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01-12-2024 | Research

Back to my future: life after surgery for tertiary hyperparathyroidism

Authors: Riccardo Morandi, Claudio Guarneri, Matteo Nardin, Stefania Maria Filomena Mitola, Nereo Vettoretto, Gianluca Zanni, Elisa Gatta, Guido Alberto Massimo Tiberio, Nazario Portolani, Carlo Cappelli, Claudio Casella

Published in: Langenbeck's Archives of Surgery | Issue 1/2024

Abstract

Purposes

Evaluate the changes in quality of life (QoL) in patients affected by tertiary hyperparathyroidism (THPT) after surgical treatment using the Parathyroidectomy Assessment of Symptoms (PAS) and Short Form-36 (SF-36) questionnaires.

Methods

Single centre longitudinal retrospective, single-institution analysis of 34 patients with THPT and submitted to parathyroidectomy between 2015 and 2021. The PAS and SF-36 questionnaires were administered before surgery and 24 months after discharge.

Results

A significative QoL amelioration was registered in physical SF-36 (42.4 ± 11.7 vs 56.7 ± 9.2; P < 0.001), mental SF-36 (47.3 ± 12.1 vs 61.8 ± 7.9; P < 0.001) and PAS score (582 ± 163 vs 293 ± 141; P < 0.001) with a significative improvement of all the 13 symptoms considered. We found that pre-operative intact parathormone (iPTH) levels, preoperative T-score and time of haemodialysis before RTX were predictors of both PAS and SF-36 mental score modifications. A positive correlation was also fund between pre-operative PAS values and their post operative cutback.

Conclusions

Parathyroidectomy for THPT brings to a concrete amelioration of all the disease-related and nonspecific symptoms with significative improvement of QoL. To develop a tailored approach of every patient’s needs, from diagnosis to future treatment, we suggest to introduce the symptoms assessment scale as standard stage in periodic evaluations.

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Title: Back to my future: life after surgery for tertiary hyperparathyroidism
Authors: Riccardo Morandi
Claudio Guarneri
Matteo Nardin
Stefania Maria Filomena Mitola
Nereo Vettoretto
Gianluca Zanni
Elisa Gatta
Guido Alberto Massimo Tiberio
Nazario Portolani
Carlo Cappelli
Claudio Casella
Publication date: 01-12-2024
Publisher: Springer Berlin Heidelberg
Published in: Langenbeck's Archives of Surgery / Issue 1/2024
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-024-03539-x

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Abstract

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Methods

Results

Conclusions

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Abstract

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