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Published in: Pulmonary Therapy 3/2023

Open Access 18-06-2023 | Bronchial Asthma | Review

Gaps and Future Directions in Clinical Research on Obesity-Related Asthma

Authors: Andi C. Hudler, Isaías Raymundo Ramírez Díaz, Sunita Sharma, Fernando Holguin

Published in: Pulmonary Therapy | Issue 3/2023

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Abstract

Obesity is a major comorbidity for the development and worsening of asthma. It is associated with increased disease incidence, reduced response to inhaled and systemic steroids, increased asthma exacerbations, and poor disease control. Over the past two decades, we have learned that there are clinical asthma phenotypes associated with obesity, which have unique immune, inflammatory, and metabolic disease mechanisms. The objectives of this review are to provide a brief overview of the associations and gaps between these chronic inflammatory diseases and the role that traditional therapies have on treating patients with obesity-related asthma, and to describe new clinical research of therapeutic developments targeting mechanisms that are more specific to this patient population.
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Metadata
Title
Gaps and Future Directions in Clinical Research on Obesity-Related Asthma
Authors
Andi C. Hudler
Isaías Raymundo Ramírez Díaz
Sunita Sharma
Fernando Holguin
Publication date
18-06-2023
Publisher
Springer Healthcare
Published in
Pulmonary Therapy / Issue 3/2023
Print ISSN: 2364-1754
Electronic ISSN: 2364-1746
DOI
https://doi.org/10.1007/s41030-023-00230-2

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