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Current Nutrition Reports

Neural Basis of Dysregulation of Palatability-Driven Appetite in Autism

Published in:
Authors
Anica Klockars
Tapasya Pal
Allen S. Levine
Pawel K. Olszewski
Published in
Current Nutrition Reports | Issue 4/2021

Abstract

Purpose of Review

In research on autism spectrum disorder (ASD), cognitive, speech- and anxiety-related impairments have been the focus of the majority of studies. One consistently reported ASD symptom that has rarely attracted attention is disordered appetite. The goal of this paper is to assess whether ASD-related dysregulation of food intake impacts consumption of palatable foods, including sugar.

Recent Findings

Aberrant neural processing at the reward system level is at least partially responsible for excessive intake of palatable tastants, including sugar. Impaired oxytocin (OT) signaling likely contributes to the magnitude of this overconsumption.

Summary

Since intake for reward is generally elevated in individuals with ASD, one strategy to curb sugar overconsumption might utilize presentation of alternative palatable food choices that are more nutritionally adequate than sucrose. Furthermore, OT, which is clinically tested to alleviate other ASD symptoms, might be an effective tool to curb overconsumption of sugar, as well as — likely — of other excessively ingested palatable foods, especially those that have sweet taste.
Title
Neural Basis of Dysregulation of Palatability-Driven Appetite in Autism
Authors
Anica Klockars
Tapasya Pal
Allen S. Levine
Pawel K. Olszewski
Publication date
01-12-2021
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 4/2021
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-021-00368-y
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