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Current Cardiology Reports

Beyond the Heartbeat: Single-Cell Omics Redefining Cardiovascular Research

  • 19-08-2024
  • Regenerative Medicine (SM Wu, Section Editor)
Published in:
Authors
Sabine Seeler
Kristjan Arnarsson
Martina Dreßen
Markus Krane
Stefanie A. Doppler
Published in
Current Cardiology Reports | Issue 11/2024

Abstract

Purpose of Review

This review aims to explore recent advances in single-cell omics techniques as applied to various regions of the human heart, illuminating cellular diversity, regulatory networks, and disease mechanisms. We examine the contributions of single-cell transcriptomics, genomics, proteomics, epigenomics, and spatial transcriptomics in unraveling the complexity of cardiac tissues.

Recent Findings

Recent strides in single-cell omics technologies have revolutionized our understanding of the heart’s cellular composition, cell type heterogeneity, and molecular dynamics. These advancements have elucidated pathological conditions as well as the cellular landscape in heart development.

Summary

We highlight emerging applications of integrated single-cell omics, particularly for cardiac regeneration, disease modeling, and precision medicine, and emphasize the transformative potential of these technologies to advance cardiovascular research and clinical practice.
Title
Beyond the Heartbeat: Single-Cell Omics Redefining Cardiovascular Research
Authors
Sabine Seeler
Kristjan Arnarsson
Martina Dreßen
Markus Krane
Stefanie A. Doppler
Publication date
19-08-2024
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 11/2024
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-024-02117-3
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New MRI contrast agents are reshaping diagnostic imaging, promising lower gadolinium exposure amid evolving practice guidelines. How can you optimise contrast selection, dosing, and patient care in this rapidly advancing field?

This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window
Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME