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Current Cardiology Reports

Updates on Patent Foramen Ovale (PFO) Closure

  • 24-06-2024
  • Atrial Septal Defect
  • New Therapies for Cardiovascular Disease (AA Bavry and M Massoomi, Section Editors)
Published in:
Authors
Konstantinos V. Voudris
Marie-France Poulin
Clifford J. Kavinsky
Published in
Current Cardiology Reports | Issue 7/2024

Abstract

Purpose of Review

Patent foramen ovale (PFO) has been previously linked to left circulation thromboembolism and stroke. This review article aims to discuss the latest evidence, updated societal guidelines, diagnostic algorithms and novel therapeutic devices for PFO closure.

Recent Findings

PFO closure for cryptogenic stroke and systemic embolization is supported by a large body of evidence and has a strong societal recommendation. Limited data are available for platypnea-orthodeoxia syndrome, although closure appears to be beneficial. Current data do not support routine closure for migraines and decompression Illness. Development of heart-brain teams can improve identification of patients most likely to benefit from closure, utilizing a combination of imaging test and risk score algorithms. Multiple novel devices aiming at reducing complications and improving the long-term impact of current available devices are being evaluated.

Summary

PFO closure has significantly progressed over the last years, with new data supporting its superiority in reducing risk of recurrent embolic stroke in patients with PFO-related stroke. Additional clinical data are required to provide further refinements on patient selection and guidance on treatment of specific subgroups.
Title
Updates on Patent Foramen Ovale (PFO) Closure
Authors
Konstantinos V. Voudris
Marie-France Poulin
Clifford J. Kavinsky
Publication date
24-06-2024
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 7/2024
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-024-02073-y
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window
Image Credits
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