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Open Access 01-12-2024 | Research

Body composition as a prognostic factor in cholangiocarcinoma: a meta-analysis

Authors: Lilong Zhang, Kunpeng Wang, Rongqiang Liu, Tianrui Kuang, Chen Chen, Feng Yao, Weixing Wang

Published in: Nutrition Journal | Issue 1/2024

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Abstract

This investigation seeks to scrutinize the relationships between body composition metrics and the clinical outcomes observed in patients with cholangiocarcinoma (CCA). A comprehensive exploration was conducted across three prominent online databases: Embase, PubMed, and the Cochrane Library. This endeavor spanned the entirety of each database up to the cutoff date of September 29, 2023. To evaluate the quality of the included studies, the Newcastle-Ottawa scale was employed. This comprehensive analysis included a total of 26 articles with a combined patient cohort of 4398 individuals. The results demonstrated that CCA patients with low skeletal muscle index (SMI) had significantly inferior OS (HR: 1.93, p < 0.001) and RFS (HR: 2.02, p < 0.001), as well as a higher incidence of postoperative complications (OR: 1.69, 95% CI: 1.20–2.38, p < 0.001) compared to those with high SMI. The presence of sarcopenia in CCA patients was significantly related to poorer OS (HR: 1.96, p < 0.001) and RFS (HR: 2.05, p < 0.001), and a higher rate of postoperative complications (OR: 1.39, p = 0.049) in comparison to those without sarcopenia. Moreover, lower psoas muscle index (PMI) and myosteatosis were associated with shorter OS (PMI, HR: 1.56, p < 0.001; myosteatosis, HR: 1.49, p = 0.001) and RFS (PMI, HR: 2.16, p < 0.001; myosteatosis, HR: 1.35, p = 0.023). Our findings highlight incorporating body composition screening into clinical practice can help develop treatment strategies and optimize perioperative care, potentially improving patient outcomes.
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Metadata
Title
Body composition as a prognostic factor in cholangiocarcinoma: a meta-analysis
Authors
Lilong Zhang
Kunpeng Wang
Rongqiang Liu
Tianrui Kuang
Chen Chen
Feng Yao
Weixing Wang
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Nutrition Journal / Issue 1/2024
Electronic ISSN: 1475-2891
DOI
https://doi.org/10.1186/s12937-024-01037-w

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