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Journal of Translational Medicine
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Open Access 01-12-2024 | Breast Cancer | Letter to the Editor

Clinical trial landscape for histone deacetylation inhibitors in breast cancer: a dawn in the darkness?

Authors: Jiajun Li, Yining Yan, Feng Chen

Published in: Journal of Translational Medicine | Issue 1/2024

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Excerpt

Breast cancer (BRCA) is a highly malignant solid tumor with poor prognosis and a high mortality rate among woman worldwide [1]. Conventional therapeutic methods include surgical resection, chemotherapy, radiotherapy, hormone therapy as well as targeted therapy [2]. However, the poor response of some patients to current standard-of-care strategies prompts the exploration of new treatment approaches. Recent studies have highlighted the roles epigenetic modification play in BRCA, among which histone deacetylation (HDAC) has been reported to be associated with tumor progression and drug resistance [3, 4]. Notably, several HDAC inhibitors have been approved by the U.S. Food and Drug Administration (FDA) to treat Cutaneous T-cell lymphoma (CTCL) and Multiple Myeloma (MM), both of which have received favorable results. Therefore, it is worthwhile to evaluate the trial landscape of HDAC inhibitors and its potential in BRCA treatment. …
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Literature
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Sung H, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.CrossRefPubMed
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Giordano F, et al. Valproic acid inhibits cell growth in both MCF-7 and MDA-MB231 cells by triggering different responses in a cell type-specific manner. J Transl Med. 2023;21(1):165.CrossRefPubMedPubMedCentral
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Saatci O, Huynh-Dam KT, Sahin O. Endocrine resistance in BRCA: from molecular mechanisms to therapeutic strategies. J Mol Med. 2021;99(12):1691–710.CrossRefPubMed
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Baretti M, et al. Entinostat in combination with nivolumab in metastatic pancreatic ductal adenocarcinoma: a phase 2 clinical trial. Nat Commun. 2024;15(1):9801.CrossRefPubMedPubMedCentral
Metadata
Title
Clinical trial landscape for histone deacetylation inhibitors in breast cancer: a dawn in the darkness?
Authors
Jiajun Li
Yining Yan
Feng Chen
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2024
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/s12967-024-05911-3

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