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BMC Medicine

Issue 1/2025

Content (418 Articles)

Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts

Lewis Steell, Stefanie J. Krauth, Sayem Ahmed, Grace O. Dibben, Emma McIntosh, Peter Hanlon, Jim Lewsey, Barbara I. Nicholl, David A. McAllister, Susan M. Smith, Rachael Evans, Zahira Ahmed, Sarah Dean, Colin Greaves, Shaun Barber, Patrick Doherty, Nikki Gardiner, Tracy Ibbotson, Kate Jolly, Paula Ormandy, Sharon A. Simpson, Rod S. Taylor, Sally J. Singh, Frances S. Mair, Bhautesh D. Jani

Understanding the dynamics driving obesity in socioeconomically deprived urban neighbourhoods: an expert-based systems map

Fleur ter Ellen, Joost Oude Groeniger, Karien Stronks, Luc L. Hagenaars, Carlijn B.M. Kamphuis, Joreintje D. Mackenbach, Mariëlle A. Beenackers, Karen Freijer, Pieter Coenen, Maartje Poelman, Karen M. Oude Hengel, Frank J. van Lenthe

Non-small cell lung cancer in ever-smokers vs never-smokers

  • Open Access
  • NSCLC
  • Research

Jeremy R. Burt, Naim Qaqish, Greg Stoddard, Amani Jridi, Parker Sage Anderson, Lacey Woods, Anna Newman, Malorie R. Carter, Reham Ellessy, Jordan Chamberlin, Ismail Kabakus

Investigating the causal effects of childhood and adulthood adiposity on later life mental health outcome: a Mendelian randomization study

  • Open Access
  • Obesity
  • Research article

Sweta Pathak, Tom G. Richardson, Eleanor Sanderson, Bjørn Olav Åsvold, Laxmi Bhatta, Ben M. Brumpton

Multimorbidity latent classes in relation to 11-year mortality, risk factors and health-related quality of life in Malaysia: a prospective health and demographic surveillance system study

  • Open Access
  • Research

Michelle M. C. Tan, Charlotte Hanlon, Graciela Muniz-Terrera, Tatiana Benaglia, Roshidi Ismail, Devi Mohan, Ann Breeze Joseph Konkoth, Daniel Reidpath, Pedro José M. Rebello Pinho, Pascale Allotey, Zaid Kassim, Matthew Prina, Tin Tin Su

Effect of intravenous urokinase vs best medicine treatment on functional outcome for patients with acute minor stroke (TRUST): a randomized controlled trial

Yongli Tao, Yuan Gao, Lu Zhao, Yafang Xu, Chenyang Jiang, Kai Liu, Hui Fang, Lulu Pei, Xin Wang, Rui Zhang, Jun Wu, Jing Yang, Xinsheng Han, Hongling Guo, Baoguo Xue, Jinlou Li, Yuqian Liu, Hongqiu Gu, Kejin Du, Xin Cheng, Qiang Dong, Duolao Wang, Ferdinando S. Buonanno, MingMing Ning, Yuming Xu, Bo Song

Association between pre-pregnancy maternal stress and small for gestational age: a population-based retrospective cohort study

  • Open Access
  • Research

Manman Chen, Qiongjie Zhou, Yuanyuan Li, Qu Lu, Anying Bai, Fangyi Ruan, Yandan Liu, Yu Jiang, Xiaotian Li

Future atherosclerotic cardiovascular disease in systemic lupus erythematosus based on CSTAR (XXVIII): the effect of different antiphospholipid antibodies isotypes

Can Huang, Yufang Ding, Zhen Chen, Lijun Wu, Wei Wei, Cheng Zhao, Min Yang, Shudian Lin, Qian Wang, Xinping Tian, Jiuliang Zhao, Mengtao Li, Xiaofeng Zeng

Correction: Parental epigenetic age acceleration and risk of adverse birth outcomes: the Norwegian mother, father and child cohort study

Maria C. Magnus, Yunsung Lee, Ellen Ø. Carlsen, Lise A. Arge, Astanand Jugessur, Liv G. Kvalvik, Nils-Halvdan Morken, Cecilia H. Ramlau-Hansen, Mikko Myrskylä, Per Magnus, Siri E. Håberg

Promising new drugs and therapeutic approaches for treatment of ovarian cancer—targeting the hallmarks of cancer

Julia Hillmann, Nicolai Maass, Dirk O. Bauerschlag, Inken Flörkemeier

Pharmacological treatment in autism: a proposal for guidelines on common co-occurring psychiatric symptoms

Mariah A. Manter, Kirstin B. Birtwell, James Bath, Nora D. B. Friedman, Christopher J. Keary, Ann M. Neumeyer, Michelle L. Palumbo, Robyn P. Thom, Emily Stonestreet, Hannah Brooks, Kelly Dakin, Jacob M. Hooker, Christopher J. McDougle

Dystonia caused by ANO3 variants is due to attenuated Ca2+ influx by ORAI1

Jiraporn Ousingsawat, Khaoula Talbi, Hilario Gómez-Martín, Anne Koy, Alberto Fernández-Jaén, Hasan Tekgül, Esra Serdaroğlu, Juan Darío Ortigoza-Escobar, Rainer Schreiber, Karl Kunzelmann

Subgroups of cognitive impairments in schizophrenia characterized by executive function and their morphological features: a latent profile analysis study

Yuyan Huang, Weiyan Wang, Gangrui Hei, Tiannan Shao, Li Li, Ye Yang, Xiaoyi Wang, Yujun Long, Jingmei Xiao, Xingjie Peng, Chuhan Song, Jingda Cai, Xueqin Song, Xijia Xu, Shuzhan Gao, Jing Huang, Dongyu Kang, Ying Wang, Jingping Zhao, Yunzhi Pan, Renrong Wu

The Healthy Supermarket Coach: effects of a nutrition peer-education intervention in Dutch supermarkets on adolescents’ food purchases

Marlijn Huitink, Maartje P. Poelman, Jacob C. Seidell, Jos W. R. Twisk, S. Coosje Dijkstra

Neighborhood environment associations with cognitive function and structural brain measures in older African Americans

Dima L. Chaar, Le Tu, Kari Moore, Jiacong Du, Lauren A Opsasnick, Scott M Ratliff, Thomas H Mosley, Sharon L. R. Kardia, Wei Zhao, Xiang Zhou, Ana V Diez Roux, Fazlay S Faruque, Kenneth R Butler, Jennifer A Smith

Correction: Periodontitis and systemic inflammation as independent and interacting risk factors for mortality: evidence from a prospective cohort study

  • Open Access
  • Correction

Christiane Pink, Birte Holtfreter, Henry Völzke, Matthias Nauck, Marcus Dörr, Thomas Kocher

Proteomics-based mortality prediction modeling in type 2 diabetes: new promise for personalized treatment and prevention

Lu Gan, Changde Wang, Xiaoying Liu

Prenatal maternal stress: triangulating evidence for intrauterine exposure effects on birth and early childhood outcomes across multiple approaches

  • Open Access
  • Research

Ingunn Olea Lund, Laurie J. Hannigan, Helga Ask, Adrian D. Askelund, Laura Hegemann, Elizabeth C. Corfield, Robyn E. Wootton, Yasmin I. Ahmadzadeh, George Davey Smith, Tom A. McAdams, Eivind Ystrom, Alexandra Havdahl

“If that would have lessened my symptoms, that would have been great...”: a qualitative study about the acceptability of tecovirimat as treatment for mpox

  • Open Access
  • Mpox
  • Research

Sara Paparini, Rosalie Hayes, Benjamin Weil, Will Nutland, Ismael Maatouk, Teodora Wi, Chloe M. Orkin, Rosamund Lewis

Qualitative evaluation of the implementation and national roll-out of the NHS App in England

Claire Reidy, Chrysanthi Papoutsi, Sukriti KC, Bernard Gudgin, Anthony A. Laverty, Felix Greaves, John Powell

Regular versus as-needed treatments for mild asthma in children, adolescents, and adults: a systematic review and network meta-analysis

Prapaporn Pornsuriyasak, Sunatee Sa-nguansai, Kunlawat Thadanipon, Pawin Numthavaj, Gareth J. McKay, John Attia, Ammarin Thakkinstian

Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis

Zhe Chen, Mingyang Tang, Nan Wang, Jiangjiang Liu, Xiaoyan Tan, Haitao Ma, Jing Luo, Kai Xie

Robust circulating microRNA signature for the diagnosis and early detection of pancreatobiliary cancer

Shuichi Mitsunaga, Masafumi Ikeda, Makoto Ueno, Satoshi Kobayashi, Masahiro Tsuda, Ikuya Miki, Takamichi Kuwahara, Kazuo Hara, Yukiko Takayama, Yutaro Matsunaga, Keiji Hanada, Akinori Shimizu, Hitoshi Yoshida, Tomohiro Nomoto, Kenji Takahashi, Hidetaka Iwamoto, Hideaki Iwama, Etsuro Hatano, Kohei Nakata, Masafumi Nakamura, Hiroko Sudo, Satoko Takizawa, Atsushi Ochiai

Postpartum depression in relation to chronic diseases and multimorbidity in women’s mid-late life: a prospective cohort study of UK Biobank

Yue Zhang, Yangyang Cheng, Rodrigo M. Carrillo-Larco, Yaguan Zhou, Hui Wang, Xiaolin Xu

Potential roles of cigarette smoking on gut microbiota profile among Chinese men

Jiayao Fan, Fangfang Zeng, Haili Zhong, Jun Cai, Wentao Shen, Chunxiao Cheng, Chunfeng He, Yuanjiao Liu, Yuan Zhou, Shujie Chen, Yimin Zhu, Tao Liu, Ju-Sheng Zheng, Lan Wang, Yu-Ming Chen, Wenjun Ma, Dan Zhou

Psoriasis increases the risk of Sjögren’s syndrome: evidence from a propensity score-matched cohort study and transcriptomic analysis

Zijian Kang, Yu Du, Ran Cui, Qian Wang, Miao Chen, Yu-Hsun Wang, James Cheng‐Chung Wei, Sheng-Ming Dai

Patterns of pharmacological treatment in patients with atrial fibrillation: an analysis from the prospective GLORIA-AF Registry Phase III

Bernadette Corica, Giulio Francesco Romiti, Giuseppe Boriani, Brian Olshansky, Tze-Fan Chao, Menno V. Huisman, Marco Proietti, Gregory Y. H. Lip

Beyond LDL cholesterol: remnant cholesterol is associated with cardiometabolic risk factors in children

Ana Torres-Costoso, Vicente Martínez-Vizcaíno, Andreia Oliveira, Mairena Sánchez-López, Eva Rodríguez-Gutiérrez, Sergio Núñez de Arenas-Arroyo, Montserrat Solera-Martínez, Blanca Notario-Pacheco, Vanessa Martínez-Madrid, Arthur Eumann Mesas

Association of childhood maltreatment and adverse lifetime experiences with post-injury psychopathology: evidence from the China Severe Trauma Cohort

  • Open Access
  • Research

Shu Wen, Yu Zeng, Yueyao Xu, Shishi Xu, Wenwen Chen, Guanglin Wang, Wei Zhang, Huan Song

A realist evaluation to explain and understand the role of paramedics in primary care

  • Open Access
  • Research

Georgette Eaton, Geoff Wong, Stephanie Tierney, Veronika Williams, Kamal R. Mahtani

Green sanctuaries: residential green and garden space and the natural environment mitigate mental disorders risk of diabetic patients

Erxu Xue, Jianhui Zhao, Jingyu Ye, Jingjie Wu, Dandan Chen, Jing Shao, Xue Li, Zhihong Ye

Adding salt to foods and risk of incident depression and anxiety

Weiwei Wang, Xiaotian Chang, Feifei Lin, Lei Feng, Mengying Wang, Jie Huang, Tao Wu

Association between adolescent obesity and early adulthood healthcare utilization—a two-cohort prospective study

Emilia Hagman, Vidar Halsteinli, Resthie R. Putri, Christina Hansen Edwards, Gudrun Waaler Bjørnelv, Claude Marcus, Rønnaug A. Ødegård

Global, regional, and national burden of early-onset colorectal cancer from 1990 to 2021: a systematic analysis based on the global burden of disease study 2021

Yang Meng, Zongbiao Tan, Junhai Zhen, Di Xiao, Liwei Cai, Weiguo Dong, Changzheng Chen

Knowledge, attitude, and reasons for non-uptake of human papilloma virus vaccination among nursing students

Soni Chauhan, Surya Kant Tiwari, Vishal Dubey, Pragya Tripathi, Priyanka Pandey, Anuj Singh, Narendra Pal Singh Choudhary

Evaluating agreement between individual nutrition randomised controlled trials and cohort studies - a meta-epidemiological study

Julia Stadelmaier, Gina Bantle, Lea Gorenflo, Eva Kiesswetter, Adriani Nikolakopoulou, Lukas Schwingshackl

Translation of PET radiotracers for cancer imaging: recommendations from the National Cancer Imaging Translational Accelerator (NCITA) consensus meeting

Martina A. McAteer, Daniel R. McGowan, Gary J. R. Cook, Hing Y. Leung, Tony Ng, James P. B. O’Connor, Luigi Aloj, Anna Barnes, Phil J. Blower, Kevin M. Brindle, John Braun, Craig Buckley, Daniel Darian, Paul Evans, Vicky Goh, David Grainger, Carol Green, Matt G. Hall, Thomas A. Harding, Catherine D. G. Hines, Simon J. Hollingsworth, Penny L. Hubbard Cristinacce, Rowland O. Illing, Martin Lee, Baptiste Leurent, Sue Mallett, Radhouene Neji, Natalia Norori, Nora Pashayan, Neel Patel, Kieran Prior, Thomas Reiner, Adam Retter, Alasdair Taylor, Jasper van der Aart, Joseph Woollcott, Wai-Lup Wong, Jan van der Meulen, Shonit Punwani, Geoff S. Higgins

Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia

  • Open Access
  • Research

Huiling Guo, Yao Xiao, Shuai Dong, Jingyu Yang, Pengfei Zhao, Tongtong Zhao, Aoling Cai, Lili Tang, Juan Liu, Hui Wang, Ruifang Hua, Rongxun Liu, Yange Wei, Dandan Sun, Zhongchun Liu, Mingrui Xia, Yong He, Yankun Wu, Tianmei Si, Fay Y. Womer, Fuqiang Xu, Yanqing Tang, Jie Wang, Weixiong Zhang, Xizhe Zhang, Fei Wang

Development a glycosylated extracellular vesicle-derived miRNA Signature for early detection of esophageal squamous cell carcinoma

  • Open Access
  • Research

Jianlin Chen, Yue Zheng, Zhen Wang, Qi Gao, Kun Hao, Xiongfeng Chen, Nantian Ke, Xiang Lv, Jiamiao Weng, Yuhong Zhong, Zhixin Huang, Miao Fu, Lilan Zhao, Fan Lin, Hui Mi, Haijun Tang, Chundong Yu, Yi Huang

Performance of the 2023 diagnostic criteria for MOGAD: real-world application in a Chinese multicenter cohort of pediatric and adult patients

  • Open Access
  • Research

Meng-Ting Cai, Yi Hua, Qi-Lun Lai, Sheng-Yao Su, Chun-Hong Shen, Song Qiao, Yong-Feng Xu, Zhe-Feng Yuan, Yin-Xi Zhang

Persistent effect of salt reduction in schoolchildren and their families: 1-year follow-up after an application-based cluster randomized controlled trial

  • Open Access
  • Research

Yuan Li, Puhong Zhang, Feng J. He, Rong Luo, Jing Song, Changqiong Wang, Fengge Chen, Wei Zhao, Yuhong Zhao, Hang Chen, Tianyong Wu, Xiaoyan Wang, Hui Zhou, Zhi Han, Jie Zhang

Obstructive sleep apnea and structural and functional brain alterations: a brain-wide investigation from clinical association to genetic causality

Kang Wu, Qiming Gan, Yuhong Pi, Yanjuan Wu, Wenjin Zou, Xiaofen Su, Sun Zhang, Xinni Wang, Xinchun Li, Nuofu Zhang

Effect of enhanced recovery after surgery on older patients undergoing transvaginal pelvic floor reconstruction surgery: a randomised controlled trial

Xuezhu Huang, Sisi Deng, Xiaofeng Lei, Shentao Lu, Ling Dai, Chunyan She

Habitual sleep duration, healthy eating, and digestive system cancer mortality

Diana A. Nôga, Elisa M. S. Meth, André P. Pacheco, Jonathan Cedernaes, Pei Xue, Christian Benedict

Which factors influence the transition towards a healthy and sustainable food environment in Dutch hospitals? A qualitative view from stakeholders

  • Open Access
  • Research

Joline J. Wierda, Femke van Nassau, Sanne K. Djojosoeparto, Maartje P. Poelman

Changes in the critical nutrient content of packaged foods and beverages after the full implementation of the Chilean Food Labelling and Advertising Law: a repeated cross-sectional study

  • Open Access
  • Research article

Natalia Rebolledo, Pedro Ferrer-Rosende, Marcela Reyes, Lindsey Smith Taillie, Camila Corvalán

Childhood body size, adulthood adiposity, underlying mechanisms, and risk of incident hypertension: a prospective cohort study of 180,527 participants

Shujing Ma, Xue Liu, Ruilang Lin, Ye Yao, Min Zhao, Yongfu Yu, Costan G. Magnussen, Bo Xi

Global, regional, and national burdens of type 1 and type 2 diabetes mellitus in adolescents from 1990 to 2021, with forecasts to 2030: a systematic analysis of the global burden of disease study 2021

Xing Chen, Luying Zhang, Wen Chen

Virtual biopsy for non-invasive identification of follicular lymphoma histologic transformation using radiomics-based imaging biomarker from PET/CT

Chong Jiang, Chunjun Qian, Qiuhui Jiang, Hang Zhou, Zekun Jiang, Yue Teng, Bing Xu, Xin Li, Chongyang Ding, Rong Tian

Private sector delivery of care for maternal and newborn health: trends over a decade in the Indian state of Bihar

  • Open Access
  • Research

G. Anil Kumar, Sibin George, Moutushi Majumder, S. Siva Prasad Dora, Md Akbar, Tanmay Mahapatra, Rakhi Dandona

Economic loss attributable to premature deaths and morbidity among adolescents in India and its states

  • Open Access
  • Research

G Anil Kumar, Anamika Pandey, Rakhi Dandona

Using a clinical decision support system to reduce excess driving pressure: the ALARM trial

Ursula Burger-Klepp, Mathias Maleczek, Robin Ristl, Bettina Kroyer, Marcus Raudner, Claus G. Krenn, Roman Ullrich

Long COVID and its risk factors in migrants: a nationwide register study from Sweden

Agneta Cederström, George Frederick Mkoma, Thomas Benfield, Charles Agyemang, Marie Nørredam, Mikael Rostila

Pharmacological pain management in patients with rheumatoid arthritis: a narrative literature review

Natasha Cox, Christian D. Mallen, Ian C. Scott

Understanding the local-level variations in seasonality of human respiratory syncytial virus infection: a systematic analysis

Sheng Ye, Shuyu Deng, Yumeng Miao, David Torres-Fernandez, Quique Bassat, Xin Wang, You Li

Initial treatment with a single capsule containing half-dose quadruple therapy vs standard-dose dual therapy in hypertensive patients (QUADUAL): a randomized, blinded, crossover trial

Xiexiong Zhao, Tao Liu, Qiong Yang, Guoping Yang, Xingli Li, Xiaohong Tang, Jingle Li, Zhongshu Liang, Anying Li, Lixiong Zeng, Juan Wen, Xiaoyan Wang, Liping Peng, Wenjuan Wang, Jingjing Cai, Ye Chen, Miao Huang, Ruixuan Li, Ru Fu, Lin Zhao, Xiaogang Li, Weihong Jiang

Visceral adipose tissue area and proportion provide distinct reflections of cardiometabolic outcomes in weight loss; pooled analysis of MRI-assessed CENTRAL and DIRECT PLUS dietary randomized controlled trials

  • Open Access
  • Research

Hadar Klein, Hila Zelicha, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Alon Kaplan, Yoash Chassidim, Yftach Gepner, Matthias Blüher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Ilan Shelef, Lu Qi, Jun Li, Frank B. Hu, Meir J. Stampfer, Iris Shai

Positive hepatitis B surface antigen leads to a decrease in ovarian reserve in infertile patients receiving first in vitro fertilization treatment

Yutao Li, Xuejiao Wang, Ye Jiang, Qun Lv, Yi Zhang, Yu Wang

Immune microenvironment spatial landscapes of tertiary lymphoid structures in gastric cancer

Yi Xie, Haoxin Peng, Yajie Hu, Keren Jia, Jiajia Yuan, Dan Liu, Yanyan Li, Xujiao Feng, Jian Li, Xiaotian Zhang, Yu Sun, Lin Shen, Yang Chen

Exploring DNA methylation, telomere length, mitochondrial DNA, and immune function in patients with Long-COVID

Andrea Polli, Lode Godderis, Dries S. Martens, Madhura Shekhar Patil, Jolien Hendrix, Arne Wyns, Jente Van Campenhout, Emma Richter, Lara Fanning, Olivia Vandekerckhove, Eveline Claeys, Wim Janssens, Natalie Lorent

Exploration of treatment burden through examination of workload and patient capacity during transition onto kidney replacement therapy: a systematic review of qualitative research

Catrin Jones, Ross Cairns, Heather Walker, Silje Welsh, Benjamin Edgar, Karen Stevenson, Bhautesh D. Jani, Patrick B. Mark, David Kingsmore, Katie I. Gallacher

Association of accelerated phenotypic aging, genetic risk, and lifestyle with progression of type 2 diabetes: a prospective study using multi-state model

Lulu Pan, Yahang Liu, Chen Huang, Yifang Huang, Ruilang Lin, Kecheng Wei, Ye Yao, Guoyou Qin, Yongfu Yu

Implementation of a rapid host-protein diagnostic test for distinguishing bacterial and viral infections in adults presenting to urgent care centers: a pragmatic cohort study

Boaz Kalmovich, Daniella Rahamim-Cohen, Ilan Yehoshua, Sara Kivity, Noam Orvieto, Shirley Shapiro Ben David

Moments that matter: childhood pain treatment shapes pain for life—we can do better every time in every child

Rebeccah Slater, Suellen Walker, Christopher Eccleston, Carlo Bellieni, Tanvi Hirekodi, Ricardo Carbajal, Lucinda Smart, William Laughey, Maria M. Cobo, Stefan Friedrichsdorf

Single-nucleotide polymorphisms in dizygotic twin ovine fetuses are associated with discordant responses to antenatal steroid therapy

Erin L. Fee, Haruo Usuda, Sean W. D. Carter, Hideyuki Ikeda, Tsukasa Takahashi, Yuki Takahashi, Yusaku Kumagai, Michael W. Clarke, Demelza J. Ireland, John P. Newnham, Masatoshi Saito, Sebastian E. Illanes, Binny Priya Sesurajan, Liang Shen, Mahesh A. Choolani, Gokce Oguz, Adaikalavan Ramasamy, Sara Ritchie, Andrew Ritchie, Alan H. Jobe, Matthew W. Kemp

Did the resurgence of childhood lower respiratory infections offset the initial benefit of COVID-19-related non-pharmaceutical interventions in children? A time-series analysis

Inès Fafi, Zein Assad, Léa Lenglart, Zaba Valtuille, Florentia Kaguelidou, Camille Aupiais, Aurélie Bourmaud, Alexis Rybak, Stéphane Bechet, Corinne Levy, Robert Cohen, Bruno Frandji, Andreas Werner, François Angoulvant, Romain Basmaci, Naïm Ouldali

Global cervical cancer elimination: quantifying the status, progress, and gaps

Liangru Zhou, Yi Li, Hongyun Wang, Ruixi Qin, Zhen Han, Ruifeng Li

Assessing brain-muscle networks during motor imagery to detect covert command-following

Emilia Fló, Daniel Fraiman, Jacobo Diego Sitt

Socioeconomic factors and sex effects of postpartum maternal depression on offspring internalizing symptoms: a systematic review and meta-analysis

Yang Geng, Wenlan Liu, Zhiying Yu, Hui Zhang, Yun Li, Weihua Zhao

Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis

Li-wei Huang, Hua-min Li, Bei He, Xiao-bo Wang, Qi-zhi Zhang, Wen-xing Peng

Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia

Shuwen Zheng, Yingying Wang, Chuxuan Ni, Rui Guo, Xunan Qiu, Jijun Chen, Lu Wang, Xiaohu Sun, Moye Chen, Yunen Liu, Yuan Yuan, Yuehua Gong

Adverse events in the nervous system associated with blinatumomab: a real-world study

Wen Gao, Jingwei Yu, Yifei Sun, Zheng Song, Xia Liu, Xue Han, Lanfan Li, Lihua Qiu, Shiyong Zhou, Zhengzi Qian, Xianhuo Wang, Huilai Zhang

Anxiety disorder, depression and coronary artery disease: associations and modification by genetic susceptibility

Shinya Nakada, Joey Ward, Rona J. Strawbridge, Paul Welsh, Carlos Celis-Morales, Frederick K. Ho, Jill P. Pell

Global, regional, and national disease burden attributable to high systolic blood pressure in youth and young adults: 2021 Global Burden of Disease Study analysis

Chuan He, Saien Lu, Haijie Yu, Yingxian Sun, Xueyao Zhang

A case–control study based on the National Health and Nutrition Examination Survey to evaluate the effects of human papilloma virus on bone health in women

Xiang Li, Guangjun Jiao, Yunzhen Chen

High risk for life-threatening adverse events of fluoroquinolones in young adults: a large German population-based cohort study

Julia Wicherski, Jonas Peltner, Cornelia Becker, Katrin Schüssel, Gabriela Brückner, Andreas Schlotmann, Helmut Schröder, Winfried V. Kern, Britta Haenisch

Generative artificial intelligence (GAI) usage guidelines for scholarly publishing: a cross-sectional study of medical journals

Shuhui Yin, Simu Huang, Peng Xue, Zhuoran Xu, Zi Lian, Chenfei Ye, Siyuan Ma, Mingxuan Liu, Yuanjia Hu, Peiyi Lu, Chihua Li

Distinct metabolic perturbations link liver steatosis and incident CVD in lean but not obese PWH

Louise E. van Eekeren, Nadira Vadaq, Marc J. T. Blaauw, Albert L. Groenendijk, Wilhelm A. J. W. Vos, Erni J. Nelwan, Annelies Verbon, Janneke E. Stalenhoef, Marvin A. H. Berrevoets, Jan van Lunzen, Mihai G. Netea, Gert Weijers, Niels P. Riksen, Joost H. W. Rutten, Quirijn de Mast, Eric T. T. L. Tjwa, Leo A. B. Joosten, André J. A. M. van der Ven

Metabolomics- and proteomics-based multi-omics integration reveals early metabolite alterations in sepsis-associated acute kidney injury

Pengfei Huang, Yanqi Liu, Yue Li, Yu Xin, Chuanchuan Nan, Yinghao Luo, Yating Feng, Nana Jin, Yahui Peng, Dawei Wang, Yang Zhou, Feiyu Luan, Xinran Wang, Xibo Wang, Hongxu Li, Yuxin Zhou, Weiting Zhang, Yuhan Liu, Mengyao Yuan, Yuxin Zhang, Yuchen Song, Yu Xiao, Lifeng Shen, Kaijiang Yu, Mingyan Zhao, Lixin Cheng, Changsong Wang

Modifiable factors and 10-year and lifetime cardiovascular disease risk in adults with new-onset hypertension: insights from the Kailuan cohort

Shouling Wu, Yanxiu Wang, Jiangshui Wang, Jun Feng, Furong Li, Liming Lin, Chunyu Ruan, Zhifang Nie, Jinwei Tian, Cheng Jin

Assessment of psychosocial aspects in adults in post-COVID-19 condition: the EURONET-SOMA recommendations on core outcome domains for clinical and research use

Stefan Salzmann, Lars de Vroege, Petra Engelmann, Per Fink, Susanne Fischer, Stephan Frisch, Lise Kirstine Gormsen, Katharina Hüfner, Willem J. Kop, Ferenc Köteles, Nadine Lehnen, Bernd Löwe, Christoph Pieh, Victor Pitron, Charlotte Ulrikka Rask, Markku Sainio, Rainer Schaefert, Meike Shedden-Mora, Anne Toussaint, Roland von Känel, Ursula Werneke, Winfried Rief

Antidepressant use and cognitive decline in patients with dementia: a national cohort study

Minjia Mo, Tamar Abzhandadze, Minh Tuan Hoang, Simona Sacuiu, Pol Grau Jurado, Joana B. Pereira, Luana Naia, Julianna Kele, Silvia Maioli, Hong Xu, Maria Eriksdotter, Sara Garcia-Ptacek

Correction: Efficacy, safety, and biomarker analysis of first-line immune checkpoint inhibitors with chemotherapy versus chemotherapy for advanced gastric cancer: a multicenter, retrospective cohort study

Xue Zhang, Xin Dai, Aina Liu, Meili Sun, Lei Cong, Jing Liang, Zimin Liu, Zhen Li, Jinling Zhang, Jing Lv, Fangli Cao, Linli Qu, Haiyan Liu, Lu Yue, Yi Zhai, Fujun Yang, Jiahui Chu, Shuang Wang, Qian Xu, Jianyuan Zhou, Shulun Nie, Miao Huang, Ruitao Xu, Qiushi Wang, Xinyu Song, Di Zhang, Zhaodi Nan, Song Li, Lian Liu

Tear-fluid-derived biomarkers of ocular complications in diabetes: a systematic review and meta-analysis

Mya Polkamp, Nhan H. T. Pham, Wilson K. M. Wong, Hrishikesh P. Hardikar, Pooja S. Kunte, Morven A. Cameron, Anandwardhan A. Hardikar, Mugdha V. Joglekar

Estimated contributions and future mitigation strategies for HIV risk around funeral practices in western Kenya: a mathematical modeling study

Samuel M. Mwalili, Duncan K. Gathungu, Josiline Chemutai, Evalyne Musyoka, Daniel Bridenbecker, Clark Kirkman IV, David Kaftan, Hae-Young Kim, Ingrida Platais, Anna Bershteyn

Neuroinflammatory disorders of the central nervous system associated with monkeypox virus: a systematic review and call to action

Shramana Deb, Ritwick Mondal, Purbita Sen, Dipanjan Chowdhury, Shramana Sarkar, Granthik Banerjee, Vramanti Sarkar, Anjan Chowdhury, Julián Benito-León

Healthy lifestyle factors and combined macrovascular and microvascular events in diabetes patients with high cardiovascular risk: results from ADVANCE

Shoujiang You, Danni Zheng, Yanan Wang, Qiang Li, Tu N. Nguyen, Ruth Peters, Xiaoying Chen, Xia Wang, Yongjun Cao, Diederick E. Grobbee, Stephen Harrap, Giuseppe Mancia, Bryan Williams, Neil R. Poulter, Liu Lisheng, Michel Marre, Pavel Hamet, Craig S. Anderson, Mark Woodward, John Chalmers, Katie Harris

Mitigating HIV risk associated with widow cleansing and wife inheritance using combined biomedical and structural interventions in western Kenya: a mathematical modeling study

Duncan K. Gathungu, Viona N. Ojiambo, Mark E. Kimathi, David Kaftan, Hae-Young Kim, Daniel T. Citron, Ingrida Platais, Daniel Briedenbecker, Clark Kirkman IV, Samuel M. Mwalili, Anna Bershteyn

Cryoablation-induced modulation of Treg cells and the TGF-β pathway in lung adenocarcinoma: implications for increased antitumor immunity

  • Open Access
  • Research

Shicheng Lin, Dianna Liu, Tianyu Liang, Yaoxue Zhuang, Xiaofan Wang, Shengmao Ma, Quanwang Li, Kaiwen Hu

Prospective validation study: a non-invasive circulating tumor DNA-based assay for simultaneous early detection of multiple cancers in asymptomatic adults

  • Open Access
  • Research

Luu Hong Dang Nguyen, Thi Hue Hanh Nguyen, Van Hoi Le, Vinh Quang Bui, Lan Hieu Nguyen, Nhu Hiep Pham, Thanh Hai Phan, Huu Thinh Nguyen, Van Song Tran, Chi Viet Bui, Van Kha Vo, Pham Thanh Nhan Nguyen, Ha Huu Phuoc Dang, Van Dung Pham, Van Thinh Cao, Ngoc Minh Phan, Ba Linh Tieu, Giang Thi Huong Nguyen, Dac Ho Vo, Trung Hieu Tran, Thanh Dat Nguyen, Van Thien Chi Nguyen, Trong Hieu Nguyen, Vu Uyen Tran, Minh Phong Le, Thi Minh Thu Tran, Minh Nguyen Nguyen, Thi Tuong Vi Van, Anh Nhu Nguyen, Thi Thanh Nguyen, Nhu Nhat Tan Doan, Hoang Tan Nguyen, Phuoc Loc Doan, Le Anh Khoa Huynh, Tien Anh Nguyen, Huu Tam Phuc Nguyen, Y.-Thanh Lu, Chi Thuy Tien Cao, Van Tung Nguyen, Thi Le Quyen Le, Thi Lan-Anh Luong, Thi Kim Phuong Doan, Thi Trang Dao, Canh Duy Phan, Thanh Xuan Nguyen, Nguyen Tuong Pham, Bao Toan Nguyen, Thi Thu Thuy Pham, Huu Linh Le, Cong Thanh Truong, Thanh Xuan Jasmine, Minh Chi Le, Van Bau Phan, Quang Binh Truong, Thi Huong Ly Tran, Minh Thien Huynh, Tu Quy Tran, Si Tuan Nguyen, Vu Tran, Van Khanh Tran, Huu Nguyen Nguyen, Duy Sinh Nguyen, Thi Van Phan, Thi Thanh-Thuy Do, Dinh Kiet Truong, Hung Sang Tang, Hoa Giang, Hoai-Nghia Nguyen, Minh-Duy Phan, Le Son Tran

Life course trajectories of maternal cardiovascular disease risk factors by obstetric history: a UK cohort study using electronic health records

Kate Birnie, Laura D. Howe, Timothy Jones, Paul Madley-Dowd, Florence Z. Martin, Harriet Forbes, Maria Theresa Redaniel, Rosie Cornish, Maria C. Magnus, Neil M. Davies, Kate Tilling, Alun D. Hughes, Deborah A. Lawlor, Abigail Fraser

Correction: Visceral adipose tissue area and proportion provide distinct reflections of cardiometabolic outcomes in weight loss; pooled analysis of MRI-assessed CENTRAL and DIRECT PLUS dietary randomized controlled trials

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Hadar Klein, Hila Zelicha, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Alon Kaplan, Yoash Chassidim, Yftach Gepner, Matthias Blüher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Ilan Shelef, Lu Qi, Jun Li, Frank B. Hu, Meir J. Stampfer, Iris Shai

Prospective associations between muscle strength and genetic susceptibility to type 2 diabetes with incident type 2 diabetes: a UK Biobank study

Mengyao Wang, Paul James Collings, Haeyoon Jang, Ziyuan Chen, Qiaoxin Shi, Hin Sheung Ho, Shan Luo, Shiu Lun Au Yeung, Youngwon Kim

Persistent impact of antenatal maternal anaemia on child brain structure at 6–7 years of age: a South African child health study

Jessica E. Ringshaw, Chanelle J. Hendrikse, Catherine J. Wedderburn, Layla E. Bradford, Simone R. Williams, Charmaine N. Nyakonda, Sivenesi Subramoney, Marilyn T. Lake, Tiffany Burd, Nadia Hoffman, Annerine Roos, Katherine L. Narr, Shantanu H. Joshi, Steven C. R. Williams, Heather J. Zar, Dan J. Stein, Kirsten A. Donald

Investigating intestinal epithelium metabolic dysfunction in celiac disease using personalized genome-scale models

Chloe V. McCreery, Drew Alessi, Katarina Mollo, Alessio Fasano, Ali R. Zomorrodi

Patient-physician communication of health and risk information in the management of cardiovascular diseases and diabetes: a systematic scoping review

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Aloysius Wei-Yan Chia, Winnie Li-Lian Teo, Sanchalika Acharyya, Yasmin Lynda Munro, Rinkoo Dalan

Multi-cancer early detection based on serum surface-enhanced Raman spectroscopy with deep learning: a large-scale case–control study

Yuxiang Lin, Qiyi Zhang, Hanxi Chen, Shuhang Liu, Kaiming Peng, Xiaojie Wang, Liyong Zhang, Jun Huang, Xiuqing Yan, Xueliang Lin, Uddin M. D. Hasan, Mahabub Sarwara, Fangmeng Fu, Shangyuan Feng, Chuan Wang

Development and external validation of a machine learning-based model to predict postoperative recurrence in patients with duodenal adenocarcinoma: a multicenter, retrospective cohort study

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Xu Liu, Qifeng Xiao, Zongting Gu, Xin Wu, Chunhui Yuan, Xiaolong Tang, Fanbin Meng, Dong Wang, Ren Lang, Kaiqing Guo, Xiaodong Tian, Yu Zhang, Enhong Zhao, Zhenzhou Wu, Jingyong Xu, Ying Xing, Feng Cao, Chengfeng Wang, Jianwei Zhang

A retrospective study evaluating the effect of trastuzumab addition to carboplatin/paclitaxel on overall survival in patients with advanced-stage HER2/neu-overexpressing uterine serous carcinoma or carcinosarcoma

Ting-Fang Lu, Lou Sun, Yu-Hsiang Shih, Yen-Fu Chen, Chun-Ting Fan, Shao-Jing Wang, Shih-Tien Hsu, Chih-Ku Liu, Sheau-Feng Hwang, Chien-Hsing Lu

Prevalence and associated factors of complementary feeding practices of mothers having children 6–23 months in rural disadvantaged areas, Ben Tre province, Vietnam: a cross-sectional study

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Thuy Ngoc Vuong, Hang Thi Diem Tran

Assessing lung cancer progression and survival with infrared spectroscopy of blood serum

Kosmas V. Kepesidis, Mircea-Gabriel Stoleriu, Nico Feiler, Lea Gigou, Frank Fleischmann, Jacqueline Aschauer, Sabine Eiselen, Ina Koch, Niels Reinmuth, Amanda Tufman, Jürgen Behr, Mihaela Žigman

Cost-effectiveness of nirsevimab and maternal RSVpreF for preventing respiratory syncytial virus disease in infants across Canada

Samara Bugden, Shweta Mital, Hai V. Nguyen

Risk factors for developing irritable bowel syndrome: systematic umbrella review of reviews

Farisah Sulaimi, Timothy Sheng Khai Ong, Ansel Shao Pin Tang, Jingxuan Quek, Renish M. Pillay, Damien Tianle Low, Charisse Kai Ling Lee, Kewin Tien Ho Siah, Qin Xiang Ng

Analysis of the prognostic efficacy of syndecan-1 for patients with ACLF and its functional role in liver regeneration

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Yingli He, Xiaoli Zhang, Yichen Yao, Juan Li, Shan Fu, Yali Feng, Tianzhi Ni, Ruojing Wang, Qiao Zhang, Yushan Liu, Zhijun Liu, Jinfeng Liu, Yuan Yang, Yingren Zhao, Yalei Zhao

Association between levothyroxine supplementation for hypothyroidism in late pregnancy and risk of prematurity: a population-based cohort study

Maya Laham, Odile Sheehy, Anick Bérard

Normal-weight central obesity and cardiometabolic disorders among Aboriginal and Torres Strait Islander Australians

Kedir Y. Ahmed, Utpal K. Mondal, M. Mamun Huda, Setognal B. Aychiluhm, Jamie Newman, Subash Thapa, Peter Gibbs, Shakeel Mahmood, Feleke H. Astawesegn, Anayochukwu E. Anyasodor, Allen G. Ross

Smartphone screen time reduction improves mental health: a randomized controlled trial

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Christoph Pieh, Elke Humer, Andreas Hoenigl, Julia Schwab, Doris Mayerhofer, Rachel Dale, Katja Haider

Effect of combination of multiple anti-inflammatory drugs strategy on postoperative delirium among older patients undergoing hip fracture surgery: a pilot randomized controlled trial

Ayixia Nawan, Zilong Wu, Bailin Jiang, Geng Wang, Wenchao Zhang, Yi Feng

Ultra-processed food consumption in the central division of Fiji

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Aliyah Palu, Joseph Alvin Santos, Daisy Coyle, Maria Shahid, Juliette Crowther, Gade Waqa, Colin Bell, Jacqui Webster, Briar McKenzie

Single-round performance of colorectal cancer screening programs: a network meta-analysis of randomized clinical trials

Teruhiko Terasawa, Toshihiro Tadano, Koichiro Abe, Seiju Sasaki, Satoyo Hosono, Takafumi Katayama, Keika Hoshi, Tomio Nakayama, Chisato Hamashima

Minimum and optimal combined variations in sleep, physical activity, and nutrition in relation to all-cause mortality risk

Emmanuel Stamatakis, Nicholas A. Koemel, Raaj K. Biswas, Matthew N. Ahmadi, Margaret Allman-Farinelli, Stewart G. Trost, Elif Inan-Eroglu, Borja del Pozo Cruz, Yu Sun Bin, Svetlana Postnova, Mitch J. Duncan, Dorothea Dumuid, Helen Brown, Carol Maher, Luigi Fontana, Stephen Simpson, Peter A. Cistulli

Long-term outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention without standard modifiable cardiovascular risk factors: findings from the OPT-CAD cohort

Zaixin Jiang, Haiwei Liu, Miaohan Qiu, Jing Li, Wei Zhao, Donghong Zhang, Daoshen Liu, Kun Na, Yi Li, Yaling Han

Development and validation of the systemic nutrition/inflammation index for improving perioperative management of non-small cell lung cancer

Peiyu Wang, Shaodong Wang, Qi Huang, Xiankai Chen, Yongkui Yu, Ruixiang Zhang, Mantang Qiu, Yin Li, Xue Pan, Xiao Li, Xiangnan Li

Guidelines for the use of lung ultrasound to optimise the management of neonatal respiratory distress: international expert consensus

Jing Liu, Riccardo Inchingolo, Pradeep Suryawanshi, Bin-Bin Guo, Dalibor Kurepa, Rafael González Cortés, Wei Yan, Jing-Han Chi, Cecilia M. Acosta, Mateusz Jagła, Deepak Sharma, Erich Sorantin, Kai-Sheng Hsieh, Giulia Graziani, Bruna Malta, Patricia Woods, Qiong Meng, Chu-Ming You, Piotr Kruczek, Martin Kneyber, Natalia Buda, Andrea Smargiassi, Jovan Lovrenski, Xiao-Ling Ren, Ya-Li Guo, Ru-Xin Qiu, Abdul Razak, Francesco Feletti

Relationship of tobacco smoking to cause-specific mortality: contemporary estimates from Australia

Grace Joshy, Kay Soga, Katherine A. Thurber, Sam Egger, Marianne F. Weber, Peter Sarich, Jennifer Welsh, Rosemary J. Korda, Amelia Yazidjoglou, Mai T H Nguyen, Ellie Paige, Michelle Gourley, Karen Canfell, Emily Banks

Forecasting total and cause-specific health expenditures for 116 health conditions in Norway, 2022–2050

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Jonas Minet Kinge, Henning Øien, Joseph L. Dieleman, Bjørn-Atle Reme, Ann Kristin Skrindo Knudsen, Geir Godager, Geir Selbæk, Jan C. Frich, Enis Barış, Christopher J. L. Murray, Stein Emil Vollset

Association between antibiotics and treatment efficacy in metastatic urothelial carcinoma patients

Avery Braun, Mengying Deng, Jill S. Hasler, Laura Bukavina, Elizabeth Handorf, Philip H. Abbosh

Increased risk of chronic diseases and multimorbidity in middle-aged and elderly individuals with early vision, hearing, or dual sensory impairments: insights from prospective cohort studies and Mendelian randomization analysis

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Yaoling Wang, Fang Cheng, Niuniu Hou, Yuting Tan, Shaomin Zhang, Yanbing Hou, Wen Guo, Jin Peng, Wei Li, Jinhui Wu

Association between general anesthesia for cesarean delivery and subsequent developmental disorders in children: a nationwide retrospective cohort study

Yi-Chen Chen, Fu-Wen Liang, Ping-Heng Tan, Chung-Han Ho, Ying-Jen Chang, Kuo-Chuan Hung, Jen-Yin Chen, Chia-Hung Yu

Plant-based, fast-food, Western-contemporary, and animal-based dietary patterns and risk of premature aging in adult survivors of childhood cancer: a cross-sectional study

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Tuo Lan, Mei Wang, AnnaLynn M. Williams, Matthew J. Ehrhardt, Jennifer Q. Lanctot, Shu Jiang, Kevin R. Krull, Gregory T. Armstrong, Melissa M. Hudson, Graham A. Colditz, Leslie L. Robison, Kirsten K. Ness, Yikyung Park

Anti-hypertensive medication adherence, socioeconomic status, and cognitive aging in the Chinese community-dwelling middle-aged and older adults ≥ 45 years: a population-based longitudinal study

Chenglong Li, Daijun He, Yufan Liu, Chao Yang, Luxia Zhang

Exploration of the clonal evolution and construction of the tumor clonal evolution rate as a prognostic indicator in metastatic breast cancer

Dan Lv, Bo Lan, Qihan Guo, Zongbi Yi, Haili Qian, Yanfang Guan, Xuenan Peng, Ting Chen, Fei Ma

Sensitivity to thyroid hormones in children developing acute kidney injury at the onset of type 1 diabetes mellitus

Stefano Guarino, Valeria Calcaterra, Anna Di Sessa, Lucia Labati, Maria Maddalena Marrapodi, Anna Grandone, Angela Zanfardino, Gianvincenzo Zuccotti, Dario Iafusco, Emanuele Miraglia del Giudice, Pierluigi Marzuillo

MTHFD2 promotes osteoclastogenesis and bone loss in rheumatoid arthritis by enhancing CKMT1-mediated oxidative phosphorylation

Yujing Li, Minglong Cai, Yi Qin, Xiaojuan Dai, Liyuan Liang, Zhenyu Li, Xi Wen, Huizhi Jin, Chao Yang, Zhu Chen

Accelerometer-measured physical activity, frailty, and all-cause mortality and life expectancy among middle-aged and older adults: a UK Biobank longitudinal study

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Yang Yang, Liangkai Chen, Filippos T. Filippidis

Induction chemotherapy plus camrelizumab combined with concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma in non-endemic areas: a phase 2 clinical trial in North China

Zhongqiu Wang, Yao Sun, Qingxin Wang, Yanlan Chai, Jian Sun, Ximei Zhang, Qi Wang, Wei Wang, Peiguo Wang

Development of an artificial intelligence-based multimodal diagnostic system for early detection of biliary atresia

Ya Ma, Yuancheng Yang, Yuxin Du, Luyang Jin, Baoyu Liang, Yuqi Zhang, Yedi Wang, Luyu Liu, Zijian Zhang, Zelong Jin, Zhimin Qiu, Mao Ye, Zhengrong Wang, Chao Tong

Non-invasive diagnosis of vulvar dysplasia using cervical methylation markers—a case control study

Sabeth Becker, Lena Dübbel, Dana Behrens, Kristin Knoll, Juliane Hippe, Karin Loser, Eduard Malik, Meike Schild-Suhren

Global and regional incidence of intrahepatic cholestasis of pregnancy: a systematic review and meta-analysis

Ali Jamshidi Kerachi, Mohammad Amin Shahlaee, Pardis Habibi, Niloofar Dehdari Ebrahimi, Moein Ala, Alireza Sadeghi

Impact of coronary artery calcium on progression of diastolic dysfunction: a cohort study

Ki Hong Choi, Danbee Kang, Seung Hun Lee, Darae Kim, Sung Won Cho, Soo-Hee Choi, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Soo Jin Cho, Jeong Hoon Yang

A systematic analysis of temporal trends, characteristics, and citations of retracted stem cell publications

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Fei Song, Binghuo Wu, Gang Wei, Songtao Cheng, Lichao Wei, Wei Xiong, De Luo

Confounder adjustment in observational studies investigating multiple risk factors: a methodological study

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Yinyan Gao, Linghui Xiang, Hang Yi, Jinlu Song, Dingkui Sun, Boya Xu, Guochao Zhang, Irene Xinyin Wu

Lifestyle behaviours do not moderate the association between childhood maltreatment and comorbid depression and cardiometabolic disease in older adults: a meta-analysis

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Olujolagbe Layinka, Camille Souama, Serena Defina, Vilte Baltramonaityte, Charlotte A. M. Cecil, Punit Shah, Yuri Milaneschi, Femke Lamers, Brenda W. J. H. Penninx, Esther Walton

Longitudinal multi-omics analysis of convalescent individuals with respiratory sequelae 6–36 months after COVID-19

Huqin Yang, Lujia Guan, Yi Xue, Xuyan Li, Leyi Gao, Zhijin Zhang, Haifan Zhang, Haomiao Ma, Fengjiao Liu, Xuan Huang, Zhaohui Tong, Jieqiong Li

Value of cannabidiol as adjunctive treatment for Lennox Gastaut syndrome: cost-effectiveness and budget impact analysis

Zahra Goudarzi, Farhad Lotfi, Rahil sadat Shahtaheri, Nasrin Moradi, Mohsen Taghizadeh, Khosro Keshavarz

Spatiotemporal heterogeneity in malaria transmission across Indonesia: analysis of routine surveillance data 2010–2019

Bimandra A. Djaafara, Ellie Sherrard-Smith, Thomas S. Churcher, Sri Budi Fajariyani, Hellen Dewi Prameswari, Herdiana Herdiana, Riskha Tiara Puspadewi, Karina D. Lestari, Iqbal R. F. Elyazar, Patrick G. T. Walker

Agomelatine as adjunctive therapy with SSRIs or SNRIs for major depressive disorder: a multicentre, double-blind, randomized, placebo-controlled trial

Yumeng Ju, Wenwen Ou, Haoran Chen, Limin Yang, Yan Long, Hui Liang, Zhenman Xi, Mei Huang, Wentao Chen, Guanyi Lv, Fangzhou Shao, Bangshan Liu, Jin Liu, Zexuan Li, Mei Liao, Weiye Liang, Zhijian Yao, Yan Zhang, Lingjiang Li

Elevated CD10− neutrophils correlate with non-response and poor prognosis of CD19 CAR T-cell therapy for B-cell acute lymphoblastic leukemia

Jinli Zhu, Ji Zhou, Xue Liang, Furun An, Yangyang Ding, Xunyi Jiao, Meng Xiao, Fan Wu, Yingwei Li, Hao Xiao, Ying Pan, Huiping Wang, Zhimin Zhai

Cost-effectiveness of universal genetic screening for familial hypercholesterolemia in young adults aged 18–40 years in China

Rui Meng, Fenghao Shi, Baoming Zhang, Chao Li, Jinyan Wang, Lingqin Song, Lei Zhang, Mingwang Shen

Risk, determinants, and persistence of long-COVID in a population-based cohort study in Catalonia

Manolis Kogevinas, Marianna Karachaliou, Ana Espinosa, Susana Iraola-Guzmán, Gemma Castaño-Vinyals, Laura Delgado-Ortiz, Xavier Farré, Natàlia Blay, Neil Pearce, Magda Bosch de Basea, Eva Alonso Nogués, Carlota Dobaño, Gemma Moncunill, Rafael de Cid, Judith Garcia-Aymerich

Correction: The use and impact of surveillance-based technology initiatives in inpatient and acute mental health settings: a systematic review

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Jessica L. Griffiths, Katherine R. K. Saunders, Una Foye, Anna Greenburgh, Ciara Regan, Ruth E. Cooper, Rose Powell, Ellen Thomas, Geoff Brennan, Antonio Rojas-García, Brynmor Lloyd-Evans, Sonia Johnson, Alan Simpson

A decision-analytical perspective on incorporating multiple outcomes in the production of clinical prediction models: defining a taxonomy of risk estimands

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Glen P. Martin, Alexander Pate, Siân Bladon, Matthew Sperrin, Richard D. Riley

Correction: Metabolomics- and proteomics-based multi-omics integration reveals early metabolite alterations in sepsis-associated acute kidney injury

Pengfei Huang, Yanqi Liu, Yue Li, Yu Xin, Chuanchuan Nan, Yinghao Luo, Yating Feng, Nana Jin, Yahui Peng, Dawei Wang, Yang Zhou, Feiyu Luan, Xinran Wang, Xibo Wang, Hongxu Li, Yuxin Zhou, Weiting Zhang, Yuhan Liu, Mengyao Yuan, Yuxin Zhang, Yuchen Song, Yu Xiao, Lifeng Shen, Kaijiang Yu, Mingyan Zhao, Lixin Cheng, Changsong Wang

Psychiatric and neuropsychiatric sequelae of COVID-19 within 2 years: a multinational cohort study

Yi Chai, Ivan C. H. Lam, Kenneth K. C. Man, Joseph F. Hayes, Eric Y. F. Wan, Xue Li, Celine S. L. Chui, Wallis C. Y. Lau, Xiaoyu Lin, Can Yin, Min Fan, Esther W. Chan, Ian C. K. Wong, Hao Luo

Effect of a single-dose denosumab on mineral homeostasis in infertile men: insights from a pilot intervention study and a randomized controlled trial

Sam Kafai Yahyavi, Rune Holt, Li Juel Mortensen, Ida Marie Boisen, Lív Bech Árting, Anne Jørgensen, Anders Juul, Martin Blomberg Jensen

Smoking-related gut microbiota alteration is associated with obesity and obesity-related diseases: results from two cohorts with sibling comparison analyses

Yiting Duan, Chengquan Xu, Wenjie Wang, Xiaoyan Wang, Nuo Xu, Jieming Zhong, Weiwei Gong, Weifang Zheng, Yi-Hsuan Wu, April Myers, Lisa Chu, Ying Lu, Elizabeth Delzell, Ann W. Hsing, Min Yu, Wei He, Shankuan Zhu

Research prioritisation in preparedness for and response to outbreaks of high-consequence pathogens: a scoping review

Emilia Antonio, Nicolas Pulik, Susan Khader Ibrahim, Adebisi Adenipekun, Shanthi Levanita, Isabel Foster, Dorothy Chepkirui, Eli Harriss, Louise Sigfrid, Alice Norton

Distinct airway mycobiome signature in patients with pulmonary hypertension and subgroups

Chenting Zhang, Bihua Zhong, Qian Jiang, Wenju Lu, Hongkai Wu, Yue Xing, Xuefen Wu, Zizhou Zhang, Yulin Zheng, Peiwen Li, Zhenxiang Li, Ziying Lin, Yuqin Chen, Cheng Hong, Zhuxiang Zhao, Tingting Zhang, Weiquan Liang, Yi Zhang, Caojin Zhang, Jason X.-J. Yuan, Chunli Liu, Jian Wang, Kai Yang

Socioeconomic variations in the proportions of stroke attributable to reproductive profiles among postmenopausal women in China

Weidi Sun, Jing Wu, Shiyi Shan, Leying Hou, Zeyu Luo, Jiali Zhou, Peige Song

Can (dynamic) social norms encourage plant-based food purchases? a quasi-experimental study in real-world Dutch supermarkets

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Sofia M. M. Wolfswinkel, Sanne Raghoebar, Josine M. Stuber, Emely de Vet, Maartje P. Poelman

International evidence-based recommendations for polycystic ovary syndrome in adolescents

Alexia S Peña, Selma Feldman Witchel, Jacky Boivin, Tania S. Burgert, Carolyn Ee, Kathleen M Hoeger, Marla E. Lujan, Aya Mousa, Sharon Oberfield, Chau Thien Tay, Helena Teede

Efficacy and safety of cadonilimab (PD-1/CTLA-4 bispecific) in combination with chemotherapy in anti-PD-1-resistant recurrent or metastatic nasopharyngeal carcinoma: a single-arm, open-label, phase 2 trial

Yaofei Jiang, Weixin Bei, Lin Wang, Nian Lu, Cheng Xu, Hu Liang, Liangru Ke, Yanfang Ye, Shuiqing He, Shuhui Dong, Qin Liu, Chuanrun Zhang, Xuguang Wang, Weixiong Xia, Chong Zhao, Ying Huang, Yanqun Xiang, Guoying Liu

Long-term cost-effectiveness of health behaviour intervention to manage type 2 diabetes in Nepal

Padam Kanta Dahal, Corneel Vandelanotte, Lal Rawal, Rashidul Alam Mahumud, Grish Paudel, Melanie Lloyd, Yeji Baek, Biraj Karmacharya, Tomohiko Sugishita, Zanfina Ademi

Modifications to the National Early Warning Score 2: a Scoping Review

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Victoria Riccalton, Lynsey Threlfall, Ananya Ananthakrishnan, Cen Cong, Madison Milne-Ives, Peta Le Roux, Chris Plummer, Edward Meinert

Modifiable risk factors of vaccine hesitancy: insights from a mixed methods multiple population study combining machine learning and thematic analysis during the COVID-19 pandemic

Omid V. Ebrahimi, Ella Marie Sandbakken, Sigrun Marie Moss, Sverre Urnes Johnson, Asle Hoffart, Sarah Bauermeister, Ole André Solbakken, Lars T. Westlye, Esten H. Leonardsen

Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse

Chong-Yin Huang, Meng-Ting Zuo, Xue-Jia Qi, Meng-Die Gong, Wen-Bo Xu, Si-Yu Meng, Jiang-Yu Long, Pi-Shun Li, Zhi-Liang Sun, Xiao-Feng Zheng, Zhao-Ying Liu

Reduced risks of influenza-associated hospitalization and complications following vaccination among over 2 million older individuals: a nationwide study using target trial emulation framework

Zi-Yang Peng, Yun-Ting Hua, Wan-Ting Huang, Jin-Shang Wu, Huang-Tz Ou

Prevalence, trends, and geographic distribution of human papillomavirus infection in Chinese women: a summative analysis of 2,728,321 cases

Sirui Han, Mengyue Lin, Mengyu Liu, Shiwan Wu, Pi Guo, Jiubiao Guo, Longxu Xie, Song Qiu, Aijuan Xu, Yingmu Cai, Yequn Chen

Differences in plasma metabolome between non-Hispanic White and non-Hispanic Black women

Ghazaleh Pourali, Liang Li, Myung Sik Jeon, Jingqin Luo, Chongliang Luo, Adetunji T. Toriola

Lenvatinib plus pembrolizumab compared to carboplatin plus paclitaxel for carboplatin and paclitaxel pretreated, recurrent, or advanced endometrial cancer

Shao-Jing Wang, Lou Sun, Yu-Hsiang Shih, Ting-Fang Lu, Yen-Fu Chen, Shih-Tien Hsu, Chin-Ku Liu, Sheau-Feng Hwang, Jem-Kun Chen, Hsin-Hua Chen, Chien-Hsing Lu

The interdependence of mid-trimester blood pressure and glucose levels in shaping fetal growth and neonatal outcomes: implications for risk–benefit assessment and co-management

Lijuan Lv, Jingbo Yang, Linjie Li, Chuanyi Huang, Huihua Shi, Yiwen Fang, Lushu Zuo, Ting Liu, Hongli Duan, Jiying Wen, Qing Yang, Amanda Henry, Cha Han, Aihua Yin, Xin Zhou

Denoised recurrence label-based deep learning for prediction of postoperative recurrence risk and sorafenib response in HCC

Yixin Li, Ji Xiong, Zhiqiu Hu, Qimeng Chang, Ning Ren, Fan Zhong, Qiongzhu Dong, Lei Liu

Tobacco and alcohol use; suicide ideation, plan, and attempt among adolescents; and the role of legal purchase age restrictions: a pooled population-based analysis from 58 countries

Manman Chen, Xijie Wang, Din Son Tan, Huan Wang, Jianhui Guo, Jing Li, Zhiyong Zou, Yu Jiang, Wannian Liang

Cellular sentinels: empowering survival and immune defense in hematopoietic stem cell transplantation through mesenchymal stem cells and T lymphocytes

Tzong-Shyuan Tai, Yun-Hsiang Chen, Chao-Ling Yao, Jiun-Han Lin, Yu-Shao Yang, Jai-Wen Shi, Li-Wen Fang, Duen-Wei Hsu, Shu-Chen Kuo, Shu-Ching Hsu

Reconsideration of lowering gestational weight gain guidelines in pregnant women diagnosed with gestational diabetes: evidence from a Belgian study

Katrien Benhalima, Caro Minschart, Ina Geerts, Lieveke Ameye, Bart Van Der Schueren, Roland Devlieger, Annick Bogaerts, Chantal Mathieu

The validation of prediction models deserves more recognition

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Ulrich Mansmann, Begüm Irmak Ön

Association of activity-based food environment index with obesity-related cancer mortality in the US

Qinyun Lin, Xiang Chen, Xukun Xiang, Weixuan Lyu, Congcong Miao, Gaofei Zhang, Ran Xu

Correction: Assessing lung cancer progression and survival with infrared spectroscopy of blood serum

  • Open Access
  • Correction

Kosmas V. Kepesidis, Mircea-Gabriel Stoleriu, Nico Feiler, Lea Gigou, Frank Fleischmann, Jacqueline Aschauer, Sabine Eiselen, Ina Koch, Niels Reinmuth, Amanda Tufman, Jürgen Behr, Mihaela Žigman

Designing novel “Smell-Aids” to improve olfactory function in post COVID-19 era

Veronica L. Formanek, Barak M. Spector, Gabriela Zappitelli, Zhenxing Wu, Kai Zhao

Influential drivers of the cost-effectiveness of respiratory syncytial virus vaccination in European older adults: a multi-country analysis

Xiao Li, Lander Willem, Caroline Klint Johannesen, Arantxa Urchueguía-Fornes, Toni Lehtonen, Richard Osei-Yeboah, Heini Salo, Alejandro Orrico-Sánchez, Javier Díez-Domingo, Mark Jit, Harish Nair, Harry Campbell, Louis Bont, Philippe Beutels, Peter Openshaw, Andrew Pollard, Hanna Nohynek, John Paget, Eva Molero, Javier Díez-Domingo, Rolf Kramer, Jim Janimak, Veena Kumar, Elizabeth Begier, Jenny Hendri, Joke Bilcke, Harish Nair, Philippe Beutels

Association between urbanization levels and frailty among middle-aged and older adults in China: evidence from the CHARLS

Xinlan Xie, Jiaqun Que, Linsu Sun, Tao Sun, Feng Yang

The risk associated with ultra-processed food intake on depressive symptoms and mental health in older adults: a target trial emulation

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Belayneh Mengist, Mojtaba Lotfaliany, Julie A. Pasco, Bruno Agustini, Michael Berk, Malcolm Forbes, Melissa M. Lane, Suzanne G. Orchard, Joanne Ryan, Alice J. Owen, Robyn L. Woods, John J. McNeil, Mohammadreza Mohebbi

Distal radial access to prevent radial artery occlusion for STEMI patients (RAPID III): a randomized controlled trial

Zixuan Li, Yujie Wang, Jiahui Song, Senhu Wang, Yuntao Wang, Yongxia Wu, Haotian Wang, Zijing Liu, Rui Yan, Guangyao Zhai, Jincheng Guo

Language complexity of patient-physician chat communication on hypertension control: results of the cluster-randomised PIA study

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Simon-Konstantin Thiem, Lucas Küppers, Benjamin Aretz, Arezoo Bozorgmehr, Arian Karimzadeh, Frauke Leupold, Birgitta Weltermann

Association of Life’s Essential 8 with incidence of heart failure modified by depressive symptoms: a prospective cohort study from UK Biobank

Wei Hu, Chun-Hua Zhao, Jia-Ning Wang, Zhen-Zhen Shen, Ge Tian, Yue-Qing Huang, Bao-Peng Liu, Cun-Xian Jia

Association of circulating metabolic biomarkers with risk of lung cancer: a population-based prospective cohort study

Lan Wu, Jun Yang, Yu Chen, Jiahao Lin, Wenkai Huang, Mengmeng Li

Exploring the interaction effects of subclinical hypothyroidism and major depressive disorder on brain networks

Shuai Zhao, Jindan Wu, Xiaomei Liu, Yishan Du, Xiaoqin Wang, Yi Xia, Hao Sun, Haowen Zou, Xumiao Wang, Zhilu Chen, Rui Yan, Hao Tang, Qing Lu, Zhijian Yao

Sensitive diagnosis of paucibacillary tuberculosis with targeted next-generation sequencing: a molecular diagnostic study

Yu Chen, Lichao Fan, Zhong Ren, Yanhong Yu, Jiao Sun, Miaoran Wang, Chang Liu, Ying Zhang, Shuihua Lu, Xuhui Liu, Zhen Huang

Therapeutic hypothermia in patients with acute myocardial infarction complicated by out-of-hospital cardiac arrest

Oh-Hyun Lee, Seok-Jae Heo, Moon-Hyun Kim, Je-Wook Park, SungA Bae, Minkwan Kim, Ji Woong Roh, Yongcheol Kim, Eui Im, In Hyun Jung, Deok-Kyu Cho

A comparative study of shoulder replacement outcomes using linked national registry and hospital data from England and Denmark

  • Open Access
  • Research

Epaminondas Markos Valsamis, Josefine Beck Larsen, Theis M. Thillemann, Stephen E. Gwilym, Gary S. Collins, Inger Mechlenburg, Jonathan L. Rees

Cancer incidence inconsistency between UK Biobank participants and the population: a prospective cohort study

Chenxi Li, Gillian S. Dite, Tuong L. Nguyen, John L. Hopper, Shuai Li

Diagnosis of celiac disease on a gluten-free diet: a multicenter prospective quasi-experimental clinical study

Sara Gómez-Aguililla, Sergio Farrais, Natalia López-Palacios, Beatriz Arau, Carla Senosiain, María Corzo, Nora Fernandez-Jimenez, Ángela Ruiz-Carnicer, Fernando Fernández-Bañares, Bárbara P. González-García, Eva Tristán, Ana Montero-Calle, María Garranzo-Asensio, Isabel Casado, Mar Pujals, Juana María Hernández, Jorge Infante-Menéndez, Garbiñe Roy, Carolina Sousa, Concepción Núñez

Gut virome and its implications in the pathogenesis and therapeutics of inflammatory bowel disease

Yushan Wu, Rui Cheng, Hao Lin, Lili Li, Yongbin Jia, Anna Philips, Tao Zuo, Hu Zhang

Adjacent spillover efficacy of Wolbachia for control of dengue: emulation of a cluster randomised target trial

  • Open Access
  • Research

Jue Tao Lim, Diyar Mailepessov, Chee Seng Chong, Borame Dickens, Yee Ling Lai, Youming Ng, Deng Lu, Caleb Lee, Li Yun Tan, Grace Chain, Soon Hoe Ho, Chia-Chen Chang, Pei Ma, Somya Bansal, Vernon Lee, Shuzhen Sim, Cheong Huat Tan, Lee Ching Ng

A pilot cluster-controlled trial of interventions to improve detection of depression in primary healthcare in Ethiopia

Abebaw Fekadu, Barkot Milkias, Rahel Birhane, Bethlehem Tekola, Mahlet Yared, Tigist Eshetu, Tomas Getahun, Heidi Lempp, Andre Tylee, Merga Belina, Girmay Medhin, Kassahun Habtamu, Atalay Alem, Crick Lund, Inge Petersen, Graham Thornicroft, Anthony J. Cleare, Rosie Mayston, Esubalew A. Assefa, Mekdes Demissie, Charlotte Hanlon, Martin J. Prince

Exploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial

Wolfgang Omlor, Giacomo Cecere, Gao-Yang Huang, Tobias Spiller, Akhil Ratan Misra, Finn Rabe, Nils Kallen, Matthias Kirschner, Werner Surbeck, Achim Burrer, George Garibaldi, Štefan Holiga, Juergen Dukart, Daniel Umbricht, Philipp Homan

Efficacy of digital therapeutics for perioperative management in patients with lung cancer: a randomized controlled trial

Jinming Xu, Heng Ni, Hanyu Zhan, Hongfan Yu, Zhongjie Lu, Jieping Zhang, Hongbo Meng, Lin Hang, Lin Mao, Xiaoying Xu, Xiaojian Ma, Qiongyin Wu, Wen Xu, Danyu Xiang, Yufang Zeng, Di Meng, Xiao Teng, Li Yu, Liping Zeng, Pengzhi Ni, Huiwen Miao, Shaozi Fu, Luming Wang, Zhehao He, Chong Zhang, Xiayi Lv, Heyun Xu, Yihua Wu, Wang Lv, Qiuling Shi, Jian Hu

Ketorolac in the perioperative management of acute type A aortic dissection: a randomized double-blind placebo-controlled trial

Zhi-Kang Lv, Hai-Tao Zhang, Xiu-Juan Cai, Wen-Xin Su, Er-Jun Zhu, Hoshun Chong, Xi-Yu Zhu, You-Ru Kong, Yu-Xian Tang, Xin Li, Yuan-Xi Luo, Han-Qing Luo, Hao-Dong Pan, Yan-Hua Sun, Kai Li, Min Jin, Shu-Chun Li, Hong-Yu Chen, Ze-Qi Bi, Ying-Liang Zhao, Zhen-Jun Xu, Yong-Qing Cheng, Wan-Zi Xu, Cheng Chen, Wei-Wei Zhao, Zhi-Gang Wang, Li-Chong Lu, Jun Pan, Fu-Dong Fan, Yun-Xing Xue, Bo-Ming Zhang, Min Ge, Jia-Xin Ye, Chui-Yu Kong, Bao-Dong Xie, Tuo Pan, Dong-Jin Wang

Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8+T-cell subpopulations

Ruiling Zhao, Zhangyao Su, Junjie Gu, Hang Zhao, Lingling Bian, Yin Jiang, Yun Cai, Tao Yang, Yong Gu, Xinyu Xu

Improving type 2 diabetes detection among at-risk individuals – comparing the effectiveness of active opportunistic screening using spot capillary-HbA1c testing and venous HbA1c testing: a cluster randomized controlled trial

Linda Chan, Esther Yee Tak Yu, Eric Yuk Fai Wan, Samuel Yeung Shan Wong, David Vai Kiong Chao, Welchie Wai Kit Ko, Catherine Xiao Rui Chen, Paul Po Ling Chan, Emma Victoria Marianne Bilney, Eng Sing Lee, Wei Leik Ng, Cindy Lo Kuen Lam

tesG expression as a potential clinical biomarker for chronic Pseudomonas aeruginosa pulmonary biofilm infections

Dhammika Leshan Wannigama, Cameron Hurst, Peter N. Monk, Gunter Hartel, William Graham Fox Ditcham, Parichart Hongsing, Phatthranit Phattharapornjaroen, Puey Ounjai, Pattama Torvorapanit, Kamonwan Jutivorakool, Sirirat Luk-in, Sumanee Nilgate, Ubolrat Rirerm, Chanikan Tanasatitchai, Kazuhiko Miyanaga, Longzhu Cui, Naveen Kumar Devanga Ragupathi, S. M. Ali Hosseini Rad, Aisha Khatib, Robin James Storer, Hitoshi Ishikawa, Mohan Amarasiri, Somrat Charuluxananan, Asada Leelahavanichkul, Talerngsak Kanjanabuch, Paul G. Higgins, Jane C. Davies, Stephen M. Stick, Anthony Kicic, Tanittha Chatsuwan, Kenji Shibuya, Shuichi Abe

Cancer risk subsequent to cardiovascular disease: a prospective population-based study and meta-analysis

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  • Research

Chi Shu, Huiqiao Han, Hong Li, Linru Wei, Hong Wu, Changtao Li, Xuan Xie, Bin Zhang, Zhexuan Li, Xin Chen, Jichun Zhao, Yanhong Zhou, Yazhou He, Chuan Xu

Correction: The chemoprotective effect of anti-platelet agents on cancer incidence in people with non-alcoholic fatty liver disease (NAFLD): a retrospective cohort study

Matthew Anson, Jun Shang Poon, Alex E. Henney, David Riley, Gema H. Ibarbaru, Cyril Sieberhagen, Daniel J. Cuthbertson, Uazman Alam, Theresa Hydes

School-age outcomes among IVF and ICSI-conceived children: a causal inference analysis using linked population-wide data

  • Open Access
  • ICSI
  • Research

Amber L. Kennedy, Richard J. Hiscock, Beverley J. Vollenhoven, Catharyn J. Stern, Lyle C. Gurrin, Tiki Osianlis, Aleah Kink, Susan P. Walker, Jeanie L. Y. Cheong, Jon L. Quach, David Wilkinson, John McBain, Mark P. Green, Jessica A. Atkinson, Franca Agresta, Susan P. Baohm, Stephen Tong, Roxanne Hastie, Anthea C. Lindquist

Effect of intra-articular corticosteroid injections for knee osteoarthritis on the rates of subsequent knee replacement and post-operative outcomes: a national cohort study of England

Samuel Hawley, Albert Prats-Uribe, Gulraj S. Matharu, Antonella Delmestri, Daniel Prieto-Alhambra, Andrew Judge, Michael R. Whitehouse

Efficacy and safety of photobiomodulation combined with oral cryotherapy on oral mucosa pain in patients with burning mouth syndrome: a multi-institutional, randomized, controlled trial

Chenghui Lu, Xuan Zhou, Chenglong Yang, Xinxiang Jiang, Xin Li, Zefan Huang, Qing Du, Guoyao Tang

The pharmacodynamics-based prophylactic benefits of GLP-1 receptor agonists and SGLT2 inhibitors on neurodegenerative diseases: evidence from a network meta-analysis

Ping-Tao Tseng, Bing-Yan Zeng, Chih-Wei Hsu, Chao-Ming Hung, Andre F. Carvalho, Brendon Stubbs, Yen-Wen Chen, Tien-Yu Chen, Wei-Te Lei, Jiann-Jy Chen, Kuan-Pin Su, Yow-Ling Shiue, Chih-Sung Liang

The response to anti-seizure medications and the development of pharmacoresistant epilepsy in malformations of cortical development

Pu Miao, Meiping Ying, Ruotong Chen, Yuyu Yang, Yao Ding, Junming Zhu, Jianhua Feng, Jin Wang, Thandar Aung, Shuang Wang, Bo Jin

Comparative outcomes of invasive versus conservative strategy in stable coronary artery disease patients: a risk-stratification-based hypothesis-generative study

Zizhao Qi, Miaohan Qiu, Ying Xu, Kai Xu, Haiwei Liu, Xiaozeng Wang, Jing Li, Bin Liu, Shaoliang Chen, Jiyan Chen, Yaling Han, Yi Li

Cilnidipine exerts antiviral effects in vitro and in vivo by inhibiting the internalization and fusion of influenza A virus

Yinyan Li, Sizu Yang, Feng Jiang, Siqi Luo, Jinlong Liang, Linrui Jiang, Zhixuan Chen, Xin Chen, Jie Yang

Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapse

Xinghao Yu, Yiyin Chen, Lei Lei, Pengfei Li, Dandan Lin, Ying Shen, Chang Hou, Jia Chen, Yi Fan, Yi Jin, Huimin Lu, Depei Wu, Yang Xu

Evaluating SinergiAPS, an intervention based on patient feedback to improve patient safety in primary care: a cluster randomized trial

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Maria Antònia Fiol-deRoque, José María Valderas, María Jesús Serrano-Ripoll, Montserrat Gens-Barbarà, Francisco Martín-Luján, Encarna Sánchez-Freire, Juan José Montaño, Sofía Mira-Martínez, Guadalupe Pastor-Moreno, Rocío Zamanillo-Campos, Pau Riera-Serra, Ignacio Ricci-Cabello

Increased vision impairment reports linked to semaglutide: analysis of FDA adverse event data

Marine Massy, Stefanie Marti, Helly Hammer, Robert Hoepner

Associations between education and ideal cardiovascular health metrics across 36 low- and middle-income countries

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Yi Zhang, Guangyu Tong, Ning Ma, Shaoru Chen, Yuhao Kong, Lhuri Dwianti Rahmartani, Justice Moses K. Aheto, Andrew Marvin Kanyike, Pengyang Fan, Md Ashfikur Rahman, Abdallah Mkopi, Rockli Kim, Peter Karoli, John Lapah Niyi, Melkamu Aderajew Zemene, Lin Zhang, Feng Cheng, Chunling Lu, S. V. Subramanian, Pascal Geldsetzer, Yue Qiu, Zhihui Li

Changes in the healthfulness of food and beverage purchases from 2006 to 2022 by outlet type in Mexico

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Ana Paula Domínguez-Barreto, Irene Farah, Nancy López-Olmedo, Carolina Pérez-Ferrer, Yenisei Ramírez-Toscano, Brent A. Langellier, M. Arantxa Colchero, Juan A. Rivera-Dommarco, Tonatiuh Barrientos-Gutiérrez, Dalia Stern

Heterogeneous treatment effects of stress ulcer prophylaxis among ICU patients at risk for gastrointestinal bleeding

Yongpeng Xie, Yao Yan, Qixiang Hong, Hui Zheng, Lijuan Cao, Xiaoming Li, Songqiao Liu, Hui Chen

Cumulative social disadvantage and its impact on long COVID: insights from a U.S. national survey

Junwei Xiang, Hu Zheng, Yuhang Cai, Siyuan Chen, Yuanyin Wang, Ran Chen

Assessing healthcare payment reforms’ effects on economic inequities and catastrophic expenditures among cancer patients in ethnic minority regions of China

  • Open Access
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Xin Xiang, Yu Li, Ning Liang, Bangqin Wang, Hongzhi Wang

Double-negative T cells in combination with ursodeoxycholic acid ameliorates immune-mediated cholangitis in mice

Chunpan Zhang, Guangyong Sun, Hua Jin, Yunxiong Wei, Shimeng Zheng, Xiyu Wang, Xinyan Zhao, Dong Zhang, Jidong Jia

Mapping the Global distribution, risk factors, and temporal trends of COPD incidence and mortality (1990–2021): ecological analysis

Shafaq Naeem, Fang Wang, Rabia Mubarak, Hui Shen, Xuechun Li, Irene Mommers, Syeda Rija Hussain, Saima Shakil Malik, Chuanhua Yu, Eelko Hak, Xiaolin Xu, Muhammad Fawad, Sumaira Mubarik

Putting health facilities on the map: a renewed call to create geolocated, comprehensive, updated, openly licensed dataset of health facilities in sub-Saharan African countries

  • Open Access
  • Debate

Peter M. Macharia, Lenka Beňová, Nicolas Ray, Aline Semaan, Moses M. Musau, John Kapoi Kipterer, Mark Herringer, Robert W. Snow, Emelda A. Okiro

Bile acid metabolism in multiple sclerosis is perturbed and associated with the risk of confirmed disability worsening

Ida Erngren, Aina Vaivade, Henrik Carlsson, Asma Al-Grety, Torbjörn Åkerfeldt, Ingrid Kockum, Anna Karin Hedström, Lars Alfredsson, Tomas Olsson, Joachim Burman, Kim Kultima

Plasma CCL3 predicts adverse heart failure outcomes in patients with arrhythmogenic cardiomyopathy

Hao Cui, Songren Shu, Ningning Zhang, Mangyuan Wang, Tianshuo Yang, Zhen Wang, Xiao Chen, Mengxia Fu, Mengda Xu, Yicheng Yang, Peizhi Wang, Chuangshi Wang, Qiaoxi Yang, Huimin Gao, Yao Jiang, Jiangping Song

Evaluating digital nudge interventions for the promotion of cancer screening behavior: a systematic review and meta-analysis

  • Open Access
  • Review

Fangfang Wang, Yonglin Li, Chenxing Zhang, Rachel Arbing, Wei-Ti Chen, Feifei Huang

Sexual dimorphism in the association of umbilical cord blood lipidome with abdominal fat in early childhood

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Kothandaraman Narasimhan, Mya Thway Tint, Li Chen, Sartaj Ahmad Mir, Suresh Anand Sadananthan, Navin Michael, Adaikalavan Ramasamy, Karen Mei-Ling Tan, Priti Mishra, Anne K. Bendt, Kok Hian Tan, David Cameron-Smith, Yap Seng Chong, Peter D. Gluckman, Peter J. Meikle, Melvin Khee Shing Leow, Fabian Yap, Yung Seng Lee, Chan Shiao Yng, Johan G. Eriksson, S Sendhil Velan, Neerja Karnani, Markus R. Wenk

Differential attainment in UK postgraduate medical examinations: examining the relationship between sociodemographic differences and examination performance

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Ricky Ellis, Andy Knapton, Jane Cannon, Amanda J. Lee, Jennifer Cleland

The impact of metabolic reprogramming on tertiary lymphoid structure formation: enhancing cancer immunotherapy

Meng-Jie Zhang, Yan Wen, Zhi-Jun Sun

Comforting styles of serious illness conversations: a Swiss wide factorial survey study

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Robert Staeck, Carsten Sauer, Steven M. Asch, Sofia C. Zambrano

Compositional associations of 24-h physical activities, sedentary time and sleep with depressive symptoms in urban and rural residents: a cross-sectional study

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Marjo Seppänen, Tiina Lankila, Maisa Niemelä, Nina Rautio, Maija Korpisaari, Markku Timonen, Raija Korpelainen, Vahid Farrahi

Correction: Phase 1b study of first-line fuzuloparib combined with modified FOLFIRINOX followed by fuzuloparib maintenance monotherapy in pancreatic adenocarcinoma

  • Open Access
  • Correction

Miaoyan Wei, Rujiao Liu, Yunyun Xu, Xiaobing Chen, Chao Liu, Xueli Bai, Xiaochen Zhang, Shuiping Gao, Jialin Li, Zhen Sheng, Jianpo Lian, Wenliang Wang, Jian Zhang, Si Shi, Jin Xu, Xianjun Yu

Empirical assessment of functional somatic disorder (FSD): frequency, applicability, and diagnostic refinement in a population-based sample

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Abigail Smakowski, Judith Rosmalen, Bernd Löwe, Christopher Burton, Anne Toussaint

Relationship between multimorbidity, SARS-COV-2 infection and long COVID: a cross-sectional population-based French survey

Tatjana T. Makovski, Olivier Steichen, Melissa Rushyizekera, Marjan van den Akker, Joël Coste

Osimertinib plus anlotinib for advanced NSCLC with acquired EGFR T790M mutation: results from a multicenter phase II study with ctDNA analysis

Xinyue Wang, Zhaona Li, Liuchun Wang, Yan Liang, Chun Huang, Peng Chen, Dingzhi Huang, Xia Song, Cuimin Ding, Changli Wang, Richeng Jiang

Combining genetic and non-genetic factors to predict the risk of pancreatic cancer in patients with new-onset diabetes mellitus

Yu Zhou, Zhuo Wu, Liangtang Zeng, Rufu Chen

Correction: Robust circulating microRNA signature for the diagnosis and early detection of pancreatobiliary cancer

  • Open Access
  • Correction

Shuichi Mitsunaga, Masafumi Ikeda, Makoto Ueno, Satoshi Kobayashi, Masahiro Tsuda, Ikuya Miki, Takamichi Kuwahara, Kazuo Hara, Yukiko Takayama, Yutaro Matsunaga, Keiji Hanada, Akinori Shimizu, Hitoshi Yoshida, Tomohiro Nomoto, Kenji Takahashi, Hidetaka Iwamoto, Hideaki Iwama, Etsuro Hatano, Kohei Nakata, Masafumi Nakamura, Hiroko Sudo, Satoko Takizawa, Atsushi Ochiai

Association of high-normal blood pressure defined by the 2023 European Society of Hypertension guideline with mortality in the Chinese population: a nationwide, population-based, prospective study of 3.6 million adults

Zhiwei Li, Mengmeng Liu, Bowang Chen, Yuelin Wu, Hui Jia, Ruirui Geng, Yixiao Wang, Xiaoyan Zhang, Yang Yang, Jianlan Cui, Jiapeng Lu, Zhiping Guo, Xi Li, Weili Zhang

The story of pain in people with dementia: a rationale for digital measures

Monica Patrascu, Line I. Berge, Ipsit V. Vahia, Brice Marty, Wilco P. Achterberg, Heather Allore, Richard R. Fletcher, Bettina S. Husebo

The role of environmental access to exercise opportunities in cardiovascular mortality: evidence from a nationwide study

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Xiaowen Wang, Yongshi Gu, Ying Wang, Yuqing Qiu, Tianling Chen, Philip K. Hopke, Kai Zhang, Shao Lin, Yanji Qu, Ziqiang Lin, Xinlei Deng, Jie Sun, Shuming Zhu, Xueqing Deng, Sizhe Li, Xian Lin, Zhicheng Du, Yuantao Hao, Wangjian Zhang

Exploring patterns in pediatric type 1 diabetes care and the impact of socioeconomic status

Christopher Nussbaum, Anna Novelli, Amelie Flothow, Leonie Sundmacher

Helicobacter pylori reversing the landscape of neoadjuvant immunotherapy for microsatellite stable gastric cancer: a multicenter cohort study

Chengyu Hu, Hongming Liu, Bo Hong, Li Wang, Zelai Wu, Weixun Xie, Bixian Luo, Dong Cao, Yuxin Zhong, Yong Liu, Weihua Gong

Understanding healthcare demand and supply through causal loop diagrams and system archetypes: policy implications for kidney replacement therapy in Thailand

Siobhan Botwright, Yot Teerawattananon, Natcha Yongphiphatwong, Jeerath Phannajit, Kinanti Khansa Chavarina, Jiratorn Sutawong, Le Khanh Ngan Nguyen

Maternal B12 deficiency during pregnancy dysregulates fatty acid metabolism and induces inflammation in human adipose tissue

Jinous Samavat, Joseph Boachie, Philip G. McTernan, Mark Christian, Ponnusamy Saravanan, Antonysunil Adaikalakoteswari

Remnant cholesterol predicts risk of recurrent thrombosis beyond LDL-cholesterol in patients with antiphospholipid syndrome

Bin Cai, Yangzhong Zhou, Xinzhuang Yang, Zhaoqing Wang, Can Huang, Qingqing Xiao, Hui Jiang, Yuan Zhao, Xinping Tian, Qian Wang, Guanqiao Li, Mengtao Li, Xiaofeng Zeng, Jiuliang Zhao

The role of estimated glucose disposal rate in predicting cardiovascular risk among general and diabetes mellitus population: a systematic review and meta-analysis

Lei Guo, Jun Zhang, Ran An, Wenrui Wang, Jie Fen, Yanshuang Wu, Yanqing Wang

Machine learning technique-based four-autoantibody test for early detection of esophageal squamous cell carcinoma: a multicenter, retrospective study with a nested case–control study

Yi-Wei Xu, Yu-Hui Peng, Can-Tong Liu, Hao Chen, Ling-Yu Chu, Hai-Lu Chen, Zhi-Yong Wu, Wen-Qiang Wei, Li-Yan Xu, Fang-Cai Wu, En-Min Li

Effect of sodium-reduced potassium-enriched salt substitutes on stomach cancer: the Salt Substitute and Stroke Study (SSaSS)

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Xinyi Zhang, Xuejun Yin, Mei Ling Yap, Qiang Li, Liping Huang, Yishu Liu, Bo Zhou, Zhifang Li, Yi Zhao, Jixin Sun, Yan Yu, Lijing L. Yan, Yangfeng Wu, Bruce Neal, Maoyi Tian

Clonal hematopoiesis of indeterminate potential and risk of autoimmune thyroid disease

Xue Zhang, Yuqing Wang, Huiwen Xue, Yingsuo Zhao, Mingcheng Liu, Hui Wei, Qianwei Liu

Probiotic mitigates gut hypoperfusion-associated acute gastrointestinal injury in patients undergoing cardiopulmonary bypass: a randomized controlled trial

Xiaofang Yang, Ruisheng Liu, Zhijing An, Boxia Li, Yanyan Lin, Yuanmin Li, Bing Song, Jinqiu Yuan, Wenbo Meng, Christian Waydhas

Longitudinal association of cumulative risk factors in early life, genetic risk, and healthy lifestyles during adulthood with the risk of type 2 diabetes

Jiajin Hu, Honghao Yang, Yilin Liu, Lu Zheng, Xiaoyan Zhang, Jing Yang, Zhe Yang, Xiaochuan Wang, Borui Liu, Hong Cui, Izzuddin M Aris, Yang Xia

Neurocognitive resilience as a predictor of psychosis onset and functional outcomes in individuals at high risk

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TianHong Zhang, XiaoChen Tang, YanYan Wei, LiHua Xu, HuiRu Cui, HaiChun Liu, ZiXuan Wang, Tao Chen, LingYun Zeng, YingYing Tang, ZhengHui Yi, ChunBo Li, JiJun Wang

When health data go dark: the importance of the DHS Program and imagining its future

Jessie Jane Khaki, Jil Molenaar, Sulata Karki, Emmanuel Olal, Manuela Straneo, Marie Alice Mosuse, Jovanny Tsuala Fouogue, Bernadette Hensen, Adama Baguiya, Angèle Musau Nkola, Kerry L. M. Wong, Oumar Aly Ba, Amani Kikula, Fassou Mathias Grovogui, Aline Semaan, Anteneh Asefa, Peter M. Macharia, Chido Dziva Chikwari, Mariame Oumar Ouédraogo, Aliki Christou, Emelda A. Okiro, Martin Kavao Mutua, Abioye Amodu, Mwelwa Phiri, Rukundo Athanase, David Lagoro Kitara, Onikepe Owolabi, Andrea B. Pembe, Bosede B. Afolabi, Lenka Beňová

What evidence is required to justify the NHS Health Check programme?

  • Open Access
  • Matters Arising

Karsten Juhl Jørgensen, Minna Johansson, Steven Woloshin

Reply to: What evidence is required to justify the NHS Health Check programme?

Zahra Raisi-Estabragh, Stefan Neubauer, Thomas E. Nichols, John Robson

Artificial intelligence tool development: what clinicians need to know?

Boon-How Chew, Kee Yuan Ngiam

Circulating linoleic acid and its interplay with gut microbiota during pregnancy for gestational diabetes mellitus

Jiahui Qiu, Ping Hu, Fan Li, Yichao Huang, Yunhaonan Yang, Fengjiang Sun, Ping Wu, Yuwei Lai, Yi Wang, Xiangwang He, Yidan Dong, Peiqi Zhang, Shanshan Zhang, Nianwei Wu, Tianlei Wang, Shizhuo Yang, Shuo Li, Jiaying Yuan, Xiaojuan Liu, Gang Liu, Yayi Hu, Jason H. Y. Wu, Da Chen, An Pan, Xiong-Fei Pan

The safety and efficacy of a single dose of oral azithromycin given in labour to prevent skin and soft tissue infections in young infants in Fiji: a randomised controlled trial

Maeve Hume-Nixon, Stephanie Clark, Tupou Ratu, Cattram D. Nguyen, Eleanor F. G. Neal, Kathryn Bright, Aneley Getahun Strobel, Emma Watts, John Hart, James Fong, Eric Rafai, Kelera Sakumeni, Andrew Steer, Ilisapeci Tuibeqa, Fiona M. Russell

Evaluating the COVID-19 responses of Belgium, Denmark, Germany, the Netherlands, Sweden, and the United Kingdom, February–June 2020: a counterfactual modeling study

Pieter de Boer, Fuminari Miura, Giske Lagerweij, Jacco Wallinga

Orthogeriatric co-management and incident nursing home admissions in older patients with fragility fractures other than the hip—a retrospective cohort study using insurance claims data from Germany

Daniel Schoene, Kilian Rapp, Patrick Roigk, Clemens Becker, Andrea Jaensch, Claudia Konnopka, Hans-Helmut König, Thomas Friess, Gisela Büchele, Dietrich Rothenbacher

Molecular characteristics and responses to EGFR tyrosine kinase inhibitors in non-small cell lung cancer patients with EGFR exon 19 insertions

Yang Li, Yunfeng Ni, Feng Lv, Yan Shi, Yedan Chen, Xiaoying Wu, Jiaohui Pang, Long Huang, Yang Shao, Tao Wang, Jie Min, Yang Song

Integration of multi-omics data to unveil the molecular landscape and role of piRNAs in early-onset colorectal cancer

Siyun Zhou, Lili Yu, Jianhui Zhao, Qian Xiao, Jing Sun, Lijuan Wang, Yuan Zhou, Yadong Lu, Malcolm G Dunlop, Evropi Theodoratou, Honghe Zhang, Kefeng Ding, Xue Li

Using machine learning involving diagnoses and medications as a risk prediction tool for post-acute sequelae of COVID-19 (PASC) in primary care

Seika Lee, Marta A. Kisiel, Pia Lindberg, Åsa M. Wheelock, Anna Olofsson, Julia Eriksson, Judith Bruchfeld, Michael Runold, Lars Wahlström, Andrei Malinovschi, Christer Janson, Caroline Wachtler, Axel C. Carlsson

Placental and cord serum inflammatory cytokines and children’s domain-specific neurodevelopment at 18 months: effect modification by maternal vitamin D status

Menglong Geng, Zhen Yu, Yafei Wang, Juan Tong, Hui Gao, Hong Gan, Jixing Zhou, Baolin Wang, Peng Ding, Shuangqin Yan, Kun Huang, Xiaoyan Wu, Fangbiao Tao

Disability-inclusive graduation programme intervention on social participation among ultra-poor people with disability in North Uganda: a cluster randomized trial

  • Open Access
  • Research

Shanquan Chen, Lena Morgon Banks, Mark T. Carew, Elijah Kipchumba, Calum Davey, Munshi Sulaiman, Hannah Kuper

Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics

Chaonan Wang, Yuyao Feng, Xiaoyan Liu, Haidan Sun, Zhengguang Guo, Jiang Shao, Kang Li, Junye Chen, Keqiang Shu, Deqiang Kong, Jiaxian Wang, Yiran Li, Xiangling Lei, Chen Li, Bao Liu, Wei Sun, Zhichao Lai

COVID- 19 vaccination reduces new-onset fibromyalgia risk in survivors

Aihui Liu, PeiLun Liao, Hongyang Jiang, Shan Huang, Shinan Li, James Cheng-Chung Wei, Zhenhua Ying

Effects of an integrated social-art intervention on cognitive and psychosocial outcomes among older adults with mild cognitive impairment in nursing homes: a mixed methods study

Chenshan Huang, Yuanjiao Yan, Wilson Wai San Tam, Wenqian Sun, Yu Ye, Nafang Wang, Yanhong Shi, Ziping Zhu, Danting Chen, Lin Chen, Junyu Zhao, Rong Lin, Hong Li

Exploring secondary extramedullary myeloma disease: a five-predictor scoring system with spotlight on double-hit cytogenetics

Yi Tao, Shi-Wei Jin, Zhe Wang, Mengmeng Pan, Wanyan Ouyang, Jie Xu, Yuanfang Liu, Yan Wang, Weiping Zhang, Jian Li, Jian-Qing Mi

Normative structural connectome constrains spreading transient brain activity in generalized epilepsy

Jie Xia, Siqi Yang, Jiao Li, Yao Meng, Jinpeng Niu, Huafu Chen, Zhiqiang Zhang, Wei Liao

Disparities in neighborhood food environment and cognitive decline among US older adults: a cohort study

Boeun Kim, Roland J. Thorpe Jr, Sarah L. Szanton, Paris B. Adkins-Jackson, Laura J. Samuel

Dissecting the clinical and pathological prognosis of MCI patients who reverted to normal cognition: a longitudinal study

Hai-Hong Yu, Lan Tan, Meng-Jiao Jiao, Yi-Ju Lv, Xin-Hao Zhang, Chen-Chen Tan, Wei Xu

Molecular mechanisms explaining sex-specific functional connectivity changes in chronic insomnia disorder

Liyong Yu, Zhifu Shen, Wei Wei, Zeyang Dou, Yucai Luo, Daijie Hu, Wenting Lin, Guangli Zhao, Xiaojuan Hong, Siyi Yu

A complex intervention to reduce hospital admissions for people living with dementia in shared-housing arrangements in Germany: results of the multicenter, cluster-randomized controlled DemWG-study

Julia Misonow, Karin Wolf-Ostermann, Janissa Altona, Annika Schmidt, Susanne Stiefler, Serhat Guenay, André Kratzer, Antonia Keck, Carolin Donath, Elmar Graessel

Gut-immune-brain interactions during neurodevelopment: from a brain-centric to a multisystem perspective

Greta Volpedo, Antonella Riva, Lino Nobili, Federico Zara, Teresa Ravizza, Pasquale Striano

Nimotuzumab combined with docetaxel and cisplatin as first-line treatment for patients with recurrent or metastatic nasopharyngeal carcinoma: a multicenter, phase 2 trial

Qihua Zou, Yi Cao, Yulin Lai, Yu Fang, Yuchen Zhang, Panpan Liu, Lixia Lu, Hao Wu, Tianying Huang, Ning Su, Zhihua Li, Xicheng Wang, Xiaopeng Tian, Lirong Li, Yingxian Liu, Qingqing Cai, Yi Xia

Comparative Discrimination of Life’s Simple 7, Life’s Essential 8, and Life’s Crucial 9: Evaluating the impact of added complexity on mortality prediction

  • Open Access
  • Research

Xu Zhu, Iokfai Cheang, Yiyang Fu, Sitong Chen, Gengmin Liang, Huaxin Yuan, Ling Zhu, Haifeng Zhang, Xinli Li

Synergistic benefit of thiazolidinedione and sodium-glucose cotransporter 2 inhibitor for metabolic dysfunction-associated steatotic liver disease in type 2 diabetes: a 24-week, open-label, randomized controlled trial

Minyoung Lee, Sukchul Hong, Yongin Cho, Hyungjin Rhee, Min Heui Yu, Jaehyun Bae, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha

A deep learning model combining circulating tumor cells and radiological features in the multi-classification of mediastinal lesions in comparison with thoracic surgeons: a large-scale retrospective study

Feng Wang, Minwei Bao, Bo Tao, Fugui Yang, Guangxue Wang, Lei Zhu

Association of childhood-to-adulthood body size change with cancer risk: UK Biobank prospective cohort

Marko Mandic, Fatemeh Safizadeh, Ben Schöttker, Michael Hoffmeister, Hermann Brenner

Risk of hypothyroidism in meat-eaters, fish-eaters, and vegetarians: a population-based prospective study

Catharina J. Candussi, William Bell, Alysha S. Thompson, Sven Knüppel, Martina Gaggl, Martin Světnička, Jan Gojda, Aedín Cassidy, Cornelia Weikert, Reynalda Córdova, Tilman Kühn

Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trial

Shi Zhang, Yi Wang, Xincheng Wang, Mingxin Leng, Renjiao Liu, Zhouhuiling Li, Jing Li, Jixuan Xiao, Dangmin Hou, Xinying Gao, Chunjun Li

A randomized, open-label, multi-center, active-controlled phase II study comparing abiraterone acetate tablets (II), an improved formulation, versus originator abiraterone acetate in patients with metastatic castration-resistant prostate cancer

Xiaolin Lu, Tao Dai, Xue Chen, Bin Wu, Hui Chen, Jitao Wu, Dexin Yu, Huixin Ge, Jian Li, Houbao Huang, Tiwu Fan, Linzhong Cheng, Xiaoping Zhang, Xuepei Zhang, Xin Yao, Junli Wei, Zhenqiang Xu, Wenzeng Yang, Chaohong He, Jiexin Luo, Ling Guan, Bin Fu, Qilin Wang, Xiaofeng Chen, Yongdong Zhang, Benkang Shi, Bin Zheng, Yong Wang, Hong Luo, Guoqiang Chen, Huan Wang, Quanren Wang, Dingwei Ye

Integrated palliative care and oncology: a realist synthesis

  • Open Access
  • Review

Natasha Bradley, Tracey McConnell, Carolyn Blair, Peter O’Halloran, Gillian Prue, Fiona Lynn, Nia Roberts, Geoff Wong, Elspeth Banks, Joanne Reid

Neoadjuvant short-course radiotherapy followed by camrelizumab and chemotherapy for locally advanced rectal cancer: 3-year survival from a phase 2 study

Zhenyu Lin, Peng Zhang, Ming Cai, Gang Li, Tao Liu, Kailin Cai, Jing Wang, Junli Liu, Hongli Liu, Weikang Zhang, Jinbo Gao, Chuanqing Wu, Linfang Wang, Zheng Wang, Zhiguo Hou, Hongyi Kou, Kaixiong Tao, Tao Zhang

COVID-19 infection history as a risk factor for early pregnancy loss: results from the electronic health record-based Southeast Texas COVID and Pregnancy Cohort Study

Micaela N. Sandoval, Michelle R. Klawans, MacKinsey A. Bach, Jennifer Mikhail, Edward A. Graviss, Tru Cao, Jacqueline G. Parchem, Junaid Husain, Eric Boerwinkle

Hepatic artery infusion of FOLFOX chemotherapy plus camrelizumab combined with sorafenib for advanced hepatocellular carcinoma in Barcelona Clinic Liver Cancer stage C (Double-IA-001): a phase II trial

Lujun Shen, Fei Cao, Ying Liu, Gulijiayina Nuerhashi, Letao Lin, Hontong Tan, Chunyong Wen, Yujia Wang, Shuanggang Chen, Hongliang Zou, Lin Xie, Weijun Fan

Frailty-free life expectancy and its association with socio-economic characteristics: an analysis of the English Longitudinal Study of Ageing cohort study

  • Open Access
  • Research

David R. Sinclair, Asri Maharani, Andrew Kingston, Terence W. O’Neill, Fiona E. Matthews

Physical therapy vs. glucocorticoid injection in patients with meniscal tears and knee osteoarthritis: a multi-center, randomized, controlled trial

Mingzhu Lee, Chao Jing, Kainan Lee

Discovery and validation of a novel dual-target blood test for the detection of hepatocellular carcinoma across stages from cirrhosis

Wenhao Teng, Hui Li, Hao Yang, Yu Chen, Liying Xi, Fuli Xin, Aiyuan Zhang, Lihui Yu, Lu Zheng, Ming Wang, Jian Bai, Fayong Ke, Yin Wang, Fuming Sun, Hui Zhang, Lin Wu, Jingfeng Liu

Understanding the underlying systems dynamics contributing to the continued predominance of the unhealthy motorway food environment in the Netherlands: identifying leverage points and actions for change

  • Open Access
  • Research

Lisanne Geboers, Coosje Dijkstra, Frédérique C. Rongen, Sanne K. Djojosoeparto, Maartje P. Poelman

Disease and mortality trajectories of cognitively able autistic individuals in mid- and later adulthood

Yiwei Pu, Feng Li, Tailin Zhu, Jiong Li, Wei Zhou, Lingli Zhang, Jingyu Chen, Qianlong Zhang, Tai Ren, Fei Li

Phenotypic and genotypic characteristics of macrolide, lacosamide, and streptogramin resistance in clinically resistant Streptococci and their correlation with reduced biocide susceptibility

Safaa A. Abdel-Karim, Fathy M. Serry, Eman M. Elmasry, Wael A. H. Hegazy

Major depressive disorder recognition based on electronic handwriting recorded in psychological tasks

  • Open Access
  • Research

Chong Li, Kunxue Zhang, Qunxing Lin, Shan Huang, Wanying Cheng, Yueshiyuan Lei, Xinyu Zhao, Jiubo Zhao

Exploring metabolomics for colorectal cancer risk prediction: evidence from the UK Biobank and ESTHER cohorts

Teresa Seum, Rafael Cardoso, Joshua Stevenson-Hoare, Bernd Holleczek, Ben Schöttker, Michael Hoffmeister, Hermann Brenner

Outcomes and cost-effectiveness of an integrated holistic care package on persons affected by podoconiosis, lymphatic filariasis and leprosy and community members in north-western Ethiopia: an implementation research study

Oumer Ali, Awoke Mihretu, Natalia Hounsome, Vasso Anagnostopoulou, Stephen A. Bremner, Mersha Kinfe, Asrat Mengiste, Maya Semrau, Abebaw Fekadu, Gail Davey

Gut microbiota-derived glutathione from metformin treatment alleviates intestinal ferroptosis induced by ischemia/reperfusion

Fangyan Wang, Xinyu Wang, Chaoyi Wang, Wangxin Yan, Junpeng Xu, Zhengyang Song, Mingli Su, Jingjing Zeng, Qiannian Han, Gaoyi Ruan, Eryao Zhang, Wantie Wang

Higher adherence to the EAT-Lancet reference diet is inversely associated with mortality in a UK population of cancer survivors

  • Open Access
  • Research

Nena Karavasiloglou, Alysha S. Thompson, Giulia Pestoni, Flurina Suter, Keren Papier, Aedín Cassidy, Tilman Kühn, Sabine Rohrmann

The portfolio dietary pattern and risk of cardiovascular disease mortality during 1988–2019 in US adults: a prospective cohort study

Meaghan E. Kavanagh, Andreea Zurbau, Andrea J. Glenn, Julianah O. Oguntala, Robert G. Josse, Vasanti S. Malik, Laura Chiavaroli, Simin Liu, Cyril W. C. Kendall, David J. A. Jenkins, John L. Sievenpiper

Comparative risk of severe constipation in patients treated with opioids for non-cancer pain: a retrospective cohort study in Northwest England

  • Open Access
  • Research

Belay Birlie Yimer, Mehreen Soomro, John McBeth, Carlos Raul Ramirez Medina, Mark Lunt, William G. Dixon, Meghna Jani

Unveiling lipoprotein subfractions signature in high-FNPO PCOS: implications for PCOM diagnosis and risk assessment using advanced machine learning models

Xueqi Yan, Ziyi Yang, Hui Zhao, Gengchen Feng, Shumin Li, Yimeng Li, Yu Sun, Jinlong Ma, Han Zhao, Xueying Gao, Shigang Zhao

Physical disability and psychological distress before and after a diagnosis of cancer: evidence on multiple cancer types from a large Australian cohort study, compared to people without a cancer diagnosis

  • Open Access
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Yuehan Zhang, Joanne Thandrayen, Kay Soga, Marianne Weber, Bogda Koczwara, Rebekah Laidsaar‑Powell, Chloe Yi Shing Lim, Grace Joshy, Emily Banks

Optimising digital advance care planning implementation in palliative and end-of-life care: a multi-phase mixed-methods national research programme and recommendations

  • Open Access
  • Research

Matthew J. Allsop, Jacqueline Birtwistle, Michael I. Bennett, Andy Bradshaw, Paul Carder, Catherine J. Evans, Robbie Foy, Ciara Heavin, Barbara Hibbert, Pablo Millares Martin, Sam D. Relton, Suzanne H. Richards, Maureen Twiddy, Katherine E. Sleeman

Marburg virus disease in Rwanda: an observational study of the first 10 days of outbreak response, clinical interventions, and outcomes

  • Open Access
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Gashaija Absolomon, Canita R. Brent, Emmanuel C. Nyabyenda, Kelly Mwiza, Piero Irakiza, Zuki Chiwandire, Caroline Mudereri, Nathalie Umutoni, Sabine Musange, Eric Seruyange, Felix K. Rubuga, Theogene Twagiramugabe, Sanctus Musafiri, Edson Rwagasore, Jeanine Condo

Associations of pretreatment emotional distress with adherence to therapy for patients with locally advanced rectal cancer: a post hoc analysis of the Chinese FOWARC phase 3 randomized clinical trial

Lishuo Shi, Jianwei Zhang, Yanhong Deng

Smartwatch-monitored physical activity and myopia in children: a 2-year prospective cohort study

Daixi Chen, Jingjing Wang, Jun Chen, Meng Lu, Yuchen Du, Ziyan Zhu, Padmaja Sankaridurg, Zhuoting Zhu, Bo Zhang, Linlin Du, Jinliuxing Yang, Xiangui He, Xun Xu

Correction: Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals

  • Open Access
  • Correction

Timur Liwinski, Matthias K. Auer, Johanna Schröder, Ina Pieknik, Christian Casar, Dorothee Schwinge, Lara Henze, Günter K. Stalla, Undine E. Lang, Alina von Klitzing, Peer Briken, Thomas Hildebrandt, Jeanne C. Desbuleux, Sarah V. Biedermann, Paul-Martin Holterhus, Corinna Bang, Christoph Schramm, Johannes Fuss

Total and regional fat-to-muscle mass ratio and risks of pan-cancer: a prospective cohort study

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Ruizhi Wang, Yudi Xu, Yuyuan Zhang, Yushuai Wu, Anning Zuo, Shutong Liu, Yuhao Ba, Hui Xu, Siyuan Weng, Zhaokai Zhou, Hongxuan Ma, Peng Luo, Quan Cheng, Xinwei Han, Zaoqu Liu

Economic burden attributable to high BMI-caused cancers: a global level analysis between 2002 and 2021

Jiacheng Zheng, Laiang Yao, Katie Lei, Wanying Huang, Yi Jie Zhou Luo, Priscilla Hui–Xuan Tran, Aaron Guan, Yueyi Qiu, Yusuff Adebayo Adebisi, Don Lucero-Prisno Eliseo III, Claire Chenwen Zhong, Martin C.S. Wong, Junjie Huang

Slowing fetal growth velocity from the mid-trimester may signal increased risks of perinatal morbidity and mortality: a retrospective cohort study

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Chloe Jamieson-Grigg, Pawel Kalinowski, Stephen Tong, Esther Turner, Sarah A. Banting, Susan P. Walker, Teresa M. MacDonald

Is a voluntary healthy food policy effective? evaluating effects on foods and drinks for sale in hospitals and resulting policy changes

Cliona Ni Mhurchu, Magda Rosin, Stephanie Shen, Bruce Kidd, Elaine Umali, Yannan Jiang, Sarah Gerritsen, Sally Mackay, Lisa Te Morenga

Excessive iron accumulation in the striatum associated with addictive behaviors of medication-overuse headache: a prospective study

Xun Pei, Xiaoyan Bai, Xue Zhang, Zhangxuan Hu, Wei Wang, Xueyan Zhang, Yingkui Zhang, Hefei Tang, Yaqing Zhang, Xueying Yu, Ziyu Yuan, Peng Zhang, Tong Chen, Yuanbin Zhao, Xiuqin Jia, Qi Yang, Yonggang Wang, Binbin Sui

Intrathecal pemetrexed efficacy and cerebrospinal fluid tumor marker response in refractory leptomeningeal metastasis of non-small-cell lung cancer: a single-arm phase II trial

Qingsheng Xu, Kaiyuan Huang, Luqing Tong, Danfang Yan, Yilei Zhao, Hanjin Yang, Weili Jin, Luyuan Zhang, Jinquan Cai, Qun Chen

Effectiveness of socioecological model-guided, smart device-based, and self-management-oriented lifestyle (3SLIFE) intervention on healthy lifestyles and metabolic syndrome risk in community residents: a cluster-randomized controlled trial

  • Open Access
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Bin Yu, Yuchen Li, Chunlan Ma, Jan D. Reinhardt, Qingyu Dou, Haojiang Zuo, Xue Yang, Ming Li, Changwei Cai, Yunzhe Fan, Zixing Huang, Tong Pang, Qi Tang, Fen Yang, Tingting Ye, Peng Jia, Shujuan Yang

Widening gap in life expectancy between patients with heart failure living in most and least deprived areas: a longitudinal cohort study

O. I. Brown, M. Drozd, H. MacGowan, M. McGinlay, R. Burgess, S. Straw, A. D. Simms, V. K. Gatenby, A. Sengupta, A. M. N. Walker, C. Saunderson, M. F. Paton, K. I. Bridge, J. Gierula, K. K. Witte, R. M. Cubbon, M. T. Kearney

Targeted limbic self-neuromodulation for alleviating central sensitization symptoms in fibromyalgia

Ayelet Or-Borichev, Yulia Lerner, Yael Hamrani, Guy Gurevitch, Netali Mor, Maayan Doron, Noam Sarna, Jacob N. Ablin, Talma Hendler, Haggai Sharon

Disentangling the divergent causal pathways underlying the association between body mass index and bone mineral density: a comprehensive Mendelian randomization study

Xunying Zhao, Lin He, Xueyao Wu, Li Zhang, Jinyu Xiao, Changfeng Xiao, Yang Qu, Jingwei Zhu, Chenjiarui Qin, Deqin Huang, Pengyue Shen, Tao Han, Mengyu Fan, Jiayuan Li, Stephen Burgess, Xia Jiang

Exploring the link between age at menarche, anthropometry and body fat composition with type II diabetes in a Singapore multi-ethnic cohort

Paula Benny, Qian Yang, Beverly Wen-Xin Wong, Cuilin Zhang, Eu-Leong Yong, Ling-Jun Li, Zhongwei Huang

Compliance to tobacco and alcohol zoning regulations around schools in Bangladesh, India, Pakistan and Sri Lanka using environmental mapping data

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Lathika Athauda, Zoey Verdun, Petya Atanasova, Sajjad Ahmad, Ali Ahsan, Md Mokbul Hossain, Menka Loomba, Rajendra Pradeepa, Vindya Rajakaruna, Manuja Kaluarachchi, Anuradhani Kasturiratne, Khadija Irfan Khawaja, Malay K. Mridha, Prasad Katulanda, Vinitaa Jha, Ranjit Mohan Anjana, John C. Chambers, Gary Frost, Franco Sassi, Marisa Miraldo

A highly scalable deep learning language model for common risks prediction among psychiatric inpatients

Enzhao Zhu, Jiayi Wang, Guoquan Zhou, Chunbo Li, Fazhan Chen, Kang Ju, Liangliang Chen, Yichao Yin, Yi Chen, Yanping Zhang, Xu Zhang, Xinlin Zhou, Zongyuan Wang, Jianping Qiu, Hui Wang, Weizhong Shi, Feng Wang, Dong Wang, Zhihao Chen, Jiaojiao Hou, Hui Li, Zisheng Ai

A matters arising: discussion on urokinase dosing and individualized treatment strategies in the TRUST trial

Yue Qiao, Xunming Ji, Wenbo Zhao

Effect of human papillomavirus infection on semen quality and assisted reproductive technology outcomes: a prospective observational cohort study

Sara Stigliani, Erika Coppo, Maria Bonaffini, Elena Maccarini, Francesca Bovis, Ida Casciano, Claudia Massarotti, Fausta Sozzi, Anna Marchese, Paola Scaruffi, Paola Anserini

Investigating the associations between weekend catch-up sleep and insulin resistance: NHANES cross-sectional study

Xianling Liu, Aihui Chu, Xiahao Ding

Adults in Ghana generate higher and more durable neutralising antibody titres following primary course COVID-19 vaccination than matched UK adults: The HERITAGE Study

Eliza Mari Kwesi-Maliepaard, Yakubu Alhassan, Emmanuel K. Quaye, Vera M. Kotey, Aisha M. Mohammed, Seth Agyemang, Adelaide K. Sromani, Stephanie Darko, Erica Buadii, Randy Tackie, Harry Akligoh, Barikisu Ibrahim, David Hutchful, Lily Paemka, Emmanuella Amoako, Joyce M. Ngoi, Aida Manu, Emmanuel Agbeli, Wisdom Akotia, Susan Amoako, Apetsi Ampiah, Charles Ansong, Seyram B Atukpa, Wisdom Aveey, Frank Danquah, Stephen L Darkoh, Patricia Kaba, Ruth Kiome, Esmy Kotey, Silas Lawer, David Greenwood, Edward J. Carr, Mary Y. Wu, David L. V. Bauer, Emma C. Wall, Lorin Adams, Karen Ambrose, Philip Bawumia, James Bazire, Rupert Beale, Bobbi Clayton, Tumena Corrah, Giulia Dowgier, Ashley S Fowler, Joshua Gahir, Steve Gamblin, Sonia Gandhi, Richard Gilson, Ruth Harvey, Agnieszka Hobbs, George Kassiotis, Gavin Kelly, Sven Kjar, Vincenzo Libri, Murad Miah, Mauro Miranda, Nicola O’Reilly, Padmasayee Papineni, Callie Smith, Phoebe Stevenson-Leggett, Charles Swanton, Scott Warchal, Bryan Williams, Dzifa Dey, Abdul Razak Quao, Akosua Ayisi, Kwame Amponsa-Achiano, Franklin Asiedu Bekoe, Gordon Awandare, Peter K. Quashie, Yaw Bediako

Transarterial chemoembolization plus apatinib for unresectable hepatocellular carcinoma: a multicenter, randomized, open-label, phase III trial

Xue-Feng Kan, Bin Liang, Xiao-Lin Zhang, Lei Yu, Yao-Chang Luo, Shi Zhou, Rui-Bao Liu, Guo-Hui Xu, Hai-Liang Li, Zheng-Yin Liao, Hua Xiang, Wei Lu, Lin-Feng Xu, Yi-Long Ma, Xiang-Wen Xia, Kun Qian, Xiang-Jun Dong, Fu Xiong, Song-Lin Song, Chang Zhao, Ming Huang, Chuan-Sheng Zheng

Interpreting results from biomarker-guided clinical trials: avoiding “negative” or “failed” terminology

Nurulamin M. Noor, Haiyan Zheng, David S. Robertson, Joshua Savage, Christina Yap, Andrea L. Jorgensen, James M. S. Wason

Cost-effectiveness of risk model-based lung cancer screening in smokers and nonsmokers in China

Tiantian Zhang, Yue Wang, Xuechen Chen, Xueer Yang, Leyao Zhang, Nagham Bazzi, Ling Bai, Aaron Finley, Jie Jiang, Jianxing He, Wenhua Liang

The regulatory variant rs1950834 confers the risk of depressive disorder by reducing LRFN5 expression

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Di Luan, Yifan Li, Aini Zhang, Qingqing Bai, Te Zhao, Xi Chen, Xinglun Dang, Junyang Wang, Shaolei Jiang, Yun Sun, Yingjie Zhu, Yan Kong, Xiong-Jian Luo, Zhijun Zhang

Increased weight-load improves body composition by reducing fat mass and waist circumference, and by increasing lean mass in participants with obesity: a single-centre randomised controlled trial

Jakob Bellman, Klaas Westerterp, Loek Wouters, Marit Johannesson, Niklas Lundqvist, Joel Kullberg, Christel Larsson, Mikael Gustafsson, Stefan Pettersson, Jonatan Fridolfsson, Daniel Arvidsson, Mats Börjesson, Dan Curiac, John-Olov Jansson, Per-Anders Jansson, Claes Ohlsson

Patterns of left ventricular trabeculation in hypertrophic cardiomyopathy

Yu Zhang, Di Zhou, Yuming Zhu, Qiya Huang, Jizheng Wang, Channa Zhang, Lianming Kang, Minjie Lu, Lei Song

Childhood maltreatment and depression: mediating role of lifestyle factors, personality traits, adult traumas, and social connections among middle-aged and elderly participants

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Xuemei Wang, Zhi Cao, Shaohua Yin, Tingshan Duan, Tao Sun, Chenjie Xu

Connection between trajectory of primary cancer monitoring indicators and mortality after cancer in South Korea

  • Open Access
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Jung Hyun Kim, Haedong Kim, Man S. Kim, Mison Chun, Jaeyong Shin

Exploring the pathways linking fasting insulin to coronary artery disease: a proteome-wide Mendelian randomization study

Xin Huang, Jie V. Zhao

The effect of clonal hematopoiesis on long-term outcomes in patients undergoing coronary artery bypass grafting

  • Open Access
  • CABG
  • Research

Zhiwei Zeng, Fangzhou Li, Shujie Gai, Runze Chen, Peng Wang, Juncheng Wang, Yuhui Yang, Jinhua Chen, Xingyi Zhang, Xueying Wang, Yi Han, Chuxiang Lei, Xi Li, Hanning Liu, Zhe Zheng

Safety and efficacy of sirolimus combined with cyclosporine in primary membranous nephropathy: a randomized controlled trial

Fang Wang, Chao Yang, Yue Shu, Cai-xia Lin, Yao Yao, Yue Li, Yi-miao Zhang, Xin Wang, Li-qiang Meng, Xu-yang Cheng, Gang Liu, Ming-hui Zhao, Zhao Cui

Sex-related absolute inequalities in tuberculosis incidence in 47 countries in Africa

Aliu Mohammed, Richard Gyan Aboagye, Precious Adade Duodu, Qorinah Estiningtyas Sakilah Adnani, Florence Gyembuzie Wongnaah, Abdul-Aziz Seidu, Bright Opoku Ahinkorah

Rapid diagnosis of adult-type diffuse glioma using a layered scheme

Jinsong Wu, Shuai Wu, Dandan Cao, Zhang Xiong, Jianhua Zhang, Yourui Zou, Zanyi Wu, Yanli Nie, Chen Luo, Ye Yao, Yanyan Song, Yuchen Jiao, Hong Chen, Hui Ma, Dezhi Kang, Ying Mao, Hai Yan

Evaluating metabolome-wide causal effects on risk for psychiatric and neurodegenerative disorders

Lachlan Gilchrist, Julian Mutz, Pirro Hysi, Cristina Legido-Quigley, Sulev Kõks, Cathryn M. Lewis, Petroula Proitsi

High-risk human papillomavirus testing in first-void urine as a novel and non-invasive cervical cancer screening modality—a Danish diagnostic test accuracy study

Mette Tranberg, Severien Van Keer, Jørgen Skov Jensen, Pia Nørgaard, Line Winther Gustafson, Anne Hammer, Pinar Bor, Karen Omann Binderup, Christina Blach, Alex Vorsters

Unsupervised learning-based quantitative analysis of CT intratumoral subregions predicts risk stratification of bladder cancer patients

Ying Wang, Hexiang Wang, Na Li, Siyu Wu, Rongchao Shi, Kui Sun, Ximing Wang

Device-measured physical activity and adiposity in schoolchildren: a 30-week follow-up study

Eva Rodríguez-Gutiérrez, Vicente Martínez-Vizcaíno, Irene Sequí-Domínguez, Sergio Núñez de Arenas-Arroyo, Pontus Henriksson, Ángel Herraiz-Adillo, Ana Torres-Costoso

Associations of aortic and carotid artery health with cerebrovascular markers and cognition in older adults from the Whitehall II imaging study

Georgina Hobden, Graham Reid, Scott T. Chiesa, Congxiyu Wang, Lucy Jobbins, Clare E. Mackay, Alun D. Hughes, Klaus P. Ebmeier, Jemma Pitt, Mika Kivimäki, Archana Singh-Manoux, Sana Suri

Lactate links exercise to synaptic protection and cognitive enhancement in Alzheimer’s disease models

Hao Han, Yi Wu, Ru Mi, Cijia Zhang, Fengying Guan, Xiaoyan Lu, Guangwei Zhang, Zhaojie Meng, Li Chen, Ming Zhang

SARS-CoV-2-specific humoral immunity in a Norwegian cohort between 2020 and 2023

Marjut Sarjomaa, Kristine Karlsrud Berg, Keson Jaioun, Yngvar Tveten, Hege Kersten, Harald Reiso, Randi Eikeland, Carina Thilesen, Svein Arne Nordbø, Ingeborg S. Aaberge, Neil Pearce, Anne Kristin Moeller Fell

Impact of multifaceted health education on influenza vaccination health literacy in primary school students: a cluster randomized controlled trial

Jingyi Chen, Weiguang Xie, Xuehua Huang, Anzhong Huang, Tingyu Lu, Ruihang Zhang, Jingyi Xiao, Shaoyi He, Jiao Wang, Lin Xu

Alleviating cognitive impairments in bipolar disorder with a novel DTI-guided multimodal neurostimulation protocol: a double-blind randomized controlled trial

Minmin Wang, Hetong Zhou, Xiaomei Zhang, Qianfeng Chen, Qiqi Tong, Qiai Han, Xudong Zhao, Dandan Wang, Jianbo Lai, Hongjian He, Shaomin Zhang, Shaohua Hu

The indirect effect of the bivalent human papillomavirus vaccination program: an observational cohort study

Marit Middeldorp, Janneke W. Duijster, Mirjam J. Knol, Birgit H. B. van Benthem, Johannes Berkhof, Audrey J. King, Hester E. de Melker

Intraoperatively preventive intraperitoneal perfusion chemotherapy with lobaplatin in colorectal cancer: a prospective, randomised, controlled, multicentre study

Hao Su, Rui Zhang, Yunfeng Li, Yanke Li, Wei Pei, Zhigang Jie, Zhimin Liu, Meijin Huang, Jing Zhuang, Qian Jiang, Ming Xie, Guiying Wang, Wenbin Zhang, Ming Liu, Jiansi Chen, Zejun Wang, Kang Wang, Xinghong Zhang, Guoxin Li, Xiangfu Zeng, Xinxiang Li, Xuejun Sun, Ju Wang, Dongzhu Zeng, Changlong Zhuang, Haitao Zhou, Xishan Wang

Circulating short-chain fatty acids and Mediterranean food patterns. A potential role for the prediction of type 2 diabetes risk: The Di@bet.es Study

Gemma Llauradó, Lídia Cedó, Elisenda Climent, Joan Badia, Gemma Rojo-Martínez, Juana Flores-Le Roux, Oscar Yanes, Maria Vinaixa, Minerva Granado-Casas, Didac Mauricio, Sonia Fernández-Veledo, Joan Vendrell

The impact of GnRH agonists on endometrial immune cells in patients with adenomyosis: a prospective cohort study

Anna Lena Zippl, Christiana Kyvelidou, Monika Frank, Elisa Gapp, Elisabeth Reiser, Anne-Sophie Braun, Katharina Feil, Stefanie Schuchter, Patrick Rockenschaub, Bettina Toth, Beata Seeber

Projected health and economic effects of nonavalent versus bivalent human papillomavirus vaccination in preadolescence in the Netherlands

Birgit Sollie, Johannes Berkhof, Johannes A. Bogaards

Short-term mortality after opioid initiation among opioid-naïve and non-naïve patients with dementia: a retrospective cohort study

Yeon-Mi Hwang, Jennifer M. Hah, Jennifer E. Bramen, Jennifer J. Hadlock, Tina Hernandez-Boussard

Microbiota boost immunotherapy? A meta-analysis dives into fecal microbiota transplantation and immune checkpoint inhibitors

Anqi Lin, Lihaoyun Huang, Aimin Jiang, Lingxuan Zhu, Weiming Mou, Yu Li, Chunyan Zhang, Zaoqu Liu, Jian Zhang, Quan Cheng, Ting Wei, Peng Luo

Artificial intelligence-assisted diagnosis and prognostication in low ejection fraction using electrocardiograms in inpatient department: a pragmatic randomized controlled trial

Dung-Jang Tsai, Chin Lin, Wei-Ting Liu, Chiao-Chin Lee, Chiao-Hsiang Chang, Wen-Yu Lin, Yu-Lan Liu, Da-Wei Chang, Ping-Hsuan Hsieh, Chien-Sung Tsai, Yuan-Hao Chen, Yi-Jen Hung, Chin-Sheng Lin

Longitudinal plasma amino acids during pregnancy and neonatal anthropometry: findings from the NICHD Fetal Growth Studies-Singleton Cohort

  • Open Access
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Claire Guivarch, Jing Wu, Ruijin Lu, Jagteshwar Grewal, Guoqi Yu, Ling-Jun Li, Jiaxi Yang, Wei Wei Pang, Dong D. Wang, Natalie L. Weir, Zhen Chen, Michael Y. Tsai, Cuilin Zhang

Nut consumption, linoleic and α-linolenic acid intakes, and genetics: how fatty acid desaturase 1 impacts plasma fatty acids and type 2 diabetes risk in EPIC-InterAct and PREDIMED studies

  • Open Access
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Susanne Jäger, Olga Kuxhaus, Marcela Prada, Inge Huybrechts, Tammy Y. N. Tong, Nita G. Forouhi, Cristina Razquin, Dolores Corella, Miguel A. Martinez-Gonzalez, Christina C. Dahm, Daniel B. Ibsen, Anne Tjønneland, Jytte Halkjær, Chloé Marques, Claire Cadeau, Xuan Ren, Verena Katzke, Benedetta Bendinelli, Claudia Agnoli, Alberto Catalano, Marta Farràs, Maria-Jose Sánchez, María Dolores Chirlaque López, Marcela Guevara, Dagfinn Aune, Stephen J. Sharp, Nicholas J. Wareham, Matthias B. Schulze

Fusion analysis of sMRI-DTI in patients with ulcerative colitis by multimodal CCA + joint ICA and associated neurotransmitter profiles

Chengxiang Liu, Zi Wei, Jian Tang, Yintao Liu, Jingdong Lu, Yujia Li, Xin Liu, Peng Liu, Fenrong Chen

Platelets in preeclampsia: an observational study of indices associated with aspirin nonresponsiveness, activation and transcriptional landscape

Gashaw Garedew Woldeamanuel, Kenean Getaneh Tlaye, Xueqin Wang, Long Nguyen-Hoang, Qiongjie Zhou, Yinan Wang, Bo Wah Leung, Yao Wang, Liona C. Poon, Chi Chiu Wang

Association of biological aging acceleration transitions and burdens with incident cardiovascular disease: longitudinal insights from a national cohort study

  • Open Access
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Xin Zhang, Yu Yan, Yuxin Liu, Zixin Wang, Yuchen Jiang, Shuo Zhang, Tongda Xu, Ke Wang, Chu Zheng, Ping Zeng

Maternal immune-mediated conditions and ADHD risk in offspring

Kjersti Mæhlum Walle, Kristin Gustavson, Siri Mjaaland, Ragna Bugge Askeland, Per Magnus, Ezra Susser, W. Ian Lipkin, Camilla Stoltenberg, Michaeline Bresnahan, Ted Reichborn-Kjennerud, Mady Hornig, Helga Ask

Metformin-improved cognitive impairment in patients with schizophrenia is correlated with activation of tricarboxylic acid cycle and restored functional connectivity of hippocampus

Jingda Cai, Jingmei Xiao, Yujun Long, Ting Cao, Chenquan Lin, Gangrui Hei, Weiyan Wang, Dongyu Kang, Jing Huang, Tiannan Shao, Hualin Cai, Renrong Wu

Low-level viremia increases the risk of diabetes mellitus in people with HIV in China: a 7-year retrospective longitudinal cohort study

Chunxing Tao, Liangjia Wei, Minn Thit Aung, Longyu Liao, Aidan Nong, Li Huang, Rongye Huang, Lijing Huang, Shuixia Wang, Xiaohuan Huang, Yanbing Yao, Li Ye, Hao Liang, Chuanyi Ning, Salma Gayed, Lijuan Bao, Bingyu Liang

A systematic review and network meta-analysis of interventions to preserve insulin-secreting beta cell function in people newly diagnosed with type 1 diabetes: results from randomised controlled trials of immunomodulatory therapies

Sophie E. Beese, Malcolm J. Price, Claire Tomlinson, Pawana Sharma, Isobel M. Harris, Ada Adriano, Lauren M. Quinn, Ritu Gada, Thomas J. Horgan, Fiona Maggs, Martin Burrows, Krishnarajah Nirantharakumar, G. Neil Thomas, Robert C. Andrews, David J. Moore, Parth Narendran

Association between vegetarian diet and risk of frailty in Chinese older adults: a prospective study

  • Open Access
  • Research

Yilun Huang, Guliyeerke Jigeer, Yuebing Lv, Kaiyue Wang, Xinyi Ma, Jiaojiao Zou, Ruiqi Xia, Xiuhua Shen, Xiaoming Shi, Yaqi Li, Xiang Gao

Risk thresholds for soft versus hard cardiovascular disease outcome models for initiating statin therapy among Chinese adults: a cost-utility analysis

  • Open Access
  • Research

Zhijia Sun, Haijun Zhang, Yinqi Ding, Canqing Yu, Dianjianyi Sun, Yuanjie Pang, Pei Pei, Ling Yang, Yiping Chen, Huaidong Du, Dan Huang, Xiaoming Yang, Maxim Barnard, Robert Clarke, Junshi Chen, Zhengming Chen, Liming Li, Jun Lv

Long-term exposure to multiple air pollutants and multi-level socioeconomic status: joint effects on age-related macular degeneration, subsequent ocular comorbidity, and death in middle-aged and older adults

Yang Yang, Liangkai Chen, Qichen Liu, Min Mu, Jing Huang, Guangming Zhang, Qianqian Song

Pediatric computed tomography scan and subsequent risk of malignancy: a nationwide population-based cohort study in Korea using National Cancer Institute dosimetry system for computed tomography (NCICT)

Sangsoo Han, Jaewan Soh, Sangun Nah, Kyungdo Han, Jin-Hyung Jung, Jiwon Park, YoonJoong Hwang, Choonsik Lee, Jae-Young Hong

Physiological serum uric acid concentrations correlate with arterial stiffness in a sex-dependent manner

  • Open Access
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Oliver Thews, Thomas Schmid, Alexander Kluttig, Andreas Wienke, Melanie Zinkhan, Wolfgang Ahrens, Till Bärnighausen, Hermann Brenner, Stefanie Castell, Berit Lange, Wolfgang Lieb, Karin Halina Greiser, Marcus Dörr, Lilian Krist, Stefan N. Willich, Volker Harth, Nadia Obi, Michael Leitzmann, Annette Peters, Börge Schmidt, Matthias B. Schulze, Henry Völzke, Matthias Nauck, Stephanie Zylla, Anke Hannemann, Tobias Pischon, Ilais Moreno Velásquez, Matthias Girndt, Claudia Grossmann, Michael Gekle

Impact of kindergarten structures on the dynamics of hand, foot, and mouth disease and the effects of intervention strategies: an agent-based modeling study

Qing Zou, Xin-Fu Shi, Chang-Wei Liang, Meng-Meng Ma, Jing-Hua Li, Jing Gu, Ying-Si Lai

Prevalence and attributes of cervicovaginal human papillomavirus infection among a 35-year- age- cohort of ever-married women in a district of Sri Lanka: a cross-sectional study

K. C. M. Perera, N. Mapitigama, H. T. C. S. Abeysena

Causal link between humid heatwaves and ischemic heart disease: assessing hospitalizations and economic burden across 955 Chinese counties

  • Open Access
  • Research

Teng Wang, Hanxu Shi, Zhisheng Liang, Haojun Fan, Taojiang Meng, Fan Dai, Wei Huang, Ming Xu, Huining Yang, Shyam Biswal, Murugappan Ramanathan, Gorden G. Liu, Minghui Ren, Shengzhi Sun, Zhenyu Zhang

Policy implementation and recommendations to address the double burden of malnutrition in South Africa: expert assessment using the expanded Healthy Food Environment Policy Index (Food-EPI)

Nicole Holliday, Peter Delobelle, Carmen Klinger, Zandile June-Rose Mchiza, Olufunke Alaba, Stefanie Vandevijvere, Peter von Philipsborn, Karin Geffert

Physical activities, longevity gene, and all-cause mortality among older adults: a prospective community-based cohort study

  • Open Access
  • Research

Lanjing Xu, Jun Wang, Xinwei Li, Yang Li, Chen Chen, Zinan Xu, Yuan Xia, Zihan Lu, Jinghui Zhou, Min Zhang, Yuan Wei, Bing Wu, Zheng Zhang, Fangyu Li, Yufei Luo, Guangdi Chen, Yuebin Lv, Xiaoming Shi

Impact of antihypertensive drug classes on cardiovascular outcomes: insights from the STEP study

Xinyi Peng, Michael Hecht Olsen, Manan Pareek, Jingjing Bai, Yang Liu, Qirui Song, Jun Cai

Cost-effectiveness of self-sampling and enhanced strategies for HPV prevention among men who have sex with men in China: a modeling study

Zhen-Hao Wu, Yu-Jing An, Zhen-Xing Chu, Xin-Ru Li, An-Yang Hou, Yong-Jun Jiang, Qing-Hai Hu

Cross-national differences in the association between estimated cardiorespiratory fitness and depressive symptoms among older adults: findings from three nationwide cohort studies

  • Open Access
  • Research

Xue He, Cong Li, GuangYao Hua, Yan Wang, Lijun Zhang, Chingyu Cheng, Jinghua Jiao, Honghua Yu, Xiaohong Yang, Lei Liu

A conceptual model of factors potentially influencing prescribing decisions for chronic conditions: an overview of systematic reviews

  • Open Access
  • Research

Matthew Gittus, Alicia O’Cathain, Katherine Miller, Anja Oklopcic, Albert C. Ong, James Fotheringham

Sympathetic reactivity to physiological stress is associated with expanded cardiac extracellular volume in humans

Hazel C. Blythe, Zoe H. Adams, Katrina A. Hope, Richard P. Baker, Melanie J. Hezzell, M. Saadeh Suleiman, Ana Paula Abdala Sheikh, Nathan Manghat, Konstantina Mitrousi, Angus K. Nightingale, Emma C. Hart

Early weaning from oxygen therapy in African children with severe pneumonia

Kathryn Maitland, Elisa Giallongo, Mainga Hamaluba, Florence Alaroker, Robert O. Opoka, Abner Tagoola, Damalie Nalwanga, Eva Nabawanuka, William Okiror, Margaret Nakuya, Denis Aromut, Thomas N. Williams, Karen Thomas, David A. Harrison, Paul Mouncey, Andrew Bush, J. F. Fraser, Kathy Rowan, Peter Olupot-Olupot, Sarah Kiguli

Effect of a ketogenic diet, time-restricted eating, or alternate-day fasting on weight loss in adults with obesity: a randomized clinical trial

José Ignacio Martínez-Montoro, Borja Bandera, Mario Gutiérrez-Bedmar, Ana María Gómez-Pérez, Manuel Macías-González, Isabel Moreno-Indias, Francisco J. Tinahones

Long-term efficacy and updated survival outcomes of sintilimab plus anlotinib in patients with PD-L1-positive recurrent or metastatic cervical cancer

Jing Liu, Chunyan Lan, Tongyu Liu, Qin Liu, Lele Chang, Lele Zang, Fei Zhu, Mingxuan Zhu, Huiqi Zhang, Yaxin Kang, Yuqin Wang, Huaiwu Lu, Yang Sun, Qin Xu

Temporal multimorbidity patterns and cluster identification: a longitudinal analysis of administrative data

Jennifer K. Ferris, Brandon Wagar, Alex Choi, Jonathan Simkin, Hind Sbihi, Kari Harder, Kate Smolina

The promoting effects of digital targeted cognitive training in medication treatment for children with ADHD: a randomized controlled trial

  • Open Access
  • Research

Chen Dang, Yu Zhu, Xiangsheng Luo, Lu Liu, Yuan Feng, Guisen Wu, Shaogen Zhong, Xin Wang, Jianzhao Zhang, Yike Zhu, Siqi Liu, Ziqi Liu, Li Qin, Xiaohui Ma, Yufeng Wang, Xiaoyi Wang, Jian Yang, Changming Wang, Li Sun

Differential effects of inulin and fructooligosaccharides on gut microbiota composition and glycemic metabolism in overweight/obese and healthy individuals: a randomized, double-blind clinical trial

  • Open Access
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Jie Li, Feitong Liu, Yuemei Luo, Anisha Wijeyesekera, Shan Wang, Xiaojiao Chen, Yamei Lv, Jing Jin, Huafang Sheng, Guopan Wang, Yuanan Wei, Zhuang Li, Muxuan Chen, Hongwei Zhou

Molecular signatures of invasive and non-invasive pituitary adenomas: a comprehensive analysis of DNA methylation and gene expression

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Yike Chen, Ningning Zhao, Jiahao Zhang, Xinyi Wu, Jian Huang, Xiaohui Xu, Feng Cai, Sheng Chen, Liyin Xu, Wei Yan, Yuan Hong, Yunfei Wang, Hui Ling, Jianxiong Ji, Gao Chen, Hongcang Gu, Jianmin Zhang, Qun Wu

Comparison between mixed reality with artificial algorithms and ultrasound in localization of anterior thigh flap perforators: a prospective randomized controlled study

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Yixiu Liu, Wanlin Fan, Miao Yu, Jian Wu, Shuangjiang Wu, Lian Zhou, Qi Chen

Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings

Feiwen Wang, Jie Yang, Jun Yang, Peng Cheng, Wenjian Tan, Danqing Huang, Maoxing Zhong, Xiawei Liu, Weiqing Huang, Zhening Liu, Lena Palaniyappan

The impact of the COVID-19 pandemic on maternal healthcare costs: a time series analysis of pregnancies of multi-ethnic mothers in South London, United Kingdom

Alice McGreevy, Marina Soley-Bori, Florence Tydeman, Kathryn V. Dalrymple, Sara L. White, Asma Khalil, Lucilla Poston, Emma L. Duncan, Tisha Dasgupta, Hiten D. Mistry, Julia Fox-Rushby, Peter von Dadelszen, Laura A. Magee

Lactobacillus ameliorates myocardial ischemia reperfusion injury by attenuating apoptosis, inflammation, oxidative stress, and ferroptosis

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Yan Liang, Lili Zhao, Xu Zhang, Shan Liu, Pengju Lu, Jingxian Wang, Liqun Chen, Yin Liu, Jing Gao

Trend analysis and future predictions of global burden of alzheimer’s disease and other dementias: a study based on the global burden of disease database from 1990 to 2021

Miao Hao, Jiajun Chen

Disability in mitochondrial aerobic metabolism and Mg2+ transport: linking biomarkers and mechanisms of ischemic heart disease to diesel particulate matter exposure

Ze Zhang, Gan Miao, Juan Ma, Ziyuan Li, Chuer Zheng, Jian Ding, Hao Yin, Xiangcheng Cui, Shoujie Dai, Rifat Zubair Ahmed, Yong Niu, Shanfa Yu, Xiaoting Jin, Yuxin Zheng

Multisensory BCI promotes motor recovery via high-order network-mediated interhemispheric integration in chronic stroke

  • Open Access
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Rongrong Lu, Zhen Pang, Tianhao Gao, Zhijie He, Yiqian Hu, Jie Zhuang, Qin Zhang, Zhengrun Gao

Association of sociodemographic factors and comorbidity with non-receipt of medications for secondary prevention: a cohort study of 12,204 myocardial infarction survivors

Ike Dhiah Rochmawati, Jocelyn M. Friday, Daniel Ang, Tran Q. B. Tran, Clea du Toit, Alan Stevenson, Jim Lewsey, Daniel Mackay, Ruth Dundas, Bhautesh Jani, S. Vittal Katikireddi, Christian Delles, Sandosh Padmanabhan, Carlos Celis-Morales, Paul Welsh, Frederick K. Ho, Jill P. Pell

Evaluation of a national supermarket intervention supporting vulnerable families in healthy meal practices: a natural experiment

Marjolijn Vos, Viktor L. J. Proesmans, Anneleen Van Kerckhove, Benedicte Deforche, Nathalie Michels, Maartje P. Poelman, Wendy Van Lippevelde

Effectiveness of the WeChat-based mini-program (“Sober Time ACT”) on individuals with hazardous drinking in China: a randomized controlled trial

  • Open Access
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Chengcong Wu, Peiqiong Yang, Yuzhen Tang, Tianzhen Chen, Shuo Li, Shucai Huang, Jiang Du

Pre-pregnancy inflammatory and insulinemic dietary patterns and risk of gestational diabetes mellitus: a prospective cohort study of 14,674 women

  • Open Access
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Peipei Liu, Jiaxi Yang, Deirdre K. Tobias, Fred K. Tabung, Frank B. Hu, Cuilin Zhang

Cumulative health burden and adjustment challenges following road traffic injuries: a controlled prospective study

  • Open Access
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Ilaria Pozzato, Yvonne Tran, Mohit Arora, Candice McBain, James W. Middleton, Ian D. Cameron, Ashley Craig

Sex and gender considerations in randomized controlled trials in critical care nephrology: a meta-epidemiologic study

  • Open Access
  • Research

Nuttha Lumlertgul, Anyarin Wannakittirat, Janice Y. Kung, Nattachai Srisawat, David Collister, Emily J. See, Neesh Pannu, Ravindra L. Mehta, Danielle E. Soranno, Marlies Ostermann, Sean M. Bagshaw

Faecalibacterium prausnitzii promotes anti-PD-L1 efficacy in natural killer/T-cell lymphoma by enhancing antitumor immunity

Zhuangzhuang Shi, Wenxing Jiang, Hongwen Li, Yue Zhang, Weili Xue, Yingjun Wang, Mingzhi Zhang, Zhaoming Li

The genetic spectrum features of 2261 Chinese children with epilepsy and intellectual disability

Nan Pang, Chen Chen, Lifen Yang, Ciliu Zhang, Xiaolu Deng, Li Yang, Leilei Mao, Fangyun Liu, Guoli Wang, Haolin Duan, Xiaole Wang, Fei Yin, Fang He, Jing Peng

Predicting postoperative motor outcomes in the surgical management of Rolandic focal cortical dysplasia: the role of glucose metabolism

Weiyuan Luo, Bowen Yang, Xiaobin Zhao, Baotian Zhao, Chao Zhang, Xiu Wang, Jiajie Mo, Xiangzhi Lu, Zhong Zheng, Xiaoqiu Shao, Jianguo Zhang, Kai Zhang, Wenhan Hu

Exponential uptake of HPV self-collected cervical screening testing 2 years since universal availability in Victoria, Australia

Alvin Lee, David Hawkes, Daniel Sweeney, Kerryann Wyatt, Claire Nightingale, Corey Chalmers, Marion Saville

Objective sleep quality in diverse older adults: a cross-sectional study on the importance of race and ethnicity and sex

  • Open Access
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Clémence Cavaillès, Katie L. Stone, Yue Leng, Carrie Peltz, Kristine Yaffe

Associations and mediators of estimated sodium intake with cardiovascular mortality: data based on a national population cohort

  • Open Access
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Yuan Tian, Chunying Lin, Hui Zhong, Chaoqun Wu, Yi Wu, Bowang Chen, Xiaoyan Zhang, Xueke Bai, Yang Yang, Yanping Wang, Libo Hou, Jianlan Cui, Wei Xu, Lijuan Song, Hao Yang, Wenyan He, Yan Zhang, Weili Zhang, Haibo Zhang, Xi Li, Shengshou Hu

Smoking cessation for people accessing homeless support centres (SCeTCH): comparing the provision of an e-cigarette versus usual care in a cluster randomised controlled trial in Great Britain

  • Open Access
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Lynne Dawkins, Kirstie Soar, Francesca Pesola, Allison Ford, Caitlin Notley, Rachel Brown, Emma Ward, Lauren McMillan, Debbie Robson, Anna Varley, Charlotte Mair, Jessica Lennon, Janine Brierley, Amy Edwards, Peter Hajek, Allan Tyler, Steve Parrott, Jinshuo Li, Linda Bauld, Bethany Gardner, Sharon Cox

Evaluating the agreement between sensitivity and primary analyses in observational studies using routinely collected healthcare data: a meta-epidemiology study

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Jiayue Xu, Yuning Wang, Qiao He, Shuangyi Xie, Sheng Feng, Xiaofei Wang, Wen Wang, Xin Sun

Prevalence and progress of underdiagnosis of probable dementia: a repeated cross-sectional study in 19 European countries

Jiazhou Yu, Pengyun Wang, Shangkun Xie, Jay Amin, Christoph Mueller, Xiaohui Hou, Xi Chen, Benjamin R. Underwood, Shangfeng Tang, Shanquan Chen

Clinical outcomes of flomoxef versus cefmetazole in hospitalized patients with urinary tract infections: combined retrospective analyses of two real-world databases and in vitro data

Takahiro Niimura, Mitsuhiro Goda, Satoshi Nakano, Toshiki Kajihara, Koji Yahara, Aki Hirabayashi, Koji Miyata, Marie Ikai, Motoko Shinohara, Yusuke Minato, Masato Suzuki, Keisuke Ishizawa

Single low dose primaquine to block the transmission of Plasmodium falciparum—proposed stand-alone and ACT-adapted regimens

Walter R. J. Taylor, Peter Olupot-Olupot, Marie A. Onyamboko, Natenapa Chimjinda, Chiraporn Taya, Julie Nguyen Ngoc Pouplin, Thomas N. Williams, Kathryn Maitland, Caterina A. Fanello, Nicholas P. J. Day, Joel Tarning, Nicholas J. White, Mavuto Mukaka

The COVID-19 pandemic increased the incidence of newly diagnosed cancers: evidence from a large cohort study in Southern Italy

Valentina Trimarco, Raffaele Izzo, Daniela Pacella, Maria V. Manzi, Fahimeh Varzideh, Maria Lembo, Paola Gallo, Roberto Piccinocchi, Carmine Morisco, Francesco Rozza, Gaetano Piccinocchi, Michelangelo Mercogliano, Stanislovas S. Jankauskas, Giovanni Esposito, Raffaele Palladino, Gaetano Santulli, Bruno Trimarco

A scoping review of outcome selection and accuracy of conclusions in complex digital health interventions for young people (2017–2023): methodological proposals for population health intervention research

Claire Collin, Clara Eyraud, Philippe Martin, Morgane Michel, Enora Le Roux, Corinne Alberti

Enhancing protection against vector-borne diseases in forcibly displaced communities: evaluating the efficacy of spatial repellents for cutaneous leishmaniasis control in North-East Syria

Richard Allan, Ramona Scherrer, Ozge Erisoz Kasap, Laura Paris, Thomas Scott, Hendrik Sauskojus, Olivia Wetherill, Sara Estecha-Querol, Zaid Alkhalaf, Mehmet Karakus, Ayda Yilmaz, Bülent Alten, Louisa A. Messenger

Phase 1 trial of HR070803 (an Irinotecan liposome) in combination with 5-fluorouracil, leucovorin, and oxaliplatin for untreated advanced or metastatic pancreatic ductal adenocarcinoma

Qiang Xu, Xue Zhao, Xianze Wang, Ruizhe Zhu, Yuejuan Cheng, Tao Xia, Heshui Wu, He Tian, Yuping Sun, Mingjun Zhang, Chuntao Gao, Deliang Fu, Xiaojie Wu, Tongsen Zheng, Xiaoyu Yin, Yili Chen, Xiaobing Chen, Zhihua Li, Rufu Chen, Xue Yang, Huan Wang, Quanren Wang, Xiaohong Han, Wenming Wu

Chronic care provision in general practices and association with patient level outcomes: a nationwide cohort study

  • Open Access
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Anders Prior, Claus Høstrup Vestergaard, Nynne Bech Utoft, Peter Vedsted, Susan M. Smith, Mogens Vestergaard, Morten Fenger-Grøn

Predictors and outcomes associated with prolonged hospital length of stay in intracerebral hemorrhage: a multicenter prospective cohort study in China

Zhuangzhuang Zhang, Jieyu Li, Wenzhe Wang, Haowei Wang, Junlong Shu, Haiqiang Jin, Peng Sun, Craig S. Anderson, Zhaoxia Wang, Yining Huang, Weiping Sun

Molecular Mechanisms and Clinical Divergences in HPV-Positive Cervical vs. Oropharyngeal Cancers: A Critical Narrative Review

Canio Martinelli, Alfredo Ercoli, Silvana Parisi, Giuseppe Iatì, Stefano Pergolizzi, Luigi Alfano, Francesca Pentimalli, Michelino De Laurentiis, Antonio Giordano, Salvatore Cortellino

Dynamics of contact behaviour by self-reported COVID-19 vaccination and infection status during the COVID-19 pandemic in Germany: an analysis of two large population-based studies

Lena Böff, Antonia Bartz, Manuela Harries, Monika Strengert, Alex Dulovic, Nicole Schneiderhan-Marra, Stefanie Castell, Jana-Kristin Heise, Carolina Klett-Tammen, Gérard Krause, Pilar Hernandez, Daniela Gornyk, Monike Schlüter, Tobias Kerrines, Gerhard Bojara, Kerstin Frank, Knut Gubbe, Torsten Tonn, Oliver Kappert, Winfried V. Kern, Thomas Illig, Norman Klopp, Gottfried Roller, Michael Ziemons, Tom Berger, Madhav Chaturvedi, Christopher I. Jarvis, Nicole Rübsamen, Stefan Scholz, Jasmin Walde, Nils Bardeck, Wolfgang Bock, Michael Boehm, Laura-Inés Böhler, Johannes Bracher, Sebastian Contreras, Claudia Denkinger, Philipp Dönges, Cornelia Gottschick, Felix Guenther, Torben Heinsohn, Olga Hovardovska, Daniel Junker, Rolf Kaiser, Lisa Koeppel, Tyll Krueger, Alexander Kuhlmann, Patrick Marsall, Viola Priesemann, Ulrich Reinacher, Isti Rodiah, Melanie Schienle, Daniel Wolffram, André Karch, Annette Aigner, Veronika K. Jaeger, Berit Lange

Vagus nerve stimulation inhibits pyroptosis and improves outcome of cerebral ischemic stroke by upregulating osteopontin (SPP1) to disturb ASC oligomerization

Jun Wen, Hao Tang, Ling Wang, Qinghuan Yang, Yong Zhao, Yu Ren, Ting Qin, Xuemei Li, Jianfeng Xu, Gongwei Jia, Qin Yang

Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis

Xinwen Yan, Xinlong Lin, Jianhua Wu, Lijun Zheng, Yangyang Liu, Fang Wu, Ying Lin, Yishi Lu, Chongyang Huang, Binhai Shen, Hongbin Liu, Ruo Huang, Fengyi Hou, Qian Zhou, Mengyao Song, Ke Liu, Fangqing Zhu, Sheng Li, Yuqing Lin, Wei Wang, Ping Li, Wangjun Liao, Fachao Zhi

Prognostic and predictive microRNA panels for heart failure patients with reduced or preserved ejection fraction: a meta-analysis of Kaplan–Meier-based individual patient data

Reza Parvan, Victoria Becker, Milad Hosseinpour, Yousef Moradi, William E. Louch, Alessandro Cataliotti, Yvan Devaux, Michael Frisk, Gustavo Jose Justo Silva

Multi-dimensional sleep health and dementia risk: a prospective study in the UK Biobank

Tianyi Huang, May A. Beydoun, Sina Kianersi, Susan Redline, Lenore J. Launer

Do women need a change in dose of prescription drugs with onset of menopause? Time to find out

Iris E. C. Sommer, Bodyl A. Brand, Tanja R. Zijp, Marian J.E. Mourits, Daan J. Touw

Baseline functional connectivity of the basal forebrain-cortical circuit predict taVNS treatment response in primary insomnia: a randomized controlled trial and fMRI study

Meng Qi, Yiting Huang, Runru Mai, Zhaoxian Yan, Biyun Xu, Bo Liu, Yue Zhang

The unwell patient with advanced chronic liver disease: when to use each score?

Oliver Moore, Wai-See Ma, Scott Read, Jacob George, Golo Ahlenstiel

Increased prevalence of cardio-cerebrovascular risk factors during the COVID-19 pandemic lockdown: a large, single center, cross-sectional study

Jinjing Lu, Yanyan Shen, Xiaoying Liu, Yuqiang Mao, Li Jing, Zhiyong Yang, Dongmei Pei, Weiwei Dong

Sjögren’s syndrome is associated with a reduction in the surface area of the right caudal anterior cingulate gyrus

Ping Wang, Yunpeng Tai, Xiaofang Zhu, Xinyi Wan, An Sun, Jiajia Wang, Hui Cheng, Jingwei Hong, Yi Zhang, Xiaobing Wang

Obsessive-compulsive disorder in the World Mental Health surveys

Dan J. Stein, Ayelet Meron Ruscio, Yasmin Altwaijri, Wai Tat Chiu, Nancy A. Sampson, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Jordi Alonso, Stephanie Chardoul, Oye Gureje, Chiyi Hu, Elie G. Karam, John J. McGrath, Fernando Navarro-Mateu, Kate M. Scott, Juan Carlos Stagnaro, Yolanda Torres, Cristian Vladescu, Jacek Wciórka, Miguel Xavier, Ronald C. Kessler, Yasmin A. Altwaijri, Laura Helena Andrade, Lukoye Atwoli, Corina Benjet, Guilherme Borges, Ronny Bruffaerts, Brendan Bunting, Jose Miguel Caldas-de-Almeida, Graça Cardoso, Louisa Degenhardt, Giovanni de Girolamo, Josep Maria Haro, Meredith G. Harris, Hristo Hinkov, Chiyi Hu, Peter de Jonge, Aimee Nasser Karam, Georges Karam, Alan E. Kazdin, Norito Kawakami, Andrzej Kiejna, Viviane Kovess-Masfety, Maria Elena Medina-Mora, Jacek Moskalewicz, Daisuke Nishi, Marina Piazza, José Posada-Villa, Annelieke Roest, Margreet ten Have, Nathan Tintle, Maria Carmen Viana, Daniel V. Vigo, David R. Williams, Bogdan Wojtyniak, Alan M. Zaslavsky

Sexual identity inequalities in the co-occurrence of poor mental health and health risk behaviours—a national cross-sectional study

Amal R. Khanolkar, Alexis Karamanos, Laia Becares

Health insurance status and severe mpox disease outcomes among sexual minority men in NYC: a retrospective cohort study

  • Open Access
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Ofole Mgbako, Cecilia Castellano, Kathryn Jano, Anthony Lo Piccolo, Madeline A. DiLorenzo, Dorothy Knutsen, Yusra Shah, Joyce C. Pressley, Dustin T. Duncan, Jason Felder, Dana Mazo

Firesorb bioresorbable scaffold for de novo coronary artery disease: 1-year clinical outcomes

Jun Jiang, Changling Li, Delong Chen, Lei Song, Zhanqian Cui, Ping Li, Lijun Gan, Yundai Chen, Hui Li, Shaobin Jia, Shenghu He, Wen Lu, Runlin Gao, Jianan Wang

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Keynote webinar | Spotlight on innovations in retinal disease

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Retinal diseases are a significant cause of vision impairment and blindness worldwide, but the diagnostic and treatment landscape is rapidly evolving. Explore groundbreaking advances in retinal imaging and gene therapy, before taking a deep dive into emerging treatments for wet AMD.

Prof. Giuseppe Querques
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