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Current Cardiology Reports

Atrial FDG Uptake: Etiologies, Clinical Significance, and Implications

Published in:
Authors
Julie Lanctôt-Bédard
Hassan Bachir Melhem
Francois Harel
Matthieu Pelletier-Galarneau
Published in
Current Cardiology Reports | Issue 1/2025

Abstract

Purpose of Review

: This review aims to explore the clinical significance of atrial fluorodeoxyglucose (FDG) uptake observed in positron emission tomography (PET) scans, focusing on its association with atrial fibrillation (AF), cardiac sarcoidosis, and myocarditis. We discuss the implications of atrial uptake for patient management and prognosis.

Recent Findings

: Recent studies have demonstrated that atrial FDG uptake is frequently present in patients with AF, particularly those with persistent AF, and is linked to increased risks of stroke and poorer outcomes after ablation. In cardiac sarcoidosis, atrial uptake correlates with inflammation and an elevated risk of AF. Additionally, non-granulomatous myocarditis has been associated with localized atrial FDG uptake, necessitating careful differentiation from other causes.

Summary

: Atrial FDG uptake reflects underlying pathological processes such as inflammation, which can significantly impact patient management and outcomes across various cardiovascular diseases. Recognizing these findings can facilitate early intervention, improve prognosis, and support the development of clear guidelines for clinical practice, emphasizing the need for continued research in this area.
Title
Atrial FDG Uptake: Etiologies, Clinical Significance, and Implications
Authors
Julie Lanctôt-Bédard
Hassan Bachir Melhem
Francois Harel
Matthieu Pelletier-Galarneau
Publication date
01-12-2025
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 1/2025
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-024-02166-8
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
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Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME