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Open Access 01-12-2024 | Atrial Fibrillation | Research

Plasma metabolomic characteristics of atrial fibrillation patients with spontaneous echo contrast

Authors: Bingshuo Shi, Rong Suo, Wenhua Song, Haipeng Zhang, Daiqi Liu, Xinya Dai, Ruining Zhang, Xuewen Wang, Guangping Li, Tong Liu, Xing Liu

Published in: BMC Cardiovascular Disorders | Issue 1/2024

Abstract

Background

The spontaneous echo contrast (SEC) in patients with atrial fibrillation (AF) indicates a prethrombic state that ultimately progresses into thrombus formation. A comprehensive understanding of specific plasma metabolomics characteristics may protect AF patients from thrombus, particularly in the early stage.

Objectives

Through the investigation of metabolic pathways, we endeavor to uncover the metabolomic characteristics associated with SEC states, and to examine the differential metabolites by which may exert their influence on thrombotic states.

Methods

Patients with AF were enrolled, and the participants were divided into three groups based on the results of the echocardiogram: non-SEC, low-SEC and high-SEC group. Samples were collected and subjected to non-targeted metabolomics analysis. The analytical process included data quality control, metabolite difference analysis, component analysis, Kegg cluster analysis, etc.

Results

Our metabolic phenotype revealed a clear differential metabolic pattern between the SEC and non-SEC. Specifically, we identified 35 and 142 significantly differential metabolites in venous and atrial plasma, respectively, suggesting that SEC may be involved in pervasive metabolic dysregulation and that the degree of metabolic dysregulation in atrial plasma is more severe than that in venous blood.

Conclusion

Patients with SEC have a significantly different metabolic pattern compared to those without SEC. Our work promoted the understanding of mechanism of the occurrence and development of SEC, facilitated the screening of the target metabolites for its therapeutic intervention, and provided evidence for the prevention and treatment of SEC or thrombosis in AF. Our work also provided new directions for subsequent research in related fields. In conclusion, our study not only provides a theoretical basis for understanding the occurrence and development of SEC in AF, but also provides recommendations for the daily diet of AF patients with SEC, such as a balanced intake of essential amino acids, avoiding excessive intake of benzoic acid, and intake of appropriate inositol.

Clinical trial number

Not applicable.

Available only for authorised users

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Title: Plasma metabolomic characteristics of atrial fibrillation patients with spontaneous echo contrast
Authors: Bingshuo Shi
Rong Suo
Wenhua Song
Haipeng Zhang
Daiqi Liu
Xinya Dai
Ruining Zhang
Xuewen Wang
Guangping Li
Tong Liu
Xing Liu
Publication date: 01-12-2024
Publisher: BioMed Central
Keyword: Atrial Fibrillation
Published in: BMC Cardiovascular Disorders / Issue 1/2024
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-024-04306-y

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