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European Archives of Psychiatry and Clinical Neuroscience

Open Access 05-03-2025 | Autism Spectrum Disorder | Original Paper

What autism features in first episode psychosis? Results from a 2-year follow-up study

Authors: Lorenzo Pelizza, Antonio Federico, Emanuela Leuci, Emanuela Quattrone, Derna Palmisano, Simona Pupo, Giuseppina Paulillo, Clara Pellegrini, Pietro Pellegrini, Marco Menchetti

Published in: European Archives of Psychiatry and Clinical Neuroscience

Abstract

The PANSS Autism Severity Score (PAUSS) is a popular measure of autistic features in First Episode Psychosis (FEP) samples. However, evidence on its longitudinal stability, course and treatment response is poor. Therefore, the main aim of this research was to compare clinical outcomes between FEP individuals with or without “autistic features” enrolled within an “Early Intervention in Psychosis” (EIP) service across 2 years of follow-up, as well as any significant association with EIP treatment components. FEP subjects completed the Positive And Negative Syndrome Scale (PANSS), the Global Assessment of Functioning (GAF), and the Health of the Nation Outcome Scale (HoNOS) at entry and across the follow-up. Statistical tests included Kaplan-Meyer survival analysis, mixed-design ANOVA, and multiple linear logistic regression analysis. 301 FEP subjects were enrolled (85 [28.0%] scored above the PAUSS cut-off score). Across the follow-up, the PAUSS + subgroup showed lower incidence rates of both symptomatic and functional remission. No PAUSS long-term stability was observed, but a statistically significant reduction in its values. This longitudinal change was mainly predicted by the total number of case management sessions offered within the EIP program. Our results suggest that the PAUSS could not represent a valid instrument to assess “trait-like” autistic features in FEP subjects. On contrary, it seems to capture a FEP subgroup characterized by higher severity levels in psychopathology and poorer outcomes and prognosis.

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Huang Y, Arnold SR, Foley KR, Trollor JN (2020) Diagnosis of autism in adulthood: a scoping review. Autism 24:1311–1327. https://doi.org/10.1177/1362361320903128CrossRefPubMed

Taylor MJ, Rosenqvist MA, Larsson H, Gillberg C, D’Onofrio BM, Lichtenstein P, Lundström S (2020) Etiology of autism spectrum disorders and autistic traits over time. JAMA Psychiat 77:936–943. https://doi.org/10.1001/jamapsychiatry.2020.0680CrossRef

Blanco-Suárez E, Caldwell AL, Allen NJ (2017) Role of astrocyte-synapse interactions in CNS disorders. J Physiol 595:1903–1916. https://doi.org/10.1113/JP270988CrossRefPubMed

Kalin NH (2022) Insights into the genomic underpinnings of psychopathology. Am J Psychiatry 179:171–174. https://doi.org/10.1176/appi.ajp.2021.22010056CrossRefPubMed

Bleuler E (1911) Dementia praecox oder gruppe der schizophrenien. Deuticke, Leipzig

Kanner L (1943) Autistic disturbance of affective contact. Nervous Child 2:217–250

Varcin KJ, Herniman SE, Lin A, Chen Y, Perry Y, Pugh C, Chisholm K, Whitehouse AJO, Wood SJ (2022) Occurrence of psychosis and bipolar disorder in adults with autism: a systematic review and meta-analysis. Neurosci Biobehav Rev 134:104543. https://doi.org/10.1016/j.neubiorev.2022.104543CrossRefPubMed

Kincaid DL, Doris M, Shannon C, Mulholland C (2017) What is the prevalence of autism spectrum disorder and ASD traits in psychosis? A systematic review. Psychiatry Res 250:99–105. https://doi.org/10.1016/j.psychres.2017.01.017CrossRefPubMed

De Crescenzo F, Postorino V, Siracusano M, Riccioni A, Armando M, Curatolo P, Mazzone L (2019) Autistic symptoms in schizophrenia spectrum disorders: a systematic review and meta-analysis. Front Psychiatry 10:78. https://doi.org/10.3389/fpsyt.2019.00078CrossRefPubMedPubMedCentral

10.

Ferrara M, Curtarello EMA, Simonelli G, Yoviene Sykes LA, Fusar-Poli L, Folesani F, Belvederi Murri M, Aguglia E, Politi P, Grassi L (2023) First-episode psychosis and autism spectrum disorder: a scoping review and a guide to overcome diagnostic challenges. Int J Ment Health 53:4–35. https://doi.org/10.1080/00207411.2023.2276872CrossRef

11.

Guerrera S, Pontillo M, Chieppa F, Passarini S, Di Vincenzo C, Casula L, Di Luzio M, Valeri G, Vicari S (2024) Autism spectrum disorder and early psychosis: a narrative review from a neurodevelopmental perspective. Front Psychiatry 15:1362511. https://doi.org/10.3389/fpsyt.2024.1362511CrossRefPubMedPubMedCentral

12.

Jutla A, Foss-Feig J, Veenstra-VanderWeele J (2022) Autism spectrum disorder and schizophrenia: an updated conceptual review. Autism Res 15:384–412. https://doi.org/10.1002/aur.2659CrossRefPubMed

13.

Hajdúk M, Straková A, Januška J, Ivančík V, Dančík D, Čavojská N, Valkučáková V, Heretik A, Pečeňák J, Abplanalp SJ, Green MF (2023) Connections between and within extended psychosis and autistic phenotypes and social relationships in the general population. J Psychiatr Res 157:36–42. https://doi.org/10.1016/j.jpsychires.2022.11.022CrossRefPubMed

14.

Upthegrove R, Abu-Akel A, Chisholm K, Lin A, Zahid S, Pelton M, Apperly I, Hansen PC, Wood SJ (2018) Autism and psychosis: clinical implications for depression and suicide. Schizophr Res 195:80–85. https://doi.org/10.1016/j.schres.2017.08.028CrossRefPubMed

15.

Chisholm K, Pelton M, Duncan N, Kidd K, Wardenaar KJ, Upthegrove R, Broome MR, Lin A, Wood SJ (2019) A cross-sectional examination of the clinical significance of autistic traits in individuals experiencing a first episode of psychosis. Psychiatry Res 282:112623. https://doi.org/10.1016/j.psychres.2019.112623CrossRefPubMed

16.

Sunwoo M, O’Connell J, Brown E, Lin A, Wood SJ, McGorry P, O’Donoghue B (2020) Prevalence and outcomes of young people with concurrent autism spectrum disorder and first episode of psychosis. Schizophr Res 216:310–315. https://doi.org/10.1016/j.schres.2019.11.037CrossRefPubMed

17.

Davut G, Onur D, Hüseyin G (2023) Autistic features and executive functions in first episode psychosis: associations with functionality and quality of life. Early Interv Psychiatry 17:814–823. https://doi.org/10.1111/eip.13372CrossRefPubMed

18.

Frigaux A, Evrard R, Lighezzolo-Alnot J (2019) ADI-R and ADOS and the differential diagnosis of autism spectrum disorders: interests, limits and openings. Encephale 45:441–448. https://doi.org/10.1016/j.encep.2019.07.002CrossRefPubMed

19.

Abu-Akel A, Wood SJ, Upthegrove R, Chisholm K, Lin A, Hansen PC, Gillespie SM, Apperly IA, Montag C (2022) Psychosocial functioning in the balance between autism and psychosis: evidence from three populations. Mol Psychiatry 27:2976–2984. https://doi.org/10.1038/s41380-022-01543-5CrossRefPubMedPubMedCentral

20.

Kästner A, Begemann M, Michel TM, Everts S, Stepniak B, Bach C, Poustka L, Becker J, Banaschewski T, Dose M, Ehrenreich H (2015) Autism beyond diagnostic categories: characterization of autistic phenotypes in schizophrenia. BMC Psychiatry 15:115. https://doi.org/10.1186/s12888-015-0494-xCrossRefPubMedPubMedCentral

21.

American Psychiatric Association (APA) (2000) Diagnostic and Statistical Manual of mental disorders, IV edition, text revised. American Psychiatric Association, Washington D.C.

22.

Jeong JH, Kim SW, Yu JC, Won SH, Lee SH, Kim SH, Kang SH, Kim E, Chung YC, Lee KY (2024) Clinical, cognitive, and functional characteristics of recent-onset psychosis with autistic features: a 2-year longitudinal study. Schizophr Res 270:304–316. https://doi.org/10.1016/j.schres.2024.06.009CrossRefPubMed

23.

Pina-Camacho L, Boada L, Díaz-Caneja CM, García-Alcón A, Burdeus M, Serrano-Drozdowskyj E, Fraguas D, Moreno C, Parellada M (2020) The positive and negative syndrome scale for schizophrenia autism severity scale (PAUSS) in young people with autism and schizophrenia. Rev Psiquiatr Salud Ment 13:118–130. https://doi.org/10.1016/j.rpsm.2020.05.006CrossRef

24.

Deste G, Barlati S, Gregorelli M, Lisoni J, Turrina C, Valsecchi P, Vita A (2018) Looking through autistic features in schizophrenia using the PANSS autism severity score (PAUSS). Psychiatry Res 270:764–768. https://doi.org/10.1016/j.psychres.2018.10.074CrossRefPubMed

25.

Zheng S, Chua YC, Tang C, Tan GM, Abdin E, Lim VWQ, Koh AS, Verma S, Magiati I (2021) Autistic traits in first-episode psychosis: rates and association with 1-year recovery outcomes. Early Interv Psychiatry 15:849–855. https://doi.org/10.1111/eip.13021CrossRefPubMed

26.

Nibbio G, Barlati S, Calzavara-Pinton I, Necchini N, Invernizzi E, Dell’Ovo D, Lisoni J, Deste G, Vita A (2022) Assessment and correlates of autistic symptoms in schizophrenia spectrum disorders measured with the PANSS autism severity score: a systematic review. Front Psychiatry 13:934005. https://doi.org/10.3389/fpsyt.2022.934005CrossRefPubMedPubMedCentral

27.

Vaskinn A, Abu-Akel A (2019) The interactive effect of autism and psychosis severity on theory of mind and functioning in schizophrenia. Neuropsychology 33:195–202. https://doi.org/10.1037/neu0000499CrossRefPubMed

28.

Chisholm K, Schirmbeck F, Pinkham AE, Sasson NJ, Simons CJP, de Haan L, Harvey PD, Penn DL, Ziermans T (2023) A cross-sectional conceptual replication and longitudinal evaluation of the PANSS-Autism-Severity-Score measure suggests it does not capture autistic traits in individuals with psychosis. Schizophr Bull. https://doi.org/10.1093/schbul/sbad161CrossRefPubMedCentral

29.

Ribolsi M, Albergo G, Fiori Nastro F, Pelle M, Contri V, Niolu C, Di Lazzaro V, Siracusano A, Di Lorenzo G (2022) Autistic symptomatology in UHR patients: a preliminary report. Psychiatry Res 313:114634. https://doi.org/10.1016/j.psychres.2022.114634CrossRefPubMed

30.

Leuci E, Quattrone E, Pellegrini P, Pelizza L (2020) The “Parma-Early Psychosis” program: general description and process analysis after 5 years of clinical activity. Early Interv Psychiatry 14:356–364. https://doi.org/10.1111/eip.12897CrossRefPubMed

31.

Pelizza L, Leuci E, Quattrone E, Azzali S, Pupo S, Paulillo G, Pellegrini P, Menchetti M (2024) Rates and predictors of service disengagement in adolescents with first episode psychosis: results from the 2-year follow-up of the Pr-EP program. Eur Child Adolesc Psychiatry 33:2217–2229. https://doi.org/10.1007/s00787-023-02306-5CrossRefPubMed

32.

American Psychiatric Association (APA) (2013) Diagnostic and Statistical Manual of mental disorders, 5th edition. American Psychiatric Association, Washington D.C.

33.

Malla A (2022) Reducing duration of untreated psychosis: the neglected dimension of early intervention services. Am J Psychiatry 179:259–261. https://doi.org/10.1176/appi.ajp.20220154CrossRefPubMed

34.

Shah JL, Jones N, van Os J, McGorry PD, Gülöksüz S (2022) Early intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis. Lancet Psychiatry 9:413–422. https://doi.org/10.1016/S2215-0366(21)00467-3CrossRefPubMed

35.

Pelizza L, Leuci E, Maestri D, Quattrone E, Azzali S, Paulillo G, Pellegrini P (2022) Examining disorganization in patients with first episode psychosis: findings from a 1-year follow-up of the “Parma early psychosis” program. Early Interv Psychiatry 16:552–560. https://doi.org/10.1111/eip.13198CrossRefPubMed

36.

Mills JG, Fusar-Poli P, Morgan C, Azis M, McGuire P (2017) People meeting ultra-high risk for psychosis criteria in the community. World Psychiatry 16:322–323. https://doi.org/10.1002/wps.20463CrossRefPubMedPubMedCentral

37.

Pelizza L, Maestri D, Leuci E, Quattrone E, Azzali S, Paulillo G, Pellegrini P (2022) Association between case management and longitudinal decrease in negative symptoms in patients with first episode psychosis: a 2-year follow-up. Early Interv Psychiatry 16:1185–1191. https://doi.org/10.1111/eip.13267CrossRefPubMed

38.

Kay SR, Fiszbein A, Opler LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13:261–276. https://doi.org/10.1093/schbul/13.2.261CrossRefPubMed

39.

Wing J, Curtis RH, Beevor A (1999) Health of the Nation Outcome Scales (HoNOS): glossary for HoNOS score sheet. Br J Psychiatry 174:432–434. https://doi.org/10.1192/bjp.174.5.432CrossRefPubMed

40.

Pelizza L, Leuci E, Quattrone E, Azzali S, Pupo S, Paulillo G, Pellegrini P, Menchetti M (2024) Rates and predictors of service disengagement in first episode psychosis: results from a 2-year follow-up study in an Italian real-world care setting. Schizophr Res 274:142–149. https://doi.org/10.1016/j.schres.2024.09.015CrossRefPubMed

41.

Liechti S, Capodilupo G, Opler DJ, Opler M, Yang LH (2017) A developmental history of the positive and negative syndrome scale (PANSS). Innov Clin Neurosci 14:12–17PubMedPubMedCentral

42.

Pelizza L, Leuci E, Maestri D, Quattrone E, Azzali S, Paulillo G, Pellegrini P (2022) Longitudinal persistence of negative symptoms in young individuals with first episode schizophrenia: a 24-month multi-modal program follow-up. Nord J Psychiatry 76:530–538. https://doi.org/10.1080/08039488.2021.2015431CrossRefPubMed

43.

Shafer A, Dazzi F (2019) Meta-analysis of the Positive and Negative Syndrome Scale (PANSS) factor structure. J Psychiatr Res 115:113–120. https://doi.org/10.1016/j.jpsychires.2019.05.008CrossRefPubMed

44.

Andreasen NC, Carpenter WT Jr, Kane JM, Lasser RA, Marder SR, Weinberger DR (2005) Remission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry 162:441–449. https://doi.org/10.1176/appi.ajp.162.3.441CrossRefPubMed

45.

Pelizza L, Leuci E, Maestri D, Quattrone E, Azzali S, Paulillo G, Pellegrini P (2022) Negative symptoms in first episode schizophrenia: treatment response across the 2-year follow-up of the “Parma Early Psychosis” program. Eur Arch Psychiatry Clin Neurosci 272:621–632. https://doi.org/10.1007/s00406-021-01374-5CrossRefPubMed

46.

Yang H, Gao S, Li J, Yu H, Xu J, Lin C, Yang H, Teng C, Ma H, Zhang N (2022) Remission of symptoms is not equal to functional recovery: psychosocial functioning impairment in major depression. Front Psychiatry 13:915689. https://doi.org/10.3389/fpsyt.2022.915689CrossRefPubMedPubMedCentral

47.

Pelizza L, Leuci E, Quattrone E, Azzali S, Pupo S, Paulillo G, Pellegrini P, Menchetti M (2024) Short-term disengagement from early intervention service for first-episode psychosis: findings from the “Parma Early Psychosis” program. Soc Psychiatry Psychiatr Epidemiol 59:1201–1213. https://doi.org/10.1007/s00127-023-02564-3CrossRefPubMed

48.

Morosini P, Gigantesco A, Mazzarda A, Gibaldi L (2003) HoNOS-Rome: an expanded, customized, and longitudinally oriented version of the HoNOS. Epidemiol Psichiatr Soc 12:53–62. https://doi.org/10.1017/S1121189X00006059CrossRefPubMed

49.

Kortrijk HE, Mulder CL, van der Gaag M, Wiersma D (2012) Symptomatic and functional remission and its associations with quality of life in patients with psychotic disorder in assertive community treatment teams. Compr Psychiatry 53:1174–1180. https://doi.org/10.1016/j.comppsych.2012.05.001CrossRefPubMed

50.

Pelizza L, Leuci E, Quattrone E, Azzali S, Paulillo G, Pupo S, Pellegrini P (2023) Depressive features in individuals with first episode psychosis: psychopathological and treatment considerations from a 2-year follow-up study. Clin Neuropsychiatry 20:39–47. https://doi.org/10.36131/cnfioritieditore20230105CrossRefPubMedPubMedCentral

51.

Silverman MM, Berman AL, Sanddal ND, O’carroll PW, Joiner TE (2007) Rebuilding the tower of Babel: a revised nomenclature for the study of suicide and suicidal behaviors—part 2: suicide-related ideations, communications, and behaviors. Suicide Life Threat Behav 37:264–277. https://doi.org/10.1521/suli.2007.37.3.264CrossRefPubMed

52.

Pelizza L, Di Lisi A, Leuci E, Quattrone E, Palmisano D, Pellegrini C, Pellegrini P, Paulillo G, Pupo S, Menchetti M (2024) Suicidal thinking and behavior in young people at Clinical High Risk for Psychosis: psychopathological considerations and treatment response across a 2-year follow-up study. Suicide Life Threat Behav. https://doi.org/10.1111/sltb.13136CrossRefPubMed

53.

Robson E, Greenwood K (2022) Rates and predictors of disengagement and strength of engagement for people with a first episode of psychosis using early intervention services: a systematic review of predictors and meta-analysis of disengagement rates. Schizophr Bull Open 3:012. https://doi.org/10.1093/schizbullopen/sgac012CrossRef

54.

Roncone R, Ventura J, Impallomeni M, Falloon IR, Morosini PL, Chiaravalle E, Casacchia M (1999) Reliability of an Italian standardized and expanded Brief Psychiatric Rating Scale (BPRS 4.0) in raters with high vs. low clinical experience. Acta Psychiatr Scand 100:229–236. https://doi.org/10.1111/j.1600-0447.1999.tb10850.xCrossRefPubMed

55.

Silva MA, Restrepo D (2019) Functional recovery in schizophrenia. Rev Colomb Psiquiatr (Engl Ed) 48:252–260. https://doi.org/10.1016/j.rcp.2017.08.004CrossRefPubMed

56.

First MB, Williams JBW, Karg RS, Spitzer RL (2017) SCID-5-CV: intervista clinica strutturata per i disturbi del DSM-5 - versione per il clinico. Raffaello Cortina Editore, Milano

57.

Pelizza L, Paterlini F, Azzali S, Garlassi S, Scazza I, Pupo S, Simmons M, Nelson B, Raballo A (2019) The approved Italian version of the comprehensive assessment of at-risk mental states (CAARMS-ITA): field test and psychometric features. Early Interv Psychiatry 13:810–817. https://doi.org/10.1111/eip.12669CrossRefPubMed

58.

Paterlini F, Pelizza L, Galli G, Azzali S, Scazza I, Garlassi S, Chiri LR, Poletti M, Pupo S, Raballo A (2019) Interrater reliability of the authorized Italian version of the comprehensive assessment of at-risk mental states (CAARMS-ITA). J Psychopathol 15:24–28

59.

Pelizza L, Quattrone E, Leuci E, Paulillo G, Azzali S, Pupo S, Pellegrini P (2022) Anxious-depressive symptoms after a first episode of schizophrenia: response to treatment and psychopathological considerations from the 2-year “Parma Early Psychosis” program. Psychiatry Res 317:114887. https://doi.org/10.1016/j.psychres.2022.114887CrossRefPubMed

60.

Galletly C, Castle D, Dark F, Humberstone V, Jablensky A, Killackey E, Kulkarni J, McGorry P, Nielssen O, Tran N (2016) Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the management of schizophrenia and related disorders. Aust N Z J Psychiatry 50:410–472. https://doi.org/10.1177/0004867416641195CrossRefPubMed

61.

Regione Emilia-Romagna Working Group (2024) Linee di indirizzo per la promozione della salute e del benessere nelle persone alla prima manifestazione psicotica o ad alto rischio di psicosi. Centro Stampa della Regione Emilia-Romagna, Bologna. https://salute.regione.emilia-romagna.it/salute-mentale/documentazione/linee_di_indirizzo_esordi_psicotici_2024_rev3.pdf/@@download/file/Linee_di_indirizzo_Esordi_psicotici_2024_rev3.pdf. Accessed 01 Dec 2024

62.

SPSS Inc. (2010) Statistical package for social sciences, version 15.0. SPSS Inc. Press, Chicago (IL)

63.

Jung SH (2014) Stratified Fisher’s exact test and its sample size calculation. Biom J 56:129–140. https://doi.org/10.1002/bimj.201300048CrossRefPubMed

64.

Armstrong RA (2014) When to use the Bonferroni correction. Ophthalmic Physiol Opt 34:502–508. https://doi.org/10.1111/opo.12131CrossRefPubMed

65.

Li Z, Weng M, Lin L, Chen Y, Lin J, Cui J, Jiang D, Fu B, Li G, Chen C, Xu Y, Wan J (2023) Acute kidney injury in patients with idiopathic membranous nephropathy: influencing factors and prognosis. Ren Fail 45:2194451. https://doi.org/10.1080/0886022X.2023.2194451CrossRefPubMedPubMedCentral

66.

Ver Hoef JM (2012) Who invented the delta method? Am Stat 66:124–127. https://doi.org/10.1080/00031305.2012.687494CrossRef

67.

Ziermans TB, Schirmbeck F, Oosterwijk F, Geurts HM, de Haan L, Genetic Risk and Outcome of Psychosis (GROUP) Investigators (2021) Autistic traits in psychotic disorders: prevalence, familial risk, and impact on social functioning. Psychol Med 51:1704–1713. https://doi.org/10.1017/S0033291720000458CrossRefPubMed

68.

Poon VWK, Shu DST, Chan RWS, Leung CNW, Leung PWL (2020) Comparing the psychometric properties of the self- and parent-report versions of autism-spectrum quotient-adult in Hong Kong (AQ-Adult-HK). J Autism Dev Disord 50:524–528. https://doi.org/10.1007/s10803-019-04276-7CrossRefPubMed

69.

Baron-Cohen S, Wheelwright S, Skinner R, Martin J, Clubley E (2001) The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. J Autism Dev Disord 31:5–17CrossRefPubMed

70.

Deste G, Vita A, Penn DL, Pinkham AE, Nibbio G, Harvey PD (2019) Autistic symptoms predict social cognitive performance in patients with schizophrenia. Schizophr Res 215:113–119. https://doi.org/10.1016/j.schres.2019.11.008CrossRefPubMedPubMedCentral

71.

Deste G, Vita A, Nibbio G, Barlati S, Penn DL, Pinkham AE, Harvey PD (2021) Autistic symptoms in people with schizophrenia: neurocognitive, socio-cognitive, clinical and real-world functional characteristics of individuals without autistic features. Schizophr Res 236:12–18. https://doi.org/10.1016/j.schres.2021.07.037CrossRefPubMed

72.

Vita A, Barlati S, Deste G, Rocca P, Rossi A, Bertolino A, Aguglia E, Amore M, Bellomo A, Biondi M, Carpiniello B, Collantoni E, Cuomo A, D’Ambrosio E, Dell’Osso L, di Giannantonio M, Giordano GM, Marchesi C, Monteleone P, Montemagni C, Oldani L, Pompili M, Roncone R, Rossi R, Siracusano A, Zeppegno P, Nibbio G, Galderisi S, Maj M, Italian Network for Research on Psychoses (2020) The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: evidence from the Italian network for research on psychoses multicenter study. Eur Psychiatry 63:e98. https://doi.org/10.1192/j.eurpsy.2020.99CrossRefPubMedPubMedCentral

73.

Aboraya A, Nasrallah HA (2016) Perspectives on the Positive and Negative Syndrome Scale (PANSS): use, misuse, drawbacks, and a new alternative for schizophrenia research. Ann Clin Psychiatry 28:125–131PubMed

74.

Pelizza L, Leuci E, Leucci AC, Quattrone E, Azzali S, Pupo S, Plazzi E, Paulillo G, Pellegrini P, Menchetti M (2024) Diagnostic shift in first episode psychosis: results from the 2-year follow-up of the “Parma Early Psychosis” program. Schizophr Res 267:99–106. https://doi.org/10.1016/j.schres.2024.03.010CrossRefPubMed

75.

Pelizza L, Plazzi E, Leuci E, Leucci AC, Quattrone E, Azzali S, Pupo S, Paulillo G, Pellegrini P, Menchetti M (2024) Diagnostic shift in adolescents with first episode psychosis: findings from the 2-year follow-up of the “Parma Early Psychosis” program. Soc Psychiatry Psychiatr Epidemiol. https://doi.org/10.1007/s00127-024-02721-2CrossRefPubMedPubMedCentral

Title: What autism features in first episode psychosis? Results from a 2-year follow-up study
Authors: Lorenzo Pelizza
Antonio Federico
Emanuela Leuci
Emanuela Quattrone
Derna Palmisano
Simona Pupo
Giuseppina Paulillo
Clara Pellegrini
Pietro Pellegrini
Marco Menchetti
Publication date: 05-03-2025
Publisher: Springer Berlin Heidelberg
Keywords: Autism Spectrum Disorder
Autism Spectrum Disorder
Published in: European Archives of Psychiatry and Clinical Neuroscience
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-025-01986-1

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What autism features in first episode psychosis? Results from a 2-year follow-up study

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