Le, Martin McCandless, Yunxi Zhang, Ritesh Patel, Nita Maihle, William Hillegass

Homologous recombination deficiency (HRD) diagnostics: underlying mechanisms and new perspectives

  • REVIEW

Andrey Kechin, Maksim Koryukov, Regina Mikheeva, Maksim Filipenko

Neuropeptide Y in cancer—biological functions and potential clinical implications

Dawid Sigorski, Aleksandra Sejda, Nouran Abualsaud, Ewa Krawczyk, Ewa Izycka-Swieszewska, Joanna Kitlinska

The transcription factor FOXQ1 in cancer

Stefan Koch

LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistance

Wanqi Wang, Noor A. Lokman, Simon C. Barry, Martin K. Oehler, Carmela Ricciardelli

Advancements in gene therapies targeting mutant KRAS in cancers

Yuhang Wang, Thuy Anh Bui, Xinpu Yang, Gyorgy Hutvagner, Wei Deng

Sympathetic nerve signaling rewires the tumor microenvironment: a shift in “microenvironmental-ity”

  • Open Access
  • REVIEW

Ariana Sattler, Tetiana Korzun, Kasmira Gupta, Parham Diba, Natasha Kyprianou, Sebnem Ece Eksi

Cellular plasticity and non-small cell lung cancer: role of T and NK cell immune evasion and acquisition of resistance to immunotherapies

Sarra Mestiri, Ana Sami, Naresh Sah, Dina Moustafa Abo El-Ella, Sabiha Khatoon, Khadija Shafique, Afsheen Raza, Darin Mansor Mathkor, Shafiul Haque

Efficacy of innovative systemic treatments in combination with radiotherapy for bone metastases: a GEMO (the European Study Group of Bone Metastases) state of the art

Anna Gueiderikh, Jean-Christophe Faivre, Constance Golfier, Alexandre Escande, Sébastien Thureau

Minimally invasive biomarkers for triaging lung nodules—challenges and future perspectives

Waqar Ahmed Afridi, Samandra Hernandez Picos, Juliana Muller Bark, Danyelle Assis Ferreira Stamoudis, Sarju Vasani, Darryl Irwin, David Fielding, Chamindie Punyadeera

Immunomodulatory role of oncogenic alterations in non-small cell lung cancer: a review of implications for immunotherapy

Maritza Ramos-Ramírez, Enrique Caballe-Pérez, José Lucio-Lozada, Eunice Romero-Nuñez, Cesar Castillo-Ruiz, Lorena Dorantes-Sánchez, Diana Flores-Estrada, Gonzalo Recondo, Pedro Barrios-Bernal, Luis Cabrera-Miranda, Heyman Bravo-Dominguez, Norma Hernández-Pedro, Oscar Arrieta

Neuronal mimicry in tumors: lessons from neuroscience to tackle cancer

Hanan Bloomer, Haley B. Dame, Savannah R. Parker, Madeleine J. Oudin

CTGF (CCN2): a multifaceted mediator in breast cancer progression and therapeutic targeting

Priya Ghosh, Ankita Dey, Suvendu Nandi, Ranabir Majumder, Subhayan Das, Mahitosh Mandal

Mitochondrial alterations and signatures in hepatocellular carcinoma

Tsung-Hsien Chen, Shu-Hsien Lin, Ming-Yang Lee, Hsiang-Chen Wang, Kun-Feng Tsai, Chu-Kuang Chou

Monocyte-related markers as predictors of immune checkpoint inhibitor efficacy and immune-related adverse events: a systematic review and meta-analysis

Aiarpi Ezdoglian, Michel Tsang-A-Sjoe, Fatemeh Khodadust, George Burchell, Gerrit Jansen, Tanja de Gruijl, Mariette Labots, Conny J. van der Laken

Epigenetic drugs in cancer therapy

Amila Suraweera, Kenneth J. O’Byrne, Derek J. Richard

The functions and modifications of tRNA-derived small RNAs in cancer biology

Abdulaziz Ahmed A. Saad, Kun Zhang, Qianqian Deng, Jiawang Zhou, Lichen Ge, Hongsheng Wang

2025 ESMO Congress hub

Unlock your free and exclusive access to expert interviews, news, and more from the annual congress of the European Society for Medical Oncology.

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Keynote webinar | Spotlight on progress in colorectal cancer

  • Live
  • Webinar | 11-12-2025 | 18:00 (CET)

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Watch it live: Thursday 11 December 2025, 18:00-19:30 (CET)

Prof. Antoni Castells
Prof. Edward Giovannucci
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Are you up to date on targeted therapies for relapsed/refractory AML? 

Join Prof. Amer Zeidan and his expert guests to hear about innovations in molecular testing, emerging therapies, and IDH-targeted treatments, and get practical advice for improving your patient care.

Supported by: independent educational grant from Rigel

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Image Credits
Cancer cell screening and treatment concept/© artacet / iStock / Getty Images Plus, Colon cancer illustration/© (M) KATERYNA KON/SCIENCE PHOTO LIBRARY / Getty Images