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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

18-12-2023 | CABG | Short Communication

Quantitative analysis of myocardial blood flow in surgically revascularized and not revascularized myocardial segments. A pilot PET study

Authors: M. Grandinetti, G. Locorotondo, L. Leccisotti, A. Guarneri, P. Bruno, A. Marcolini, P. Farina, M. F. Gaudino, G. A. Lanza, F. Crea, A. Giordano, M. Massetti

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 6/2024

Abstract

Purpose

To prospectively compare changes in myocardial blood flow (MBF) and myocardial flow reserve (MFR) in multivessel coronary artery disease (MVCAD) patients undergoing incomplete revascularization (IR) versus complete revascularization (CR) by coronary artery bypass grafting (CABG).

Methods

Seven male patients (age 68 ± 9 years) with MVCAD underwent myocardial perfusion PET/CT with [13N]ammonia before and at least 4 months after CABG. Segmental resting and stress MBF as well as MFR were measured. Resting and during stress left ventricle ejection fraction (LVEF) were also calculated.

Results

Three patients (43%) underwent CR and four (57%) IR. Among 119 myocardial segments, 101 (85%) were revascularized, and 18 (15%) were not. After CABG, stress MBF (mL/min/gr) and MFR are significantly increased in all myocardial segments, with a greater increase in the revascularized segments (p = 0.013). In both groups, LVEF significantly decreased during stress at baseline PET (p = 0.04), but not after CABG.

Conclusion

Stress MBF and MFR significantly improve after CABG in both revascularized and not directly revascularized myocardial segments. IR strategy may be considered in patients with high surgical risk for CR.

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Title: Quantitative analysis of myocardial blood flow in surgically revascularized and not revascularized myocardial segments. A pilot PET study
Authors: M. Grandinetti
G. Locorotondo
L. Leccisotti
A. Guarneri
P. Bruno
A. Marcolini
P. Farina
M. F. Gaudino
G. A. Lanza
F. Crea
A. Giordano
M. Massetti
Publication date: 18-12-2023
Publisher: Springer Berlin Heidelberg
Keywords: CABG
CABG
Positron Emission Tomography
Arterial Diseases
Computed Tomography
Computed Tomography
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 6/2024
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-023-06563-z

2024 ESC Congress

Springer Medicine

Quantitative analysis of myocardial blood flow in surgically revascularized and not revascularized myocardial segments. A pilot PET study

Abstract

Purpose

Methods

Results

Conclusion

2024 ESC Congress

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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