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Open Access 01-12-2022 | Astrocytoma | Research

Grading of IDH-mutant astrocytoma using diffusion, susceptibility and perfusion-weighted imaging

Authors: Xiefeng Yang, Zhen Xing, Dejun She, Yu Lin, Hua Zhang, Yan Su, Dairong Cao

Published in: BMC Medical Imaging | Issue 1/2022

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Abstract

Background

The accurate grading of IDH-mutant astrocytoma is essential to make therapeutic strategies and assess the prognosis of patients. The purpose of this study was to investigate the usefulness of DWI, SWI and DSC-PWI in grading IDH-mutant astrocytoma.

Methods

One hundred and seven patients with IDH-mutant astrocytoma who underwent DWI, SWI and DSC-PWI were retrospectively reviewed. Minimum apparent diffusion coefficient (ADCmin), intratumoral susceptibility signal intensity(ITSS) and maximum relative cerebral blood volume (rCBVmax) values were assessed. ADCmin, ITSS and rCBVmax values were compared between grade 2 vs. grade 3, grade 3 vs. grade 4 and grade 2 + 3 vs. grade 4 tumors. Logistic regression, tenfold cross-validation,and receiver operating characteristic (ROC) curve analyses were used to assess their diagnostic performances.

Results

Grade 4 IDH-mutant astrocytomas showed significantly lower ADCmin and higher rCBVmax as compared to grade 3 tumors (adjusted P < 0.001). IDH-mutant grade 3 astrocytomas showed significantly lower ITSS levels as compared with grade 4 tumors (adjusted P < 0.001). ITSS levels between IDH-mutant grade 2 and grade 3 astrocytomas were significantly different (adjusted P = 0.002). Combined the ADCmin, ITSS and rCBVmax resulted in the highest AUC for differentiation grade 2 and grade 3 tumors from grade 4 tumors.

Conclusion

ADCmin, rCBVmax and ITSS can be used for grading the IDH-mutant astrocytomas. The combination of ADCmin, ITSS and rCBVmax could improve the diagnostic performance in grading of IDH-mutant astrocytoma.
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Metadata
Title
Grading of IDH-mutant astrocytoma using diffusion, susceptibility and perfusion-weighted imaging
Authors
Xiefeng Yang
Zhen Xing
Dejun She
Yu Lin
Hua Zhang
Yan Su
Dairong Cao
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Medical Imaging / Issue 1/2022
Electronic ISSN: 1471-2342
DOI
https://doi.org/10.1186/s12880-022-00832-3

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