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Furry Animal Allergy: Lipocalins, Serum Albumins, and Secretoglobins—Cross-Reactivity, Diagnosis, and Management Strategies

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Abstract

Furry animals are familiar companions in modern society. Despite multiple beneficial roles in economic and social contexts, they can be the source of allergenic compounds. Moreover, research indicates that these allergens could be detected even in households where animals are not present. Consequently, the risk of asthma exacerbation is increased. Furthermore, accurately diagnosing a genuine allergy to furry animals remains a significant challenge for medical practitioners. Therefore, this review aims to gather and summarize valid information regarding three main groups of allergens associated with furry animals, including lipocalins, serum albumins, and secretoglobins. In this manuscript, we clarify the molecular structure of allergens, discuss cross-reactions between them, and highlight their clinical importance. We also outline the diagnostic techniques for furry animal allergy, as well as novel, emerging therapies. Additionally, we discuss the occupational risks of allergies for both laboratory workers and cattle farmers.

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Title
Furry Animal Allergy: Lipocalins, Serum Albumins, and Secretoglobins—Cross-Reactivity, Diagnosis, and Management Strategies
Authors
Weronika Gromek
Natalia Kołdej
Marcin Kurowski
Emilia Majsiak
Publication date
01-12-2025
Publisher
Springer US
Published in
Clinical Reviews in Allergy & Immunology / Issue 1/2025
Print ISSN: 1080-0549
Electronic ISSN: 1559-0267
DOI
https://doi.org/10.1007/s12016-025-09086-7
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