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Current Nutrition Reports

Calcium and Vitamin D Intake Interactions with Genetic Variants on Bone Phenotype

  • 01-09-2012
  • GENETICS (GVZ DEDOUSSIS, SECTION EDITOR)
Published in:
Authors
Maria G. Stathopoulou
Efi Grigoriou
George V. Z. Dedoussis
Published in
Current Nutrition Reports | Issue 3/2012

Abstract

The notion that environmental factors interact with genetic variants to affect phenotypes associated with complex diseases has arisen since the early days of genetic research. Among the environmental factors, nutrition holds a strong and permanent position, as it is a factor present throughout the life span. Calcium and vitamin D are the most important nutrients with regard to the development and health of the skeleton and have been associated with a variety of bone metabolic diseases (eg, osteoporosis). Multiple interactions between these two nutrients and genetic variants have been identified in the genetic research on bone phenotypes. A summary of these interactions is presented in this review. Furthermore, some ideas for the improvement of the studies in this field are also discussed within the current framework of the genetic research into bone phenotypes.
Title
Calcium and Vitamin D Intake Interactions with Genetic Variants on Bone Phenotype
Authors
Maria G. Stathopoulou
Efi Grigoriou
George V. Z. Dedoussis
Publication date
01-09-2012
Publisher
Current Science Inc.
Published in
Current Nutrition Reports / Issue 3/2012
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-012-0016-0
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