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Current Cardiology Reports

Contemporary Insights into LMNA Cardiomyopathy

Published in:
Authors
Iswaree D. Balakrishnan
Neal K. Lakdawala
Published in
Current Cardiology Reports | Issue 1/2025

Abstract

Purpose of review

This review aims to explore how a diagnosis of LMNA-related cardiomyopathy (LMNA-CM) informs clinical management, focusing on the prevention and management of its complications, through practical clinical strategies.

Recent findings

Longitudinal studies have enhanced our understanding of the natural history of LMNA-CM including its arrhythmic and non-arrhythmic complications. A LMNA specific ventricular arrhythmia risk prediction strategy has been integrated into clinical practice guidelines. Although less robust, observational studies are shaping gene-specific strategies for mitigating other complications including atrioventricular block, atrial fibrillation and cardiomyopathy, while novel therapies have been evaluated in clinical trials.

Summary

LMNA-CM follows an aggressive yet generally stereotyped course. Early recognition of anticipated complications allows for more effective prevention and management in both symptomatic and asymptomatic patients.
Title
Contemporary Insights into LMNA Cardiomyopathy
Authors
Iswaree D. Balakrishnan
Neal K. Lakdawala
Publication date
01-12-2025
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
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Learn more Link opens in a new window
Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME