Top

Published in:

Open Access 18-06-2023 | Bronchial Asthma | Review

Gaps and Future Directions in Clinical Research on Obesity-Related Asthma

Authors: Andi C. Hudler, Isaías Raymundo Ramírez Díaz, Sunita Sharma, Fernando Holguin

Published in: Pulmonary Therapy | Issue 3/2023

Abstract

Obesity is a major comorbidity for the development and worsening of asthma. It is associated with increased disease incidence, reduced response to inhaled and systemic steroids, increased asthma exacerbations, and poor disease control. Over the past two decades, we have learned that there are clinical asthma phenotypes associated with obesity, which have unique immune, inflammatory, and metabolic disease mechanisms. The objectives of this review are to provide a brief overview of the associations and gaps between these chronic inflammatory diseases and the role that traditional therapies have on treating patients with obesity-related asthma, and to describe new clinical research of therapeutic developments targeting mechanisms that are more specific to this patient population.

Adult Obesity Facts. Centers for Disease Control and Prevention; 2022 [cited 2023 1/03/2023]. https://www.cdc.gov/obesity/data/adult.html. Accessed 18 Dec 2022.

Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med. 2007;175(7):661–6. https://doi.org/10.1164/rccm.200611-1717OC ( Epub 20070118). CrossRefPubMedCentralPubMed

Miethe S, Karsonova A, Karaulov A, Renz H. Obesity and asthma. J Allergy Clin Immunol. 2020;146(4):685–93. https://doi.org/10.1016/j.jaci.2020.08.011. CrossRefPubMed

Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D’Agostino R Jr, Castro M, Curran-Everett D, Fitzpatrick AM, Gaston B, Jarjour NN, Sorkness R, Calhoun WJ, Chung KF, Comhair SA, Dweik RA, Israel E, Peters SP, Busse WW, Erzurum SC, Bleecker ER, National Heart L, Blood Institute's Severe Asthma Research P. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010;181(4):315–23. https://doi.org/10.1164/rccm.200906-0896OC ( Epub 20091105).

Dixon AE, Holguin F, Sood A, Salome CM, Pratley RE, Beuther DA, Celedon JC, Shore SA, American Thoracic Society Ad Hoc Subcommittee on O, Lung D. An official American Thoracic Society Workshop report: obesity and asthma. Proc Am Thorac Soc. 2010;7(5):325–35. https://doi.org/10.1513/pats.200903-013ST.

Ronmark E, Andersson C, Nystrom L, Forsberg B, Jarvholm B, Lundback B. Obesity increases the risk of incident asthma among adults. Eur Respir J. 2005;25(2):282–8. https://doi.org/10.1183/09031936.05.00054304. CrossRefPubMed

Wang E, Wechsler ME, Tran TN, Heaney LG, Jones RC, Menzies-Gow AN, Busby J, Jackson DJ, Pfeffer PE, Rhee CK, Cho YS, Canonica GW, Heffler E, Gibson PG, Hew M, Peters M, Harvey ES, Alacqua M, Zangrilli J, Bulathsinhala L, Carter VA, Chaudhry I, Eleangovan N, Hosseini N, Murray RB, Price DB. Characterization of severe asthma worldwide: data from the International Severe Asthma Registry. Chest. 2020;157(4):790–804. https://doi.org/10.1016/j.chest.2019.10.053 ( Epub 20191127). CrossRefPubMed

Taylor B, Mannino D, Brown C, Crocker D, Twum-Baah N, Holguin F. Body mass index and asthma severity in the National Asthma Survey. Thorax. 2008;63(1):14–20. https://doi.org/10.1136/thx.2007.082784. CrossRefPubMed

Vortmann M, Eisner MD. BMI and health status among adults with asthma. Obesity (Silver Spring). 2008;16(1):146–52. https://doi.org/10.1038/oby.2007.7. CrossRefPubMed

10.

Althoff M, Holguin F. Contemporary management techniques of asthma in obese patients. Expert Rev Respir Med. 2020;14(3):249–57. https://doi.org/10.1080/17476348.2020.1706486 ( Epub 20191225). CrossRefPubMed

11.

Boulet LP, Franssen E. Influence of obesity on response to fluticasone with or without salmeterol in moderate asthma. Respir Med. 2007;101(11):2240–7. https://doi.org/10.1016/j.rmed.2007.06.031 ( Epub 20070808). CrossRefPubMed

12.

Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM. Influence of body mass index on the response to asthma controller agents. Eur Respir J. 2006;27(3):495–503. https://doi.org/10.1183/09031936.06.00077205. CrossRefPubMed

13.

Khurana S, Paggiaro P, Buhl R, Bernstein JA, Haddon J, Unseld A, Engel M, Casale TB, Dixon AE. Tiotropium reduces airflow obstruction in asthma patients, independent of body mass index. J Allergy Clin Immunol Pract. 2019;7(7):2425–8 e7. https://doi.org/10.1016/j.jaip.2019.03.007 ( Epub 20190319).

14.

Kerstjens HA, Engel M, Dahl R, Paggiaro P, Beck E, Vandewalker M, Sigmund R, Seibold W, Moroni-Zentgraf P, Bateman ED. Tiotropium in asthma poorly controlled with standard combination therapy. N Engl J Med. 2012;367(13):1198–1207. https://doi.org/10.1056/NEJMoa1208606 ( Epub 20120902).

15.

Kerstjens HA, Casale TB, Bleecker ER, Meltzer EO, Pizzichini E, Schmidt O, Engel M, Bour L, Verkleij CB, Moroni-Zentgraf P, Bateman ED. Tiotropium or salmeterol as add-on therapy to inhaled corticosteroids for patients with moderate symptomatic asthma: two replicate, double-blind, placebo-controlled, parallel-group, active-comparator, randomised trials. Lancet Respir Med. 2015;3(5):367–76. https://doi.org/10.1016/S2213-2600(15)00031-4 ( Epub 20150212). CrossRefPubMed

16.

Sutherland ER, Goleva E, Strand M, Beuther DA, Leung DY. Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med. 2008;178(7):682–7. https://doi.org/10.1164/rccm.200801-076OC ( Epub 20080717). CrossRefPubMedCentralPubMed

17.

Forno E, Lescher R, Strunk R, Weiss S, Fuhlbrigge A, Celedon JC, Childhood Asthma Management Program Research G. Decreased response to inhaled steroids in overweight and obese asthmatic children. J Allergy Clin Immunol. 2011;127(3):741–9. https://doi.org/10.1016/j.jaci.2010.12.010.

18.

Goleva E, Covar R, Martin RJ, Leung DY. Corticosteroid pharmacokinetic abnormalities in overweight and obese corticosteroid resistant asthmatics. J Allergy Clin Immunol Pract. 2016;4(2):357–60 e2. https://doi.org/10.1016/j.jaip.2015.11.013 ( Epub 20160118).

19.

Wu W, Bang S, Bleecker ER, Castro M, Denlinger L, Erzurum SC, Fahy JV, Fitzpatrick AM, Gaston BM, Hastie AT, Israel E, Jarjour NN, Levy BD, Mauger DT, Meyers DA, Moore WC, Peters M, Phillips BR, Phipatanakul W, Sorkness RL, Wenzel SE. Multiview cluster analysis identifies variable corticosteroid response phenotypes in severe asthma. Am J Respir Crit Care Med. 2019;199(11):1358–67. https://doi.org/10.1164/rccm.201808-1543OC ( Epub 2019/01/27). CrossRefPubMedCentralPubMed

20.

Hammad H, Lambrecht BN. The basic immunology of asthma. Cell. 2021;184(6):1469–85. https://doi.org/10.1016/j.cell.2021.02.016 ( Epub 20210311). CrossRefPubMed

21.

Oliveira MJ, Vieira M, Coutinho D, Ladeira I, Pascoal I, Ferreira J, da Silva JM, Carvalho A, Lima R. Severe asthma in obese patients: improvement of lung function after treatment with omalizumab. Pulmonology. 2019;25(1):15–20. https://doi.org/10.1016/j.pulmoe.2018.01.005 ( Epub 20180312). CrossRefPubMed

22.

Gibson PG, Reddel H, McDonald VM, Marks G, Jenkins C, Gillman A, Upham J, Sutherland M, Rimmer J, Thien F, Katsoulotos GP, Cook M, Yang I, Katelaris C, Bowler S, Langton D, Robinson P, Wright C, Yozghatlian V, Burgess S, Sivakumaran P, Jaffe A, Bowden J, Wark PA, Yan KY, Kritikos V, Peters M, Hew M, Aminazad A, Bint M, Guo M. Effectiveness and response predictors of omalizumab in a severe allergic asthma population with a high prevalence of comorbidities: the Australian Xolair Registry. Intern Med J. 2016;46(9):1054–62. https://doi.org/10.1111/imj.13166. CrossRefPubMed

23.

FitzGerald JM, Bleecker ER, Menzies-Gow A, Zangrilli JG, Hirsch I, Metcalfe P, Newbold P, Goldman M. Predictors of enhanced response with benralizumab for patients with severe asthma: pooled analysis of the SIROCCO and CALIMA studies. Lancet Respir Med. 2018;6(1):51–64. https://doi.org/10.1016/S2213-2600(17)30344-2 ( Epub 20170911). CrossRefPubMed

24.

Menzies-Gow A, Corren J, Bourdin A, Chupp G, Israel E, Wechsler ME, Brightling CE, Griffiths JM, Hellqvist A, Bowen K, Kaur P, Almqvist G, Ponnarambil S, Colice G. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021;384(19):1800–9. https://doi.org/10.1056/NEJMoa2034975. CrossRefPubMed

25.

Dixon AE, Pratley RE, Forgione PM, Kaminsky DA, Whittaker-Leclair LA, Griffes LA, Garudathri J, Raymond D, Poynter ME, Bunn JY, Irvin CG. Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation. J Allergy Clin Immunol. 2011;128(3):508–15 e1–2. https://doi.org/10.1016/j.jaci.2011.06.009 ( Epub 20110723).

26.

Johnson O, Gerald LB, Harvey J, Roy G, Hazucha H, Large C, Burke A, McCormack M, Wise RA, Holbrook JT, Dixon AE. An online weight loss intervention for people with obesity and poorly controlled asthma. J Allergy Clin Immunol Pract. 2022;10(6):1577–86 e3. https://doi.org/10.1016/j.jaip.2022.02.040 ( Epub 20220315).

27.

Suratt BT, Ubags NDJ, Rastogi D, Tantisira KG, Marsland BJ, Petrache I, Allen JB, Bates JHT, Holguin F, McCormack MC, Michelakis ED, Black SM, Jain M, Mora AL, Natarajan V, Miller YI, Fessler MB, Birukov KG, Summer RS, Shore SA, Dixon AE, Allergy I, Inflammation A. An Official American Thoracic Society Workshop Report: obesity and metabolism. An emerging frontier in lung health and disease. Ann Am Thorac Soc. 2017;14(6):1050–9. https://doi.org/10.1513/AnnalsATS.201703-263WS ( Epub 2017/06/02).

28.

Baffi CW, Wood L, Winnica D, Strollo PJ Jr, Gladwin MT, Que LG, Holguin F. Metabolic syndrome and the lung. Chest. 2016;149(6):1525–34. https://doi.org/10.1016/j.chest.2015.12.034 ( Epub 2016/02/03).

29.

Brumpton BM, Camargo CA Jr, Romundstad PR, Langhammer A, Chen Y, Mai XM. Metabolic syndrome and incidence of asthma in adults: the HUNT study. Eur Respir J. 2013;42(6):1495–502. https://doi.org/10.1183/09031936.00046013 ( Epub 20130711). CrossRefPubMed

30.

Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV, National Heart L, Blood Institute Severe Asthma Research P. Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Lancet Respir Med. 2016;4(7):574–84. https://doi.org/10.1016/S2213-2600(16)30048-0 ( Epub 20160606).

31.

Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ, Ting JP. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol. 2011;12(5):408–15. https://doi.org/10.1038/ni.2022 ( Epub 2011/04/12). CrossRefPubMedCentralPubMed

32.

Wood LG, Garg ML, Gibson PG. A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma. J Allergy Clin Immunol. 2011;127(5):1133–40. https://doi.org/10.1016/j.jaci.2011.01.036 ( Epub 2011/03/08). CrossRefPubMed

33.

Rastogi D, Holguin F. Metabolic dysregulation, systemic inflammation, and pediatric obesity-related asthma. Ann Am Thorac Soc. 2017;14(Supplement_5):S363–7. https://doi.org/10.1513/AnnalsATS.201703-231AW ( Epub 2017/11/22). CrossRefPubMedCentralPubMed

34.

Winnica D, Que LG, Baffi C, Grasemann H, Fiedler K, Yang Z, Etling E, Wasil K, Wenzel SE, Freeman B, Holguin F. l-Citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells. Clin Exp Allergy. 2017;47(2):190–9. https://doi.org/10.1111/cea.12802 ( Epub 20161004). CrossRefPubMed

35.

Aravamudan B, Thompson MA, Pabelick CM, Prakash YS. Mitochondria in lung diseases. Expert Rev Respir Med. 2013;7(6):631–46. https://doi.org/10.1586/17476348.2013.834252 ( Epub 20130827). CrossRefPubMedCentralPubMed

36.

Prakash YS, Pabelick CM, Sieck GC. Mitochondrial dysfunction in airway disease. Chest. 2017;152(3):618–26. https://doi.org/10.1016/j.chest.2017.03.020 ( Epub 20170321). CrossRefPubMedCentralPubMed

37.

Delmotte P, Yang B, Thompson MA, Pabelick CM, Prakash YS, Sieck GC. Inflammation alters regional mitochondrial Ca(2)+ in human airway smooth muscle cells. Am J Physiol Cell Physiol. 2012;303(3):C244–56. https://doi.org/10.1152/ajpcell.00414.2011 ( Epub 20120606). CrossRefPubMedCentralPubMed

38.

Delmotte P, Zavaletta VA, Thompson MA, Prakash YS, Sieck GC. TNFalpha decreases mitochondrial movement in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2017;313(1):L166–76. https://doi.org/10.1152/ajplung.00538.2016 ( Epub 20170504). CrossRefPubMedCentralPubMed

39.

Naik E, Dixit VM. Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J Exp Med. 2011;208(3):417–20. https://doi.org/10.1084/jem.20110367 ( Epub 20110228). CrossRefPubMedCentralPubMed

40.

Winnica D, Corey C, Mullett S, Reynolds M, Hill G, Wendell S, Que L, Holguin F, Shiva S. Bioenergetic differences in the airway epithelium of lean versus obese asthmatics are driven by nitric oxide and reflected in circulating platelets. Antioxid Redox Signal. 2019;31(10):673–86. https://doi.org/10.1089/ars.2018.7627 ( Epub 20190306). CrossRefPubMedCentralPubMed

41.

Aravamudan B, Kiel A, Freeman M, Delmotte P, Thompson M, Vassallo R, Sieck GC, Pabelick CM, Prakash YS. Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2014;306(9):L840–54. https://doi.org/10.1152/ajplung.00155.2013 ( Epub 20140307). CrossRefPubMedCentralPubMed

42.

Aguilera-Aguirre L, Bacsi A, Saavedra-Molina A, Kurosky A, Sur S, Boldogh I. Mitochondrial dysfunction increases allergic airway inflammation. J Immunol. 2009;183(8):5379–87. https://doi.org/10.4049/jimmunol.0900228 ( Epub 20090928). CrossRefPubMed

43.

Zifa E, Daniil Z, Skoumi E, Stavrou M, Papadimitriou K, Terzenidou M, Kostikas K, Bagiatis V, Gourgoulianis KI, Mamuris Z. Mitochondrial genetic background plays a role in increasing risk to asthma. Mol Biol Rep. 2012;39(4):4697–708. https://doi.org/10.1007/s11033-011-1262-8 ( Epub 20110924). CrossRefPubMed

44.

Chong L, Li H, Zhu L, Yu G. Regulatory effect of mitoQ on the mtROS-NLRP3 inflammasome pathway in leptin-pretreated BEAS-2 cells. Exp Ther Med. 2021;21(5):466. https://doi.org/10.3892/etm.2021.9897 ( Epub 20210308). CrossRefPubMedCentralPubMed

45.

Lee EJ, In KH, Ha ES, Lee KJ, Hur GY, Kang EH, Jung KH, Lee SY, Kim JH, Lee SY, Shin C, Shim JJ, Kang KH, Yoo SH. Asthma-like symptoms are increased in the metabolic syndrome. J Asthma. 2009;46(4):339–42. https://doi.org/10.1080/02770900802660931. CrossRefPubMed

46.

Wu TD, Fawzy A, Akenroye A, Keet C, Hansel NN, McCormack MC. Metformin use and risk of asthma exacerbation among asthma patients with glycemic dysfunction. J Allergy Clin Immunol Pract. 2021;9(11):4014–20 e4. https://doi.org/10.1016/j.jaip.2021.07.007 ( Epub 2021/07/23).

47.

Foer D, Beeler PE, Cui J, Karlson EW, Bates DW, Cahill KN. Asthma exacerbations in patients with type 2 diabetes and asthma on glucagon-like peptide-1 receptor agonists. Am J Respir Crit Care Med. 2021;203(7):831–40. https://doi.org/10.1164/rccm.202004-0993OC ( Epub 2020/10/15). CrossRefPubMedCentralPubMed

48.

Freeman BA, O’Donnell VB, Schopfer FJ. The discovery of nitro-fatty acids as products of metabolic and inflammatory reactions and mediators of adaptive cell signaling. Nitric Oxide. 2018;77:106–11. https://doi.org/10.1016/j.niox.2018.05.002 ( Epub 2018/05/10). CrossRefPubMedCentralPubMed

49.

MacRedmond R, Singhera G, Attridge S, Bahzad M, Fava C, Lai Y, Hallstrand TS, Dorscheid DR. Conjugated linoleic acid improves airway hyper-reactivity in overweight mild asthmatics. Clin Exp Allergy. 2010;40(7):1071–8. https://doi.org/10.1111/j.1365-2222.2010.03531.x ( Epub 2010/07/21). CrossRefPubMed

50.

Manni ML, Heinrich VA, Buchan GJ, O’Brien JP, Uvalle C, Cechova V, Koudelka A, Ukani D, Rawas-Qalaji M, Oury TD, Hart R, Ellgass M, Mullett SJ, Fajt ML, Wenzel SE, Holguin F, Freeman BA, Wendell SG. Nitroalkene fatty acids modulate bile acid metabolism and lung function in obese asthma. Sci Rep. 2021;11(1):17788. https://doi.org/10.1038/s41598-021-96471-9 ( Epub 2021/09/09). No relevant conflict of interest to declare.

51.

Komakula S, Khatri S, Mermis J, Savill S, Haque S, Rojas M, Brown L, Teague GW, Holguin F. Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. Respir Res. 2007;8(1):32. https://doi.org/10.1186/1465-9921-8-32 ( Epub 20070416). CrossRefPubMedCentralPubMed

52.

Grasemann H, Holguin F. Oxidative stress and obesity-related asthma. Paediatr Respir Rev. 2021;37:18–21. https://doi.org/10.1016/j.prrv.2020.05.004 ( Epub 2020/07/15). CrossRefPubMed

53.

Berg CM, Thelle DS, Rosengren A, Lissner L, Toren K, Olin AC. Decreased fraction of exhaled nitric oxide in obese subjects with asthma symptoms: data from the population study INTERGENE/ADONIX. Chest. 2011;139(5):1109–16. https://doi.org/10.1378/chest.10-1299 ( Epub 20101223). CrossRefPubMed

54.

Scott JA, Maarsingh H, Holguin F, Grasemann H. Arginine therapy for lung diseases. Front Pharmacol. 2021;12:627503. https://doi.org/10.3389/fphar.2021.627503 ( Epub 20210323). CrossRefPubMedCentralPubMed

55.

Holguin F, Grasemann H, Sharma S, Winnica D, Wasil K, Smith V, Cruse MH, Perez N, Coleman E, Scialla TJ, Que LG. l-Citrulline increases nitric oxide and improves control in obese asthmatics. JCI Insight. 2019;4(24). https://doi.org/10.1172/jci.insight.131733 ( Epub 20191219).

56.

Que LG, Liu L, Yan Y, Whitehead GS, Gavett SH, Schwartz DA, Stamler JS. Protection from experimental asthma by an endogenous bronchodilator. Science. 2005;308(5728):1618–21. https://doi.org/10.1126/science.1108228 ( Epub 2005/05/28). CrossRefPubMedCentralPubMed

57.

Kern L, Mittenbuhler MJ, Vesting AJ, Ostermann AL, Wunderlich CM, Wunderlich FT. Obesity-induced TNFalpha and IL-6 signaling: the missing link between obesity and inflammation-driven liver and colorectal cancers. Cancers (Basel). 2018;11(1). https://doi.org/10.3390/cancers11010024 ( Epub 20181227).

58.

Deng K, Zhang X, Liu Y, Cheng GP, Zhang HP, Wang T, Wang L, Li WM, Wang G, Wood L. Visceral obesity is associated with clinical and inflammatory features of asthma: a prospective cohort study. Allergy Asthma Proc. 2020;41(5):348–56. https://doi.org/10.2500/aap.2020.41.200054. CrossRefPubMed

59.

Peters MC, Mauger D, Ross KR, Phillips B, Gaston B, Cardet JC, Israel E, Levy BD, Phipatanakul W, Jarjour NN, Castro M, Wenzel SE, Hastie A, Moore W, Bleecker E, Fahy JV, Denlinger LC. Evidence for exacerbation-prone asthma and predictive biomarkers of exacerbation frequency. Am J Respir Crit Care Med. 2020;202(7):973–82. https://doi.org/10.1164/rccm.201909-1813OC ( Epub 2020/06/02). CrossRefPubMedCentralPubMed

60.

Bates JHT, Peters U, Daphtary N, MacLean ES, Hodgdon K, Kaminsky DA, Bhatawadekar S, Dixon AE. Altered airway mechanics in the context of obesity and asthma. J Appl Physiol (1985). 2021;130(1):36–47. https://doi.org/10.1152/japplphysiol.00666.2020 ( Epub 2020/10/30). CrossRefPubMed

61.

Bhatawadekar SA, Dixon AE, Peters U, Daphtary N, Hodgdon K, Kaminsky DA, Bates JHT. Positive expiratory pressure: a potential therapy to mitigate acute bronchoconstriction in the asthma of obesity. J Appl Physiol (1985). 2021;131(6):1663–70. https://doi.org/10.1152/japplphysiol.00399.2021 ( Epub 2021/10/15). CrossRefPubMed

Title: Gaps and Future Directions in Clinical Research on Obesity-Related Asthma
Authors: Andi C. Hudler
Isaías Raymundo Ramírez Díaz
Sunita Sharma
Fernando Holguin
Publication date: 18-06-2023
Publisher: Springer Healthcare
Keywords: Bronchial Asthma
Obesity
Obesity
Published in: Pulmonary Therapy / Issue 3/2023
Print ISSN: 2364-1754
Electronic ISSN: 2364-1746
DOI: https://doi.org/10.1007/s41030-023-00230-2

Webinar | 08-11-2023 | 18:00 (CET)

Keynote Webinar | Spotlight on Diet and Diabetes

Watch now

An expert-led symposium exploring the prevention and management of type 2 diabetes through dietary interventions. Highlights include discussion of the recent EASD guidelines, therapeutic diets, food types and processing, plus psychological factors that influence patient success, and the drivers of healthy eating and diabetes control.

Prof. Mike Lean

Prof. Falko Sniehotta

Keynote Webinar | Spotlight on Diet and Diabetes

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2023

Medication Adherence and Asthma Control with Once-Daily Indacaterol/Glycopyrronium/Mometasone Furoate Breezhaler Digital Companion: 90-Day Analysis from Germany

Letter to the Editor: Anti-SARS-CoV-2 Vaccination-Related Polyradiculitis Requires Early Diagnosis and Treatment to Improve the Outcome

The 2023 GOLD Report: Updated Guidelines for Inhaled Pharmacological Therapy in Patients with Stable COPD

Small Cell Lung Cancer and Pleural Effusion: An Analysis from a District General Hospital

Triple Therapy with Mometasone/Indacaterol/Glycopyrronium or Doubling the ICS/LABA Dose in GINA Step 4: IRIDIUM Analyses

Symptoms and Experiences with Small Cell Lung Cancer: A Mixed Methods Study of Patients and Caregivers

Keynote Webinar | Spotlight on Diet and Diabetes