ASO Author Reflections: Trajectory of Subsequent Breast Cancer After Breast Atypia Diagnosis Suggests Need for Vigilant Follow-up

Proliferative atypical lesions of the breast are common benign entities that have been consistently shown to independently increase a woman’s risk of developing future breast cancer. Studies report a 20-year cumulative risk of developing in situ or invasive disease of at least 20%.^1‐3 Despite this well-established inherent risk, little is known about the timing of breast cancer development or clinicopathologic features that may influence its trajectory. …