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Open Access 26-12-2023 | Autism Spectrum Disorder | Original Paper

Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis

Authors: Xingyue Jin, Kun Zhang, Bin Lu, Xue Li, Chao-Gan Yan, Yasong Du, Yi Liu, Jianping Lu, Xuerong Luo, Xueping Gao, Jing Liu

Published in: European Child & Adolescent Psychiatry | Issue 7/2024

Abstract

Schizophrenia and autism spectrum disorders (ASD) were considered as two neurodevelopmental disorders and had shared clinical features. we hypothesized that they have some common atypical brain functions and the purpose of this study was to explored the shared brain spontaneous activity strength alterations in early onset schizophrenia (EOS) and ASD in the children and adolescents with a multi-center large-sample study. A total of 171 EOS patients (aged 14.25 ± 1.87), 188 ASD patients (aged 9.52 ± 5.13), and 107 healthy controls (aged 11.52 ± 2.82) had scanned with Resting-fMRI and analyzed surface-based amplitude of low-frequency fluctuations (ALFF). Results showed that both EOS and ASD had hypoactivity in the primary sensorimotor regions (bilateral primary and early visual cortex, left ventral visual stream, left primary auditory cortex) and hyperactivity in the high-order transmodal regions (bilateral SFL, bilateral DLPFC, right frontal eye fields), and bilateral thalamus. EOS had more severe abnormality than ASD. This study revealed shared functional abnormalities in the primary sensorimotor regions and the high-order transmodal regions in EOS and ASD, which provided neuroimaging evidence of common changes in EOS and ASD, and may help with better early recognition and precise treatment for EOS and ASD.

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Title: Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis
Authors: Xingyue Jin
Kun Zhang
Bin Lu
Xue Li
Chao-Gan Yan
Yasong Du
Yi Liu
Jianping Lu
Xuerong Luo
Xueping Gao
Jing Liu
Publication date: 26-12-2023
Publisher: Springer Berlin Heidelberg
Keywords: Autism Spectrum Disorder
Schizophrenia
Published in: European Child & Adolescent Psychiatry / Issue 7/2024
Print ISSN: 1018-8827
Electronic ISSN: 1435-165X
DOI: https://doi.org/10.1007/s00787-023-02333-2

2024 ESC Congress

Springer Medicine

Shared atypical spontaneous brain activity pattern in early onset schizophrenia and autism spectrum disorders: evidence from cortical surface-based analysis

Abstract

2024 ESC Congress

Springer Medicine

Abstract

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