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Published in: International Archives of Occupational and Environmental Health 5/2024

Open Access 04-05-2024 | Biomarkers | Original Article

A study of inflammatory biomarkers in crystalline silica exposed rock drillers

Authors: Dag G Ellingsen, Liv Ingunn Bjoner Sikkeland, May Britt Lund, Nils Petter Skaugset, Bente Ulvestad

Published in: International Archives of Occupational and Environmental Health | Issue 5/2024

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Abstract

Background

Crystalline silica (CS) exposure can cause serious lung disease in humans, but mechanisms of pulmonary toxicity have not been completely elucidated.

Aims

To assess pro-inflammatory and anti-inflammatory biomarkers and biomarkers related to the development of chronic obstructive pulmonary disease and fibrosis in serum of rock drillers exposed to CS.

Methods

Rock drillers (N = 123) exposed to CS and non-specified particulate matter (PM) were compared to 48 referents without current or past exposure to PM in a cross-sectional study.

Results

The rock drillers had been exposed to CS for 10.7 years on average. Geometric mean (GM) current exposure was estimated to 36 µg/m3. Their GM concentration of matrix metalloproteinase 12 (MMP-12) was significantly higher (16 vs. 13 ng/L; p = 0.04), while interleukin (IL) 6 and IL-8 were significantly lower compared to the referents. Also pentraxin 3 was significantly lower (3558 vs. 4592 ng/L; p = 0.01) in the rock drillers. A dose-response relationship was observed between cumulative exposure to CS and MMP-12, the highest exposed subgroup having significantly higher MMP-12 concentrations than the referents.

Conclusion

Exposure to CS may increase circulating MMP-12 concentrations in a dose-response related fashion. The results may also suggest a down-regulation of pro-inflammatory pathways.
Literature
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Metadata
Title
A study of inflammatory biomarkers in crystalline silica exposed rock drillers
Authors
Dag G Ellingsen
Liv Ingunn Bjoner Sikkeland
May Britt Lund
Nils Petter Skaugset
Bente Ulvestad
Publication date
04-05-2024
Publisher
Springer Berlin Heidelberg
Keyword
Biomarkers
Published in
International Archives of Occupational and Environmental Health / Issue 5/2024
Print ISSN: 0340-0131
Electronic ISSN: 1432-1246
DOI
https://doi.org/10.1007/s00420-024-02070-2

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